检索结果-南通市图书馆

Differences in oxidative stress dependence between gastric adenocarcinoma subtypes

World Journal of Gastroenterology 2006年第7期12卷 1005-1012页

作者： Brigitte Bancel JacauesEstève Jean-Christophe Souquet Shinya Toyokuni hiroshi ohshima Brigitte Pignatelli Hospital de la Croix-Rousse Department of PathologyLyonFrance Centre Hospital de la Croix-Rousse Department of GastroenterologyLyonFrance Department of Pathology and Biology of Diseases Graduate School of MedicineKyoto UniversityKyotoJapan Brigitte Pignatelli International Agency for Research on Cancer.Endogenous Risk Factors GroupLyon.France Clinical Epidemiology Unit Department of Medical InformationHospices Civils de LyonFrance

AIM： To investigate the extent of oxidative stress in preneoplastic and neoplastic gastric mucosa in relation to their pathological criteria and histological subtypes. METHODS： A total of 104 gastric adenocarcinomas from 98 patients （88 infiltrative and 16 intraepithelial tumors） were assessed immunohistochemically for expression of iNOS and occurrence of nitrotyrosine （NTYR）-containing proteins and 8-hydroxy-2＇-deoxyguanosine （8-OH- dG）-containing DNA, as markers of NO production and damages to protein and DNA. RESULTS： Tumor cells staining for iNOS, NTYR and 8-OH-dG were detected in 41%, 62% and 50% of infiltrative carcinoma, respectively. The three markers were shown for the first time in intraepithelial carcinoma. The expression of iNOS was significantly more frequent in tubular carcinoma （TC） compared to diffuse carcinoma （DC）（54% vs 18%; P=0.008） or in polymorphous carcinoma （PolyC）（54% vs 21% ; P=0.04）. NTYR staining was obviously more often found in TC than that in PolyC （72% vs 30% ; P=0.03）. There was a tendency towards a higher rate of iNOS staining when distant metastasis （pM） was present. In infiltrative TC, the presence of oxidative stress markers was not significantly correlated with histological grade, density of inflammation, the depth of infiltration （pT）, lymph nodes dissemination （pN） and pathological stages （pTNM）.CONCLUSION： The iNOS-oxidative pathway may play an important role in TC, but moderately in PolyC and DC. DNA oxidation and protein nitration occur in the three subtypes. Based on the significant differences of NTYR levels, TC and PolyC appear as two distinct subtypes.

关键词： Gastric neoplasms Nitric oxide synthase Hpylori Nitrotyrosine 8-hydroxydeoxyguanosine Oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

椎间盘退变生物力学的研究现状

椎间盘退变生物力学的研究现状

引用

第八届全国脊柱脊髓损伤学术会议

作者：柳根哲徐林 Hirokazu ISHIHARA hiroshi ohshima 北京中医药大学东直门医院骨科中心日本富山医科药科大学骨科日本宇宙开发事业团宇宙医学中心

＜正＞在日常活动中腰椎间盘常常承受力学负荷。腰椎椎间盘内静水压平卧休息位最低（2-3 atm）,弯腰前屈抬重物时增高（接近 30 atm）。搬运重物的体力劳动者、长时间坐位工作者在病理学上椎间盘退行性改变显著;从事机床工作、卡车司...

＜正＞在日常活动中腰椎间盘常常承受力学负荷。腰椎椎间盘内静水压平卧休息位最低（2-3 atm）,弯腰前屈抬重物时增高（接近 30 atm）。搬运重物的体力劳动者、长时间坐位工作者在病理学上椎间盘退行性改变显著;从事机床工作、卡车司机及搬

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Adult T-cell leukemia/lymphoma presenting multiple lymphomatous polyposis

引用

World Journal of Gastroenterology 2008年第42期14卷 6584-6588页

作者： Akira Hokama Takeaki Tomoyose Yu-ichi Yamamoto Takako Watanabe Tetsuo Hirata Fukunori Kinjo Seiya Kato Koichi ohshima hiroshi Uezato Nobuyuki Takasu Jiro Fujita Department of Medicine and Therapeutics (First Department of Internal Medicine) Control and Prevention of Infectious Disease Faculty of Medicine University of the Ryukyus Okinawa 903-0125 Japan Department of Endocrinology and Metabolism Faculty of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Dermatology Faculty of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Endoscopy Ryukyu University Hospital Okinawa 903-0215 Japan Division of Pathology and Cell Biology GraduateSchool and Faculty of Medicine University of the RyukyusOkinawa 903-0215 Japan Department of Pathology School of Medicine Kurume University Fukuoka 830-0011 Japan

Multiple lymphomatous polyposis (MLP) is an unusual form of non-Hodgkin's lymphoma characterized by polyps throughout the gastrointestinal tract. It has been reported that most MLP are observed in cases with mantle cell lymphoma of B-cell type. We herein present a case of a 66-year-old man with adult T-cell leukemia/lymphoma (ATLL). Colonoscopy revealed MLP throughout the colon and histopathological findings of ATLL cell infiltration. The patient died despite combination of chemotherapy. The literature of manifestations of colonic involvement of ATLL isreviewed and the importance of endoscopic evaluation to differentiate ATLL intestinal lesions from opportunistic infectious enterocolitis is discussed.

关键词： Adult T-cell leukemia/lymphoma Multiplelymphomatous polyposis Human T-cell lymphotropicvirus type 1 Strongyloides stercora/is Colonoscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：