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中国稀土学报 2002年第1期20卷 45-48页

作者：邱关明高建和张明李幼荣井上真一冈本弘长春光学精密机械学院材料化工系吉林长春130021 扬州大学工学院机械系江苏扬州225009 扬州大学理学院化学化工系江苏扬州225002 日本爱知工业大学应用化学系

用聚甲基丙烯酸甲酯 (PMMA)对水玻璃、硝酸铝和α 甲基丙烯酸形成的硅铝氧烷溶胶进行包裹 ,得到PMMA包裹的硅铝氧烷凝胶 ,同时在反应过程中用稀土离子进行掺杂 ,得到的稀土掺杂PMMA微囊粉末填充到天然橡胶之中 ,经力学性能分析发现杨氏... 详细信息

用聚甲基丙烯酸甲酯 (PMMA)对水玻璃、硝酸铝和α 甲基丙烯酸形成的硅铝氧烷溶胶进行包裹 ,得到PMMA包裹的硅铝氧烷凝胶 ,同时在反应过程中用稀土离子进行掺杂 ,得到的稀土掺杂PMMA微囊粉末填充到天然橡胶之中 ,经力学性能分析发现杨氏模量普遍提高 ,抗疲劳效果显著 ,一万次伸张疲劳后 ,拉伸强度的保持率比参照样品提高两倍以上。

关键词：稀土硅铝氧烷凝胶天然橡胶力学性能抗疲劳 PMMA 包裹聚甲基丙烯酸甲酯

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Thyroid hormone alterations in trauma patients requiring massive transfusion: An observational study

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World Journal of Emergency Medicine 2014年第4期5卷 270-274页

作者： Toru Hifumi Ichiro Okada Nobuaki Kiriu Eiju Hasegawa Tomoko Ogasawara hiroshi Kato Yuichi Koido Junichi Inoue Yuko Abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda Emergency Medical Center Kagawa University Hospital Division of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center Division of Critical Care Medicine and Trauma Yamanashi Prefectural Central Hospital

BACKGROUND: Although non-thyroidal illness syndrome(NTIS) is considered a negative prognostic factor, the alterations in free triiodothyronine(f T3) levels in trauma patients requiring massive transfusion have not been ***: A prospective observational study comparing 2 groups of trauma patients was conducted. Group M comprised trauma patients requiring massive transfusions(>10 units of packed red blood cells) within 24 hours of emergency admission. Group C comprised patients with an injury severity score >9 but not requiring massive transfusions. Levels of f T3, free thyroxine(f T4), and thyroidstimulating hormone(TSH) were evaluated on admission and on days 1, 2, and 7 after admission. The clinical backgrounds and variables measured including total transfusion amounts were compared and the inter-group prognosis was evaluated. Results are presented as mean±standard ***: Nineteen patients were enrolled in each group. In both groups, 32 were men, and the mean age was 50±24 years. In group C one patient died from respiratory failure. The initial f T3 levels in group M(1.95±0.37 pg/m L) were signifi cantly lower than those in group C(2.49±0.72 pg/m L; P<0.01) and remained low until 1 week after admission. Initial inter-group f T4 and TSH levels were not significantly different. TSH levels at 1 week(1.99±1.64 μIU/m L) were higher than at admission(1.48±0.5 μIU/m L) in group C(P<0.05).CONCLUSION: Typical NTIS was observed in trauma patients requiring massive transfusions. When initial resuscitation achieved circulatory stabilization, prognosis was not strongly associated with NTIS.

关键词： Non-thyroidal illness syndrome Massive transfusion Trauma Freetriiodothyronine Thyroid hormone

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PERCIST用于头颈部鳞状细胞癌患者放化疗疗效评价及预后预测

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中华核医学与分子影像杂志 2018年第12期38卷 839-839页

作者：唐军(译) Takayuki Katsuura Kazuhiro Kitajirma Masayuki Fujiwara Tomonori Terada Nobuhiro Uwa Kazuma Noguchi hiroshi Doi Yukihisa Tamaki Rika Yoshida Tatsuya Tsuchitani Masahiro Fujita Koichiro Yamakado 上海交通大学医学院附属苏州九龙医院核医学科 215021 Division of Nuclear Medicine and PET Center Department of Radiology Hyogo College of MedicineNishinomiya Japan

目的探讨PET实体瘤疗效评价标准(PERCIST)评价头颈部鳞状细胞癌(HNSCC)患者放化疗疗效及预测复发和死亡的价值。方法42例患者(平均年龄63岁,范围20~79岁)在放化疗前及放化疗后约3个月(平均95d,范围70~119d)行脱氧葡萄糖(FDG)-PET/CT显像... 详细信息

目的探讨PET实体瘤疗效评价标准(PERCIST)评价头颈部鳞状细胞癌(HNSCC)患者放化疗疗效及预测复发和死亡的价值。方法42例患者(平均年龄63岁,范围20~79岁)在放化疗前及放化疗后约3个月(平均95d,范围70~119d)行脱氧葡萄糖(FDG)-PET/CT显像,其中包括10例鼻咽癌、13例口咽癌、11例下咽癌及8例喉癌。与PERCIST相关的无进展生存时间(PFS)和总生存时间(OS)采用对数秩检验和Cox回归分析进行统计学处理。结果PERCIST确定的完全代谢反应(CMR,即病灶FDG摄取降低至肝脏的平均活度水平以下或病灶FDG摄取与周围组织无明显差别)、部分代谢反应[PMR,即经去脂体质量校正的高峰标准摄取值(SULpeak)下降30%及以上]、稳定代谢反应(SMD,即FDG摄取无明显变化)和病灶代谢增加(PMD,即SULpeak增加30%及以上)的患者数分别为30例(71.4%)、9例(21.4%)、3例(7.1%)和0例。

关键词：头颈部鳞状细胞癌 FDG-PET/CT PERCIST 治疗效果预后

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Meta-analysis of lymph node metastasis in Siewert type Ⅰ and Ⅱ T1 adenocarcinomas

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World Journal of Meta-Analysis 2016年第6期4卷 118-123页

作者： Hiroki Osumi Junko Fujisaki Masami Omae Tomoki Shimizu Toshiyuki Yoshio Akiyoshi Ishiyama Toshiaki Hirasawa Tomohiro Tsuchida Yorimasa Yamamoto hiroshi Kawachi Noriko Yamamoto Masahiro Igarashi Departments of Gastroenterology and Pathology Cancer Institute Hospital Japanese Foundation for Cancer Research Departments of Pathology Cancer Institute Hospital Japanese Foundation for Cancer Research

AIM To evaluate the incidence of lymph node metastasis(LNM) and its risk factors in patients with Siewert type Ⅰ and type Ⅱ pT1 *** We enrolled 85 patients [69 men, 16 women; median age(range), 67(38-84) years] who had undergone esophagectomy or proximal gastrectomy for Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas. Predictive risk factors of LNM included age, sex, location of the tumor center, confirmed Barrett's esophageal adenocarcinoma, tumor size, macroscopic tumor type, pathology, invasion depth, presence of ulceration, and lymphovascular invasion. Multivariate logistic regression analysis was used to identify factors predicting LNM. We also evaluated the frequencies of LNM for Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas in meta-data *** LNMs were found in 11 out of 85 patients(12.9%, 95%CI: 5.8-20.0). Only 1 of the 15 patients(6.6%, 95%CI: 0.0-19.2) who had a final diagnosis of pT1a adenocarcinoma had a positive LNM, whereas 10 ofthe 70 patients(14.2%, 95%CI: 6.0-22.4) with a final diagnosis of pT1b adenocarcinoma had positive LNM. Furthermore, only one of the 30 patients(3.3%, 95%CI: 0.0-9.7) with a tumor invasion depth within 500 μm from muscularis mucosae had positive LNM. Poor differentiation and lymphovascular invasion were independently associated with a risk of LNM. In meta-data analysis, 12 of the 355 patients(3.3%, 95%CI: 1.5-5.2) who had a final diagnosis of pT1a adenocarcinoma had a positive LNM, whereas 91 of the 438 patients(20.7%, 95%CI: 16.9-24.5) with a final diagnosis of pT1b adenocarcinoma had positive LNM. CONCLUSION We consider endoscopic submucosal dissection(ESD) is suitable for patients with Siewert type Ⅰ and type Ⅱ T1 a adenocarcinomas. For patients with T1b adenocarcinoma, especially invasion depth is within 500 μm from muscularis mucosae with no other risk factor for LNM, diagnostic ESD could be a treatment option according to the overall status of patients and the presence of comorbidities.

关键词： Siewert type Ⅰ and type Ⅱ adenocarcinomas Lymph node metastasis

Scoring criteria for determining the safety of liver resection for malignant liver tumors

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World Journal of Meta-Analysis 2019年第5期7卷 234-248页

作者： Kohei Harada Minoru Nagayama Yoshiya Ohashi Ayaka Chiba Kanako Numasawa Makoto Meguro Yasutoshi Kimura hiroshi Yamaguchi Masahiro Kobayashi Koji Miyanishi Junji Kato Toru Mizuguchi Departments of Surgery Surgical Scienceand OncologySapporo Medical UniversitySapporoHokkaido 060-8556Japan Division of Radiology Sapporo Medical University HospitalSapporoHokkaido 060-8556Japan Sapporo Medical University Postgraduate School of Health Science and Medicine Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Research and Education Center for Clinical Pharmacy Kitasato University School of PharmacyTokyo 108-8641Japan Department of Internal Medicine IV Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Department of Nursing and Surgical Science Sapporo Medical UniversitySapporo 0608543Japan

BACKGROUND Liver resection has become safer as it has become less ***,the minimum residual liver volume(RLV)required to maintain homeostasis is ***,the formulae used to calculate standard liver volume(SLV)are *** To review previously reported SLV formulae and the methods used to evaluate the minimum RLV,and explore the association between liver volume and *** A systematic review of Medline,PubMed,and grey literature was *** in the retrieved articles were cross-checked manually to obtain further *** last search was conducted on January 20,*** developed an SLV formula using data for 86 consecutive patients who underwent hepatectomy at our institution between July 2009 and August *** Linear regression analysis revealed the following formula:SLV(mL)=822.7×body surface area(BSA)?183.2(R2=0.419 and R=0.644,P<0.001).We retrieved 25 studies relating to SLV formulae and 12 studies about the RLV required for safe liver *** the previously reported formulae included various coefficient and constant values,a simplified version of the SLV,the common SLV(cSLV),can be calculated as follows:cSLV(mL)=710 or 770×*** minimum RLV for normal and damaged livers ranged from 20%-40%and 30%-50%,*** Sapporo score indicated that the minimum RLV ranges from 35%-95%depending on liver *** We reviewed SLV formulae and the minimum RLV required for safe liver *** Sapporo score is the only liver function-based method for determining the minimum RLV.

关键词： Standard liver volume Residual liver volume Hepatectomy Mortality Liver failure Liver function

Increase in colonic diverticular hemorrhage and confounding factors

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第3期7卷 440-446页

作者： Ken Kinjo Toshiyuki Matsui Takashi Hisabe hiroshi Ishihara Shinichiro Maki Kenta Chuman Akihiro Koga Kensei Ohtsu Noritaka Takatsu Fumihito Hirai Kenshi Yao Masakazu Washio Department of Gastroenterology Fukuoka University Chikushi Hospital Department of Community Health and Clinical Epidemiology St.Mary’s College

AIM: To classify changes over time in causes of lower gastrointestinal bleeding(LGIB) and to identify factors associated with changes in the incidence and characteristics of diverticular hemorrhage(DH).METHODS: A total of 1803 patients underwent colonoscopy for overt LGIB at our hospital from 1995 to 2013. Patients were divided into an early group(EG, 1995-2006, n = 828) and a late group(LG, 2007-2013, n = 975), and specific diseases were compared between groups. In addition, antithrombotic drug(ATD) use and nonsteroidal anti-inflammatory drug(NSAID) use were comparedbetween patients with and without DH. RESULTS: Older patients(≥ 70 years old) and those with colonic DH were more frequent in LG than in EG(P < 0.01). Patients using ATDs as well as NSAIDs, male sex, obesity(body mass index ≥ 25 kg/m2), smoking, alcohol drinking, and arteriosclerotic diseases were more frequent in patients with DH than in those without. CONCLUSION: Incidence of colonic DH seems to increase with aging of the population, and factors involved include use of ATDs and NSAIDs, male sex, obesity, smoking, alcohol drinking, and arteriosclerotic disease. These factors are of value in handling DH patients.

关键词： Lower gastrointestinal bleeding Colonic diverticular hemorrhage Increase of incidence Aging

Reduced port surgery for appendectomy:Early experience and surgical technique

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World Journal of Surgical Procedures 2013年第2期3卷 8-12页

作者： Shinichiro Mori Kenji Baba Shigehiro Yanagita Yoshiaki Kita Kosei Maemura Yuko Mataki Yasuto Uchikado hiroshi Okumura Tetsuhiro Nakajyo Shoji Natsugoe Sonshin Takao Kuniaki Aridome Department of Digestive Surgery Breast and Thyroid Surgery Graduate School of Medicine Kagoshima University Kagoshima 890-8520 Japan Frontier Science Research Center Kagoshima University Kagoshima 890-8520 Japan Department of Surgery Nanpuh Hospital NKagoshima 892-8512 Japan

AIM: To evaluate our experience and surgical technique of laparoscopic appendectomy via reduced port surgery(LARPS). METHODS: Sixteen patients(8 men and 8 women; median age: 31.0 years) who underwent LARPS between November 2009 and May 2012 were included in the present study. We performed LARPS, in which access devices were inserted through an umbilical skin incision with 1 additional skin incision in the left lower abdomen. After setting access devices, pneumoperitoneum was maintained at 10 mmH g using CO2 and a 3 mm trocar was positioned(or direct puncture was performed by the Endo Relief system) under laparoscopic guidance. The mesoappendix was dissected using an ultrasonically activated device. After mesoappendix dissection, ligation was performed near the appendix base and the appendix was dissected using an ultrasonically activated device. The appendix was then removed. At the end of surgery, we administered local anesthesia with ropivacaine 1%(10 mL) for the skin incisions. The outcomes were evaluated in terms of operation time, intraoperative blood loss, length of postoperative hospital stay and surgical complications. RESULTS: Our surgical procedure allowed operators to use instruments as in conventional laparoscopic appendectomy. The basic principle of triangulation of instrumentation was maintained to some degree. LARPS was performed in 9 patients with catarrhal appendicitis, 5 with phlegmonous appendicitis, and 2 with gangrenous appendicitis. The median surgery time was 60 min and the median intraoperative blood loss was 1.2 mL. The median length of postoperative hospitalization was 4 d. There were no conversions to open surgery, no operation-related complications or mortality. CONCLUSION: Our experience and surgical technique suggest that LARPS is a safe and feasible procedure for patients with appendicitis.

关键词： Reduced port surgery Appendectomy Laparoscopy Cosmesis Single incision

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抗老化、耐臭氧、耐油的硫化橡胶组成物

弹性体 2000年第3期10卷 60-60页

作者： Shirata,Takashi Hosoya,Mikio Kikuehi,Yoshiharu Kanda,hiroshi Kawasaki,Masaaki

本专利介绍了一种具有抗老化、耐臭氧、耐油的硫化橡胶组成物的制备。该组成物组分为：有机过氧化物；比例为1～99：1～99的二烯烃和其它共聚物所组成的混合物。其它共聚物包括：C2H4，C3-20α-烯烃和末端乙烯其降冰片烯QR^1R^2[Q=降冰... 详细信息

本专利介绍了一种具有抗老化、耐臭氧、耐油的硫化橡胶组成物的制备。该组成物组分为：有机过氧化物；比例为1～99：1～99的二烯烃和其它共聚物所组成的混合物。其它共聚物包括：C2H4，C3-20α-烯烃和末端乙烯其降冰片烯QR^1R^2[Q=降冰片烯，R^1=H或C1-10芳香基，R^2=CH2或(C2)nCHR^3CH；

关键词：组成物耐油耐臭氧硫化橡胶抗老化共聚物 α-烯烃乙烯比例专利

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化学泵浦的碘激光器

中国激光 1983年第Z1期 589-589页

作者： Kazuhiko Serizawa Akira Otsuka hiroshi Murata Taro Uchiyama Tomoo Fujioka 日本庆应大学电工系日本庆应大学电工系日本庆应大学电工系日本庆应大学电工系日本庆应大学电工系

本文给出了使用小尺寸真空泵的在低流速（2米/秒）下运转的横流化学泵浦碘激光器的性能。由化学发生器射出的气流经一个干冰乙醇吸附器,从而除去作为受激体的有效猝灭剂的水蒸气。激光器部分由一个70×2cm的管道组成,1m长的腔安装在离I... 详细信息

本文给出了使用小尺寸真空泵的在低流速（2米/秒）下运转的横流化学泵浦碘激光器的性能。由化学发生器射出的气流经一个干冰乙醇吸附器,从而除去作为受激体的有效猝灭剂的水蒸气。激光器部分由一个70×2cm的管道组成,1m长的腔安装在离I2注入点大约0.8cm的下游处,共振腔由两块反射镜组成:一块曲率半径为5米的全反射镜,另一块部分透过（T=1.5％）的平面镜。喉高为0.6cm的喷嘴放置在腔轴处,以便使分子碘和氧有效地混合。在90％（重量）H2O2,为1.1升和25％（重量）NaOH为0.5升时,采用大于40％的

关键词：碘激光器吸附器气体净化设备碘分子