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自我血压监测对药物依从性和生活方式因素的影响:系统回顾和荟萃分析

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中华高血压杂志 2016年第4期24卷 398-398页

作者： Fletcher BR Hartmann-Boyce J hinton l McManus RJ 陈云叶鹏

自我血压监测（self-monitoringofbloodpressure，SMBP）有助于降低高血压患者的血压，但是具体机制并不是十分明了。可能的解释包括药物治疗改善（遵医嘱延长药物治疗时间，改善依从性）和生活方式改善（改变膳食习惯，增加体力活动）。

关键词：自我血压监测生活方式改善药物依从性荟萃分析系统回顾高血压患者治疗时间药物治疗

世界家庭医生组织(WONCA)研究论文摘要汇编——以家庭为中心的抗抑郁疗法治疗老年男性抑郁患者遇到的挑战和解决方案:一项对利益相关者的研究

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中国全科医学 2017年第32期20卷 4073-4073页

作者： hinton l SCIOllA A F UNüTZER J 本刊编辑部

背景家庭成员在老年男性抑郁患者的生活中起到了非常重要的作用,其经常陪同患者去社区医院就诊。然而,对如何最有效地让患者家庭成员参与患者的治疗过程相关研究较少。由于一些原因,如抑郁的"病耻心"与家庭成员间的冲突,导致家庭成员很... 详细信息

背景家庭成员在老年男性抑郁患者的生活中起到了非常重要的作用,其经常陪同患者去社区医院就诊。然而,对如何最有效地让患者家庭成员参与患者的治疗过程相关研究较少。由于一些原因,如抑郁的"病耻心"与家庭成员间的冲突,导致家庭成员很难参与患者的抗抑郁治疗。本研究旨在探究家庭成员参与老年男性抑郁患者的治疗所遇到的困难及其措施。方法本项横断面定性描述性访谈研究在位于加利福尼亚中央谷地的"安全网"联邦合格健康服务中心进行。37例研究对象中包含15例老年(≥60岁)男性抑郁患者(由邮件招募、候诊室招募和转诊患者组成)、12例患者家庭成员(在参与研究的患者家庭成员中招募),以及10例全科医务人员(通过目的抽样抽取)。对研究对象关于把家庭干预列为治疗老年男性抑郁的全科疗法之一的看法,进行了半结构式的访谈。访谈内容被录音、记录。结果访谈结果表明,家庭成员参与老年男性抑郁患者的治疗所遇到的主要困难有:让患者在适当的时机接受治疗;保持患者的自主性;处理患者个人隐私问题;处理家庭成员之间的冲突。对于如何解决这些困难,研究对象也提出了可行性的建议。结论尽管以家庭为中心的抗抑郁疗法是一项治疗老年男性抑郁患者有效的全科疗法,但是实施起来尚有一定困难。此疗法的继续开展以及临床应用需要研制出解决这些困难的方案和指南。

关键词：抗抑郁治疗抗抑郁疗法以家庭为中心抑郁患者老年男性世界家庭医生组织利益相关者论文摘要

WONCA研究论文摘要汇编——高血压患者的血压自我监测:针对英国全科医生的基于互联网的调查

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中国全科医学 2016年第30期19卷 3651-3651页

作者： FlETCHER B R hinton l BRAY E P 本刊编辑部整理

背景已有研究表明,英国大多数的全科医生使用血压自我监测(SMBP)来控制而非诊断高血压。本文旨在评估SMBP的当前使用情况,以及使用中依据较多的指南建议的变化。目的调查2015年英国全科医生关于SMBP的观点和做法,并将其与2011年的调查... 详细信息

背景已有研究表明,英国大多数的全科医生使用血压自我监测(SMBP)来控制而非诊断高血压。本文旨在评估SMBP的当前使用情况,以及使用中依据较多的指南建议的变化。目的调查2015年英国全科医生关于SMBP的观点和做法,并将其与2011年的调查结果进行比较。设计与场所选择有区域代表性的样本共计300例英国全科医生进行网络调查。方法全科医生完成了关于高血压管理中使用SMBP的在线调查问卷。进行了描述性分析、组间比较及多因素logistic回归分析。结果结果来自300例全科医生。全科医生记录显示,使用SMBP的目的分别是诊断高血压〔169/291,58%,95%CI(52%,64%)〕和控制高血压〔245/291,84%,95%CI(80%,88%)〕,前者较2011年显著增加〔37%,95%CI(33%,41%),P<0.001〕,而后者没有明显变化。超过半数的全科医生使用高于指南中建议的收缩压阈值来诊断〔118/169,70%,95%CI(63%,77%)〕和治疗〔168/225,75%,95%CI(69%,80%)〕高血压,不到半数的全科医生〔120/289,42%,95%CI(36%,47%)〕调整了SMBP结果来指导治疗决策。结论自2011年新版英国国家指南推出以来,全科医生更倾向于使用SMBP来诊断高血压。然而,全科医生继续使用非标准诊断和监控阈值所占比例增多,如果使用次优的阈值采用诊室外方法来提高诊断准确性是无益处的。

关键词： WONCA 自我监测治疗决策在线调查网络调查描述性分析

Hospital outcomes and early readmission for the most common gastrointestinal and liver diseases in the United States:Implications for healthcare delivery

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World Journal of Gastrointestinal Surgery 2021年第2期13卷 141-152页

作者： Somashekar G Krishna Brandon K Chu Alecia M Blaszczak Gokulakrishnan Balasubramanian Hisham Hussan Peter P Stanich Khalid Mumtaz Alice hinton Darwin l Conwell Division of Gastroenterology Hepatology and NutritionThe Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Internal Medicine The Ohio State University Wexner Medical CenterColumbusOH 43210United States Division of Biostatistics Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Gastrointestinal(GI)and liver diseases contribute to substantial inpatient morbidity,mortality,and healthcare resource *** ways to reduce the economic burden of healthcare costs and the impact of these diseases is of crucial ***-day readmission rates and related hospital outcomes can serve as objective measures to assess the impact of and provide further insights into the most common GI *** To identify the thirty-day readmission rates with related predictors and outcomes of hospitalization of the most common GI and liver diseases in the United *** A cross-sectional analysis of the 2012 National Inpatient Sample was performed to identify the 13 most common GI *** 2013 Nationwide Readmission Database was then queried with specific International Classification of Diseases,Ninth Revision,Clinical Modification *** outcomes were mortality(index admission,calendar-year),hospitalization costs,and thirty-day readmission and secondary outcomes were predictors of thirty-day *** For the year 2013,the thirteen most common GI diseases contributed to 2.4 million index hospitalizations accounting for about$25 *** thirty-day readmission rates were highest for chronic liver disease(25.4%),Clostridium difficile(***)infection(23.6%),functional/motility disorders(18.5%),inflammatory bowel disease(16.3%),and GI bleeding(15.5%).The highest index and subsequent calendar-year hospitalization mortality rates were chronic liver disease(6.1%and 12.6%),*** infection(2.3%and 6.1%),and GI bleeding(2.2%and 5.0%),***-day readmission correlated with any subsequent admission mortality(r=0.798,P=0.001).Medicare/Medicaid insurances,≥3 Elixhauser comorbidities,and length of stay>3 d were significantly associated with thirty-day readmission for all the thirteen GI *** Preventable and non-chronic GI disease contributed to a significant economic and health

关键词： Gastrointestinal disease Thirty-day readmission Nationwide readmission database Outcomes Mortality Cost

Corrosion Behaviour of Modified HVOF Sprayed WC Based Cermet Coatings on Stainless Steel

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Journal of Minerals and Materials Characterization and Engineering 2011年第11期10卷 989-1005页

作者： l.P. Ward B. hinton D. Gerrard K. Short Aircraft Corrosion Control Group Defence Science and Technology Organisation (DSTO)Melbourne Lorimer St Vic 3207 Australia Australian Nuclear Science Technology Organisation (ANSTO) Lucas Heights New Illawarra Rd NSW 2234 Australia School of Civil Environmental and Chemical Engineering RMIT University GPO Box 2476V Melbourne Vic. 3001 Australia

WC based cermet coatings have been considered as alternative replacements to the more traditional hard chrome plating for improved surface properties of aircraft landing gear. While these coatings are used in engineering applications requiring superior hardness and improved wear resistance, little is known about the corrosion resistance. In this study, three WC based composite coatings were deposited onto ferritic stainless steel substrates using high velocity oxy fuel (HVOF) technology. Salt spray testing and potentiodynamic scanning studies in a saline environment were conducted on the coatings. Characterisation of the coating structure, composition and morphology, was carried out, prior to and after corrosion testing, using optical microscopy, scanning electron microscopy and EDX elemental analysis. The results showed that poor corrosion performance was exhibited by all three coatings. This was attributed to the high levels of porosity and the presence of micro-cracks within the coatings, resulting in attack of the substrate directly by the saline environment and possible galvanic coupling effects between the substrate and the coating. Dissolution and / or erosion of specific phases within the coating, resulting in the formation of micro-channels and increased number / size of voids may have accelerated corrosion of the system.

关键词： HVOF WC Structure Characterisation Salt Spray Testing Potentiodynamic Scanning

Quantification of Zoonotic Bacterial Pathogens within Commercial Poultry Processing Water Samples Using Droplet Digital PCR

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Advances in Microbiology 2013年第5期3卷 403-411页

作者： Michael J. Rothrock Kelli l. Hiett Brian H. Kiepper Kim Ingram Arthur hinton Poultry Processing and Swine Physiology Research Unit USDA-Agricultural Research Service Athens Georgia

Raw poultry and poultry products are a significant source of zoonotic bacterial pathogen transmission;thus the sensitive detection of major zoonotic pathogens (Salmonella spp., Campylobacter jejuni, and listeria monocytogenes) is a vital food safety issue. Recently, third generation PCR technology, known as droplet digital PCR (ddPCR) has been developed to be more accurate and sensitive to detect genetic targets than current quantification methods, but this technology has not been tested within an industrial setting. There is an on-going study within our laboratory is investigating the effects of sampling times and sampling methods on the cultural and molecular (via qPCR) quantification of dominant zoonotic pathogens within a poultry processing facility. This presents a unique opportunity to compare the quantification resulted from this emerging, third generation technology to traditional quantification methods currently employed by the poultry industry. The results show that ddPCR detected pathogen-specific genes from more pathogen:sampling time combinations than either the qPCR or culturing methods from the final scalder and chiller tanks at three stages of processing (Start, Mid, and End). In fact, both ddPCR and qPCR substantially outperformed culture methods commonly used in poultry processing food safety-related studies, with Salmonella recovered only from the Mid and End sampling times from the scalder tank. While neither C. jejuni nor l. monocytogenes were recovered culturally, ddPCR was able to detect their respective genes commonly throughout the processing day in both the scalder and chiller water samples. Additionally, the use of unfiltered processing water provided significantly greater detection of bacterial and pathogen-specific gene abundances than did an analysis of larger volumes of filtered water. Considering the ddPCR-derived concentrations of the bacterial pathogens were consistent with what was previously found culturally in commercial poultry

关键词： ddPCR Poultry Processing Zoonotic Pathogens qPCR

Outcomes of inpatient cholecystectomy among adults with cystic fibrosis in the United States

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World Journal of Gastrointestinal Endoscopy 2021年第9期13卷 371-381页

作者： Mitchell l Ramsey lindsay A Sobotka Somashekar G Krishna Alice hinton Stephen E Kirkby Susan S li Michael P Meara Darwin l Conwell Peter P Stanich Division of Gastroenterology Hepatology and NutritionThe Ohio State University Wexner Medical CenterColumbusOH 43210United States Division of Biostatistics The Ohio State University College of Public HealthColumbusOH 43210United States Division of Pulmonary and Critical Care Medicine The Ohio State University Wexner Medical CenterColumbusOH 43210United States Division of General Internal Medicine The Ohio State University Wexner Medical CenterColumbusOH 43210United States Division of General and Gastrointestinal Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Symptomatic biliary and gallbladder disorders are common in adults with cystic fibrosis(CF)and the prevalence may rise with increasing CF transmembrane conductance regulator modulator *** may be considered,but the outcomes of cholecystectomy are not well described among modern patients with *** To determine the risk profile of inpatient cholecystectomy in patients with *** The Nationwide Inpatient Sample was queried from 2002 until 2014 to investigate outcomes of cholecystectomy among hospitalized adults with CF compared to controls without CF.A propensity weighted sample was selected that closely matched patient demographics,patient’s individual comorbidities,and hospital *** propensity weighted sample was used to compare outcomes among patients who underwent laparoscopic *** outcomes of open and laparoscopic cholecystectomy were compared among adults with *** A total of 1239 inpatient cholecystectomies were performed in patients with CF,of which 78.6%were performed *** waslar to those without CF(P=0.719).In the propensity weighted analysis of laparoscopic cholecystectomy,there was no difference in mortality,or pulmonary or surgical complications between patients with CF and *** adjusting for significant covariates among patients with CF,open cholecystectomy was independently associated with a 4.8 d longer length of stay(P=0.018)and an$18449 increase in hospital costs(P=0.005)compared to laparoscopic *** Patients with CF have a very low mortality after cholecystectomy that is similar to the general *** patients with CF,laparoscopic approach reduces resource utilization and minimizes post-operative complications.

关键词： laparoscopic cholecystectomy Nationwide Inpatient Sample Cystic fibrosis Mortality length of stay Symptomatic biliary disorders

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炉卷轧机生产亚北极圈管线钢的低温韧性

炉卷轧机生产亚北极圈管线钢的低温韧性

Phytochemical analyses, antimicrobial and antioxidant activities of stem bark extracts of Distemonanthus benthamianus H. Baill. and fruit extracts of Solanum torvum Sw. from Gabon

2019全国高效连铸应用技术及铸坯质量控制研讨会

作者： J.hinton A.Harvey J.lee M.Arafin l.Collins K.Dunnett 唐杰民 Primetals Technologies UK ltd. EVRAZ Regina Steel

美国石油学会(API)对亚北极地区低温韧性管线钢管的要求是钢铁生产企业面临的一个挑战。需要了解Steckel炉卷轧机轧制的特点,并结合贯穿整个过程的微观组织和操作参数的控制关键点,包括合金设计和适当的时间-温度应变路径的开发。本文结...

美国石油学会(API)对亚北极地区低温韧性管线钢管的要求是钢铁生产企业面临的一个挑战。需要了解Steckel炉卷轧机轧制的特点,并结合贯穿整个过程的微观组织和操作参数的控制关键点,包括合金设计和适当的时间-温度应变路径的开发。本文结合Primetals技术有限公司最近在Steckel炉卷轧机项目中进行的有针对性的设备升级,综述了这些冶金和工艺因素,报道了实现这些目标的实际考虑。

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Asian Pacific Journal of Tropical Biomedicine 2019年第5期9卷 209-216页

作者： Cédric Sima Obiang Rick léonid Ngoua Meye Misso Guy Roger Ndong Atome Joseph Privat Ondo louis Clément Obame Engonga Edouard Nsi Emvo laboratory of Research in Biochemistry University of Sciences and Technology of Masuku laboratory of Natural Substances and Organometallic Synthesis University of Sciences and Technology of Masuku

Objective: To evaluate the phytochemical constituents, antimicrobial and antioxidant activities of the extracts of Distemonanthus benthamianus(D. benthamianus) stem bark and Solanum torvum(S. torvum) fruit which have been used as traditional medicinal herbs in Gabon. Methods: Plant extracts were subjected to a qualitative study(phytochemical screening) and a quantitative(dosing) study of secondary metabolites. Antioxidant activity was tested by 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid assay. Bacteria and fungi susceptibility tests were performed on Mueller hinton medium and solid Sabouraud, respectively, using the diffusion method, while minimum inhibitory concentration, minimum fungicidal concentration and minimum bactericidal concentration were evaluated by microdilution ***: The total phenol and tannin contents were significantly higher in the water-ethanol extract compared to the other extracts of D. benthamianus and S. torvum. The water-ethanol and water-acetone extracts showed significantly higher antioxidant activity than the aqueous extracts of the two medicinal plants. However, the extracts presented weak antioxidant activities compared to standards(Vitamin C, BHA). The water-acetone and water-ethanol extracts of S. torvum showed the highest antimicrobial activity against Bacillus cereus lMG 13569 BHI, Shigella dysenteriae 5451 CIP, Shigella dysenteriae and Neisseria gonorrhoeae. Conclusions: Our results show that D. benthamianus and S. torvum can be promising sources of natural products with potential antimicrobial and antioxidant activities.

关键词： Antioxidants Phytochemical Antimicrobial Distemonanthus benthamianus Solanum torvum