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浙江林业科技 1992年第2期12卷 65-68页

作者： kuroda.K. 宋玉双

一、前言在日本近几十年来松枯萎病对松林造成严重危害(Mamiya 1988)。其症状的发展极为迅速。通常病原线虫(Bursaphelenchusxylophilus)

关键词：松树枯萎病病害

Dyeing Fabrics by Using Extracts from Mulberry Branch/Trunk *** and Fluorescence Property

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American Journal of Plant Sciences 2017年第8期8卷 1888-1903页

作者： Thi Kim Thu Nguyen Akihiro kuroda Hiroshi Urakawa Hidekazu Yasunaga Department of Fibre Science and Engineering Kyoto Institute of TechnologyKyotoJapan

The dyeing of wool, silk, cotton, ramie, nylon, acrylic and polyester fabric by using the extracts from mulberry branches and trunks was tried and the dyeability was studied. While the dyeability of the ethanol-extracts from mulberry is low, that of the water-extracts is high for wool, nylon and silk fabrics. They are dyed brownish and yellowish colours. The obtained colours depend on the extracts concentration in the dye solution, dyeing time, dye solution pH and dyeing temperature. Wool, nylon and silk fabrics are dyed deeper with an increase in the dyeing temperature. The mulberry extracts show fluorescence and reducing property. The results indicate that the mulberry extracts contain flavonols such as morin, kaempferol or quercetin, which form complexes with Al3+ and show fluorescence. The wool treated with the mulberry extracts or AlCl3/mulberry extracts shows fluorescence with ultraviolet light irradiation.

关键词： Mulberry Branch Mulberry Trunk Extracts Dyeing Fluorescence Reductant Sustainable Dyestuff Material

Epidemiological Studies on the Relationship between PTSD Symptoms and Circadian Typology and Mental/Sleep Health of Young People Who Suffered a Natural Disaster, Great Hanshin-Awaji Earthquake

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Natural Science 2014年第5期6卷 338-350页

作者： Kai Wada Hiroko kuroda Miyo Nakade Hitomi Takeuchi Tetsuo Harada Department of Nutritional Management Faculty of Health and Nutrition Tokai-Gakuen University Miyoshi Japan Laboratory of Environmental Physiology Graduate School of Integrated Arts and Sciences Kochi University Kochi Japan

This study aims, first, to determine the relationship between Post Traumatic Stress Disorder (PTSD) and current circadian typology and sleep habits of adults who experienced the Great Hanshin-Awaji Earthquake in their childhood in January 1995. An integrated questionnaire was administered to 275 university students (females: 173, males: 93, unknown: 9) aged 19 - 37 (mean age: 21.9 years) in Hyogo Prefecture, Japan. The questionnaire consisted of basic questions about attributes, questions on sleep habits and sleep quality (Monroe’s sleep quality index), the Torsvall-?kerstedt Diurnal Type Scale and the Impact of Event Scale-Revised (IES-R) to obtain PTSD scores. Participants who scored 25 or more in the IES-R were placed in a high-traumatic group (HTG) and those who scored less than 25 were placed in a low-traumatic group (LTG). HTG participants exhibited significantly worse sleep quality than LTG participants (p 0.05), HTG participants woke more frequently during sleep (p < 0.001) and had more difficulty falling asleep (p = 0.001) than LHG participants. Significantly more LTG participants fell asleep easily and slept deeply than HTG participants (p = 0.005, p = 0.011). Only among females, HTG participants were more evening-typed than LTG participants (p = 0.035). These results suggest that people who suffered a disaster in childhood and currently have PTSD have difficulty achieving high sleep quality. Evening-type lifestyles may reinforce the symptoms of PTSD. The study aims, second, to examine the effects of intervention for one month using a leaflet to promote the morning-typed life for persons who suffered natural disaster entitled “Go to bed early, Get up early and Do not forget to have a breakfast for getting three benefits!”. Only one person was over the cutoff point (between 24 and 25) before intervention. This high-traumatic person’s comprehensive sleep health tended to be improved

关键词： Natural Disasters Victims PTSD Sleep Quality Circadian Typology

Differential Expression of Glu-Tubulin in Basal-Like Phenotype Carcinoma of the Mammary Gland

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Advances in Breast Cancer Research 2013年第3期2卷 66-71页

作者： Hajime kuroda Yasuo Imai Kazuko Kuroso Masato Kojima Yoshihiko Ueda Department of Pathology Dokkyo Medical University Koshigaya Hospital Koshigaya Japan Department of Pathology International University of Health and Welfare Hospital 537-3 Iguchi Nasushiobara Japan Departments of Surgery Dokkyo Medical University Koshigaya Hospital Koshigaya Japan

High levels of tubulin expression have been described in a variety of human malignant tumors, and glu-tubulin, in which the C-terminal tyrosine of α-tubulin is removed by tubulin carboxypeptidase. Over-expression has been reported in the malignant tumors of the mammary gland and correlated with poor prognosis immunohistochemically. Furthermore, Nielsen et al. proposed that the use of a panel of four markers (ER, HER 2, CK 5/6, and EGFR) could accurately identify basal-like phenotype carcinoma (BPC) with widely available standard pathologic tools. In our study, major prognostic factors such as patient age, tumor size, histological grade, axillary lymph node metastasis, vessel invasion, and local recurrence in BPC were not significantly different from non BP carcinoma (NBPC). However, the BPC group showed a higher ratio of distant metastasis than that of the NBPC group. In triple-negative carcinoma (TNC) cases, staining for glu-tubulin was observed in 46 cases (63.8%), which consisted of 42 of the 58 BPC patients (72.4%) and 4 of the 14 NBPC patients (28.6%). A significant association was found between the expression of glu-tubulin and BPC, but not NBPC. It seems that our findings also agree with the observation that BPC exhibits aggressive biological behavior and increases the content of glu-tubulin, which plays a greater role in migration and invasion.

关键词： Glu-Tubulin Basal-Like Phenotype Carcinoma Mammary Gland

Molecular mechanisms of triggering,amplifying and targeting RANK signaling in osteoclasts

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World Journal of Orthopedics 2012年第11期3卷 167-174页

作者： Yukiko kuroda Koichi Matsuo Laboratory of Cell and Tissue Biology School of MedicineKeio UniversityTokyo 160-8582Japan

Osteoclast differentiation depends on receptor activator of nuclear factor-κB(RANK) signaling,which can be divided into triggering,amplifying and targeting phases based on how active the master regulator nuclear factor of activated T-cells cytoplasmic 1(NFATc1) is. The triggering phase is characterized by immediateearly RANK signaling induced by RANK ligand(RANKL) stimulation mediated by three adaptor proteins,tumor necrosis factor receptor-associated factor 6,Grb-2-associated binder-2 and phospholipase C(PLC)γ2,leading to activation of IκB kinase,mitogen-activated protein kinases and the transcription factors nuclear factor(NF)-κB and activator protein-1(AP-1). Mice lacking NF-κB p50/p52 or the AP-1 subunit c-Fos(encoded by Fos) exhibit severe osteopetrosis due to a differentiation block in the osteoclast lineage. The amplification phase occurs about 24 h later in a RANKLinduced osteoclastogenic culture when Ca2+ oscillation starts and the transcription factor NFATc1 is abundantly produced. In addition to Ca2+ oscillation-dependent nuclear translocation and transcriptional auto-induction of NFATc1,a Ca2+ oscillation-independent,osteoblastdependent mechanism stabilizes NFATc1 protein in dif-ferentiating osteoclasts. Osteoclast precursors lacking PLCγ2,inositol-1,4,5-trisphosphate receptors,regulator of G-protein signaling 10,or NFATc1 show an impaired transition from the triggering to amplifying phases. The final targeting phase is mediated by activation of numerous NFATc1 target genes responsible for cell-cell fusion and regulation of bone-resorptive function. This review focuses on molecular mechanisms for each of the three phases of RANK signaling during osteoclast differentiation.

关键词： Receptor activator of nuclear factor-κB ligand Tumor necrosis factor receptor-associated factor 6 c-Fos Nuclear factor of activated T-cells cytoplasmic 1 Immunoreceptor tyrosine-based activation motif Ca2+oscillation

Osteoconductivity of Hydrophilic Surfaces of Zr-9Nb-3Sn Alloy with Hydrothermal Treatment

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Journal of Biomaterials and Nanobiotechnology 2015年第3期6卷 126-134页

作者： Mansjur Zuldesmi Kensuke kuroda Masazumi Okido Masato Ueda Masahiko Ikeda Department of Materials Science & Engineering Graduate School of Engineering Nagoya University Nagoya Japan Department of Mechanical Engineering Manado State University (UNIMA) Indonesia EcoTopia Science Institute Nagoya University Nagoya Japan Faculty of Chemistry Materials and Bioengineering Kansai University Suita Japan

Zirconium and its alloys are more suitable materials for implant surgery to be performed in a magnetic resonance imaging scanner compared with other implant materials. Although they have high anticorrosion properties in the body, as do titanium and its alloys, they have little use as implants in contact with bone because of their low osteoconductivity (bone-implant contact ratio). To improve the osteoconductivity of zirconium, niobium, and Zr-9Nb-3Sn alloy, we applied a single- step hydrothermal surface treatment using distilled water at a temperature of 180°C for 3 h. The hydrothermally treated samples were stored in a ×5 phosphate-buffered saline (PBS(-)) solution to keep or to improve the water contact angle (WCA), which has a strongly positive effect on osteoconductivity. The specimen surfaces were characterized using scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, surface roughness, and contact angle measurement using a 2 μL droplet of distilled water. The relationship between WCA and osteoconductivity for various surface modifications was examined using in vivo tests. The results showed that a superhydrophilic surface with a WCA ≤ 10° and a high osteoconductivity of up to 40% in cortical bone, about four times higher than the as-polished Zr-9Nb-3Sn and its pure alloy elements, was provided by the combination of hydrothermal surface treatment and storage in ×5 PBS(-).

关键词： Zirconium Alloys Hydrothermal Hydrophilic in Vivo Osteoconductivity

EBSD Analysis of the Submicron Width Fibber Shaped Grain Copper Fabricated by Drawing

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Materials Sciences and Applications 2011年第7期2卷 911-916页

作者： Masafumi Matsushita Tomoya Kuji Hiromitsu kuroda Seigi Aoyama Hiroaki Ohfuji 不详

Several drawing processes of 3N pure copper (Cu) with ultra high reduction in area have been performed, and the texture has been observed using electron back scattered diffraction. It is well known that the texture of drawn Cu is closely related to its mechanical properties;in particular nanometer scale width fibber shaped grain is interesting. Previously, it was reported that drawing 3N Cu with around 95% reduction in area changes its mechanical properties. In the present experiment, grains have been changed from round to fiber-shaped, and subsequently, submicron-width fiber grains were generated with a 94.546% reduction in area. However, above 94.546% reduction in area, dynamic recrystallization occurred and then, prevented the grains to be finer. Further recrystallized grains influence on the macroscopic mechanical properties of Cu wire. Furthermore, the distribution of the misorientation angle at grain boundaries increased with an increase in the degree of reduction in area;in particular, the distribution drastically increased between 94.546% and 99.997%. Further, the frequency of coincidence of site lattice boundaries increased. The abovementioned variations in texture are closely related to mechanical properties.

关键词： Drawing Grain Boundary EBSD Cu Fibber Shape Grain

Effect of Li Ions on Al Electrodeposition from Dimethylsulfone

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Journal of Surface Engineered Materials and Advanced Technology 2018年第4期8卷 110-125页

作者： Sangjae Kim Shota Kumeno Kenta Kamebuchi Kensuke kuroda Masazumi Okido Department of Materials Science & Engineering Graduate School of Engineering Nagoya University Nagoya Japan Institute of Materials and Systems for Sustainability IMaSS Nagoya University Nagoya Japan

The influence of LiCl coexistence with Al electrodeposition was investigated in a dimethyl sulfone, DMSO2, bath containing AlCl3 at 403 K. The electrochemical behaviors of Li and Al ions were examined using Pt electrodes in the bath and the deposition mechanism was analyzed by cyclic voltammetry, CV, with an Al reference electrode in the bath. The coexistence of LiCl in the AlCl3-DMSO2 bath inhibited the cathodic current corresponding to Al deposition in the CV experiment. The amount of ca. 500 μmol Al deposits was obtained in constant potential electrolysis for 1 h at –2 V in the bath with 10 mol% AlCl3. However, it decreased to 140 μmol Al in the bath with 10 mol% AlCl3 and 5 mol% LiCl. It was clarified that LiCl addition led to the formation of Li(DMSO2)+ more than the formation of ?from NMR measurement for the baths. This results in the suppression of Al deposition because LiCl inhibits the formation of complex ions, which is said to be necessary for Al electrodeposition.

关键词： Electrodeposition Aluminum Lithium Nuclear Magnetic Resonance Dimethylsulfone

Coevolution of Myoelectric Hand Control under the Tactile Interaction among Fingers and Objects

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Cyborg and Bionic Systems 2022年第1期2022卷 285-302页

作者： Yuki kuroda Yusuke Yamanoi Shunta Togo Yinlai Jiang Hiroshi Yokoi Joint Doctoral Program for Sustainability Research Graduate School of Informatics and Engineering The University of Electro-CommunicationsTokyoJapan Department of Mechan ical and Intelligent System Engineering Graduate School of Informatics and Engineering The University of Electro Communications TokyoJapan Center for Neuroscience and Biomedical Engineering The University of Electro Communications TokyoJapan Bejing Innovation Center for Inelligent Robots and Systems BeijingChina

The usability of a prosthetic hand difers significantly from that of a real ***,the complexity of manipulation increases as the number of degrees of freedom to be controlled increases,making manipulation with biological signals extremely *** overcome this problem,users need to select a grasping posture that is adaptive to the object and a stable grasping method that prevents the object from *** previous studies,these have been left to the operating skills of the user,which is extremely difficult to *** this study,we demonstrate how stable and adaptive grasping can be achieved according to the object regardless of the user's operation *** required grasping technique is achieved by determining the correlation bet ween the motor output and each sensor through the interaction between the prosthetic hand and the surrounding stimuli,such as myoelectricity,sense of touch,and grasping *** agents of the 16 DOF robot hand were trained with the myoelectric signals of six participants,including one child with a congenital forearm ***,each agent could open and close the hand in response to the myoeletric stimuli and could accomplish the object pickup *** the tasks,the agents successfully identified grasping patterns suitable for practical and stable positioning of the *** addition,the agents were able to pick up the object in a similar posture regardless of the partiipant,suggesting that the hand was optimized by evolutionary computation to a posture that prevents the object from being dropped.

关键词： robot Objects overcome