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Pure laparoscopic hepatectomy as repeat surgery and repeat hepatectomy

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World Journal of Gastroenterology 2015年第3期21卷 961-968页

作者： Masashi Isetani Zenichi Morise Norihiko Kawabe hirokazu Tomishige Hidetoshi Nagata Jin Kawase Satoshi arakawa Department of Surgery Fujita Health University School of MedicineBanbuntane Houtokukai HospitalAichiNagoya 454-8509Japan

AIM:To assess clinical outcomes of laparoscopic hepatectomy(LH) in patients with a history of upper abdominal surgery and repeat ***:This study compared the perioperative courses of patients receiving LH at our institution that had or had not previously undergone upper abdominal *** the 80 patients who underwent LH,22 had prior abdominal surgeries,including hepatectomy(n = 12),pancreatectomy(n = 3),cholecystectomy and common bile duct excision(n = 1),splenectomy(n = 1),total gastrectomy(n = 1),colectomy with the involvement of transverse colon(n = 3),and extended hysterectomy with extensive lymph-node dissection up to the upper abdomen(n = 1).Clinical indicators including operating time,blood loss,hospital stay,and morbidity were compared among the ***:Eighteen of the 22 patients who had undergone previous surgery had severe adhesions in the area around the ***,there were no conversions to laparotomy in this *** the 58 patients without a history of upper abdominal surgery,the median operative time was 301 min and blood loss was 150 m *** patients with upper abdominal surgical history or repeat hepatectomy,the operative times were 351 and 301 min,and blood loss was 100 and 50 m L,*** median postoperative stay was 17,13 and 12 d for patients with no history of upper abdominal surgery,patients with a history,and patients with repeat hepatectomy,*** were five cases with complications in the group with no surgical history,compared to only one case in the group with a prior *** were no statistically significant differences in the perioperative results between the groups with and without upper abdominal surgical history,or with repeat ***:LH is feasible and safe in patients with a history of upper abdominal surgery or repeat hepatectomy.

关键词： Chronic liver disease Laparoscopic hepatectomy Liv

Recent advances in the surgical treatment of hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第39期20卷 14381-14392页

作者： Zenichi Morise Norihiko Kawabe hirokazu Tomishige Hidetoshi Nagata Jin Kawase Satoshi arakawa Rie Yoshida Masashi Isetani Department of Surgery Fujita Health University School of Medicine Banbuntane Houtokukai Hospital Nagoya 454-8509 Japan

Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection(LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality in patients with HCC. The indication for LR may be expanded due to emerging evidences from laparoscopic hepatectomies and combined treatments with newly developed chemotherapies. Liver transplantation(LT) is considered as an ideal treatment for removal of existing tumors and the injured/preneoplastic underlying liver tissue with impaired liver function and the risk of multicentric carcinogenesis that results from chronically injured liver. However, LT is restricted to patients with minimal risk of tumor recurrence under immunosuppression. The expansion of criteria for LT in HCC patients is still under trial and discussion. Limited availability of grafts, as well as the risk and the cost of transplantation have led to considerable interest in expansion of the donor pool, living donor-related transplantation, and combined treatment involving LR and LT. This highlight presents evidence concerning recent studies evaluating LR and LT in HCC patients. In addition, alternative therapies for the treatment of early stage tumors and the management of patients on transplant waiting lists are discussed.

关键词： Hepatocellular carcinoma Surgical treatment Hepatectomy Liver transplantation Laparoscopic hepatectomy Tumor thrombi Chemotherapy

An interactive approach to investigate brightness perception of daylighting in Immersive Virtual Environments:Comparing subjective responses and quantitative metrics

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Building Simulation 2022年第1期15卷 41-68页

作者： Muhammad Hegazy Kensuke Yasufuku hirokazu Abe Graduate School of Engineering Osaka UniversityYamadaoka 2-1 Suita Osaka567-0047Japan Cybermedia Center Osaka UniversityJapan

Daylighting plays an eminent role in the performance of indoor environments and their occupants,thus necessitating the need to investigate daylight perception of potential occupants at early design *** present study introduces an interactive approach to collect and visualize brightness perception of daylighting in a large-scale immersive virtual environment using a game engine as a daylight simulation *** developed system allows users to explore building models freely at different day times set in virtual reality and report their perceptions in real *** a validation study(N=36)to investigate the consistency of brightness perceptions in a real environment and its virtual replica,a set of 24 participants were recruited to use the system to report their brightness perception in a virtual model of a daylit art museum,through snapshotting the scenes where they perceive as one of the following in terms of daylighting:(very dark,dark,bright,or very bright).Using an output of 419 snapshots,a"Perceptual Light Map"(PLM)was developed to visualize the collective brightness perception of participants as a heat *** responses were found to be positively correlated with four daylight metrics,with the highest correlation to mean luminance and the lowest to luminance *** findings of this exploratory study represent a step towards a user-oriented supplement tool to the existing quantitative daylight metrics,validating game engines’adequacy as a daylight simulation tool,and illustrating the potentials of immersion and interaction principles for the perception of daylit spaces in virtual reality.

关键词： immersive virtual environment daylighting game engine human perception mean luminance

Shortening of alkaline DNA unwinding time does not interfere with detecting DNA damage to mouse and human spermatozoa in the comet assay

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Asian Journal of Andrology 2011年第1期13卷 172-174页

作者： hirokazu Kusakabe Hiroyuki Tateno Department of Biological Sciences Asahikawa Medical University Asahikawa 078-8510 Japan

The comet assay was performed on mouse and human spermatozoa to examine the effect of alkaline DNA unwinding time. The spermatozoa were treated in vitrowith the DNA-damaging agents, methyl methanesulfonate （MMS） or hydrogen peroxide （Hz02）, and then embedded in agarose gel on glass sl ides. The slides were immersed in alkaline solution （〉pH 13） for 1, 5, 10 and 20 min, and then subjected to the electrophoresis under neutral conditions. In mouse spermatozoa, comet tails seen in solvent controls became brighter and longer as the alkaline DNA unwinding time increased. However, in the MMS-treated mouse spermatozoa, a smaller difference in the damage from that in the solvent control was seen with time within a dose. DNA damage induced by H2O2 could also be detected accurately after alkali treatment for 1-20 min. In human spermatozoa, DNA damage induced by MMS and H2O2 could be detected in a dose-dependent manner after alkali treatment for 1 min. The ability of the comet assay to detect DNA damage was not adversely affected by the short period （1 min） of the alkaline DNA unwinding time.

关键词： alkaline comet assay DNA unwinding human mice spermatozoa

Deformation behaviors of magnesium alloy AZ31 sheet in cold deep drawing

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中国有色金属学会会刊：英文版 2008年第1期18卷 86-91页

作者：杨连发 MORI Ken-ichiro TSUJI hirokazu School of Electromechnical Engineering Guilin University of Electronic Technology Department of Production Systems Engineering Toyohashi University of Technology

To investigate how the popular magnesium alloy AZ31 sheet(aluminum 3%,zinc 1%)behaves in cold working,deep drawing experiments at room temperature,along with finite element(FE)simulation,were performed on the cold forming sheet of the AZ31 alloy after being annealed under various *** activities were focused on the fracture pattern,limit drawing ratio(LDR),deformation load,thickness distribution,anisotropic effect,as well as the influences of the annealing conditions and tool configuration on *** results display that punch shoulder radius instead of die clearance,has much influence on the thickness *** anisotropy is remarkable in cold working,which adversely impacts the *** fracture often happens on the side wall at an angle to axis of the deformed *** results also imply that the LDR for the material under present experimental conditions is 1.72,and annealing the material at 450 ℃ for 1 h may be preferable for the cold deep drawing.

关键词： AZ31镁合金冷压制各向异性有限元素模拟

Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer

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World Journal of Gastroenterology 2006年第34期12卷 5517-5522页

作者： Makoto Ishikawa Joji Kitayama hirokazu Nagawa Department of Surgery Division of Surgical Oncology theUniversity of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655Japan

AIM: To examine the expression of leptin and its receptor, OB-R, in normal gastric mucosa and neoplasia. METHODS: By immunohistochemical staining using specifi c antibodies, we evaluated the expression of leptin and OB-R in 207 gastric carcinomas (100 early and 107 advanced carcinomas) and analyzed their relationship with clinicopathological features. RESULTS: Both normal gastric epithelium and carci- noma cells expressed a significant level of leptin. In cases with OB-R staining, carcinoma cells showed OB-R- positive expression, but the intensity was weaker than that in normal mucosa. The expression of OB-R showed a signifi cant correlation with the level of leptin expres- sion. The expression levels of both leptin and OB-R tend- ed to increase as the depth of tumor invasion or TMN stage increased (P < 0.01). Lymph node metastasis was detected in 49.5% (47/95) of leptin-strong cases and in 50.5% (48/95) of OB-R-positive cases, and the rate was 33% (37/112) in leptin-weak cases and 17% (19/112) in OB-R-negative cases. Both venous and lymphatic inva- sion also tended to be observed frequently in positive tumors as compared with negative tumors. Interestingly, in the 96 leptin- or OB-R-positive tumors, hematogenous metastasis was detected preoperatively in 3 (3.1%) pa- tients. In contrast, none of the carcinomas that lacked expression of leptin and OB-R showed hematogenous metastasis. CONCLUSION: Overexpression of leptin and expres- sion of OB-R may play a positive role in the process of progression in gastric cancer. Functional upregulation of leptin/OB-R may have a positive role in the development and initial phase of progression in gastric cancer.

关键词： Leptin OB-R Gastric cancer

Factors Impacting Participatory Post‑Disaster Relocation and Housing Reconstruction:The Case of Tsholotsho District,Zimbabwe

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International Journal of Disaster Risk Science 2024年第1期15卷 58-72页

作者： Nombulelo Kitsepile Ngulube hirokazu Tatano Subhajyoti Samaddar Department of Social Informatics Graduate School of InformaticsKyoto UniversityKyoto 606-8507Japan Disaster Prevention Research Institute(DPRI) Kyoto UniversityKyoto 611-0011Japan

Relocation is not typically considered the best planning option for post-disaster reconstruction and rehabilitation,but it may be necessary if the site has suffered severe damage or is at imminent *** is a growing recognition that strong community participation is necessary in the post-disaster relocation decision-making process since relocation can have detrimental effects on a community’s livelihood,cultural system,and way of life,among ***,the realization of this still needs to be *** of yet,few studies have examined a comprehensive account of meaningful community engagement in post-disaster relocation and reconstruction,particularly in developing *** study investigated what factors influenced local communities’ participation in post-disaster relocation and reconstruction works after the 2017Cyclone Dineo flood disaster in the Tsholotsho District of *** research methods such as face-to-face interviews,observations,and focus groups were used to collect qualitative data from a purposive sample of 25 community members and 6 *** empirical investigation showed that despite the fact that the relocation project was conceived as a community-centered project,there was no meaningful community engagement,due to the absence of a participatory framework or planning guidelines for stakeholder engagement,as well as the lack of political willingness among government *** study concluded that the lack of community involvement led to local communities abandoning the reconstruction sites because relocation projects failed to accommodate the cultural beliefs,place attachments,and livelihood concerns of local *** study suggested that it is imperative to enhance the awareness of government officials and other stakeholders about the importance of community participation for the effective implementation of post-disaster relocation *** community participation can also provide avenues fo

关键词： Community rehabilitation Housing reconstruction-Participatory relocation Zimbabwe

A method for estimating the errors in many-light rendering with supersampling

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Computational Visual Media 2019年第2期5卷 151-160页

作者： hirokazu Sakai Kosuke Nabata Shinya Yasuaki Kei Iwasaki Wakayama University WakayamaWakayama640-8510Japan Dwango CG Research KADOKAWA Hongo Bldg.5245 HongoBunkyo-kuTokyo1130033Japan

In many-light rendering, a variety of visual and illumination effects, including anti-aliasing,depth of field, volumetric scattering, and subsurface scattering, are combined to create a number of virtual point lights(VPLs). This is done in order to simplify computation of the resulting illumination. Naive approaches that sum the direct illumination from many VPLs are computationally expensive;scalable methods can be computed more efficiently by clustering VPLs, and then estimating their sum by sampling a small number of VPLs. Although significant speed-up has been achieved using scalable methods, clustering leads to uncontrollable errors, resulting in noise in the rendered images. In this paper, we propose a method to improve the estimation accuracy of manylight rendering involving such visual and illumination effects. We demonstrate that our method can improve the estimation accuracy by a factor of 2.3 over the previous method.

关键词： anti-aliasing depth of field many-light rendering participating media

Community Insights:Citizen Participation in Kamaishi Unosumai Decade-Long Recovery from the Great East Japan Earthquake

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International Journal of Disaster Risk Science 2023年第6期14卷 886-897页

Numerous scholars and researchers have long advocated for citizen engagement in post-disaster recovery and reconstruction initiatives,although unique opportunities and challenges in effectively implementing citizen engagement still *** has been 12 years since the Great East Japan Earthquake,where the government called for a citizen-centered recovery and reconstruction process,and reconstruction in most areas in the Tohoku region has almost been *** qualitative data acquired through interviews with the residents,field observations during the World Bosai Walk,and questionnaire and archival research,this study aimed to discuss the overall reconstruction of Unosumai in Iwate Prefecture,giving the residents'perspective on the benefits and challenges they faced in participating in recovery planning and reconstruction and how the community has been able to strengthen their participation in disaster reduction initiatives since the earthquake and *** discussion is crucial as it would effectively offer lessons on engaging residents in post-disaster recovery and reconstruction after mega-disasters.

关键词： Community participation Community perspective Japan Post-disaster Reconstruction Recovery planning