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Expression analyses of stress‑responsive genes in the hermatypic coral Acropora tenuis and its symbiotic dinofagellates after exposure to the herbicide Diuron

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Marine Life Science & Technology 2023年第3期5卷 289-299页

作者： hiroshi Ishibashi Seigo Minamide Ichiro Takeuchi Graduate School of Agriculture Ehime UniversityMatsuyamaEhime 790-8566Japan Center of Advanced Technology for the Environment Graduate School of AgricultureEhime UniversityMatsuyamaEhime 790-8566Japan

Diuron is one of the most frequently applied herbicides in sugarcane farming in southern Japan,and *** addition,it is used as a booster substance in copper-based antifouling *** to these various uses,Diuron is released into the marine environment;however,little information is available on gene expression in corals and their symbiotic algae exposed to *** investigated the efects of Diuron on stress-responsive gene expression in the hermatypic coral Acropora tenuis and its symbiotic *** seven days of exposure to 1µg/L and 10µg/L Diuron,no signifcant changes in the body colour of corals were ***,quantitative reverse transcription-polymerase chain reaction analyses revealed that the expression levels of stress-responsive genes,such as heat shock protein 90(HSP90),HSP70,and calreticulin(CALR),were signifcantly downregulated in corals exposed to 10µg/L of Diuron for seven ***,aquaglyceroporin was signifcantly downregulated in corals exposed to environmentally relevant concentrations of 1µg/L *** contrast,no such efects were observed on the expression levels of other stress-responsive genes,such as oxidative stress-responsive proteins,methionine adenosyltransferase,and green/red fuorescent *** exposure had no signifcant efect on the expression levels of HSP90,HSP70,or HSP40 in the symbiotic *** results suggest that stress-responsive genes,such as HSPs,respond diferently to Diuron in corals and their symbiotic dinofagellates and that *** HSPs and CALRs may be useful molecular biomarkers for predicting stress responses induced by the herbicide Diuron.

关键词： Acropora tenuis Calreticulin Coral bleaching Diuron Heat shock protein

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FIB Secondary Etching Method for Fabrication of Fine CNT Forest Metamaterials

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Nano-Micro Letters 2017年第4期9卷 73-80页

作者： Adam Pander Akimitsu Hatta hiroshi Furuta Department of Electronic and Photonic Systems Engineering Kochi University of TechnologyTosayamadaKamiKochi 782-8502Japan Center for Nanotechnology Research InstituteKochi University of TechnologyTosayamadaKamiKochi 782-8502Japan

Anisotropic materials, like carbon nanotubes(CNTs), are the perfect substitutes to overcome the limitations of conventional metamaterials; however, the successful fabrication of CNT forest metamaterial structures is still very challenging. In this study, a new method utilizing a focused ion beam(FIB) with additional secondary etching is presented, which can obtain uniform and fine patterning of CNT forest nanostructures for metamaterials and ranging in sizes from hundreds of nanometers to several micrometers. The influence of the FIB processing parameters on the morphology of the catalyst surface and the growth of the CNT forest was investigated, including the removal of redeposited material,decreasing the average surface roughness(from 0.45 to 0.15 nm), and a decrease in the thickness of the Fe *** results showed that the combination of FIB patterning and secondary etching enabled the growth of highly aligned, highdensity CNT forest metamaterials. The improvement in the quality of single-walled CNTs(SWNTs), defined by the very high G/D peak ratio intensity of 10.47, demonstrated successful fine patterning of CNT forest for the first time. With a FIB patterning depth of 10 nm and a secondary etching of 0.5 nm, a minimum size of 150 nm of CNT forest metamaterials was achieved. The development of the FIB secondary etching method enabled for the first time, the fabrication of SWNT forest metamaterials for the optical and infrared regime, for future applications, e.g., in superlenses, antennas,or thermal metamaterials.

关键词： Carbon nanotubes Metamaterial FIB patterning Secondary etching method Chemical vapor deposition

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Problems associated with glucose toxicity:Role of hyperglycemia-induced oxidative stress

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World Journal of Gastroenterology 2009年第33期15卷 4137-4142页

作者： Shinji Kawahito hiroshi Kitahata Shuzo Oshita Department of Anesthesiology Tokushima University Medical and Dental Hospital

Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic super-physiological glucose concentration negatively affects a large number of organs and tissues. Glucose toxicity means a decrease in insulin secretion and an increase in insulin resistance due to chronic hyperglycemia. It is now generally accepted that glucose toxicity is involved in the worsening of diabetes by affecting the secretion of B-cells. Several mechanisms have been proposed to explain the adverse effects of hyperglycemia. It was found that persistent hyperglycemia caused the functional decline of neutrophils. Infection is thus the main problem resulting from glucose toxicity in the acute phase. In other words, continued hyperglycemia is a life-threatening risk factor, not only in the chronic but also the acute phase, and it becomes a risk factor for infection, particularly in the perioperative period.

关键词： Glucose toxicity Diabetes Complication Surgery Surgical site infection Emergency medicine Critical care medicine

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近代日本征兵制与作为其基础的地方自治

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军事历史 2024年第3期 46-55+126-127页

作者：伊势弘志邹开宇日本三重大学人文学部

日本陆军征兵制受到陆军创建者山县有朋的重大影响。山县有朋是陆军与统括地方自治的内务省的代言人，近代日本军事制度和自治制度皆由山县一人创制，是近代日本的特点。这一特点是日本军国主义社会基础形成的原因，在阐明军事制度与自... 详细信息

日本陆军征兵制受到陆军创建者山县有朋的重大影响。山县有朋是陆军与统括地方自治的内务省的代言人，近代日本军事制度和自治制度皆由山县一人创制，是近代日本的特点。这一特点是日本军国主义社会基础形成的原因，在阐明军事制度与自治制度之间的相关性上有重要意义。本文旨在阐述近代日本征兵制的产生及其性质，以揭示与其基础——自治制之间的关系。通过观察军事和自治之间的相关性，可以了解日本陆军对一般社会所产生的影响。另外也揭示了军事史的研究积累不仅在解释政治过程中发挥了作用，同时各个领域的成果也为军事史的深入研究做出了贡献，它们之间存在着相辅相成的关系。

关键词：日本陆军征兵制山县有朋

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ADCP application for long-term monitoring of coastal water

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Acta Oceanologica Sinica 2005年第1期24卷 95-100页

作者： YOSHIOKA hiroshi TAKAYAMA Tomotsuka SERIZAWA Shigeatsu Faculty of Information Science and Technology Aichi Prefectural University Aichi 480-1198 JapanDisaster Prevention Research Institute Kyoto-University Kyoto 611-0011 JapanDisaster Prevention Research Institute Kyoto-University Kyoto 611-0011 Japan

Three kind of application of ADCP is reported for long-term monitoring in coastal sea.(1)The routine monitoring of water qualities. The water quality and ADCP echo data (600 kHz) observed in the long-term are analgzed at MT (Marine Tower) Station of Kansai International Airport in the Osaka Bay, Japan. The correlation between the turbidity and echo intensity in the surface layer is not good because air bubbles generated by breaking wave are not detected by the turbidity meter, but detected well by ADCP. When estimating the turbidity consists of plankton population from echo intensity, the effect of bubbles have to be eliminated. (2) Monitoring stirring up of bottom sediment. The special observation was carried out by using following two ADCP in the Osaka Bay, One ADCP was installed upward on the sea. The other ADCP was hanged downward at the gate type stand about 3 m above from the bottom. At the spring tide, high echo intensities indicating the stirring up of bottom sediment were observed. (3) The monitoring for the boundary condition of water mixing at an estuary. In summer season, the ADCP was set at the mouth of Tanabe Bay in Wakayama Prefecture, Japan. During the observation, water temperature near the bottom showed remarkable falls with interval of about 5-7 d. When the bottom temperature fell, the inflow current with low echo intensity water appears at the bottom layer in the ADCP record. It is concluded that when occasional weak northeast wind makes weak coastal upwelling at the mouth of the bay, the combination of upwelling with internal tidal flow causes remarkable water exchange and dispels the red tide.

关键词： ADCP echo intensity monitoring coastal water red tide stirring up

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Drag-reduction of a nonionic surfactant aqueous solution and its rheological characteristics

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Science China(Technological Sciences) 2012年第3期55卷 772-778页

作者： CAI ShuPeng SUZUKI hiroshi KOMODA Yoshiyuki Institute of High Pressure Water Jet Hunan University of TechnologyZhuzhou 412007China Graduate of Science and technology Kobe UniversityKobe 657-8501Japan

In order to develop turbulent drag-reducing technology by using an environmentally friendly additive in a water-transporting system,the drag reducing characteristics in a non-ionic surfactant(Oleyldimethylamineoxide,ODMAO) dilute aqueous solution flowing in a circular pipe of 5 mm diameter have been experimentally investigated with an air-driven fluid resistance test *** rheological characteristics of the solution have also been examined by a rheometer with a cone-plate flow *** results show that the ODMAO solutions are drag-reducing when concentration is 400 ppm or higher,that the critical Reynolds number corresponding to the maximum drag reduction rate increases with both concentration and temperature,and that the maximum drag reduction rate can reach up to 70% in the straight *** low shear rates,the shear viscosity of ODMAO solutions with a relatively high drag-reduction behaves similarly to Newtonian fluids;at above a certain critical shear rate,it is firstly shear-thickening,then *** shear-rate-dependent characteristics of the shear viscosity are attributed to the different transitions of micellar network structure induced by different shear *** of shear stress after removing an applied constant shear rate at which the solution is in the SIS(shear-induced structure) state is found to be well expressed by a 2-step Maxwell model with a tail relaxation time much shorter than that for a drag-reducing cationic surfactant,which indicates that for the ODMAO solution,a viscoelasticity as strong as a drag-reducing cationic surfactant is not needed to realize turbulent drag-reduction.

关键词： nonionic surfactant drag-reduction shear viscosity shear stress relaxation

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Do not curse the darkness of the spinal cord,light TDP-43

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Neural Regeneration Research 2021年第5期16卷 986-987页

作者： Kazuhide Asakawa hiroshi Handa Koichi Kawakami Department of Chemical Biology Tokyo Medical UniversityTokyoJapan Division of Molecular and Developmental Biology National Institute of GeneticsDepartment of GeneticsGraduate University for Advanced Studies(SOKENDAI)ShizuokaJapan

Cytoplasmic inc lus ions containing the transactivation response element(TAR)DNAbinding protein-43(TDP-43)aggregates are hallmarks of neurodegenerative disorders,such as amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(Arai et al.,2006;Neumann et al.,2006).Despite the well-recognized correlation between TDP-43 aggregation and neuronal degeneration,whether this relationship is causal has remained unclear.

关键词： al. degeneration TDP

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Adjuvant chemotherapy for early-stage cervical cancer

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Chinese Journal of Cancer Research 2016年第2期28卷 228-234页

作者： hiroshi Asano Yukiharu Todo Hidemichi Watari Department of Obstetrics and Gynecology Hokkaido University School of Medicine Division of Gynecologic Oncology National Hospital OrganizationHokkaido Cancer Center

The aim of this review is to address the current status of adjuvant chemotherapy alone in early-stage cervical cancer treatments in the literature. At present, the therapeutic effect of adjuvant chemotherapy alone after radical surgery （RS） has not yet been established, and radiation therapy （RT） or concurrent chemoradiotherapy （CCRT） is recommended as the standard adjuvant therapy after RS for early-stage cervical cancer in various guidelines. The main purpose of adjuvant therapy after RS, however, should be to reduce extrapelvic recurrence rather than local recurrence, although adjuvant RT or CCRT has survival benefits for patients with intermediate- or high-risk factors for recurrence. Moreover, several studies reported that adjuvant therapies including RT were associated with a higher incidence of complications, such as lymphedema, bowel obstruction and urinary disturbance, and a lower grade of long-term quality of life （QOL） or sexual functioning than adjuvant chemotherapy alone. The effect of adjuvant chemotherapy alone for early-stage cervical cancer with intermediate- or high-risk factors for recurrence were not fully investigated in prospective studies, but several retrospective studies suggest that the adjuvant effects of chemotherapy alone are at least similar to that of RT or CCRT in terms of recurrence rate, disease-free survival, or overall survival （OS） with lower incidence of complications. Whereas cisplatin based combination regimens were used in these studies, paclitaxel/cisplatin （TP） regimen, which is currently recognized as a standard chemotherapy regimen for patients with metastatic, recurrent or persistent cervical cancer by Gynecologic Oncology Group （GOG）, had also survival benefit as an adjuvant therapy. Therefore, it may be worth considering a prospective randomized controlled trial （RCT） of adjuvant chemotherapy alone using TP regimen versus adjuvant RT as an alternative adjuvant therapy. Because early-stage cervical cancer is a curable c

关键词： Adjuvant chemotherapy cervical cancer quality of life (QOL) survival intermediate-risk disease

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Simultaneous photoinduced generation of Fe^(2+) and H_2O_2 in rivers:An indicator for photo-Fenton reaction

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Journal of Environmental Sciences 2016年第9期28卷 34-38页

作者： Khan M.G.Mostofa hiroshi Sakugawa Institute of Surface-Earth System Science Tianjin University Graduate School of Biosphere Science Department of Environmental Dynamics and ManagementHiroshima University

The photo-Fenton reaction is a key source of the highly reactive hydroxyl radical（HOU） that is produced by the reaction of simultaneous photo-induced generation of Fe^（2＋）-dissolved organic matter（DOM） with H_2O_2 in sunlit surface waters as well as in the treatment of organic pollutants in the advanced oxidation processes（AOPs）.Concentrations of both H_2O_2 and Fe^（2＋）-DOM were dependent on time and total solar intensity flux,and their levels were highest in the diurnal samples collected at noon compared with the samples collected during the period before sunrise and after sunset.H_2O_2 and Fe^（2＋）-DOM concentrations during monthly readings were also found higher in comparison with the diurnal samples,shortly before sunrise or after sunset.A π-electron bonding system is formed between Fe and the functional groups in DOM（Fe-DOM）,through electron donation from the functional groups of DOM to an empty d-orbital of *** π-electron is loosely bound and is highly susceptible to a rapid excitation upon light exposure that will provide better understanding of the formation of aqueous electrons,superoxide radical anions,H_2O_2 and finally,photo-Fenton reactions,*** results imply that simultaneous generation of H_2O_2 and Fe^（2＋）-DOM upon sunlight exposure during the daytime is most likely to be the key photo-Fenton reaction pathway,taking place in surface waters.

关键词： Photo-Fenton reaction Fe^(3+) Fe^(2+) Dissolved organic matter H_2O_2 Light

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Improvement of aerodynamic stability of suspension bridges with H-shaped simplified stiffening girder

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Frontiers of Structural and Civil Engineering 2016年第1期10卷 93-102页

作者： hiroshi KATSUCHI Hitoshi YAMADA Mayuko NISHIO Yoko OKAZAKI Department of Civil Engineering Yokohama National University Yokohama 240-8501 Japan

Wind-tunnel study on the improvement of aerodynamic stability of simplified suspension-bridge girder structures was conducted with using a 1/40-scaled section model. Objective of the study is the development of an economically superior suspension bridge with 500-1,000 m center span length. The wind-tunnel test showed that an edge-girder type cross section exhibited large amplitude torsional vortex-induced vibration as well as torsional flutter at a low wind speed. Accordingly, aerodynamic countermeasures of open grating deck and triangular fating, and structural countermeasures of center stay, diagonal bracing and mass increase were tried to improve the aerodynamic stability. Finally, feasibility of the best combination to a full-scale bridge was examined by structural analysis.

关键词： suspension bridge aerodynamics simplified girder wind-tunnel test

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