检索结果-南通市图书馆

Linear seesaw model with a modular S_(4)flavor symmetry

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2022年第5期46卷 11-19页

作者： Takaaki Nomura hiroshi Okada College of Physics Sichuan UniversityChengdu 610065China Asia Pacific Center for Theoretical Physics(APCTP)-Headquarters San 31 Hyoja-dongNam-guPohang 790-784Korea Department of Physics Pohang University of Science and TechnologyPohang 37673Korea

We discuss a linear seesaw model with a field content as minimum as possible,introducing a modular S_(4)using gauged U(1)_(B−L) *** to the rank two neutrino mass matrix,we obtain a vanishing neutrino mass eigenvalue,and only the normal mass hierarchy of neutrinos is favored via the modular S_(4)*** our numericalΔχ^(2)analysis,we especially determine a relatively sharp prediction on the sum of neutrino masses to be approximately 60 meV,in addition to other predictions.

关键词： neutrino mass linear seesaw mechanism modular S_(4)flavor symmetry

Fixed-ratio combinations of basal insulin and glucagon-like peptide-1 receptor agonists as a promising strategy for treating diabetes

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2023年第3期14卷 188-197页

作者： hiroshi Nomoto Department of Rheumatology Endocrinology and NephrologyFaculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

The maintenance of appropriate glycemic control is important for the prevention of diabetic complications in people with type 2 diabetes(T2D). Numerous oral antidiabetic drugs are now clinically available, but in particular, the introduction of injection regimens using insulin and/or glucagon-like peptide-1 receptor agonist(GLP-1RA)s represents promising step-up options for oral antidiabetic drug treatment. The recently licensed fixed-ratio combination(FRC) products,which comprise basal insulin and a GLP-1RA, have potent anti-hyperglycemic effects and reduce the undesirable side-effects of each component, such as body weight gain, hypoglycemia, and gastrointestinal symptoms. Two FRCs-insulin degludec/Liraglutide and insulin glargine/Lixisenatide-are now clinically available and, to date, several phase Ⅱ/Ⅲ trials have been conducted in particular groups of subjects with T2D. However, their utility in real-world clinical settings is of interest for most clinicians. Recently reported real-world clinical trials of these two FRCs in various situations have demonstrated their efficacy regarding glycemic control and the quality of life of people with T2D. Their long-term safety and efficacy require confirmation, but a treatment strategy that includes an FRC may be compatible with the concept of “well-balanced” therapy in certain groups of patients with T2D who have inadequate glycemic control.

关键词： Clinical trial Diabetes mellitus,type 2 Glucagon-like peptide-1 receptor Glycemic control Insulin,long-acting Quality of life

Invariant natural killer T cells and iron metabolism orchestrate skin development and homeostasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第10期20卷 1095-1097页

作者： hiroshi Nabeshima Takayuki Niitsu Kiyoharu Fukushima hiroshi Kida Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center(WPI-IFReC)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsakaJapan Department of Host Defense Research Institute for Microbial Diseases(RIMD)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical Center5-1-1 ToneyamaOsakaJapan Global Center for Medical Engineering and Informatics 2-2 YamadaokaSuitaOsakaJapan

In recent years,innate-like T-cell populations,such as invariant natural killer T(iNKT)cells and mucosal-associated invariant T(MAIT)cells,have been identified[1].These cells are different from conventional T cells in that they reside in tissues such as the liver,lung,and skin,rather than the lymph node and spleen[2].Although iNKT and MAIT cells are abundant in the skin immediately after birth,the detailed functions or the mechanisms regulating their localization have not been clarified[3].In a study published in Nature Immunology,Wang et *** that the early homing of iNKT cells to the skin was dependent on CCR10 expression during the stage of thymic development and was critical for proper commensal bacterial colonization and skin development[4].

关键词： killer metabolism homeostasis

Expression analyses of stress‑responsive genes in the hermatypic coral Acropora tenuis and its symbiotic dinofagellates after exposure to the herbicide Diuron

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2023年第3期5卷 289-299页

作者： hiroshi Ishibashi Seigo Minamide Ichiro Takeuchi Graduate School of Agriculture Ehime UniversityMatsuyamaEhime 790-8566Japan Center of Advanced Technology for the Environment Graduate School of AgricultureEhime UniversityMatsuyamaEhime 790-8566Japan

Diuron is one of the most frequently applied herbicides in sugarcane farming in southern Japan,and *** addition,it is used as a booster substance in copper-based antifouling *** to these various uses,Diuron is released into the marine environment;however,little information is available on gene expression in corals and their symbiotic algae exposed to *** investigated the efects of Diuron on stress-responsive gene expression in the hermatypic coral Acropora tenuis and its symbiotic *** seven days of exposure to 1µg/L and 10µg/L Diuron,no signifcant changes in the body colour of corals were ***,quantitative reverse transcription-polymerase chain reaction analyses revealed that the expression levels of stress-responsive genes,such as heat shock protein 90(HSP90),HSP70,and calreticulin(CALR),were signifcantly downregulated in corals exposed to 10µg/L of Diuron for seven ***,aquaglyceroporin was signifcantly downregulated in corals exposed to environmentally relevant concentrations of 1µg/L *** contrast,no such efects were observed on the expression levels of other stress-responsive genes,such as oxidative stress-responsive proteins,methionine adenosyltransferase,and green/red fuorescent *** exposure had no signifcant efect on the expression levels of HSP90,HSP70,or HSP40 in the symbiotic *** results suggest that stress-responsive genes,such as HSPs,respond diferently to Diuron in corals and their symbiotic dinofagellates and that *** HSPs and CALRs may be useful molecular biomarkers for predicting stress responses induced by the herbicide Diuron.

关键词： Acropora tenuis Calreticulin Coral bleaching Diuron Heat shock protein

Efficacy of live attenuated vaccines after two doses of intravenous immunoglobulin for Kawasaki disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2022年第10期18卷 706-709页

作者： Yoshihiko Morikawa hiroshi Sakakibara Masaru Miura Clinical Research Support Center Tokyo Metropolitan Children’s Medical Center2-8-29 MusashidaiFuchuTokyo183-8561Japan Department of General Pediatrics Tokyo Metropolitan Children’s Medical CenterTokyoJapan Department of Cardiology Tokyo Metropolitan Children’s Medical CenterTokyoJapan

Kawasaki disease(KD)is a vasculitis of unknown etiology occurring predominantly in children under five years old[1].Coronary artery aneurysm,its most serious complica-tion,occurs in about 25%of untreated patients[2].High-dose intravenous immunoglobulin(IVIG)2 g/kg is used to prevent coronary artery aneurysms[1,3,4],but about 20%of patients are nonresponsive and require a second dose for a total of 4 g/*** appropriate timing of live attenuated vaccine(LAV)administration in such cases is unclear.

关键词： doses attenuated intravenous

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

日本地震预警系统研究综述

世界地震工程 2024年第3期40卷 72-82页

作者：宝音图王鹏翔徐茂臣川濑博内蒙古大学交通学院内蒙古呼和浩特010020 京都大学防灾研究所京都611-0011

为深入了解日本地震预警系统在防震减灾中的有效应用,本文首先,介绍了日本地震预警系统的研究现状,包括铁路地震预警系统、陆域和海域地震预警系统以及长周期地震预警系统;其次,阐述了预警发布标准、发布方式和发布后的避险措施,总结了... 详细信息

为深入了解日本地震预警系统在防震减灾中的有效应用,本文首先,介绍了日本地震预警系统的研究现状,包括铁路地震预警系统、陆域和海域地震预警系统以及长周期地震预警系统;其次,阐述了预警发布标准、发布方式和发布后的避险措施,总结了地震预警的特点、局限性和注意事项,讨论了我国在地震预警系统建设时遇到的问题。通过对日本地震预警系统的全面介绍和深入分析,有利于了解该系统的运行机制、应用效果以及面临的挑战,为我国地震预警事业的发展提供重要参考。

关键词：防震减灾日本地震预警地震预警系统长周期地震动预警发布标准

在线全文

学校读者我要写书评

暂无评论

福泽谕吉《劝学篇》首章与明治革命

日语学习与研究 2024年第1期 1-11页

作者：渡边浩陆健欢(译) 东京大学清华大学历史系

以“天不造人上之人,亦不造人下之人”为开篇的福泽谕吉《劝学篇》首章(1872年)常被认为效仿美国十三州《独立宣言》,其内容在当时的日本颇具冲击性。然而,福泽所表达的是人(男性)生来没有差别,因为有无学问才有了贫富、贵贱之差,这与... 详细信息

以“天不造人上之人,亦不造人下之人”为开篇的福泽谕吉《劝学篇》首章(1872年)常被认为效仿美国十三州《独立宣言》,其内容在当时的日本颇具冲击性。然而,福泽所表达的是人(男性)生来没有差别,因为有无学问才有了贫富、贵贱之差,这与《独立宣言》的主张截然不同。其阐述不如说是一种儒学思想,甚而言之,在当时实行科举制度的中国,这仅仅是一种社会现实。但在以身份、地位世袭制为基石的德川日本,这对政治、社会体制而言确是一种危险的理念。不仅如此,特别是在十八世纪以降,虽然日本广为学习儒学,但能够学习的大多数人实际乃是富贵阶层,“劝学”理念反过来成为了他们巩固地位的理论工具。然而同时,这种理想与现实之间的距离使得有才能之人逐渐产生积怨与愤恨。所谓“明治维新”,其作为一场破坏世袭身份制度的革命,得以发生的一大原因,便是下级武士所不断积蓄的不满与愤怒。

关键词：福泽谕吉劝学篇明治维新儒家思想科举制度

Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic

在线全文

学校读者我要写书评

暂无评论

World Journal of Nephrology 2023年第3期12卷 56-65页

作者： hiroshi Tamura Department of Pediatrics Kumamoto UniversityKumamoto 8608556Japan

BACKGROUND There are two known types of exercise-induced acute renal *** is the long-known myoglobinuria-induced acute renal failure due to severe rhabdomyolysis,and the other is the recently recognized non-myoglobinuria-induced acute renal failure with mild ***-induced acute renal failure was first reported in ***-myoglobinuria-induced acute renal failure is associated with severe low back pain and patchy renal vasoconstriction,and it is termed post-exercise acute renal failure because it usually occurs hours after *** is also called acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise(ALPE).AIM To makes a significant contribution to medical literature as it presents a study that investigated a not-widely-known type of exercise-induced acute renal failure known as *** We performed a database search selecting papers published in the English or Japanese language.A database search was lastly accessed on September 1,*** results of this study were compared with those reported in other case *** The study evaluated renal hypouricemia as a key risk factor of *** development of ALPE is due to the sum of risk factors such as exercise,hypouricemia,nonsteroidal anti-inflammatory drugs,vasopressors,and *** In conclusion,hypouricemia plays a key role in the development of ALPE and is often associated with anaerobic *** development of ALPE is a result of the cumulative effects of risk factors such as exercise,hypouricemia,NSAIDs,vasopressors,and dehydration.

关键词： Acute kidney injury Exercise Vasoconstriction Renal hypouricemia

Specific targeting of lung ILC2s via NRP1 in pulmonary fibrosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第8期19卷 869-871页

作者： Takuro Nii Kiyoharu Fukushima hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical Center5-1-1 ToneyamaOsakaJapan Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsakaJapan Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center(WPI-IFReC)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Host Defense Research Institute for Microbial Diseases(RIMD)Osaka UniversityOsaka565-0871Japan Global Center for Medical Engineering and Informatics 2-2 YamadaokaSuitaOsakaJapan

Innate lymphoid cells are predominantly tissue-resident immune cells that have diverse functions similar to T-cell subsets and regulate tissue homeostasis and innate immunity without specific antigen recognition. Prev... 详细信息

关键词： ILC2s immunity homeostasis