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Severe aconite poisoning successfully treated with veno-arterial extracorporeal membrane oxygenation:A case report

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World Journal of Clinical Cases 2024年第2期12卷 399-404页

作者： Saeko Kohara Yoshito Kamijo Ryoko Kyan Ichiro okada Eiju Hasegawa Soichiro Yamada Koichi Imai Asuka Kaizaki-Mitsumoto Satoshi Numazawa Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical CenterTokyo 1900014Japan Department of Clinical Toxicology Saitama Medical UniversitySaitama 3500495Japan Saitama Prefectural Institute of Public Health Saitama Prefectural Institute of Public HealthSaitama 3550133Japan Division of Toxicology Department of PharmacologyToxicology and TherapeuticsShowa University School of PharmacyTokyo 1428555Japan

BACKGROUND Most species of aconite contain highly toxic aconitines,the oral ingestion of which can be fatal,primarily because they cause ventricular arrhythmias.We describe a case of severe aconite poisoning that was successfully treated through venoarterial extracorporeal membrane oxygenation(VA-ECMO)and in which detailed toxicological analyses of the aconite roots and biological samples were performed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).CASE SUMMARY A 23-year-old male presented to the emergency room with circulatory collapse and ventricular arrhythmia after ingesting approximately half of a root labeled,“Aconitum japonicum Thunb”.Two hours after arrival,VA-ECMO was initiated as circulatory collapse became refractory to antiarrhythmics and vasopressors.Nine hours after arrival,an electrocardiogram revealed a return to sinus rhythm.The patient was weaned off VA-ECMO and the ventilator on hospital days 3 and 5,respectively.On hospital day 15,he was transferred to a psychiatric hospital.The other half of the root and his biological samples were toxicologically analyzed using LC-MS/MS,revealing 244.3 mg/kg of aconitine and 24.7 mg/kg of mesaconitine in the root.Serum on admission contained 1.50 ng/mL of aconitine.Beyond hospital day 2,neither were detected.Urine on admission showed 149.09 ng/mL of aconitine and 3.59 ng/mL of mesaconitine,but these rapidly decreased after hospital day 3.CONCLUSION The key to saving the life of a patient with severe aconite poisoning is to introduce VA-ECMO as soon as possible.

关键词： Aconite poisoning Fatal arrhythmia Veno-arterial extracorporeal membrane oxygenation Aconitine Mesaconitine Case report

Emotion Measurement Using Biometric Signal

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Health 2024年第5期16卷 395-404页

作者： Yukina Miyagi Saori Gocho Yuka Miyachi Chika Nakayama Shoshiro okada Kenta Maruyama Taeyuki Oshima College of Pharmacy Kinjo Gakuin University Nagoya Japan Graduate School of Medicine Aichi Medical University Nagakute Japan Department of Pharmacy Nagoya Ekisaikai Hospital Nagoya Japan Department of Pharmacy Gifu University of Medical Science Kani Japan

In recent years, research on the estimation of human emotions has been active, and its application is expected in various fields. Biological reactions, such as electroencephalography (EEG) and root mean square successive difference (RMSSD), are indicators that are less influenced by individual arbitrariness. The present study used EEG and RMSSD signals to assess the emotions aroused by emotion-stimulating images in order to investigate whether various emotions are associated with characteristic biometric signal fluctuations. The participants underwent EEG and RMSSD while viewing emotionally stimulating images and answering the questionnaires. The emotions aroused by emotionally stimulating images were assessed by measuring the EEG signals and RMSSD values to determine whether different emotions are associated with characteristic biometric signal variations. Real-time emotion analysis software was used to identify the evoked emotions by describing them in the Circumplex Model of Affect based on the EEG signals and RMSSD values. Emotions other than happiness did not follow the Circumplex Model of Affect in this study. However, ventral attentional activity may have increased the RMSSD value for disgust as the β/θ value increased in right-sided brain waves. Therefore, the right-sided brain wave results are necessary when measuring disgust. Happiness can be assessed easily using the Circumplex Model of Affect for positive scene analysis. Improving the current analysis methods may facilitate the investigation of face-to-face communication in the future using biometric signals.

关键词： Biometric Signals Electroencephalogram Electrocardiogram Emotion Communication

SPERA Hydrogen System^(TM)by LOHC-MCH Method for Massive Hydrogen Storage and Transportation

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Journal of Environmental Science and Engineering(A) 2024年第2期13卷 50-60页

作者： Yoshimi okada Kaji Naohiro Osamu Ikeda Kenichi Imagawa Hironori Kawai Masashi Nagai Yasuhiro Inoue Frontier Business Division Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan Hydrogen Business Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan R&D Center Chiyoda Corporation3-13 Moriya-cho Kanagawa-kuYokohama 2208765Japan Technology Development Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan

Expanding the hydrogen energy utilization is essential for decarbonization,and the commercialization of hydrogen energy carrier systems that can“store”and“transport”hydrogen in a large scale is necessary.The organic chemical hydride method incorporates hydrogen atoms into the molecular structure of a LOHC(Liquid Organic Hydrogen Carrier)to store and transport hydrogen in a liquid state under normal temperature and pressure,and is a highly safe method with low business risk.Chiyoda has been developing the technology since 2002,completed a pilot demonstration in 2014 and named it the SPERA Hydrogen^(TM) System,and successfully completed an international supply chain demonstration that transports hydrogen from Brunei to Japan in a large scale in 2020,moving to the commercialization stage.Currently,Chiyoda is conducting feasibility studies with a number of domestic and foreign companies with the aim of commercializing the system as soon as possible.In this paper,outline,features,development status and our efforts in commercialization of SPERA HydrogenTM System are introduced.

关键词： Hydrogen carrier LOHC Methylcyclohexane MCH toluene

Novel synthesis of single-crystalline TbCu_(7)-type Sm-Fe powder by low-temperature reduction-diffusion process using molten salt

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Journal of Rare Earths 2022年第7期40卷 1126-1133页

作者： Shusuke okada Kenta Takagi Magnetic Powder Metallurgy Research Center National Institute of Advanced Industrial Science and Technology(AIST)2266-98 AnagahoraShimoshidami MoriyamaNagoya463-8560Japan

In this study,molten salt was used as a solvent for calcium(Ca)to let a reduction-diffusion(R-D)reaction occur below the melting point of Ca(1115 K),which is the lower limit temperature of the co nventional RD process.When the R-D reaction is conducted below 923 K with LiCl molten salt,submicron-sized TbCu_(7)-type Sm-Fe powder is formed.The c/a ratio of the powder estimated by a synchrotron X-ray diffraction pattern is 0.8456,which is consistent with the Sm_(0.67)Fe_(5.667)(SmFe_(8.5))phase.An electron backscatter diffraction analysis reveals that single-crystalline TbCu_(7)-type SmFe_(8.5) powder was synthesized for the first time.

关键词： Reduction-diffusion TbCu_(7) Molten salt Permanent magnet Rare earths

Lepton mass matrix from double covering of A_(4) modular flavor symmetry

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Chinese Physics C 2022年第12期46卷 162-171页

作者： Hiroshi okada Yuta Orikasa Asia Pacific Center for Theoretical Physics(APCTP)-Headquarters San 31 Hyoja-dongNam-guPohang 790-784Korea Department of Physics Pohang University of Science and TechnologyPohang 37673Republic of Korea Institute of Experimental and Applied Physics Czech Technical University in PragueHusova 240/511000 Prague 1Czech Republic

We study a double covering of modular A_(4)flavor symmetry.To this end,we construct lepton models for canonical and radiative seesaw scenarios.Using irreducible doublet representations,heavier Majorana fermion masses are characterized by one free parameter that would differentiate from A_(4)symmetry.symmetry.Throughχsquare numerical analysis,we demonstrate that both scenarios produce some predictions in case of normal hierarchy reproducing neutrino oscillation data.However,no solution satisfies the neutrino oscillation data in case of radiative seesaw of inverted hierarchy.

关键词： flavor physics neutrino and Lepton mass beyond the standard model

Low-temperature synthesis of Sm-Fe binary compounds by reduction-diffusion process using an eutectic salt solvent

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Rare Metals 2023年第5期42卷 1724-1731页

作者： Jungryang Kim Shusuke okada Kenta Takagi Magnetic Powder Metallurgy Research Center National Institute of Advanced Industrial Science and Technology(AIST)NagoyaAichi463-8560Japan

In this study,the temperature of the low-temperature reduction-diffusion(LTRD)process was successfully decreased to below 600℃by introducing LiClKCl eutectic molten salt with a low eutectic point(352℃)as a solvent for Ca reductant.Therefore,the Sm-Fe binary compounds,which were synthesizable at previously-unexplored low temperatures by the LTRD process using LiCl-KCl eutectic molten salt,were investigated,including whether a new metastable or ThMn_(12)-type Sm-Fe binary phase was formed.The Sm-Fe phase transitions of the SmFe binary compounds at a low temperature were identified,and it was found that MgCu_(2)-type Sm-Fe,PuNi_(3)-type SmFe and TbCu_(7)-type Sm-Fe phases were synthesized and stable at 400,500 and 550℃respectively.Although no new metastable Sm-Fe and ThMn_(12)-type Sm-Fe compounds were discovered in this study,this work can demonstrate that it is possible to synthesize the Sm-Fe phase at very low temperatures by the LTRD process for the first time.

关键词： Low-temperature synthesis Reductiondiffusion process Molten salts Hard magnet Sm-Fe compounds

Review of lymphoma in the duodenum: An update of diagnosis and management

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World Journal of Gastroenterology 2023年第12期29卷 1852-1862页

作者： Masaya Iwamuro Takehiro Tanaka Hiroyuki okada Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Pathology Okayama University HospitalOkayama 700-8558Japan

The presentation,subtype,and macroscopic images of lymphoma vary depending on the site of the tumor within the gastrointestinal tract.We searched PubMed for publications between January 1,2012 and October 10,2022,and retrieved 130 articles relating to duodenal lymphoma.A further 22 articles were added based on the manual screening of relevant articles,yielding 152 articles for full-text review.The most predominant primary duodenal lymphoma was follicular lymphoma.In this review,we provide an update of the diagnosis and management of representative lymphoma subtypes occurring in the duodenum:Follicular lymphoma,diffuse large B-cell lymphoma,extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue,mantle cell lymphoma,and Tcell lymphomas.

关键词： Diagnosis Diffuse large B-cell lymphoma Duodenal neoplasms Esophagogastroduodenoscopy Follicular lymphoma Gastrointestinal lymphoma

Efficacy of incremental loads of cow's milk as a treatment for lactose malabsorption in Japan

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World Journal of Clinical Cases 2023年第4期11卷 797-808页

作者： Matsuri Hasegawa Kazuko okada Satoru Nagata Shigetaka Sugihara Department of Pediatrics Tokyo Women's Medical University Medical Center EastDepartment of PediatricsTokyo Women’s Medical University Medical Center EastArakawa-ku 116-8561TokyoJapan Department of Pediatrics Okada Pediatric ClinicShinjuku-ku 169-0072TokyoJapan Department of Pediatrics Tokyo Women’s Medical UniversityShinjuku-ku 162-8666TokyoJapan

BACKGROUND Lactose intolerance(LI)is commonly seen in East Asian countries.Several studies showed that lactose or milk loading has been used as a treatment for lactose malabsorption(LM)in Western countries,but there have been no reports regarding this type of treatment in Japan.As lactose or milk loading requires ingestion of large amounts of lactose within a short period,this is considered to be too harsh for Japanese people because of their less habitual milk consumption(175 mL per day in average)than Western people.In this study,we demonstrated lactose tolerance acquisition in a suitable way for Japanese.AIM To examine the efficacy of lactose(cow’s milk)loading treatment in patients with LM.METHODS Individuals with abdominal symptoms induced by milk or dairy products(LI symptoms)were identified with a questionnaire.A 20 g lactose hydrogen breath test(LHBT)was carried out to confirm LM diagnosis and to evaluate co-existence of small intestinal bacterial overgrowth(SIBO).Respondents diagnosed with LM were selected as study subjects and were treated with incremental loads of cow’s milk,starting from 30 mL and increasing up to 200 mL at 4-7 d intervals.After the treatment,changes in symptoms and LM diagnostic value of 20 g LHBT were investigated.Stool samples pre-and post-treatment were examined for changes in intestinal microbiota using 16S rRNA sequencing.Informed consent was obtained prior to each stage of the study.RESULTS In 46 subjects with LI symptoms(10-68 years old,mean age 34 years old)identified with the questionnaire,35(76.1%)were diagnosed with LM by 20 g LHBT,and 6 had co-existing SIBO.The treatment with incremental cow’s milk was carried out in 32 subjects diagnosed with LM(14-68 years old,median age 38.5 years old).The mean period of the treatment was 41±8.6 d.Improvement of symptoms was observed in 29(90.6%;95%confidence interval:75.0%-98.0%)subjects.Although 20 g LHBT indicated that 10(34.5%)subjects had improved diagnostic value of LM,no change was observed in 16(55.2%)subjects.Analysis of the f

关键词： Lactose Intolerance Lactose Malabsorption lactose loading treatment Intestinal bacterial flora Fecal microbiota

Tin phosphide-carbon composite as a high-performance anode active material for sodium-ion batteries with high energy density

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Journal of Energy Chemistry 2022年第1期31卷 463-474,I0012页

作者： Zhiqiang Hao Nikolay Dimov Jeng-Kuei Chang Shigeto okada Department of Chemical Engineering Faculty of EngineeringKyushu UniversityFukuoka 816-8580Japan Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 816-8580Japan Department of Materials Science and Engineering Chiao Tung University.1001 University RoadHsinchu 30010.TaiwanChina

Tin phosphide(Sn_(4)P_(3))is a promising anode material for sodium-ion batteries because of its relatively large theoretical capacity,appropriate Na^(+) alloying potential,and good cyclic stability.Herein,the Sn_(4)P_(3) embedded into a carbon matrix with good rate performance and long cycle life is reported.The Sn_(4)P_(3)-C composite exhibits excellent rate performance(540 mAh g^(-1) at 5 A g^(-1))and the highest reversible capacity(844 mAh g^(-1) at 0.5 A ^(g-1))among Sn4P3-based anodes reported so far.Its reversible capacity is as high as 705 mAh g^(-1) even after 100 cycles at 0.5 A g^(-1).Besides,its initial Coulomb efficiency can reach 85.6%,with the average Coulomb efficiency exceeding 99.75%from the 3rd to 100th cycles.Na_(2)C_(6)O_(6) is firstly used as a cathode when Sn_(4)P_(3) acts as anode,and the Na-Sn_(4)P_(3)-C//Na_(2)C_(6)O_(6) full cell shows excellent electrochemical performance.These results demonstrate that the Sn_(4)P_(3)-C composite prepared in this work displays high-rate capability and superior cyclic performance,and thus is a potential anode for sodium ion batteries.

关键词： Tin phosphide Sodium-ion batteries Sn_(4)P_(3) Conversion Alloy