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Journal of Biomaterials and Nanobiotechnology 2014年第3期5卷 146-152页

作者： Hideo Sakurai Shoji Nagaoka Maki Horikawa Tomohiro Shirosaka Shuzou Kubota Kazuhiro Hamada Makoto Takafuji hirotaka Ihara Graduate School of Science and Technology Kumamoto University Kumamoto Japan Kumamoto Industrial Research Institute Kumamoto Japan Kumamoto Institute for Photo-Electro Organics (Phoenics) Kumamoto Japan

Maltose-pendant polymer/mica nanocomposites were prepared by a solution intercalation method. For organic composite part, 1) maltose-pendant polymer (homopolymer) and 2) the copolymer of maltose-pendant monomer and a small amount of N,N-Dimethylamino propylacrylamide, methyl chloride quartenary were used. The morphological studies (XRD and FE-SEM) revealed that the hybrid of maltose-pendant polymer was a conventional phase separated composite. On the other hand, the hybrid using the copolymer exhibited exfoliated structure. Both the conventional composite of maltose-pendant polymer and the nanocomposite of copolymer were applied to a coating material for oxygen gas barrier layer on a nylon-6 film, and oxygen transmission rates of the films were evaluated. Maltose-pendant polymer had a good oxygen barrier property under dry condition, and the barrier property under wet condition was improved by the hybridization with mica. In contrast, the barrier property of copolymer was slightly inferior to that of maltosependant polymer. However, under dry condition, it can be seen that the nanocomposite of copolymer improves the barrier property more effectively than the case of conventional composite of maltose-pendant polymer.

关键词： Maltose-Pendant Polymer Nanocomposite Mica Oxygen Gas Barrier Film Food Packaging

Increase in thermal stability of proteins adsorbed on biomass charcoal powder prepared from plant biomass wastes

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Journal of Biomedical Science and Engineering 2011年第11期4卷 692-698页

作者： Hidetaka Noritomi Ryotaro Kai Daiki Iwai hirotaka Tanaka Reo Kamiya Masahiko Tanaka Kohichiroh Muneki Satoru Kato 不详

Thermal stability of lysozyme adsorbed on biomass charcoal powder (BCP), which was prepared from plant biomass wastes such as dumped adzuki bean, bamboo, and wood by pyrolysis without combustion under nitrogen atmosphere and comminution with a jet mill, was examined. Adsorbing lysozyme on BCP could sufficiently prevent proteins from denaturing and aggregating in an aqueous solution at high temperatures, and enhanced the refolding of thermally denatured proteins by cooling treatment. The remaining activities of lysozyme adsorbed on BCP of adzuki bean exhibited 51% by cooling treatment after the heat treatment at 90?C for 30 min, although that of native lysozyme was almost lost under the same experimental conditions. The thermostabilization effect of BCP on the remaining activity of adsorbed lysozyme was markedly dependent upon the kind of plant biomass wastes.

关键词： Adsorption Biomass Charcoal Powder Lysozyme Refolding Remaining Activity Thermal Stability

Parental perceptions and childhood overweight/obesity: A population-based study among school children in Japan

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Health 2012年第8期4卷 506-513页

作者： Takako Shirasawa hirotaka Ochiai Tadahiro Ohtsu Rimei Nishimura Takaya Shimizu Hiromi Hoshino Naoko Tajima Akatsuki Kokaze Department of Public Health Showa University School of Medicine Tokyo Japan Division of Diabetes Metabolism and Endocrinology Department of Internal Medicine Jikei University School of Medicine Tokyo Japan Jikei University School of Medicine Tokyo Japan

The lifestyle of children is primarily controlled by their parents, and that childhood obesity is related to family variables. The aim of this study was to investigate the relationship between parental perceptions on childhood obesity and their child’s overweight/obesity in Japan. The study subjects were 3168 school children (aged 9 or 10 years) and their parents in the town of Ina, Saitama Prefecture, Japan, between 2002 and 2009. Information regarding parental perceptions about childhood obesity and the lifestyle factors of their children was collected using self-administered questionnaires completed by the participants and their parents. Childhood over-weight was defined according to the International Obesity Task Force cutoffs. Parental perceptions on childhood obesity were significantly associated with their child’s overweight status. Specifically, low perceptions regarding childhood obesity significantly increased the odds ratio (OR) for the child’s overweight status (OR: 1.86, 95% CI: 1.32 - 2.62). However, when the analysis was limited to children with both parents being overweight, there was no statistically significant difference between levels of parental perceptions and the overweight status of their children. Accordingly, the present study suggests that, when both parents are obese, not only is raising parental awareness important, but also encouraging parents to prevent themselves from becoming overweight, leads to improvements in the lifestyle habits of children, which may contribute to the prevention of childhood overweight.

关键词： Children Childhood Obesity Parental Perceptions Parental Obesity Japan

Unexpectedly Good Neurological Outcome after Prolonged Cardiac Arrest

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Open Journal of Emergency Medicine 2019年第1期7卷 1-7页

作者： Kohei Ichinohashi Tomoaki Natsukawa Takahiro Ueda hirotaka Sawano Yasuyuki Hayashi Hironori Shigeoka Yasuhide Kitazawa Atsushi Hiraide Department of Emergency and Critical Care Medicine Faculty of Medicine Kindai University Osaka Japan

Backgoround: Generally, neurological outcome of patients who have achieved return of spontaneous circulations (ROSC) with abnormal blood tests date and some severe organ complications is extremely poor. Because we experienced a case of good neurological outcome using two different types of extracorporeal membrane oxygenation (ECMO) in spite of prolonged cardiac arrest, we reported this case and reviewed the literature. Case presentation: A 36-year-old male suddenly collapsed at bar after drinking. Initial ECG showed ventricular fibrillation (VF) and subsequently underwent advanced cardiovascular life support. On admission, the ECG still showed VF, but pupillary light reflex was faintly present. Then, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support was established 54 minutes after collapse. Blood tests showed lactate was 15.8 mmol/l and NH3 of 251 μg/dl. To improve respiratory function after cardiogenic shock, we changed to veno-venous ECMO (VV-ECMO) and removed superabundant fluid using continuous hemodiafiltration. Patient was discharged on day-26 after a full functional recovery. Conclusion: In severe respiratory disorder, it would be more effective to change to VV-ECMO after recovering from cardiogenic shock while removing superabundant fluid using continuous hemodiafiltration. In predicting the neurological outcome of a post cardiac arrest patient, the presence of a pupillary light reflex may be more significant than NH3 and lactate.

关键词： Cardiac Arrest Extracorporeal Membrane Oxygenation (ECMO) Neurological Outcome

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解码日本企业的危机韧性

董事会 2020年第7期 60-61页

作者： hirotaka Takeuchi Dina Gerdeman 不详

2011年的地震和海啸证明,日本企业具有独特的长期生存能力。这得益于日本企业在动荡时期注重投资社区而不是局限于利润2011年3月11日,一场9.1级的地震引发了强烈的海啸,超过125英尺的海浪蹂躏了日本海岸,尤其是日本最大、人口最多的岛... 详细信息

2011年的地震和海啸证明,日本企业具有独特的长期生存能力。这得益于日本企业在动荡时期注重投资社区而不是局限于利润2011年3月11日,一场9.1级的地震引发了强烈的海啸,超过125英尺的海浪蹂躏了日本海岸,尤其是日本最大、人口最多的岛屿本州岛的东北部地区。将近16000人丧生,数十万人流离失所,数百万人没有电和水。铁路和公路被毁,38.3万幢建筑受损或被毁,其中包括一座核电站的三个反应堆熔毁,引发了大规模的疏散。

关键词：海啸东北部地区生存能力核电站

新型功能化聚氨酯——含螺状原碳酸酯结构的聚氨酯的制备

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国外纺织技术 1991年第2期 46-46,15页

作者： hirotaka Tagoshi 朱其妹

据报道,螺状原碳酸酯的阳离子开环转移聚合可得到聚(醚—碳酸酯),而且,在聚合过程中不发生收缩或轻微的膨胀。此外也有人报道了不饱和的螺状原碳酸酯衍生物的自由基开环异构聚合。最近,通过不饱和螺状原碳酸酯[2,7-二亚甲基-1,4,6,9-四

关键词：原碳酸不饱和衍生物开环聚氨酯聚氨基甲酸乙酯加成聚合功能化异氰酸异氰化物

Effectiveness of Multidetector Computed Tomography in Prosthetic Valve Endocarditis

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Open Journal of Thoracic Surgery 2021年第1期11卷 31-35页

作者： Kayo Sugiyama hirotaka Watanuki Masaho Okada Masaho Okada Yasuhiro Futamura Masayuki Saito Satoshi Makino Katsuhiko Matsuyama Department of Cardiac Surgery Aichi Medical University Hospital Nagakute Japan

Background: Redo aortic valve replacement for prosthetic valve endocarditis is a challenge for surgeons. Echocardiography is occasionally not an effective modality for the detection of infectious signs in prosthetic valve endocarditis. Case presentation: Herein, we report the case of a patient whose prosthetic valve endocarditis was detected by multidetector computed tomography and who successfully underwent redo aortic valve replacement. Preoperative echocardiography revealed no remarkable findings related to endocarditis such as perivalvular leakage or vegetation;however, multidetector computed tomography revealed a thickened right coronary cusp. Intraoperatively, the right coronary cusp was confirmed to be covered with thick infected tissue. The pathological findings revealed broad destruction due to infection of the right coronary cusp. Conclusion: Multidetector computed tomography was useful in detecting infectious signs in prosthetic valves.

关键词： Prosthetic Valve Endocarditis Multidetector Computed Tomography Compromised Host

Direct imaging of shock wave splitting in diamond at Mbar pressure

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Matter and Radiation at Extremes 2023年第6期8卷 90-100页

作者： Sergey Makarov Sergey Dyachkov Tatiana Pikuz Kento Katagiri hirotaka Nakamura Vasily Zhakhovsky Nail Inogamov Victor Khokhlov Artem Martynenko Bruno Albertazzi Gabriel Rigon Paul Mabey Nicholas JHartley Yuichi Inubushi Kohei Miyanishi Keiichi Sueda Tadashi Togashi Makina Yabashi Toshinori Yabuuchi Takuo Okuchi Ryosuke Kodama Sergey Pikuz Michel Koenig Norimasa Ozaki Joint Institute for High Temperatures of Russian Academy of Sciences 13/2 Izhorskaya St.125412 MoscowRussia Institute for Open and Transdisciplinary Research Initiative Osaka UniversitySuitaOsaka 565-0871Japan Graduate School of Engineering Osaka UniversitySuitaOsaka 565-0817Japan Institute of Laser Engineering Osaka UniversitySuitaOsaka 565-0871Japan Landau Institute for Theoretical Physics of Russian Academy of Sciences 1-A Akademika Semenova Ave.ChernogolovkaMoscow Region 142432Russia LULI CNRSCEAEcole PolytechniqueUPMCUniversite Paris 06:Sorbonne UniversitesInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Graduate School of Science Nagoya UniversityChikusa KuNagoyaAichi 4648602Japan Department of Physics Experimental Biophysics and Space SciencesFreie Universitat BerlinArnimallee 1414195 BerlinGermany SLAC National Accelerator Laboratory 2575 Sand Hill RoadMenlo ParkCalifornia 94025USA Japan Synchrotron Radiation Research Institute SayoHyogo 679-5198Japan RIKEN SPring-8 Center SayoHyogo 679-5148Japan Institute for Integrated Radiation and Nuclear Science Kyoto UniversityYoshida-honmachiSakyo-kuKyoto 606-8501Japan

Understanding the behavior of matter at extreme pressures of the order of a megabar(Mbar)is essential to gain insight into various physical phenomena at macroscales—the formation of planets,young stars,and the cores of super-Earths,and at microscales—damage to ceramic materials and high-pressure plastic transformation and phase transitions in *** dynamic compression of solids up to Mbar pressures,even a solid with high strength exhibits plastic properties,causing the induced shock wave to split in two:an elastic precursor and a plastic shock *** phenomenon is described by theoretical models based on indirect measurements of material *** advent of x-ray free-electron lasers(XFELs)has made it possible to use their ultrashort pulses for direct observations of the propagation of shock waves in solid materials by the method of phase-contrast ***,there is still a lack of comprehensive data for verification of theoretical models of different ***,we present the results of an experiment in which the evolution of the coupled elastic-plastic wave structure in diamond was directly observed and studied with submicrometer spatial resolution,using the unique capabilities of the x-ray free-electron laser(XFEL).The direct measurements allowed,for the first time,the fitting and validation of the 2D failure model for diamond in the range of several *** experimental approach opens new possibilities for the direct verification and construction of equations of state of matter in the ultra-high-stress range,which are relevant to solving a variety of problems in high-energy-density physics.

关键词： shock wave solids

Immune activation during neonatal exacerbates phencyclidine-induced behavioral phenotypes in adult mice

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Immune activation during neonatal exacerbates phencyclidine-...

微重力对鸡胚前庭神经节神经元形态发育的影响

国际药理学术研讨会暨第三届两岸三地药理学学术会议

作者： Yukihiro Noda Akihiro Mouri hirotaka Hida Yu Ando Kiyofumi Yamada Toshitaka Nabeshima Division of Clinical Sciences and Neuropsychopharmacology Meijo University Graduate School of Pharmaceutical Sciences Department of Neuropsychopharmacology and Hospital Pharmacy Nagoya University Graduate School of Medicine Department of Chemical Pharmacology Meijo University Graduate School of Pharmaceutical Sciences

＜正＞Aim:Viral infection during neurodevelopment is involved in the etiology of psychiatric diseases including *** is a high prevalence of substance use disorder in first-episode *** examined whether the combination of a neonatal viral infection with an adolescent substance use affect on psychological function in ***:We subjected behavioral tests to

关键词： Viral infection Neonatal Neurodevelopment Phencyclidine Behaviors Psychiatric diseases

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郑州大学学报（医学版） 2004年第3期39卷 452-455页

作者：陈向东 Cesar D.Fermin Dale Martin hirotaka Hara Jun Hara 郑州大学第二附属医院耳鼻咽喉科 Department of Pathology&Laboratory Medicine Tulane UniversityNew OrleansLA701122699USA Department of Otolaryngology Yamaguchi UniversityUbeYamaguchi755Japan

目的 :探讨太空微重力对鸡胚前庭神经元形态发育的影响。方法 :随机选取太空发育鸡胚和地面发育鸡胚各 2只 ,利用计算机显微测量技术测量前庭神经元切面的面积、周长、形态系数 ,每只鸡胚测量 2 0 0个神经元。结果 :2只太空发育鸡胚的... 详细信息

目的 :探讨太空微重力对鸡胚前庭神经元形态发育的影响。方法 :随机选取太空发育鸡胚和地面发育鸡胚各 2只 ,利用计算机显微测量技术测量前庭神经元切面的面积、周长、形态系数 ,每只鸡胚测量 2 0 0个神经元。结果 :2只太空发育鸡胚的前庭神经元切面面积的中位数分别是 2 30 .5 5 1 μm2 和 2 0 2 .81 9μm2 ,均高于 2只地面发育鸡胚的 1 6 2 .6 5 9μm2 和 1 2 3.1 38μm2 ;周长的中位数分别是 5 8.836 μm和 5 5 .36 5 μm ,高于地面鸡胚的 4 9.35 7μm和4 3.4 81 μm ;形态系数的中位数分别是 0 .86 2和 0 .86 4 ,与地面鸡胚的 0 .85 4和 0 .86 1比较 ,差异无统计学意义 (P >0 .1 )。结论 :太空发育鸡胚的前庭神经元体积大于地面发育鸡胚前庭神经元体积 ,而形状无差异。

关键词：航天飞机鸡胚前庭神经节微重力发育