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TURMERIC-COULD IT BE A MULTI-TARGETED HERB FOR COLORECTAL CANCER ADJUVANT THERAPY?

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 74-75页

作者： Grace GL Yue hin-fai kwok Julia KM Lee Lei Jiang Si Gao Carmen KM Chan Eric CW Wong kwok-Pui Fung Ping-Chung Leung Zhong Zuo Clara BS Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) School of Biomedical Sciences School of Pharmacy The Chinese University of Hong Kong

Turmeric is a medicinal herb in Asia and as dietary supplement in western *** major active component,*** good reputation for chemopreventive effects in different ***,poor oral bioavailability of curcumin hinders the w... 详细信息

关键词： TURMERIC-COULD IT BE A MULTI-TARGETED HERB FOR COLORECTAL CANCER ADJUVANT THERAPY

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

NOVEL ANTI-ANGIOGENIC ACTIVITIES OF A TRITERPENOID DEOXYACTEIN FROM CIMICIFUGA FOETIDA

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 95-95页

作者： GraceGL Yue Julia KM Lee hin-fai kwok Yin Nian Ming-Hua Qiu Clara BS Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Institute of Chinese Medicine The Chinese University of Hong Kong State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

Deoxyactein(DA)is a triterpenoid isolated from the root of Cimicifuga foetida which is a source of traditional Chinese herb'shengma'and is traditionally used as an antipyretic and analgesic *** studies showed that DA ... 详细信息

关键词： NOVEL ANTI-ANGIOGENIC ACTIVITIES OF A TRITERPENOID DEOXYACTEIN FROM CIMICIFUGA FOETIDA

A BIFLAVONOID AMENTOFLAVONE FROM GARCINIA XANTHOCHYMUS FRUIT EXHIBITEDANTI-ANGIOGENIC ACTIVITIES IN ZEBRAFISH EMBRYOS

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 94-94页

作者： Grace GL Yue hin-fai kwok Ping Li Harini A Senthilkumar Chun-Lin Long Edward J.Kennelly Clara BS Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Institute of Chinese Medicine The Chinese University of Hong Kong College of Life and Environmental Sciences Minzu University of China Department of Biological Sciences Lehman College and The Graduate Center The City University of New York

Edible fruits of Garcinia xanthochymus were traditionally used to treat diarrhoea and *** previous work showed that some components of *** fruits induced apoptosis in colon cancer *** this study,the aril(edible pulp o... 详细信息

关键词： SIV A BIFLAVONOID AMENTOFLAVONE FROM GARCINIA XANTHOCHYMUS FRUIT EXHIBITEDANTI-ANGIOGENIC ACTIVITIES IN ZEBRAFISH EMBRYOS

Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells

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Neural Regeneration Research 2022年第1期17卷 203-209页

作者： Zhong-Qing Sun Jin-Feng Liu Wei Luo Ching-hin Wong kwok-fai So Yong Hu Kin Chiu Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administrative RegionChina Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopaedics&Traumatology The University of Hong KongHong Kong Special Administrative RegionChina

Lycium barbarum(LB)is a traditional Chinese medicine that has been demonstrated to exhibit a wide variety of biological functions,such as antioxidation,neuroprotection,and immune *** of the main mechanisms of Alzheimer’s disease is that microglia activated by amyloid beta(Aβ)transform from the resting state to an M1 state and release pro-inflammatory cytokines to the surrounding *** the present study,immortalized microglial cells were pretreated with *** extract for 1 hour and then treated with oligomeric Aβfor 23 *** results showed that LB extract significantly increased the survival of oligomeric Aβ-induced microglial cells,downregulated the expression of M1 pro-inflammatory markers(inducible nitric oxide synthase,tumor necrosis factorα,interleukin-6,and interleukin-1β),and upregulated the expression of M2 anti-inflammatory markers(arginase-1,chitinase-like protein 3,and interleukin-4).LB extract also inhibited the oligomeric Aβ-induced secretion of tumor necrosis factorα,interleukin-6,and interleukin-1βin microglial *** results of in vitro cytological experiments suggest that,in microglial cells,LB extract can inhibit oligomeric Aβ-induced M1 polarization and concomitant inflammatory reactions,and promote M2 polarization.

关键词： Alzheimer’s disease amyloid-β anti-inflammatory factors Lycium barbarum extract M1 microglia M2 microglia neuroinflammation proinflammatory factors

COMBINED EFFECTS OF METRONOMIC ZOLEDRONATE WITH CORIOLUS VERSICOLOR IN A METASTATIC BREAST TUMOR MOUSE MODEL

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 94-94页

作者： Grace GL Yue Chun-Hay Ko Si Gao Julia KM Lee hin-fai kwok Jeng-Sum Kung Lin Li kwok-Pui Fung Ping-Chung Leung Gang Li Andreas Evdokiou Clara BS Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) Institute of Chinese Medicine The Chinese University of Hong Kong Department of Surgery School of Biomedical Sciences Department of Orthopaedics and Traumatology The Chinese University of Hong Kong Discipline of Surgery and Orthopaedics Basil Hetzel Institute University of Adelaide

Incidence of breast cancer is high in women worldwide and mortality usually results from tumor *** chemotherapeutic,such as zoledronate(ZOL),has been used in metastatic breast cancer mainly for skeletal *** previous s... 详细信息

关键词： CV COMBINED EFFECTS OF METRONOMIC ZOLEDRONATE WITH CORIOLUS VERSICOLOR IN A METASTATIC BREAST TUMOR MOUSE MODEL

ANTI-ANGIOGENIC AND IMMUNOMODULATORY ACTIVITIES OF A LABDANE DITERPENE FROM LEONURUS HETEROPHYLLUS

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World Journal of Traditional Chinese Medicine 2016年第2期 81-81页

作者： Grace Gar-Lee Yue Julia Kin-Ming Lee hin-fai kwok Da-Rong Wu Shao-Hua Liu Wei-Lie Xiao Clara Bik-San Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Chengdu No.1 Pharmaceutical Group Co. Ltd. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

Introduction:Heteronone B(HB)is a labdane diterpene isolated from Leonurus heterophyllus Sweet which is known as Yimucao in Chinese medicines and is traditionally used for the treatment of gynaecological *** was first... 详细信息

关键词： HB ANTI-ANGIOGENIC AND IMMUNOMODULATORY ACTIVITIES OF A LABDANE DITERPENE FROM LEONURUS HETEROPHYLLUS RNA

TIMP-1 Production in Human Retinal Pigment Epithelial Cells after Laser Exposure

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Eye Science 2005年第1期21卷 31-37页

作者： Alvin K.H.kwok Timothy Y.Y.Lai hin-fai Yam Chi-Pui Pang Department of Ophthalmology & Visual Sciences Department of Ophthalmology & Visual SciencesDepartment of Ophthalmology & Visual SciencesDepartment of Ophthalmology & Visual Sciences The Chinese University of Hong KongHong Kong SAR Department of OphthalmologyHong Kong Sanatorium and HospitalHong Kong SARThe Chinese University of Hong KongHong Kong SARThe Chinese University of Hong KongHong Kong SARThe Chinese University of Hong KongHong Kong SAR

Purpose: To investigate changes in the production of tissue inhibitor of metalloproteinase type 1 (TIMP-1) by human retinal pigment epithelial (RPE) cells following argon laser ***: Human cultured ARPE19 cells were exposed to argon green laser at four different energy levels ranging from 60mW to 360mW. After laser exposure, the culture media were sampled at 0, 24, 72 and 144 hours for TIMP-1 concentration produced by the RPE cells. The levels of TIMP-1 in the cells treated with different laser energy levels were compared with a control group not exposed to laser *** for proliferating cell nuclear antigen (PCNA) was performed to detect any adverse effects on the RPE cells caused by laser ***: Immediately after laser exposure, the concentration of TIMP- 1 was not detectable. At 24 hours after laser exposure, the concentration of TIMP-1 increased significantly in RPE cells treated with 120mW and 240mW at 24 hours (P=0.006 and P=0.001respectively) compared with control cells. At 72 hours after treatment, RPE cells treated at 120mW, 240mW and 360mW demonstrated significantly increase in TIMP-1production compared with control (P=0.003, P ＜ 0.001 and P ＜ 0.001, respectively).No significant reduction in cell viability was observed following laser application as detected by PCNA ***: Our results demonstrated that early TIMP-1 production by RPE cells in cell cultures was enhanced following laser exposure.

关键词： TIMP-1 视网膜上皮细胞激光损伤免疫细胞学视色素

Corneal re-innervation following refractive surgery treatments

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Neural Regeneration Research 2019年第4期14卷 557-565页

作者： Francisco Bandeira Nur Zahira Yusoff Gary hin-fai Yam Jodhbir Singh Mehta Tissue Engineering and Stem Cell Group Singapore Eye Research Institute Federal University of S?o Paulo S?o Gon?alo Eye Hospital Eye-ACP Duke-NUS Graduate Medical School Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore Singapore National Eye Centre School of Material Science and Engineering Nanyang Technological University

Laser refractive surgery is one of the most performed surgical procedures in the world. Although regarded safe and efficient, it has side effects. All of the laser based refractive surgical procedures invoke corneal nerve injury to some degree. The impact of this denervation can range from mild discomfort to neurotrophic corneas. Currently, three techniques are widely used for laser vision correction: small incision lenticule extraction, laser-assisted keratomileusis in situ and photorefractive keratotomy. Each of these techniques affects corneal innervation differently and has a different pattern of nerve regeneration. The purpose of this review is to summarize the different underlying mechanisms for corneal nerve injury and compare the different patterns of corneal reinnervation.

关键词： photorefractive keratotomy small incision manual lenticule extraction laser-assisted keratomileusis in situ refractive surgery in vivo confocal microscopy corneal sensation corneal nerve