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Effect of Universal Primers on the Tensile Bond Strength between Zirconia and Resin Composites

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材料科学与工程（中英文B版） 2021年第1期11卷 1-7页

作者： Akinori Ohno Mizuki Nagata hiroaki kobayashi hiroaki Yamaguchi Katsura Ohashi Kaori Aoki Tomotaro Nihei Katsuhiko Kimoto Department of Oral Interdisciplinary Medicine Prosthodontics&Oral Implantology Graduate School of DentistryKanagawa Dental University82 Inaoka-choYokosukaKanagawa 238-8580Japan Division of Clinical Biomaterials Department of Oral ScienceGraduate School of DentistryKanagawa Dental University82 Inaoka-choYokosukaKanagawa 238-8580Japan

This study aimed to evaluate the effects of universal primers on the tensile bond strength between zirconia and resin *** specimens were divided into five groups based on the surface treatment with the following primers:MP(Monobond Plus),SU(ScotchBond Universal),AZ(AZ Primer),BM(Beauty bond Multi),and BL(Bondmer Lightless).After priming,stainless steel rods were bonded to the zirconia specimens with composite *** tensile bond strength test was performed:stored at room temperature for 1 day;stored in distilled water at 37°C for 7 days;and underwent thermal *** BL group demonstrated a significantly higher tensile bond strength than other groups when stored at room temperature for 1 day(p<0.05).The primer that acted via chemical polymerization appeared to be most effective in improving the bond strength between the two materials in this study.

关键词： Universal primer zirconia composite resin bond strength.

Mitogen-Activated Protein Kinase Pathways Following Traumatic Brain Injury

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Neuroscience & Medicine 2011年第3期2卷 208-216页

作者： Naoki Otani Hiroshi Nawashiro Kimihiro Nagatani Satoru Takeuchi hiroaki kobayashi Katsuji Shima 不详

The mechanisms underlying the secondary or delayed cell death in the hippocampus and cerebral hemisphere after traumatic brain injury (TBI) have been poorly understood. Recent data suggesting that TBI may have relationship with both an inflammatory and a neurodegenerative factors are also presented. Mitogen-activated protein kinases (MAPK), which play a crucial role in signal transduction, are activated by phosphorylation in response to a variety of mitogenic signals. In this article, we review the clinical and experimental evidence for brain damage after TBI. In addition, the MAPK pathways, closely involved in signal transduction after TBI, which could therefore be a new and potentially effective therapeutic target in TBI. Further investigations are therefore necessary to better understand cerebral traumatic damage and delineate the best practice strategies needed to improve the patient outcomes after TBI.

关键词： Traumatic Brain Injury Mitogen-Activated Protein Kinase Cell Signaling

中、日、美高等口腔医学教育体系与科研人才培养

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中华口腔医学研究杂志（电子版） 2021年第3期15卷 173-177页

作者：叶畅畅张彦小林宏明口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科成都610041 美国加州大学旧金山分校口腔颌面部科学系旧金山94143 日本东京医科齿科大学齿周病学分野东京113-8510

中国、日本、美国的医疗科技发展在很大程度上得益于其教育培养体系,口腔医学专业人才培养不仅要满足社会公共医疗需求,同时还需满足科技强国的战略需求。本文通过比较中、日、美之间高等口腔医学教育模式及课程异同,结合笔者的学习工... 详细信息

中国、日本、美国的医疗科技发展在很大程度上得益于其教育培养体系,口腔医学专业人才培养不仅要满足社会公共医疗需求,同时还需满足科技强国的战略需求。本文通过比较中、日、美之间高等口腔医学教育模式及课程异同,结合笔者的学习工作经历,介绍中、日、美有代表的口腔(牙)医学院在培养人才科研能力上采取的措施,以期为我国口腔医学人才培养模式改革与学科发展提供新的思路。

关键词：口腔医学教育科研能力

Microfluidic-based flexible reflective multicolor display

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Microsystems & Nanoengineering 2018年第1期4卷 244-254页

作者： Kazuhiro kobayashi hiroaki Onoe School of Integrated Design Engineering Graduate School of Science and TechnologyKeio UniversityYokohamaJapan

This paper describes a microfluidic-based flexible reflective display constructed using dyed water droplets and air gaps as pixel *** display is composed of a flexible polydimethylsiloxane sheet with a connected pixel-patterned *** types of dyed water droplets and air gaps are sequentially introduced to the microchannel through a suction process to display a multicolor *** displayed image is stable and can be retained without an energy *** ensure that images are displayed correctly,the geometric parameters of the dot pixel design and minimum differential pressure necessary to drive the water droplets are *** a demonstration,we successfully display three-color dot-matrix reflective images and bitmap characters in the *** proposed method can be applied to energy-less and color-changeable displays for use in future daily-life accessories,such as bags,shoes,and clothes,and can change the surface color and pattern of these accessories.

关键词： reflective fluid sequentially

Fluorescence quantum yield of Gd_(0.9-x)R_xEu_(0.1)OOH(R=Y, La) crystals

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Journal of Rare Earths 2015年第12期33卷 1256-1260页

作者： hiroaki Samata Katsutoshi kobayashi Masashi Hanioka Tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University Materials Development Group Superconducting Properties Unit National Institute for Materials Science

*** （R=Y, La） crystals were synthesized by a flux method using a mixture of NaOH and KOH as the flux. X-ray diffraction data were well refined using the Rietveld method assuming that the crystals had a monoclinic structre belonging to the P21/m space group. The unit cell volumes of the Gdo.9 *** crystals increased with increasing x, whereas those of *** decreased with increasing x. The Commission Internationale de IEclairage （CIE） chromaticity coordinates of Gdo.9 *** （R=Y, La） crystals were located in the red region and were nearly constant over the range ofx values considered. The fluorescence quantum yield Dr monotonically decreased with increasing x regardless of the ionic radii of the substitute ions. The fact that the Dr value of Lao.9EuoAOOH was greater than that of *** indicated that the observed decrease in the values of the Gdo.9-,LaxEuo.1OOH crystals up to x=0.3 could not be attributed to an increase in the distance between Eu3＋ ions or to a decrease in the Gd3＋ content. The decrease might be due to an increase of killer centers introduced by elemental substitutions with the larger ion.

关键词： rare-earth oxyhydroxide phosphor elemental substitution fluorescence quantum yield

Effect of equal-channel angular pressing on pitting corrosion resistance of anodized aluminum-copper alloy

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中国有色金属学会会刊：英文版 2009年第4期19卷 904-908页

作者： In-Joon SON hiroaki NAKANO Satoshi OUE Shigeo kobayashi Hisaaki FUKUSHIMA Zenji HORITA Department of Materials Process Engineering Graduate School of EngineeringKyushu University Department of Materials Science and Engineering Faculty of EngineeringKyushu University Department of Applied Chemistry and Biochemistry Faculty of EngineeringKyushu Sangyo University

The effect of equal-channel angular pressing(ECAP) on the pitting corrosion resistance of anodized Al-Cu alloy was investigated by electrochemical techniques in a solution containing 0.2 mol/L AlCl3 and also by surface *** was conducted for 20 min at 200 and 400 A/m2 in a solution containing 1.53 mol/L H2SO4 and 0.018 5 mol/L Al2(SO4)3·16H2O at 20 ℃.Anodized Al-Cu alloy was immediately dipped in boiling water for 20 min to seal the micro pores present in anodic oxide *** time required before initiating pitting corrosion of anodized Al-Cu alloy is longer with ECAP than without,indicating that ECAP process improves the pitting corrosion resistance of anodized Al-Cu *** phase precipitates such as Si,Al-Cu-Mg and Al-Cu-Si-Fe-Mn intermetallic compounds are present in Al-Cu alloy and the size of these precipitates is greatly decreased by application of ***-Cu-Mg intermetallic compounds are dissolved during anodization,whereas the precipitates composed of Si and Al-Cu-Si-Fe-Mn remain in anodic oxide films due to their more noble corrosion potential than ***-SEM and EPMA observation reveal that the pitting corrosion of anodized Al-Cu alloy occurs preferentially around Al-Cu-Si-Fe-Mn intermetallic compounds,since the anodic oxide films are absent at the boundary between the normal oxide films and these impurity *** improvement of pitting corrosion resistance of anodized Al-Cu alloy processed by ECAP appears to be attributed to a decrease in the size of precipitates,which act as origins of pitting corrosion.

关键词：铝铜合金抗点蚀挤压转角通道

Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury

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World Journal of Gastroenterology 2009年第36期15卷 4571-4575页

作者： hiroaki Sato Kiyohiro Oshima Katsumi kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of Medicine3-39-15 Showa-machiMaebashiGunma 371-8511 Japan Intensive Care Unit Gunma University Hospital3-39-15 Showa-machiMaebashiGunma 371-8511 Japan

AIM： To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column （DHP-PMX therapy） for warm hepatic ischemia-reperfusion （I/R） injury after total hepatic vascular exclusion （THVE） using a porcine model. METHODS： Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min. The animals were divided into two groups randomly： the DHP-PMX group （n = 5） underwent DHP-PMX at a flow rate of 80 mL/min for 220 min （beginning 10 rain before reperfusion）, while the control group did not （n = 6）. The rate pressure product （RPP）： heart rate x end-systolic arterial blood pressure, hepatic tissue blood flow （HTBF）, portal vein blood flow （PVBF）, and serum aspartate aminotransferase （AST） levels were compared between the two groups. RESULTS： RPP and HTBF were significantly （P 〈 0.05） higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion. PVBF in the DHP-PMX group was maintained at about 70% of the flow before ischemia and differed significantly （P 〈 0.05） compared to the control group 360 min after reperfusion. The serum AST increased gradually after reperfusion in both groups, but the AST was significantly （P 〈 0.05） lower in the DHP-PMX group 360 min after reperfusion. CONCLUSION： DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model.

关键词： Ischemia-reperfusion injury Total hepaticvascular exclusion Polymyxin B-immobilized fiber column

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橄榄石的局部增长和B型CPO的形成

海洋地质 2013年第4期29卷 1-1页

作者： Simon WALLIS Takayoshi NAGAYA hiroaki kobayashi 刘玉萍(翻译) 林霖(校对) 邱燕(校对)

B型橄榄石（OI）CPO模型具有一个a轴平行于主应变轴的特性。由于俯冲带地幔楔存在的地震各向异性显示，地震波快速传播的方向垂直于板块运动的方向，因此很多工作者提出了B型CPO。实验研究表明，B型CPO是在相对较高的压力下、有水的存... 详细信息

B型橄榄石（OI）CPO模型具有一个a轴平行于主应变轴的特性。由于俯冲带地幔楔存在的地震各向异性显示，地震波快速传播的方向垂直于板块运动的方向，因此很多工作者提出了B型CPO。实验研究表明，B型CPO是在相对较高的压力下、有水的存在才错动蠕变形成。也有报道地球本身就存在天然的B型CPO。然而，天然的情况和实验室结果也存在着差异：一些天然B型CPO的形成条件超出实验人员的预测；报道的天然B型CPO从未有发现过c型滑移。即便是俯冲边界揉皱相对较弱、可能会使强CPO难于形成的地区，

关键词： CPO 橄榄石 B型地震各向异性实验人员板块运动俯冲带天然

Direct hemoperfusion with a polymyxin B-immobilized cartridge in intestinal warm ischemia reperfusion

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World Journal of Gastroenterology 2008年第35期14卷 5436-5441页

作者： hiroaki Sato Kazuhisa Arakawa Katsumi kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi Kiyohiro Oshima Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of MedicineMaebashiGunma 371-8511Japan Intensive Care Unit Gunma University HospitalMaebashiGunma 371-8511Japan

AIM： To investigate the effectiveness of direct hemoperfusion with polymyxin B-immobilized fibers （DHPPMX therapy） on warm ischemia-reperfusion （I/R） injury of the small intestine.METHODS： The proximal jejunum and distal ileum of mongrel dogs were resected. Warm ischemia was performed by clamping the superior mesenteric artery （SMA） and vein （SMV） for 2 h. Blood flow to the proximal small intestine was restored 1 h after reperfusion, and the distal small intestine was used as a stoma. The experiment was discontinued 6 h after reperfusion. The dogs were divided into two groups： the DHP-PMX group （n = 6, DHP-PMX was performed for 180 min; from 10 min prior to reperfusion to 170 rain after reperfusion） and the control group （n = 5）. The rate pressure product （RPP）, SMA blood flow, mucosal tissue blood flow, and intramucosal pH （pHi） were compared between the two groups. The serum interleukin （IL）-10 levels measured 170 min after reperfusion were also compared.RESULTS： The RPP at 6 h after reperfusion was significantly higher in the PMX group than in the control group （12174 ± 1832 mmHg/min vs 8929 ± 1797 mmHg/min, P 〈 0.05）. The recovery rates of the SMA blood flow at I and 6 h after reperfusion were significantly better in the PMX group than in the control group （61%±7% vs 44% ±4%, P 〈 0.05, and 59%±5% vs 35%±5%, P 〈 0.05, respectively）. The recovery rate of the mucosal tissue blood flow and the pHi levels at 6 h after reperfusion were significantly higher in the PMX group （61%±8% vs 31%±3%, P 〈 0.05 and 7.91±0.06 vs 7.69±0.08, P 〈 0.05, respectively）. In addition, the serum IL-IO levels just before DHP-PMX removal were significantly higher in the PMX group than in the control group （1 569 ± 253 pg/mL vs 211± 40 pg/mL, P 〈 0.05）.CONCLUSION： DHP-PMX therapy reduced warm I/R injury of the small intestine. IL-10 may play a role in inhibiting I/R injury during DHP-PMX therapy.

关键词： Ischemia-reperfusion injury Interleukin-10 Polymyxin B-immobilized hemoperfusion cartridge PMX