检索结果-南通市图书馆

Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma

引用

World Journal of Gastroenterology 2017年第31期23卷 5764-5772页

作者： Kohei Nishio Kenjiro Kimura Ryosuke Amano Bunzo Nakata Sadaaki Yamazoe Go Ohira Kotaro Miura Naoki Kametani hiroaki tanaka Kazuya Muguruma Kosei Hirakawa Masaichi Ohira Department of Surgical Oncology Osaka City University Graduate School of Medicine Department of Surgery Kashiwara Municipal Hospital

To elucidate the effect of expression of doublecortin and CaM kinase-like-1 (DCLK1) in patients with pancreatic ductal adenocarcinoma (PDAC). METHODSTumor specimens were obtained from 136 patients with pancreatic cancer who had undergone resection without preoperative therapy between January 2000 and December 2013 at the Department of Surgical Oncology, Osaka City University. The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition (EMT) marker expression, and cancer stem cell (CSC) marker expression. Univariate and multivariate survival analyses were performed and we assessed the association between DCLK1 expression and clinicopathological factors, including the EMT marker and CSC marker. RESULTSIn total, 48.5% (66/136) of the pancreatic cancer samples were positive for DCLK1. Patients with DCLK1-positive tumors had significantly shorter survival times than those with DCLK1-negative tumors (median, 18.7 mo vs 49.5 mo, respectively; P < 0.0001). Positive DCLK1 expression correlated with histological grade (P = 0.0290), preoperative CA19-9 level (P = 0.0060), epithelial cell adhesion molecule (EpCAM) expression (P = 0.0235), and the triple-positive expression of CD44/CD24/EpCAM (P = 0.0139). On univariate survival analysis, five factors were significantly associated with worse overall survival: histological grade of G2 to G4 (P = 0.0091), high preoperative serum SPan-1 level (P = 0.0034), R1/2 (P < 0.0001), positive expression of DCLK1 (P < 0.0001) or CD44 (P = 0.0245). On multivariate survival analysis, R1/2 [odds ratio (OR) = 2.019, 95% confidence interval (CI): 1.380-2.933; P = 0.0004] and positive DCLK1 expression (OR = 1.848, 95%CI: 1.2854-2.661; P = 0.0009) were independent prognostic factors. CONCLUSIONDCLK1 expression was found to be an independent prognostic factor and it may play a crucial prognostic role by promoting acquisition of stemness.

关键词： Doublecortin and CaM kinase-like-1 Pancreatic cancer Epithelial mesenchymal transition Cancer stem cell Prognostic factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effectiveness of sub-maximal intermittent exercise on muscle glycogen depletion, PGC-1<i>α</i>and PDK-4 gene expression

引用

Open Journal of Molecular and Integrative Physiology 2012年第4期2卷 119-126页

作者： Keisuke Shiose Takuro Tobina Yasuki Higaki Akira Kiyonaga hiroaki tanaka Faculty of Nursing and Nutrition University of Nagasaki Nagasaki Japan Faculty of Sports and Health Science Fukuoka University Fukuoka Japan Fukuoka University Institute for Physical Activity Fukuoka Japan Graduate School of Sports and Health Science Fukuoka University Fukuoka Japan

Several metabolic gene expressions are regulated in concert with muscle glycogen status. We hypothesized that intermittent exercise performed at high but sub-maximal intensities with long recovery periods would induce a low glycogen state that would stimul- ate peroxisome proliferator-activated receptor-γ coa- ctivator-1α (PGC1-α) and pyruvate dehydrogenase kinase-4 (PDK-4) gene expression in muscle. Nine young human subjects performed two intermittent exercise sessions. One session consisted of 60 s cycling bouts at VO2max (IE100%), and the other session consisted of 75 s cycling bouts at 80% VO2max (IE80%). Twelve bouts of exercise were completed in both sessions with a 4 min rest between each bout. Muscle specimens were obtained at pre-exercise and immediately, 1.5 h and 3 h post-exercise. Muscle gly- cogen was significantly decreased after both sessions (IE100%, 94.1 ± 5.8 to 38.7 ± 5.5 mmol/kg w.w.;IE80%, 94.6 ± 9.1 to 53.3 ± 4.8 mmol/kg w.w.;both P α and PDK- 4 mRNA expression were significantly increased after exercise in both IE100% and IE80% (PGC-1α: ~3.7 and ~2.9-fold, respectively;PDK-4: ~11.1 and ~3.5-fold, respectively;all P 100% than in IE80% (P a and PDK-4 mRNA expression, suggesting that increasing exercise intensity contributes to muscle glycogen depletion and PDK-4 mRNA expression in human skeletal muscle.

关键词： Intermittent Exercise Muscle Glycogen Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Pyruvate Dehydrogenase Kinase-4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Short Report: Association of IL-15 with Peripheral and Hepatic Insulin Sensitivity in Healthy Middle-Aged Men

引用

Open Journal of Endocrine and Metabolic Diseases 2014年第3期4卷 59-67页

作者： Yuichiro Nishida Kumpei Tokuyama Shoichiro Nagasaka Akira Kiyonaga Yasuki Higaki Megumi Hara Keitaro tanaka hiroaki tanaka Department of Preventive Medicine Faculty of Medicine Saga University Saga Japan Division of Endocrinology and Metabolism Department of Medicine Jichi Medical University Tochigi Japan Laboratory of Biochemistry of Exercise and Nutrition Institute of Health and Sport Sciences University of Tsukuba Ibaraki Japan Laboratory of Exercise Physiology Faculty of Health and Sports Science Fukuoka University Fukuoka Japan

Rodent study suggests that interleukin (IL)-15 administration enhances insulin sensitivity. Although it is well known that circulating levels of typical inflammatory markers (C-reactive protein [CRP] and IL-6) are positively associated with homeostasis model assessment-insulin resistance (HOMA-IR), there are no studies investigating the associations of other inflammatory markers including IL-15 with peripheral/hepatic insulin sensitivity in humans. The current study aimed to examine the relationship between the levels of adiopokines or inflammatory cytokines and insulin sensitivity in 8 healthy middle-aged men. Circulating levels of 10 insulin sensitizing adipokines or inflammatory cytokines (total adiponectin [APN], high molecular weight adiponectin [HMW-APN], IL-4, IL-5, IL-6, IL-8, IL-15, interferon [IFN]-γ, tumor necrosis factor [TNF]-α, and TNF-β) were measured. A stable-labeled frequently sampled intravenous glucose tolerance test was performed to assess peripheral () and hepatic () insulin sensitivity estimated by 2-compartment minimal model. The levels of 3 inflammatory cytokines (IL-4, IL-6, and IL-15) were significantly and inversely correlated with either and . The association between IL-15 and either or was significant even after adjusting for age and percent body fat (p < 0.01). The current study showed a possible inverse association between serum IL-15 level and peripheral/hepatic insulin sensitivity in healthy middle-aged males, independent of percent body fat;this association in humans warrants further study.

关键词： Inflammatory Cytokine Interleukin Adipokine Insulin Sensitivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel approach to Parkinson's disease treatment with a potentially dual-acting therapeutic agent that targetsα-synuclein aggregation and neuron death

引用

Neural Regeneration Research 2024年第12期19卷 2577-2578页

作者： Allison RBalaj hiroaki Kaku Department of Investigative Medicine Western Michigan University Homer Stryker MD School of MedicineKalamazooMIUSA

Parkinson's disease(PD),a prevalent neurodegenerative disorder,is chara cterized by the loss of dopaminergic neurons and the aggregation ofα-synuclein protein into Lewy *** the current standards of therapy have been successful in providing some symptom relief,they fail to address the underlying pathophysiology of PD and as a result,they have no effect on disease progression.

关键词： aggregation death therapeutic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fractal image analysis and bruise damage evaluation of impact damage in guava

引用

Information Processing in Agriculture 2024年第2期11卷 217-227页

作者： Than Htike Rattapon Saengrayap hiroaki Kitazawa Saowapa Chaiwong School of Agro-Industry Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Agriculture Ministry of AgricultureLivestock and Irrigation 11181Myanmar Integrated Agri-Tech Ecosystem Research Group Mae Fah Luang UniversityChiang Rai 57100Thailand Institute of Food Research National Agriculture and Food Research OrganizationIbaraki 305-8642Japan

Impact bruise damage and quality of‘Gim Ju’guava were investigated for different drop heights and number of drops using fractal image *** the impact test,a stainless-steel metal ball(250 g)was dropped on fruit from three drop heights(0,0.3,0.6 m)either once or five *** quality was evaluated for impact energy,bruise area(BA),bruise volume(BV),bruise susceptibility,bruise score and pulp color(L*,a*,b*and C values).The fractal dimension(FD)value using fractal image analysis was analyzed at the bruise *** showed that five drops(0.3 m)with a high impact energy(3678.75 J)and a single drop(0.6 m)with a low impact energy(1471.50 J)exhibited no significant in BA,BV,bruise score as well as all color values(L*,a*,b*and C).While the FD value of a single drop from 0.6 m had a higher FD value than that of five drops from 0.3 *** is indicated that FD exhibited a better performance to classify impact bruising level of guava than BA,BV and color *** FD value gradually decreased with increase of storage time and bruise *** correlation coefficient(r)values of FD(r=−0.794 and−0.745)between BA and BV were more significant than those L*(r=−0.660 and−0.615)and a*(r=0.579 and 0.473).The coefficient of determination(R^(2))of the polynomial equation in bruised fruit(R^(2)=0.85 to 0.99)was greater than the control(no bruise)(R^(2)=0.80).A higher R^(2)val(0.88 and 0.92)was exhibited at five ***,FD analysis showed greater potential than color measurement to assess bruise impact damage in guava.

关键词： Bruise susceptibility Impact bruise Mechanical injury Transportation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current status in remnant gastric cancer after distal gastrectomy

引用

World Journal of Gastroenterology 2016年第8期22卷 2424-2433页

作者： Masaichi Ohira Takahiro Toyokawa Katsunobu Sakurai Naoshi Kubo hiroaki tanaka Kazuya Muguruma Masakazu Yashiro Naoyoshi Onoda Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of Medicine

Remnant gastric cancer(RGC) and gastric stump cancer after distal gastrectomy(DG) are recognized as the same clinical entity. In this review, the current knowledges as well as the non-settled issues of RGC are presented. Duodenogastric reflux and denervation of the gastric mucosa are considered as the two main factors responsible for the development of RGC after benign disease. On the other hand, some precancerous circumstances which already have existed at the time of initial surgery, such as atrophic gastritis and intestinal metaplasia, are the main factors associated with RGC after gastric cancer. Although eradication of Helicobacter pylori(H. pylori) in remnant stomach is promising, it is still uncertain whether it can reduce the risk of carcinogenesis. Periodic endoscopic surveillance after DG was reported useful in detecting RGC at an early stage, which offers a chance to undergo minimally invasive endoscopic treatment or laparoscopic surgery and leads to an improved prognosis in RGC patients. Future challenges may be expected to elucidate the benefit of eradication of H. pylori in the remnant stomach if it could reduce the risk for RGC, to build an optimal endoscopic surveillance strategy after DG by stratifying the risk for development of RGC, and to develop a specific staging system for RGC for the standardization of the treatment by prospecting the prognosis.

关键词： Remnant gastric cancer Helicobacter pylori endoscopic treatment Surveillance laparoscopic surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inflammation-based factors and prognosis in patients with colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2015年第8期7卷 111-117页

作者： Kiyoshi Maeda Masatusne Shibutani Hiroshi Otani Hisashi Nagahara Tetsuro Ikeya Yasuhito Iseki hiroaki tanaka Kazuya Muguruma Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of MedicineOsaka 545-8585 Japan

Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage is important and useful for predicting the prognosis and determining the appropriate treatment, it is well known that the survival time varies widely, even in patients with the same stage of disease. Therefore, the identification of new parameters capable of more precisely predicting patient survival is needed to help select the optimal treatment, especially in patients in the advanced stage of disease. Although the TNM stage reflects the tumor characteristics, cancer progression and survival are not determined solely based on the local characteristics of the tumor, but also the host systemic immune/inflammatory response. Therefore, using a combination of parameters that reflect both tumor characteristics and the host systemic inflammatory status is thought to be important for accurately predicting patient survival.

关键词： Colorectal cancer Platelet-to-lymphocyteratio Prognosis Glasgow Prognostic Score C-reactiveprotein Neutrophil-to-lymphocyte ratio Inflammationbasedfactor Nutritional Prognostic Index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Teukolsky-like equations with various spins in spherically symmetric spacetime

引用

Chinese Physics C 2024年第8期48卷 213-223页

作者： Ya Guo hiroaki Nakajima Wenbin Lin School of Physical Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Mathematics and Physics University of South ChinaHengyang 421001China

We study wave equations with various spins on the background of a general spherically symmetric *** obtain the unified expression of the Teukolsky-like master equations and the corresponding radial equations with the general *** also discuss the gauge dependence in the gravitational-wave equations,which have appeared in previous studies.

关键词： gravitational wave effective one-body dynamics Teukolsky equation wave equations Klein-Gordon equation Weyl equation Maxwell equation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A unified multi-view multi-person tracking framework

引用

Computational Visual Media 2024年第1期10卷 137-160页

作者： Fan Yang Shigeyuki Odashima Sosuke Yamao hiroaki Fujimoto Shoichi Masui Shan Jiang Nanjing University China 不详 Fujitsu Research

Despite significant developments in 3D multi-view multi-person (3D MM) tracking, current frameworks separately target footprint tracking, or pose tracking. Frameworks designed for the former cannot be used for the latter, because they directly obtain 3D positions on the ground plane via a homography projection, which is inapplicable to 3D poses above the ground. In contrast, frameworks designed for pose tracking generally isolate multi-view and multi-frame associations and may not be sufficiently robust for footprint tracking, which utilizes fewer key points than pose tracking, weakening multi-view association cues in a single frame. This study presents a unified multi-view multi-person tracking framework to bridge the gap between footprint tracking and pose tracking. Without additional modifications, the framework can adopt monocular 2D bounding boxes and 2D poses as its input to produce robust 3D trajectories for multiple persons. Importantly, multi-frame and multi-view information are jointly employed to improve association and triangulation. Our framework is shown to provide state-of-the-art performance on the Campus and Shelf datasets for 3D pose tracking, with comparable results on the WILDTRACK and MMPTRACK datasets for 3D footprint tracking.

关键词： multi-camera multi-person tracking pose tracking footprint tracking triangulation spatiotemporal clustering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于著作权管理团体市场支配地位的滥用

引用

内蒙古师范大学学报（哲学社会科学版） 2019年第1期48卷 58-65页

作者：田中裕明神户学院大学法学部

日本音乐著作权协会(JASRAC)案是日本初次将独占禁止法适用于著作权管理事业。事业法规制的领域也适用独占禁止法,以承认独占禁止法与事业法并存为前提。日本音乐著作权协会主张总括收取基于契约自由原则,没有"排除意图",即使造成其他... 详细信息

日本音乐著作权协会(JASRAC)案是日本初次将独占禁止法适用于著作权管理事业。事业法规制的领域也适用独占禁止法,以承认独占禁止法与事业法并存为前提。日本音乐著作权协会主张总括收取基于契约自由原则,没有"排除意图",即使造成其他事业者被"排除",本身也不应承担独占禁止法责任。本文通过欧美对著作管理事业的竞争法的适用案例,尝试进行比较法性质的考察,认为日本音乐著作权协会在音乐著作权管理行业形成了事实上的垄断地位,维持长期以来的许可费收取体系,令新规参入者经营活动变得困难。"排除意图"不能看成滥用市场支配地位不可缺少的要素。单从市场占有率的数值、本案总括收取方法实施效果的可能性来看,认定为私人垄断的"排除"行为具有充分的理由。

关键词：滥用市场支配地位日本音乐著作权协会著作权管理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：