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Novel interface regulation of Sn1.0Ag0.5Cu composite solders reinforced with modified ZrO_(2):Microstructure and mechanical properties

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Journal of Materials Science & Technology 2022年第30期125卷 157-170页

作者： Fupeng Huo Zhi Jin Duy Le Han Jiahui Li Keke Zhang hiroshi Nishikawa Joining and Welding Research Institute Osaka UniversityIbarakiOsaka 565-0047Japan Graduate School of Engineering Osaka UniversitySuitaOsaka 565-0871Japan School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Department of Welding Engineering and Metals Technology School of Mechanical EngineeringHanoi University of Science and TechnologyNo.1 Dai Co VietHai Ba TrungHanoiViet Nam

With the trends of miniaturization and high density of electronic packaging,there has been an urgent demand to open up lead-free solders with high strength and *** this study,a ZrO_(2)-reinforced Sn1.0Ag0.5Cu composite solder was ***,surface modification on ZrO_(2) was conducted with ball milling-pyrolysis ***,NiO modified ZrO_(2)(NiO/ZrO_(2))was added to the solder matrix with ultrasonic *** morphology and interface of NiO/ZrO_(2) were ***,the microstructure,interface and mechanical properties of the composite solders were systematically *** results showed that NiO nanoparticles were evenly adhered to the ZrO_(2) surface,and the interface relationship between them was semi-coherent and ***,an appropriate addition of NiO/ZrO_(2) could refine the microstructure of composite *** refinement mechanism was systematically ***,a micro-mechanical lock and non-micropored clean interface was formed between NiO/ZrO_(2) and the solder *** Sn/NiO/ZrO_(2) interface system based on mutual solid solution was ingeniously *** ultimate tensile strength and elongation were increased synergistically,and the fracture mechanism transformed from a ductile−brittle mixed fracture mode to a ductile fracture ***,a lead-free solder with high strength and ductility was obtained.

关键词： SnAgCu composite solder ZrO_(2)nanoparticles Refinement mechanism Surface modification Interface Reinforcements

Therapeutic potential of prophylactic exercise for intracerebral hemorrhage

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Neural Regeneration Research 2022年第7期17卷 1484-1485页

作者： Keita Kinoshita Kelly K.Chung hiroshi Katsuki Ken Arai Neuroprotection Research Laboratory Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA Department of Chemico-Pharmacological Sciences Graduate School of Pharmaceutical SciencesKumamoto UniversityKumamotoJapan

Exercise and brain health:Physical activity helps promote and maintain our brain health,including memory and cognitive *** has shown that exercise is a safe behavioral intervention that reduces the risk of hypokinetic... 详细信息

关键词： diseases Therapeutic hemorrhage

Generalized-Extended-State-Observer and Equivalent-Input-Disturbance Methods for Active Disturbance Rejection: Deep Observation and Comparison

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IEEE/CAA Journal of Automatica Sinica 2023年第4期10卷 957-968页

作者： Jinhua She Kou Miyamoto Qing-Long Han Min Wu hiroshi Hashimoto Qing-Guo Wang School of Engineering Tokyo University of TechnologyHachiojiTokyo 192-0982Japan K.Miyamoto is with the Institute of Technology Shimizu CorporationKotoTokyo 135-0044Japan School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourneVIC 3122Australia School of Automation China University of GeosciencesWuhan 430074 Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of EducationWuhan 430074China School of Industrial Technology Advanced Institute of Industrial TechnologyTokyo 140-0011Japan Institute of Artificial Intelligence and Future Networks Beijing Normal UniversityZhuhai 519087 Guangdong Key Lab of AI and Multi-Modal Data Processing Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science BNUHKBU United International College Zhuhai 519087China

Active disturbance-rejection methods are effective in estimating and rejecting disturbances in both transient and steady-state *** paper presents a deep observation on and a comparison between two of those methods:the generalized extended-state observer(GESO)and the equivalent input disturbance(EID)from assumptions,system configurations,stability conditions,system design,disturbance-rejection performance,and extensibility.A time-domain index is introduced to assess the disturbance-rejection performance.A detailed observation of disturbance-suppression mechanisms reveals the superiority of the EID approach over the GESO method.A comparison between these two methods shows that assumptions on disturbances are more practical and the adjustment of disturbance-rejection performance is easier for the EID approach than for the GESO method.

关键词： Active disturbance-rejection control(ADRC) disturbance observer(DOB) equivalent input disturbance(EID) extendedstate observer(ESO) generalized extended-state observer(GESO)

Intermittent compressive force induces cell cycling and reduces apoptosis in embryoid bodies of mouse induced pluripotent stem cells

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International Journal of Oral Science 2022年第1期14卷 40-50页

作者： Jeeranan Manokawinchoke Phoonsuk Limraksasin Hiroko Okawa Prasit Pavasant hiroshi Egusa Thanaphum Osathanon Division of Molecular and Regenerative Prosthodontics Tohoku University Graduate School of DentistrySendaiMiyagiJapan Dental Stem Cell Biology Research Unit and Department of Anatomy Faculty of DentistryChulalongkorn UniversityBangkokThailand Center for Advanced Stem Cell and Regenerative Research Tohoku University Graduate School of DentistrySendaiMiyagiJapan

In vitro manipulation of induced pluripotent stem cells(iPSCs) by environmental factors is of great interest for three-dimensional(3D) tissue/organ induction. The effects of mechanical force depend on many factors, including force and cell type. However,information on such effects in i PSCs is lacking. The aim of this study was to identify a molecular mechanism in i PSCs responding to intermittent compressive force(ICF) by analyzing the global gene expression profile. Embryoid bodies of mouse i PSCs, attached on a tissue culture plate in 3D form, were subjected to ICF in serum-free culture medium for 24 h. Gene ontology analyses for RNA sequencing data demonstrated that genes differentially regulated by ICF were mainly associated with metabolic processes,membrane and protein binding. Topology-based analysis demonstrated that ICF induced genes in cell cycle categories and downregulated genes associated with metabolic processes. The Kyoto Encyclopedia of Genes and Genomes database revealed differentially regulated genes related to the p53 signaling pathway and cell cycle. q PCR analysis demonstrated significant upregulation of Ccnd1, Cdk6 and Ccng1. Flow cytometry showed that ICF induced cell cycle and proliferation, while reducing the number of apoptotic cells. ICF also upregulated transforming growth factor β1(Tgfb1) at both m RNA and protein levels, and pretreatment with a TGF-β inhibitor(SB431542) prior to ICF abolished ICF-induced Ccnd1 and Cdk6 expression. Taken together,these findings show that TGF-β signaling in i PSCs enhances proliferation and decreases apoptosis in response to ICF, that could give rise to an efficient protocol to manipulate i PSCs for organoid fabrication.

关键词： cycling culture attached

Age and Gender-Related Differences in Hypotensive and Hypertensive Responses to Stellate Ganglion Block

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Open Journal of Anesthesiology 2017年第7期7卷 175-183页

作者： Shigeru yokota Chikuni Taneyama hiroshi Goto Chishukai Taneyama Clinic Nagano Japan Department of Anesthesiology University of Kansas Medical Center Kansas City USA

Purpose: The aim of the current study was to investigate: 1) Whether there is an association between age and changes in systolic blood pressure (SBP) after stellate ganglion block (SGB), and 2) Whether gender plays a role in hypotensive and hypertensive responses to SGB. Methods: We retrospectively reviewed SBP changes (ΔSBP) due to SGB, which were performed on 1641 subjects. SBP 30 min after SGB was compared to the baseline values. For the age study, average age of both sexes was calculated for six ranges of ΔSBP. For the gender study, the numbers of subjects (%) in various ranges of positive and negative values of ΔSBP were compared between men and women. Results: There was a significant association between age and both increasing (p Conclusions: There was an association between age and blood pressure changes after SGB and the association is most likely due to age-related alteration of cardiovascular functions. The different changes of SBP between men and women after SGB may well be attributable to gender differences of autonomic nervous regulation;sympathetic dominant man versus, parasympathetic dominant women.

关键词： Stellate Ganglion Block Hypertension Hypotension Gender Age

Chiral ligand-protected gold nanoclusters: Considering the optical activity from a viewpoint of ligand dissymmetric field

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Progress in Natural Science:Materials International 2016年第6期26卷 428-439页

作者： hiroshi Yao Graduate School of Material Science University of Hyogo

Chirality is a geometric property of a physical, chemical, or biological object, which is not superimposable on its mirror image. Its significant presence has led to a strong demand in the development of chiral drugs, sensors,catalysts, and photofunctional materials. In recent years, chirality of nanoscale organic/inorganic hybrids has received tremendous attention owing to potential applications in chiral nanotechnology. In particular, with the recent progress in the syntheses and characterizations of atomically precise gold nanoclusters protected by achiral thiolates, atomic level origins of their chirality have been unveiled. On the other hand, chirality or optical activity in metal nanoclusters can also be introduced via the surface chiral ligands, which should be universal for the nanosystems. This tutorial review presents some optically-active metal(gold) nanoclusters protected by chiral thiolates or phosphines, and their chiroptical(or circular dichroism; CD) properties are discussed mostly from a viewpoint of the ligand dissymmetric field scheme. The examples are the gold nanoclusters protected by(R)-/(S)-2-phenylpropane-1-thiol,(R)-/(S)-mercaptosuccinic acid, phenylboronateD/L-fructose complexes, phosphine sulfonate-ephedrinium ion pairs, or glutathione. Some methodologies for versatile asymmetric transformation and chiroptical controls of the nanocluster compounds are also *** the dissymmetric field model as the origin of optical activity, the chiroptical responses of the gold nanoclusters are strongly associated with coupled oscillator and/or CD stealing mechanisms based on the concept of induced CD(ICD) derived from a perturbation theory, so on this basis, some characteristic features of the observed CD responses of chiral ligand-protected gold nanoclusters are presented in detail. We believe that various kinds of origins of chirality found in ligand-protected gold nanoclusters may provide models for understanding those of many related nanomater

关键词： Chiral ligand Monolayer-protected gold nanoclusters Dissymmetric field model Induced CD Asymmetric transformation Alloying effect

Bayesian optimization with experimental failure for high-throughput materials growth

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npj Computational Materials 2022年第1期8卷 1746-1754页

作者： Yuki K.Wakabayashi Takuma Otsuka Yoshiharu Krockenberger hiroshi Sawada Yoshitaka Taniyasu Hideki Yamamoto NTT Basic Research Laboratories NTT CorporationAtsugiKanagawa243-0198Japan NTT Communication Science Laboratories NTT CorporationSoraku-gunKyoto619-0237Japan

A crucial problem in achieving innovative high-throughput materials growth with machine learning,such as Bayesian optimization(BO),and automation techniques has been a lack of an appropriate way to handle missing data due to experimental ***,we propose a BO algorithm that complements the missing data in optimizing materials growth *** proposed method provides a flexible optimization algorithm that searches a wide multi-dimensional parameter *** demonstrate the effectiveness of the method with simulated data as well as in its implementation for actual materials growth,namely machine-learning-assisted molecular beam epitaxy(ML-MBE)of SrRuO_(3),which is widely used as a metallic electrode in oxide *** the exploitation and exploration in a wide three-dimensional parameter space,while complementing the missing data,we attained tensile-strained SrRuO3 film with a high residual resistivity ratio of 80.1,the highest among tensile-strained SrRuO3 films ever reported,in only 35 MBE growth runs.

关键词： optimization strained resistivity

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敦煌与佛传文学

长江学术 2024年第1期 83-96页

作者： [日]荒见泰史胡逸蝶(译) 刘丹(校) 广岛大学人文科学学院日本广岛739-0046 湖北中医药大学外国语学院湖北武汉430065 武汉大学文学院湖北武汉430072

敦煌留存有大量造型艺术及文字资料,公元4世纪左右,最早期的敦煌壁画中便已有了与佛传故事相关的内容。从佛传类壁画和写本中,可以探知统治者和宗教人士传教的目的,以及宗教徒的关心点所在。壁画和写本多取材于通过各种方式传承下来的... 详细信息

敦煌留存有大量造型艺术及文字资料,公元4世纪左右,最早期的敦煌壁画中便已有了与佛传故事相关的内容。从佛传类壁画和写本中,可以探知统治者和宗教人士传教的目的,以及宗教徒的关心点所在。壁画和写本多取材于通过各种方式传承下来的佛传故事,传承的依据是从佛经中摘录出来的抄略。公元9—10世纪,口传佛传故事逐渐被整理为讲唱文本。壁画、口头传承、讲唱文学三者有着密切的联系,在相互影响的过程中流传开来。

关键词：敦煌壁画敦煌文献佛传文学

Rikkunshito increases peripheral incretin-hormone levels in humans and rats

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World Journal of Methodology 2024年第1期14卷 102-113页

作者： hiroshi Kono Shinji Furuya Hidenori Akaike Katsutoshi Shoda Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Daisuke Ichikawa The First Department of Surgery University of YamanashiChuoYamanashi 409-3898Japan

BACKGROUND It was reported that rikkunshito(TJ-43)improved the cisplatin-induced decreases in the active form of ghrelin in plasma;however,other effects on gastrointestinal hormones have not been *** To investigate the effects of TJ-43 on peripheral levels of incretin hormones,including gastric inhibitory polypeptide(GIP)and glucagon-like polypeptide-1(GLP-1),in humans and *** Patients were divided into two groups,namely patients who received TJ-43 immediately following surgery[TJ-43(+)group]and those who received TJ-43 on postoperative day 21[TJ-43(-)group],and the plasma levels of active GIP and active GLP-1 were *** animal experiments,rats were treated with TJ-43[rat(r)TJ-43(+)group]or without[rTJ-43(−)group]by gavage for 4 wk,and the plasma active GIP and active GLP-1 levels were *** expression of incretin hormones in the gastrointestinal tract and insulin in the pancreas were investigated by ***,the cyclic adenosine monophosphate activities were assessed in pancreatic tissues from rats treated with or without TJ-43 in vivo,and the blood glucose levels and plasma insulin levels were measured in rats treated with or without TJ-43 in oral glucose tolerance *** In humans,the active incretin hormone levels increased,and values were significantly greater in the TJ-43(+)group compared those in the TJ-43(-)*** rats,the plasma active incretin levels significantly increased in the rTJ-43(+)group compared with those in the rTJ-43(-)*** and GLP-1 expressions were enhanced by TJ-43 ***,plasma insulin levels increased and blood glucose levels were blunted in the rTJ-43(+)*** The results show that TJ-43 may be beneficial for patients who undergo pancreatic surgery.

关键词： Incretin hormone Japanese traditional herbal medicine Gastric inhibitory polypeptide Glucagon-like polypeptide-1 Islet cells Insulin