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World Journal of Hepatology 2018年第7期10卷 523-529页

作者： Toru goto hiroak. Terajima Takehito Yamamoto Yoichiro Uchida Department of Gastroenterological Surgery and Oncology Tazuke Kofukai Medical Research Institute Kitano Hospital

Right-sided ligamentum teres(RSLT) is a congenital anomaly in which the right umbilical ligament becomes dominant and anomalous ramifications of the hepatic vessels and biliary system are present. A male patient in his 70 s was diagnosed with advanced gallbladder cancer directly infiltrating the right hepatic duct(RHD), together with RSLT. Preoperative three-dimensional simulation of the liver based on multiple detector computed tomography images after cholangiography revealed ramifications of all segmental portal veins from the portal trunk and discordance of the arterial and biliary branching patterns of segment 8. Fusion analysis of the biliary architecture and segmental volumetry showed that the RHD drained segments 1 r, 5, 6, and 7. We successfully performed a modified right-sided hepatectomy sparing segment 8(i.e., resection of the RHD drainage territory), with negative surgical margins. This report is the first to describe major hepatectomy for advanced gallbladder cancer with RSLT.

关键词： Right-sided ligamentum teres Hepatectomy Gallbladder cancer Preoperative liver simulation Anomaly of the portal vein

Preparation of rutile TiO_(2) thin films by laser chemical vapor deposition method

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Journal of Advanced Ceramics 2013年第2期2卷 162-166页

作者： Dongyun GUO Akihiko ITO Takashi goto Rong TU Chuanbin WANG Qiang SHEN Lianmeng ZHANG State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China Institute for Materials Research Tohoku UniversitySendai 980-8577Japan

TiO_(2) thin films were prepared on Pt/Ti/SiO_(2)/Si substrate by laser chemical vapor deposition(LCVD)*** effects of laser power(P_(L))and total pressure(p_(tot))on the microstructure of TiO_(2) thin films were *** deposition temperature(T_(dep))was mainly affected by P_(L),increasing with P_(L) *** single-phase rutile TiO_(2) thin films with different morphologies were *** morphologies of TiO_(2) thin films were classified into three typical types,including the powdery,Wulff-shaped and granular microstructures.p_(tot) and T_(dep) were the two critical factors that could be effectively used for controlling the morphology of the films.

关键词： rutile TiO_(2)thin film laser chemical vapor deposition(LCVD) laser power total pressure microstructure

Easy removing of phenol from wastewater using vegetable oil-based organic solvent in emulsion liquid membrane process

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Chinese Journal of Chemical Engineering 2017年第1期25卷 45-52页

作者： Norasikin Othman Norul Fatiha Mohamed Noah Lim Yin Shu Zing-Yi Ooi Norela Jusoh Mariani Idroas Masahiro goto Centre of Lipids Engineering and Applied Research (CLEAR) Ibnu Sina Institute for Scientuific and Industrial Research (Ibnu Sina ISIR) Universiti Teknologi Malaysia 81310 UTM Johor BahruJohor Malaysia Faculty of Chemicul and Energy Engineering Universiti Teknologi Malaysia 81310 UTM Johor BahruJohor Malaysia Department of Applied Chemistry Graduate School of Engineering Kyushu University 744 Motooka Nishi-ka Fukuoka-shi fukuoka 819-0395Japan

Phenol is considered as pollutant due to its toxicity and carcinogenic ***,variety of innovative methods for separation and recovery of phenolic compounds is developed in order to remove the unwanted phenol from wastewater and obtain valuable phenolic *** of potential method is extraction using green based liquid organic ***,the feasibility of using palm oil was *** this research,palm oil based organic phase was used as diluents to treat a simulated wastewater containing 300×10^(-6) of phenol solution using emulsion liquid membrane process(ELM).The stability of water-in-oil(W/O) emulsion on diluent composition and the parameters affecting the phenol removal efficiency and stability of the emulsion;such as emulsification speed,emulsification time,agitation speed,surfactant concentration,pH of external phase,contact time,stripping agent concentration and treat ratio were carried *** results of ELM study showed that at ratio7 to 3 of palm oil to kerosene,5 min and 1300 r·min^(-1) of emulsification process the stabile primary emulsion were ***,no carrier is needed to facilitate the phenol *** experimental conditions of500 r·min^(-1) of agitation speed,3%Span 80,pH 8 of external phase,5 min of contact time,0.1 mol·L^(-1) NaOH as stripping agent and 1:10 of treat ratio,the ELM process was very promising for removing the phenol from the *** extraction performance at about 83%of phenol was removed for simulated wastewater and an enrichment of phenol in recovery phase as phenolate compound was around 11 times.

关键词：苯酚溶液模拟废水膜法处理乳化液有机溶剂油基稳定性参数酚类化合物

Rare case of fecal impaction caused by a fecalith originating in a large colonic diverticulum: A case report

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World Journal of Clinical Cases 2021年第2期9卷 416-421页

作者： Hiroki Tanabe Kazuyuki Tanaka Mitsuru goto Tomonobu Sato Keisuke Sato Mikihiro Fujiya Toshikatsu Okumura Division of Gastroenterology and Hematology/Oncology Department of MedicineAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Department of Gastroenterology Asahikawa Kousei HospitalAsahikawa 078-8211HokkaidoJapan Department of Pathology Asahikawa Kousei HospitalAsahikawa 078-8211HokkaidoJapan

BACKGROUND Fecal impaction is defined as a large mass of compacted feces in the colon and has the potential to induce a serious medical condition in elderly *** impaction is generally preventable,and early recognition of the typical radiological findings is important for making an early *** factors that lead to fecal impaction are usually similar to those causing *** cases with fecal impaction associated with a diverticulum have been *** SUMMARY We present the case of a 62-year-old woman who suffered from abdominal pain and vomiting,had a medical history of repeated acute abdomen and was diagnosed with fecal impaction in the descending colon based on X-ray and computed tomography(CT)*** examination by gastrografinenhanced colonography following colonoscopy and CT colonography,the fecalith was suspected to have been produced at the site of a large diverticulum in the transverse *** fecalith was surgically resected,and a histological diagnosis of pseudodiverticulum was *** was no recurrence during 33 mo of *** This case highlights the importance of accurate identification and treatment of a fecal *** case indicated that the endoscopic evacuation and subsequent colonography were effective for identifying a diverticulum that might have caused fecal impaction.A fecal impaction was associated with the ***,the planned diverticulectomy was *** emergency medical treatment and maintenance treatments should be selected in such cases to prevent recurrence.

关键词： Colonic ileus Constipation Acute abdomen Computed tomography colonography Case report Colonoscopy

Observation of Impurity Accumulation After Hydrogen Multi-Pellet Injection in Large Helical Device

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Plasma Science and Technology 2013年第3期15卷 230-234页

作者：董春凤 Shigeru MORITA Motoshi goto 王二辉 Gen MOTOJIAMA Izumi MURAKAMI Ryuichi SAKAMOTO Norimasa YAMAMOTO National Institute for Fusion Science Department of Fusion Science Graduate University for Advanced Studies Center of Applied Superconductivity & Sustainable Energy Research Chubu University

Impurity accumulation is studied for neutral beam-heated discharges after hydrogen multi-pellet injection in Large Helical Device （LHD）. Iron density profiles are derived from radial profiles of EUV line emissions of FeXV-XXIV with the help of the collisional-radiative model. A peaked density profile of Fe2a＋ is simulated by using one-dimensional impurity transport code. The result indicates a large inward velocity of -6 m/s at the impurity accumulation phase. However, the discharge is not entirely affected by the impurity accumulation, since the concentration of iron impurity, estimated to be 3.3x10-5 to the electron density, is considerably small. On the other hand, a flat profile is observed for the carbon density of C6＋, which is derived from the Zeff profile, indicating a small inward velocity of -1 m/s. These results suggest atomic number dependence in the impurity accumulation of LHD, which is similar to the tokamak result.

关键词： impurity accumulation EUV spectrometer inward velocity

Cut-Off Points of Head, Chest, and Arm Circumferences to Identify Low Birthweight: Meta-Analysis

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Open Journal of Epidemiology 2017年第2期7卷 175-189页

作者： Eita goto Department of Medicine and Public Health Nagoya Medical Science Research Institute Nagoya Japan

Background: The cut-off points of newborn anthropometric variables to identify low birthweight (i.e., birthweight Methods: Meta-analysis was performed to summarize cut-off points in studies judged as good quality based on the Quality Assessment of Diagnostic Accuracy Studies tool (QUADAS). PubMed (MEDLINE) and nine other databases were searched (January, 2015). PubMed related-citations and references of potentially eligible articles and related reviews were also investigated. The Egger test was used to assess publication bias. Results: With respect to head, chest, and arm circumferences, the cut-off points that involved no publication bias could be summarized based on the data from large numbers of newborns (=21,793, 8917, and 12,912, respectively) in relatively sufficient numbers of studies (=17, 15, and 19, respectively). The optimal cut-off points to identify low birthweight were 33.0 cm (95% confidence interval [CI], 32.8 - 33.2), 30.4 cm (95% CI, 30.3 - 30.6), and 9.3 cm (95% CI, 9.1 - 9.4) for head circumference, chest circumference, and arm circumference, respectively. The summarized cut-off point of birth height, i.e., 47.2 cm (95% CI, 46.7 - 47.7), used to identify low birthweight involved publication bias (n = 13). Conclusion: The cut-off points were determined to identify low birthweight using head, chest, and arm circumferences.

关键词： Anthropometry Infant Meta-Analysis Newborn Low Birth Weight

衰老中蛋白质和DNA氧化损伤的影响及其通过热量摄入限制与锻炼产生的干预

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Journal of Sport and Health Science 2013年第2期2卷 75-80页

作者： Sataro goto Zsolt Radak Institute of Health and Sports Science & Medicine Juntendo University Graduate School Research Institute of Sport Science Semmelweis University

本文将与年龄相关的蛋白质改变和DNA氧化称为"生物性衰老的公共机制"。氧化修饰的蛋白质和DNA随增龄而加剧,这一结论已在啮齿类动物中得到证实。通过调养可使老年动物蛋白质半衰期延长,DNA修复活动下降。在动物晚年限制饮食,可将蛋白质... 详细信息

本文将与年龄相关的蛋白质改变和DNA氧化称为"生物性衰老的公共机制"。氧化修饰的蛋白质和DNA随增龄而加剧,这一结论已在啮齿类动物中得到证实。通过调养可使老年动物蛋白质半衰期延长,DNA修复活动下降。在动物晚年限制饮食,可将蛋白质半衰期缩短降至年轻时的水平,从而降低老年动物体内变异蛋白质的水平。有规律的锻炼能减少大脑中氧化修饰的蛋白质,改善认知功能;还能缓解肝脏的氧化应激:改善NF-κB活性,增加还原型谷胱甘肽,并降低细胞核和线粒体DNA中的氧化鸟嘌呤。研究结果表明,有规律的运动对降低氧化应激有全身效应。因此,饮食控制和锻炼等生活方式能够扩大健康的范围,通过调节整体的抗氧能力(包括蛋白质转换和DNA修复),从而减少促使生理和病理性衰老的潜在受损蛋白质和DNA。

关键词：蛋白质水平 DNA修复氧化损伤运动老龄化制热量还原型谷胱甘肽摄入

Mutations in carboxy-terminal part of E2 including PKR/eIF2αphosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b:Their correlation with response to interferon monotherapy and viral load

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World Journal of Gastroenterology 2006年第23期12卷 3722-3728页

作者： Koji Ukai Masatoshi Ishigami Kentaro Yoshioka Naoto Kawabe Yoshiaki Katano Kazuhiko Hayashi Takashi Honda Motoyoshi Yano Hidemi goto Division of Gastroenterology Department of Internal MedicineNagoya University Graduate School of MedicineNagoyaJapan Division of Liver and Biliary Diseases Department of Internal MedicineFujita Health University School of MedicineAichiJapan

AIM: To study the amino acid substitutions in the carboxy (C)-terminal part of E2 protein and in the interferon (IFN) sensitivity determining region (ISDR) and their correlation with response to IFN and viral load in 85 hepatitis C virus (HCV)-lb-infected patients treated with IFN. METHODS: The C-terminal part of E2 (codons 617-711) including PKR/eIF2a phosphorylation homology domain (PePHD) and ISDR was sequenced in 85 HCV-1b-infected patients treated by IFN monotherapy. RESULTS: The amino acid substitutions in PePHD detected only in 4 of 85 patients were not correlated either with response to IFN or with viral load. The presence of substitutions in a N-terminal variable region (codons 617-641) in the C-terminal part of E2 was significantly correlated with both small viral load (33.9% vs 13.8%, P = 0.0394) and sustained response to IFN (25.0% vs 6.9 %, P = 0.0429). Four or more substitutions in ISDR were significantly correlated with both small viral load (78.6% vs 16.2%, P < 0.0001) and sustained response to IFN (85.7% vs 2.9%, P < 0.0001). In multivariate analysis, ISDR in nonstructural (NS) 5A (OR = 0.39, P < 0.0001) and N-terminal variable region (OR = 0.51, P = 0.039) was selected as the independent predictors for small viral load, and ISDR (OR = 39.0, P < 0.0001) was selected as the only independent predictor for sustained response. CONCLUSION: The N-terminal variable region in the C-terminal part of E2 correlates with both response to IFN monotherapy and viral load and is one of the factors independently associated with a small viral load.

关键词：基因突变羧基端子磷酸化作用干扰素丙型肝炎病毒

Nd^(3+):Lu_2O_3放电等离子烧结及光学性能

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无机材料学报 2017年第12期32卷 1315-1320页

作者：安丽琼章健范润华 goto Takashi 王士维上海海事大学海洋科学与工程学院上海201306 中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室上海200050 日本东北大学金属材料研究所

Lu_2O_3是具有高热导率而成为极具潜力的高功率激光介质材料。实验以商用氧化物粉体为原料,Li F为烧结助剂,采用放电等离子烧结法制备了不同Nd^(3+)掺杂浓度(C_(Nd)=0,1at%,3at%和5at%)Lu_2O_3透明陶瓷,并研究了Nd^(3+)掺杂浓度对Lu_2O_... 详细信息

Lu_2O_3是具有高热导率而成为极具潜力的高功率激光介质材料。实验以商用氧化物粉体为原料,Li F为烧结助剂,采用放电等离子烧结法制备了不同Nd^(3+)掺杂浓度(C_(Nd)=0,1at%,3at%和5at%)Lu_2O_3透明陶瓷,并研究了Nd^(3+)掺杂浓度对Lu_2O_3陶瓷的物相、烧结性能、微观结构及光学性能的影响。结果表明:在高Nd^(3+)浓度(5at%)掺杂后烧结样品仍为纯Lu_2O_3相;Nd^(3+)掺杂对Lu_2O_3陶瓷烧结性能及微观形貌的影响有限;所有样品最终均表现出高致密性(99.5%以上)和优异的透光性能,其中3at%Nd^(3+):Lu_2O_3的透过率最高,在1064和2000 nm处的透过率分别为82.7和83.2%。Nd^(3+):Lu_2O_3透明陶瓷的最强发射峰位于1076和1080 nm;且随着Nd^(3+)掺杂浓度的增加,荧光强度降低,寿命变短,发生浓度淬灭。

关键词：放电等离子烧结 Nd^3+:Lu2O3 Nd^3+掺杂浓度

Autonomic nervous system network and liver regeneration

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World Journal of Gastroenterology 2018年第15期24卷 1616-1621页

作者： Kenya Kamimura Ryosuke Inoue Takuro Nagoya Norihiro Sakai Ryo goto Masayoshi Ko Yusuke Niwa Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

To date, various signal transducers, cytokines, growth factors, and hormones have been reported to play an important role in homeostasis of various organs. Various cells and organs are involved in the hepatic regeneration process, which proceeds as a result of the coordination of many factors. While these factors are well known to be involved in the liver regeneration after the liver injury, however, as the details of such mechanisms have not been sufficiently elucidated, the practical applicability of hepatic regeneration based on the action of these and cytokines growth factors is still unclear. In terms of the involvement of the autonomic nervous system in hepatic regeneration, cell proliferation resulting from direct signal transduction to the liver has also been reported and recent studies focusing on the inter-organ communication via neural network opened a novel aspect of this field for therapeutic applicability. Therefore, the appropriate understanding of the relationship between autonomic neural network and liver regeneration through various organs including brain, afferent nerve, efferent nerve, etc. is essential. This mini-review explains the principle of neural system involved in the inter-organ communication and its contribution on the liver regeneration upon the liver injury reviewing recent progress in this field.

关键词： Autonomic nerve Neural network Liver regeneration Hormone