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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu saito Akira saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Dorsal approach for isolated volar fracture-dislocation of the base of the second metacarpal:A case report

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世界临床病例杂志 2023年第28期11卷 6871-6876页

作者： Taketo Kurozumi Masato saito Kazuhiko Odachi Fumiaki Masui Trauma Center Toranomon HospitalTokyo 105-8470Japan Department of Orthopedic Surgery Chiba-Nishi General HospitalChiba 270-2251Japan

BACKGROUND We report a case with the displacement of an articular fracture fragment of the base of the second metacarpal from the ulnar to the volar side,treated via the dorsal approach.The dorsal approach can be a good option not only because it allows direct observation of ligament damage and fixation of bone fragments but also because the thin subcutaneous tissue makes the approach easier.CASE SUMMARY A 45-year-old man with a right hand injury visited the hospital.A small bone fragment was identified using plain radiography.Lateral radiography revealed the fragment as lying over the volar aspect of the carpometacarpal(CMC)joint.Computed tomography revealed that approximately one-third of the CMC joint surface of the second metacarpal was damaged.We provisionally diagnosed an intra-articular fracture with significant CMC joint instability and performed open reduction and internal fixation.We made a dorsal longitudinal incision over the CMC joint between the second and third metacarpals.The dorsal ligament of the third CMC joint was torn.We thought it had been dislocated to the volar side and spontaneously reduced to that position.There are only few reports of volar dislocation of CMC joint fractures,particularly of the second and third metacarpals;our report is unique as our patient had an intact interosseous ligament between the second and third metacarpals.CONCLUSION Although past reports have used a palmar approach,the dorsal approach is a good option for these cases.

关键词： Metacarpal bone Fracture-dislocation Mechanism Dorsal approach Carpometacarpal joint Case report

Desorption of Cl^(-) from Mg-Al layered double hydroxide intercalated with Cl^(-) using CO_(2) gas and water

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Chinese Journal of Chemical Engineering 2021年第1期34卷 131-134页

作者： Tomohito Kameda hiroki Uchida Shogo Kumagai Yuko saito Keiichi Mizushina Ichirou Itou Tianye Han Toshiaki Yoshioka Graduate School of Environmental Studies Tohoku University6-6-07 AobaAramakiAoba-kuSendai 980-8579Japan Kurita Water Industries Ltd. Nakano Central Park East4-10-1 NakanoNakano-kuTokyo 164-0001Japan

Mg-Al layered double hydroxide intercalated with CO_(3)^(2-)(CO_(3)·Mg-Al LDH) is effective for treating HCl exhaust gas.HCl reacts with CO_(3)^(2-) in CO_(3)·Mg-Al LDH, resulting in the formation of Cl·Mg-Al LDH.We propose that CO_(2) can be used for the desorption of Cl^(-)from Cl·Mg-Al LDH to regenerate CO_(3)·Mg-Al LDH.Herein,we studied the desorption of a from CI-Mg-Al LDH by adding water to Cl·Mg-Al LDH and blowing CO_(2) into it.We also analyzed the effects of temperature and water addition speed on the desorption of CI^(-)from Cl·Mg-Al LDH.Our results show that the added water adhered to CI·Mg-Al LDH and that CO_(2) in the gaseous phase was dissolved in this adhered water,thus generating CO_(3)^(2-).Therefore,anion exchange occurred between CO_(3)^(2-) and Cl^(-)in the Cl·Mg-Al LDH,thus desorbing Cl^(-).

关键词： Mg-Al layered double hydroxide CO_(2)gas Cl^(-)desorption Semi-dry method

Drug-induced entero-colitis due to interleukin-17 inhibitor use;capsule endoscopic findings and pathological characteristics:A case report

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世界胃肠病学杂志:英文版 2023年第32期29卷 4912-4919页

作者： Keita saito Kiichiro Yoza Shinichiro Takeda Yoshihiro Shimoyama Ken Takeuchi Department of Gastroenterology Tsujinaka Hospital Kashiwano-HaKashiwa 277-0871Japan

BACKGROUND Interleukin-17(IL-17)inhibitors are known to cause exacerbation or new onset of inflammatory bowel disease upon administration.However,few reports have described characteristic endoscopic and histopathologic findings,and no small intestinal lesions have been reported so far.CASE SUMMARY A woman in her 60s with psoriasis was administered ixekizumab(IXE),an anti-IL-17A antibody,for the treatment of psoriasis.Twenty months after commencing treatment,the patient visited our hospital because of persistent diarrhea.Blood tests performed at the time of the visit revealed severe inflammation,and colonoscopy revealed multiple round ulcers throughout the colon.A tissue biopsy of the ulcer revealed infiltration of inflammatory cells and granuloma-like findings in the submucosal layer.Capsule endoscopy revealed multiple jejunal erosions.After the withdrawal of IXE,the symptoms gradually improved,and ulcer reduction and scarring of the colon were endoscopically confirmed.CONCLUSION To the best of our knowledge,17 reports have documented IL-17 inhibitorinduced entero-colitis with endoscopic images,endoscopic findings,and pathological characteristics,including the present case.Nine of these cases showed diffuse loss of vascular pattern,coarse mucosa/ulcer formation in the left colon,and endoscopic findings similar to those of ulcerative colitis.In the remaining eight cases,discontinuous erosions and ulcerations from the terminal ileum to the rectum were seen,with endoscopic findings similar to those of Crohn’s disease.In this case,the findings were confirmed by capsule endoscopy,which has not been previously reported.

关键词： Interleukin-17 inhibitor Ixekizumab Drug-induced entero-colitis Capsule endoscopy Case report

Evolving roles of magnifying endoscopy and endoscopic resection for neoplasia in inflammatory bowel diseases

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 646-653页

作者： Shintaro Akiyama Taku Sakamoto Joshua M Steinberg Yutaka saito Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaIbaraki 305-8575Japan Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Department of Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

Magnifying endoscopy is a useful technique to differentiate neoplasia from non-neoplastic lesions. Data regarding the clinical utility of magnifying endoscopy for neoplasia in patients with inflammatory bowel disease(IBD) has been emerging.While Kudo’s pit pattern types Ⅲ-Ⅴ are findings suggestive of neoplasia in non-IBD patients, these pit patterns are predictive of IBD-associated neoplasia as well.However, active chronic inflammatory processes, particularly regenerative changes, can mimic neoplastic pit patterns and may affect a meticulous evaluation of pit pattern diagnosis in patients with IBD. The clinical evidence regarding the utility of magnifying endoscopy with narrow band imaging or endocytoscopy has also been evolving in regard to the diagnosis of IBD-associated neoplasia. These advanced endoscopic techniques are promising for multiple reasons;not only for making an accurate diagnosis of neoplasia, but also in determining if endoscopic resection is appropriate for such lesions in patients with IBD. In this review, we discuss the diagnostic accuracy and limitations of magnifying endoscopy in assessing IBD-associated neoplasia and examine the feasibility and outcomes of endoscopic resection for these lesions.

关键词： Magnifying endoscopy Neoplasia Ulcerative colitis Inflammatory bowel disease Endoscopic resection

Stability improvement mechanism due to less charge accumulation in ternary polymer solar cells

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npj Flexible Electronics 2022年第1期6卷 194-203页

作者： Dong Xue Masahiko saito Itaru Osaka Kazuhiro Marumoto Division of Materials Science University of TsukubaTsukubaIbaraki 305-8573Japan Graduate School of Advanced Science and Engineering Hiroshima UniversityHigashihiroshimaHiroshima 739-8527Japan Tsukuba Research Center for Energy Materials Science(TREMS) University of TsukubaTsukubaIbaraki 305-8571Japan

Ternary polymer solar cells based on a thiazolothiazole-based polymer donor(PTzBT)and a fullerene acceptor(PC61BM)have attracted attention because they show high efficiency and stability by addition of a non-fullerene acceptor(ITIC).However,the performance improvement mechanism is not completely elucidated.Here,we show the stability improvement mechanism due to less charge accumulation in the PTzBT cells with ITIC using operando electron spin resonance from a microscopic viewpoint.We observed two correlations between device performance and number of spins(N_(spin))under solar irradiation.One correlation is the decrease in short-circuit current and the N_(spin) increase in electrons on PC_(61)BM and holes in PTzBT,where the ITIC addition causes the less these N_(spin).The other correlation is the increase in open-circuit voltage and the N_(spin) decrease in holes in ZnO.These findings explain the stability improvement mechanism,showing the correlation between less charge accumulation and higher stability,which is valuable for the development of further efficient and stable polymer solar cells.

关键词： charge stability polymer

Increased utilization and mass activity of PtRu on reduced graphene oxide by heat treatment of its aerogel followed by composite with nanomaterials

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Carbon Resources Conversion 2023年第3期6卷 205-214页

作者： Kenta Dejima Hirokazu Ishitobi He Gao Mai saito Nobuyoshi Nakagawa Graduate School of Science and Technology Gunma University1-5-1Tenjin-choKiryuGunma 376-8515Japan Division of Environmental Engineering Science Gunma University1-5-1Tenjin-choKiryuGunma 376-8515Japan Faculty of Science and Technology Gunma University1-5-1Tenjin-choKiryuGunma 376-8515Japan

The method to increase PtRu utilization and its catalytic activity of PtRu nanoparticles supported on reduced graphene oxide(RGO)by avoiding its restacking was proposed with the aim of developing an active catalyst for a direct methanol fuel cell.The heat treatment at 200◦C of the GO aerogel(GOA)prepared by freeze drying of GO ice was introduced to weaken the attractive force of the hydrogen bonding between the GO sheets followed by the composite with the nanoparticles,i.e.,ketjenblack(KB),TiO_(2)and Ti_(4)O_(7),at different weight ratios.The catalyst supported on the heat-treated GOA(RGOA),PtRu/RGOA,improved the PtRu utilization to some extent and also increased the ECSA and mass activity compared to that of PtRu/RGO.RGOA had fewer oxygen functional groups,especially the epoxy groups.Due to the treatment and composite,the PtRu utilization was increased from 66.5%for PtRu/RGO to 128.6%for PtRu/RGOA+Ti_(4)O_(7)(4:1)and the mass activity was improved from 50.7 A/g-PtRu for PtRu/RGO to 130.5 A/g-PtRu for PtRu/RGOA+Ti_(4)O_(7)(1:1).The Ti_(4)O_(7)nanoparticles showed the best catalytic performance for the composite suggesting that the strong interaction between Ti_(4)O_(7)and the Pt nanoparticles was effective due to its high electronic conductivity.

关键词： Reduced graphene oxide Restacking Catalyst utilization Mass activity Composite catalyst Methanol oxidation Ti4O7

Eustachian tube involvement in a patient with relapsing polychondritis detected by magnetic resonance imaging:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1441-1446页

作者： Daisuke Yunaiyama Akiko Aoki Hiroshi Kobayashi Miwako Someya Mitsuru Okubo Kazuhiro saito Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Radiology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Rheumatology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Otorhinolaryngology Head and Neck SurgeryTokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan

BACKGROUND Relapsing polychondritis(RP)is a rare inflammatory disease involving the systemic cartilage,such as the auricle,trachea,and bronchiole,among others.A patient with RP shows variable symptoms based on the involved cartilage.CASE SUMMARY A 72-year-old Japanese woman with a history of redness of the bilateral auricles for 3 d was referred to a clinician.The clinician prescribed antibiotics to the patient;however,the symptoms worsened;thus,she was referred to our hospital.Head and neck magnetic resonance imaging(MRI)showed edematous auricle with remarkable contrast,fluid collection in the bilateral mastoid cells,suggesting otitis media.The eustachian tube(ET)on the right side was also edematous with contrast enhancement.The patient was suspected of RP according to the diagnostic criteria.A biopsy of the auricular cartilage was performed by an otorhinolaryngologist,confirming pathological proof of RP.Treatments with steroids were immediately administered thereafter.CONCLUSION We highlight a rare case of RP with radiologically confirmed involvement of ET in the MRI.

关键词： Relapsing polychondritis Magnetic resonance imaging Contrast enhancement Otitis media with effusion Eustachian tube Case report

不同外源寡糖对设施黄瓜生理特性及产量和品质影响差异

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中国农业气象 2024年第4期45卷 390-403页

作者：杨倚钢韩燕高丽娟宋吉青斋藤信白文波中国农业科学院农业环境与可持续发展研究所/农业农村部农膜污染防控重点实验室北京100081 北京市科学技术研究院分析测试研究所(北京市理化分析测试中心) 北京100089 日本株式会社力森诺科东京1058518

选择壳寡糖(GT)和复合寡糖(KP)为制剂处理,以大棚常规对照(CG)和清水对照(CK)为对比,分析黄瓜叶片叶绿素相对含量(SPAD)、叶绿素荧光参数和超微结构,根系表观形态和根系活力(RV),以及抗氧化酶和内源激素的变化,比较不同类型寡糖制剂对... 详细信息

选择壳寡糖(GT)和复合寡糖(KP)为制剂处理,以大棚常规对照(CG)和清水对照(CK)为对比,分析黄瓜叶片叶绿素相对含量(SPAD)、叶绿素荧光参数和超微结构,根系表观形态和根系活力(RV),以及抗氧化酶和内源激素的变化,比较不同类型寡糖制剂对设施黄瓜生长及产量的调控作用。结果表明:与其他处理相比,KP处理能有效促进黄瓜叶片和根系生长,其SPAD、最大光化学量子产量(Fv/Fm)、光化学淬灭系数(qP)、非光化学淬灭系数(NPQ)和RV均显著增加4.15%~15.63%、6.49%~20.03%、33.33%~152.63%、10.37%~71.62%和8.51%~171.43%;超氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(CAT)活性显著提升6.75%~91.49%、3.85%~97.62%和3.00%~28.15%;此外,促使黄瓜生育后期叶片生长素(IAA)含量显著提高5.43%以上,脱落酸(ABA)含量显著降低4.35%~18.63%;黄瓜产量和可溶性糖含量显著增加13.72%和11.52%以上。比较而言,GT处理对黄瓜根冠生长,内源激素和抗氧化酶活性的影响表现出不稳定性,仅坐果期叶片光合生理特性(SPAD、叶绿素荧光参数和叶片超微结构)和RV有所改善。相较于GT处理,KP处理在促进黄瓜根冠生长,调控抗氧化酶活性和内源激素平衡方面具有明显优势。结合相关性分析发现,黄瓜产量与NPQ、RV、SOD和POD活性呈极显著正相关(P<0.01),与Fv/Fm显著正相关(P<0.05);且SOD和POD活性均与ABA含量显著负相关(P<0.05)。综上,外源复合寡糖主要通过促进黄瓜根冠协调生长,维持生育后期高光合效率、根系活力和叶片功能结构稳定,调节抗氧化酶活性,促进生长激素和抑制生长激素间的平衡,保障生育后期细胞膜功能稳定,延缓叶片自然衰老,实现黄瓜的提质增产。

关键词：设施黄瓜复合寡糖壳寡糖生理特性产量品质