检索结果-南通市图书馆

Diffuse Large B-Cell Lymphoma of the Central Nervous System. Immunophenotype, Clinicopathological Features and Differential Diagnosis

引用

Open Journal of Pathology 2012年第4期2卷 133-139页

作者： Mónica Belinda Romero-Guadarrama María Esther Gutiérrez Díaz-Ceballos Fiacro Jiménez-ponce Samantha Thingen-Velarde Hemathology Service Hospital General de México Mexico City Mexico Mónica Belinda Romero-Guadarrama Neurosurgery Unit Hospital General de México Mexico City Mexico Unit Pathology Hospital General de México Medicine School Autonomous University of Mexico Mexico City Mexico

Background: Diffuse large B-cell lymphomas of the central nervous system (DLBCL CNS) represent less than 1% of all lymphomas and between 2% and 3% of all cerebral tumors. They occur in adults of 60 years of age or more. The objective of this work is to describe the clinical-pathological characteristics, the immunophenotype and the differential diagnosis. Clinical Case: From the files of the surgical pathology unit we found four cases of primary diffuse large B cell lymphoma of the central nervous system in a 6-year period. Three corresponded to women over 47 years of age and the other to a 42-year-old man. The time of evolution was between 2 and 4 months. The symptoms were headache, blurred vision, hemiparesis, and seizures. Localization was in the pineal region, the frontal, parietal regions, and the right thalamus. Morphologically, large lymphoid cells with a diffuse growth pattern and necrosis were observed. Immunohistochemical markers, such as CD 20 and bcl2 were positive, one was positive to CD3. Expression of bcl6 and CD 10 was positive in one case, and muM-1 was positive in three cases. All the cases were negative for Epstein-Barr virus. Conclusions: The diffuse large-B cell lymphoma of the central nervous system is rare. Its average age of presentation is at 60 years or older. The localization is in the pineal, frontal, parietal and thalamic regions. Three cases were originated by activated B lymphocyte (muM-1 expression) and other from the Germinal Center (GC) (CD 10 expression). The clinical course was bad. The four patients died shortly after the diagnosis.

关键词： Primary Lymphoma Central Nervous System

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

XAANTAL2 （AGL14） Is an Important Component of the Complex Gene Regulatory Network that Underlies Arabidopsis Shoot Apical Meristem Transitions

引用

Molecular Plant 2015年第5期8卷 796-813页

作者： Rigoberto V. Perez-R.u.iz Berenice Garcia-ponce Nayelli Marsch-Martinez Yamel Ugartechea-Chirino Mitzi Villajuana-Bonequi Stefan de Folter Eugenio Azpeitia Jose Davila-Velderrain David Cruz-Sanchez Adriana Garay-Arroyo Maria de la Paz Sanchez Juan M. Estevez-Palmas Elena R. Alvarez-Buylla Instituto de Ecologia Universidad Nacionat Autonoma de Moxico 3er Circuito Exterior s/no Junto al Jardin Bot~nico and Centro de Ciencias de la ComplejidadCiudad Universitaria Coyoacan 04510 Mexico D.F. Mexico Laboratorio Nacional de Genemica para la Biodiversidad (Langebio) Centro de Investigaci6n y de Estudios Avanzados del Instituto Polit~cnico Nacional(CINVESTAV-IPN) Km. 9.6 Carretera Irapuato - Leen AP 629 36821 Irapuato Guanajuato Mexico University of California 431 Koshland Hall Berkeley CA 94720 USA These authors contributed equally to this article. present address: Departamento de Biotecnologia y Biquimica Centro de )nvestigaci6n y de Estudios Avanzados del Instituto Polit6cnico Nacional(CINVESTAV-IPN) Km. 9.6 Libramiento Norte Carr. Irapuato-Leen 36821 Irapuato Guanajuato Mexico present address: Max Planck Institute for Plant Breeding Research D-50829 Cologne Germany Present address: INRIA Project-Team Virtual Plants/CIRAD/INRA UMR AGAP Campus St Priest - BAT 5 CC 05018 860 rue de St Priest 34095 Montpellier Cedex5 France

In Arabidopsis thaliana, multiple genes involved in shoot apical meristem （SAM） transitions have been char- acterized, but the mechanisms required for the dynamic attainment of vegetative, inflorescence, and floral meristem （VM, IM, FM） cell fates during SAM transitions are not well understood. Here we show that a MADS-box gene, XAANTAL2 （XAL2/AGL14）, is necessary and sufficient to induce flowering, and its regula- tion is important in FM maintenance and determinacy, xal2 mutants are late flowering, particularly under short-day （SD） condition, while XAL2 overexpressing plants are early flowering, but their flowers have vege- tative traits. Interestingly, inflorescences of the latter plants have higher expression levels of LFY, AP1, and TFL1 than wild-type plants. In addition we found that XAL2 is able to bind the TFL1 regulatory regions. On the other hand, the basipetal carpels of the 35S：：XAL2 lines lose determinacy and maintain high levels of WUS expression under SD condition. To provide a mechanistic explanation for the complex roles of XAL2 in SAM transitions and the apparently paradoxical phenotypes of XAL2 and other MADS-box （SOCl, AGL24） over- expressors, we conducted dynamic gene regulatory network （GRN） and epigenetic landscape modeling. We uncovered a GRN module that underlies VM, IM, and FM gene configurations and transition patterns in wild- type plants as well as loss and gain of function lines characterized here and previously. Our approach thus provides a novel mechanistic framework for understanding the complex basis of SAM development.

关键词： XAL2/AGL14 MADS-box TFL1 SAM transitions floral reversion gene regulatory networks,epigenetic landscape modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

药物引起的高钾等血症

引用

临床荟萃 1987年第12期 570-571页

作者： S·P·ponce 郑光礼

近十年来应用和推广了多种直接或间接增加血钾浓度的药物,药物引起的高钾血症急骤增多。高血钾的心脏并发症——尤其是猝死使得高血钾症的预防比它的紧急治疗更为重要。钾摄入增多引起的高钾血症补充氯化钾:1.正常人单次口服0.5mEq/k... 详细信息

近十年来应用和推广了多种直接或间接增加血钾浓度的药物,药物引起的高钾血症急骤增多。高血钾的心脏并发症——尤其是猝死使得高血钾症的预防比它的紧急治疗更为重要。钾摄入增多引起的高钾血症补充氯化钾:1.正常人单次口服0.5mEq/kg氯化钾并不引起血钾的明显变化,但当病人肾功能不良时,常规剂量氯化钾的补充即可引起严重的高钾血症。Paise等报告住院病人中高钾血症的发生率为2～10％。2.非治疗性补钾。如用枸椽酸钾碱化尿液;补充营养性蛋白,使用代盐(含钾10～13mEq/gr)等也可引起致命性后果。3.大剂量静

关键词：高钾血症血钾发生率住院病人醛固酮减少症水-电解质代谢紊乱住院患者药物高血钾症

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Use of wastes from the tea and coffee industries for the production of cellulases using fungi isolated from the Western Ghats of India

引用

Systems Microbiology and Biomanufacturing 2021年第1期1卷 33-41页

作者： S.A.Saldana-Mendoza J.A.Ascacio-Valdes A.S.Palacios-ponce J.C.Contreras-Esquivel R.Rodriguez-Herrera H.A.Ruiz J.L.Martinez-Hernandez S.Sugathan C.N.Aguilar Bioprocesses and Bioproducts Research Group Food Research DepartmentAutonomous University of Coahuila25280 SaltilloMexico Faculty of Engineering in Mechanics and Production Sciences Polytechnic School of LitoralESPOLCampus Gustavo Galindo Km.30.5 Vía PerimetralP.O.Box 09-01-5863GuayaquilEcuador Microbiology Division Jawaharial Nehru Botanical Garden and Research InstitutePalodeThiruvananthapuramKerala 695562India

In this study,coffee pulp(Coffea arabica)and green tea(Camellia sinensis)residues were characterized for use as a substrate of solid-state fermentation for cellulases *** invasion rate was evaluated,as well as cellulases production by strains of Aspergillus niger and Trichoderma asperellum from the western Ghats of India,on coffee pulp,green tea,and a mixture of both substrates(50:50).***(AFP)strain was found to have the highest growth rate(0.409±0.021 mm/h)using a mixture of both *** production of cellulases by *** was unsatisfactory due to the presence of polyphenols in the supports to which *** cellulases are more *** production of cellulases by *** was linked to the pH of the supports,favouring the use of T and *** was found that the extracts produced by ***(28A strain using a mixture substrate,28A,and 20A strains using only green tea as a substrate)presented the highest cellulase activities when evaluated using a plate technique producing degradation halos of 2.3±0.1 cm of *** 28A strain did not require mineral enrichment media for cellulase production using green tea residues as support of solid-state fermentation.

关键词： Cellulases Fungal strains Solid-state fermentation Agroindustrial wastes Coffee pulp Green tea

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Side Effects of Vincristine and L-Asparaginase in Patients with Acute Lymphoblastic Leukemia in a Mexican Pediatric Hospital

引用

Pharmacology & Pharmacy 2013年第3期4卷 347-354页

作者： Mario I.Ortiz Sandra Rivera-Roldan Marco A.Escamilla-Acosta Georgina Romo-Hernandez Hector A.ponce-Monter Rita Escarcega-Angeles Area Academica de Medicina Instituto de Ciencias de la SaludUniversidad Autonoma del Estado de HidalgoPachucaMexico Graduate Coordination Universidad del Futbol y Ciencias del DeporteSan Agustin TlaxiacaMexico Hospital del Nino DIF Hidalgo PachucaMexico Area Academica de Farmacia Instituto de Ciencias de la SaludUniversidad Autonoma del Estado de HidalgoPachucaMexico

Background: The treatment used to combat acute lymphoblastic leukemia (ALL) is multidrug;therefore it is important to use active pharmacovigilance to detect, assess and analyze the likely adverse reactions which may occur during the same period. Objective: To determine the frequency of adverse reactions to chemotherapeutic drugs in children with ALL. Material and Methods: Intensive pharmacovigilance was used to record the reports of adverse reactions to vincristine, L-asparaginase and the vincristine-L-asparaginase combination in children with ALL in a paediatric hospital. For each notification, the adverse reactions were analyzed in order to verify causality. Results: Forty patients were evaluated. Twenty children were female (50.0%) and 20 were male (50%). The children had a mean age, weight and height (±standard deviation: SD) of 8.1 (±3.4) years, 31.4 (±13.9) kg and 1.3 (±0.2) m, respectively. Vincristine was administered to 19 patients, vincristine plus L-asparaginase were given to 19 patients and only 2 patients used L-asparaginase. One-hundred-ninety adverse reactions were detected in the patients, with an average (±SD) of 4.8 (±2.6). Ondansetron was the drug administered for the treating of nausea and vomiting. One hundred eighty-one (95.3%) adverse reactions were identified as “definite”, 5 (2.6%) as “probable” and 4 (2.1%) as “doubtful”. Conclusions: There is a high incidence of adverse reactions by the administration of vincristine and L-asparaginase;the reactions of highest incidence were: nausea, vomiting, neutropenia, diarrhea, constipation, mucositis, headache, and abdominal pain. It is important to promote the detection, collection, reporting, assessment and treatment of ARD’s in children. It is necessary to promote the conduct further studies on pharmacovigilance with this type of treatments and to increase the duration of the studies.

关键词： Pharmacovigilance Acute Lymphoblastic Leukemia Vincristine L-Asparaginase Children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metal Input in Lettuce Grown in Urban Agricultural Soils

引用

Open Journal of Soil Science 2020年第4期10卷 137-157页

作者： Silke Cram Pilar Fernández Horacio Carranza Manuel Hernández Claudia ponce de León Ana M. Noguez Gálvez Instituto de Geografía Universidad Nacional Autónoma de México Ciudad Universitaria Ciudad de México México Facultad de Ciencias Universidad Nacional Autónoma de México Ciudad Universitaria Ciudad de México México

Urban agriculture plays an important role in supplying produces to big cities;however, the quality of water used for irrigation can hinder this activity. Hence, the purpose of this study was to evaluate metal inputs, as well as their transfer and translocation factors, in lettuce (Lactuca sativa L.) crops cultivated in an urban plot. The research was conducted during the dry and rainy seasons. In the former, crops were irrigated with treated wastewater, whereas during the latter, crops were maintained just with rainwater. Composite samples for soils and plants were collected from the same plot during two crop cycles in 2013. Some edaphic variables were measured. Total metal concentration was determined, for both, soils and lettuce plants (leaves and roots). Water soluble and exchangeable soil metal fractions were also analyzed. A multivariate analysis of variance was performed to test for differences between seasons, among the variables analyzed. There were significant differences in edaphic characteristics between seasons. However, there was no difference in total metal content, except for Mn. Concentration of soluble metals was lower than exchangeable metal concentration, for both seasons. There was no correlation in total metal concentration between soils and plants. Transfer factor values were higher for Cd, Mn and Zn for the dry season, while for Cu, Fe and Pb were higher during the rainy season, as well as the translocation factors for all metals. Soil characteristics, together with transfer and translocation factors, showed temporal variations, leading to different metal concentrations in the edible lettuce tissues between the two analyzed crop cycles. The incorporation of metals is particular for each site, season and crop management type. Our results indicate that the metal concentration in lettuce tissues places no harm to human health. However, management strategies for urban agriculture must consider specific studies for each site.

关键词： Transfer Factor Translocation Factor Seasonal Variation Wastewater Irrigation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of Morphology and Immunophenotype in Diffuse Large B-Cell Lymphomas with Bone Marrow Infiltration in a Sample Mexican Population

引用

Open Journal of Pathology 2012年第2期2卷 29-37页

作者： Mónica-Belinda Romero-Guadarrama Fiacro Jiménez ponce Armando Medina Cruz Elsa Lorena Durán Ramírez Icela Palma Lara Molecular and Celular Morphology Laboratory Escuela Superior de Medicina Instituto Politécnico Nacional and Morphology Department Facultad de Medicina Veterinaria y Zootecnia (UNAM) México City México Unidad de Patología del Hospital General de México Facultad de Medicina Universidad Nacional Autónoma de México (UNAM) México City México

Introduction: Diffuse large B-cell lymphoma (DLBCL), not otherwise specified, is a large B-cell lymphoma with a diffuse growth pattern and aggressive clinical course. It is divided in subgroups according to its morphology, immunophenotype, and primary site. Dissemination to bone marrow occurs in 11% to 35% of cases and can be of concordant or discordant morphology. Objective: To examine the association, the type of bone marrow involvement in relation to the primary site, morphology, immunohistochemistry of DLBCLs and to determine the cases of Epstein-Barr virus positive DLBCLs. Materials and Methods: We reviewed lymph node and extranodal biopsies as well as the respective bone marrow biopsies in all cases of DLBCL diagnosed in the Hospital General de México during the period from 2002 to 2010. We used immunohystochemistry for immunophenotype identification (Hans’s algorithm) and an in-situ hybridization technique to detect presence of Epstein Barr encoded RNA (EBER). Results: We included 108 patients with a mean age of 51.9 years, 59 (55%) were men. DLBCL involved lymph nodes in 60% of cases and palatine tonsils in 13%. The centroblastic variant predominated (80%) and 58% originated from activated B-cells. Infiltration of bone marrow was present in 30% of cases and was discordant in 55% of these cases. Correlation between morphology and bone marrow infiltration was statistically significant (P = 0.0003). Presence of Epstein-Barr virus was demonstrated in 15% of patients older than 50 years. Conclusions: Dissemination to bone marrow occurred in 30% of cases and discordant involvement was most common. DLBCL originating from activated B-lymphocytes predominated and the most common extranodal sites were palatine tonsils, suggesting that our population has a clinical behavior similar to Asiatic populations.

关键词： Dissemination to Bone Marrow Diffuse Large B-Cell Lymphoma Immunophenotype

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuromyelitis optica and myelin oligodendrocyte glycoprotein

引用

Annals of Eye Science 2018年第1期3卷 147-157页

作者： Angela Huang Aroucha Vickers Claudia M.Prospero ponce Andrew G.Lee Baylor College of Medicine HoustonTXUSA Department of Ophthalmology Blanton Eye InstituteHouston Methodist HospitalHoustonTXUSA Department of Ophthalmology and Visual Sciences The University of Texas Medical BranchGalvestonTXUSA Departments of Ophthalmology Neurologyand NeurosurgeryWeill Cornell MedicineNew York CityNYUSA The University of Texas MD Anderson Cancer Center HoustonTXUSA Texas A and M College of Medicine College StationBryanTXUSA The University of Iowa Hospitals and Clinics Iowa CityIAUSA The University of Buffalo BuffaloNYUSA

Neuromyelitis optica(NMO)refers to an antibody mediated,inflammatory disorder of the central nervous system(CNS)characterized by recurrent or monophasic attacks of optic neuritis and *** patients with NMO possess a specific serum immunoglobin,NMO-IgG,which can serve as a biomarker for *** autoantibodies target aquaporin-4(AQP4),the main water channel protein found in the CNS including the brain,spinal cord,and optic *** remaining 10-25%of patients are seronegative for NMO-IgG despite meeting the diagnostic criteria for *** studies have shown that a subset of these patients is seropositive for antibodies against myelin oligodendrocyte glycoprotein(MOG).This paper will provide an overview of the current English scientific literature published regarding the history,epidemiology,AQP4 biomarker,MOG biomarker,diagnosis,clinical features,related diseases in NMO spectrum disorder(NMOSD),and treatments of NMO.

关键词： Neuromyelitis optica(NMO) Devic disease aquaporin-4 myelin oligodendrocyte glycoprotein(MOG)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

墨西哥城环境文化中心

引用

现代装饰 2023年第4期 54-59页

作者： Rafael ponce Ortiz Margarita Gorbea Angeles Cesar Avila OscarDiaz Gaspar Abigail Esparza Diego Buenode la Paz Valerio Lopez Acevedo Margarita Gorbea(摄影) Marcos Betanzos(摄影) 范嘉苑(编译) 不详

“环境文化中心”作为墨西哥城Bosquede Chapultepec第二部分的全新文化、景观和环境节点,是由Gabriel Orozco操刀的“查普特佩克自然与文化”总体规划的一部分。该项目方案在墨西哥城政府与联邦政府共同举办的公开竞赛中脱颖而出,得以... 详细信息

“环境文化中心”作为墨西哥城Bosquede Chapultepec第二部分的全新文化、景观和环境节点,是由Gabriel Orozco操刀的“查普特佩克自然与文化”总体规划的一部分。该项目方案在墨西哥城政府与联邦政府共同举办的公开竞赛中脱颖而出,得以落成。环境文化中心是一座被植物花园包围的展馆,展现出自然主义设计与民族植物学相结合的理念。设计参考了墨西哥盆地山谷的多样化生态系统和自然景观,包括温带森林、草原、湿地和植被等,并与查普特佩克现有的植被、地形和设施进行细致整合,由此最大化地增加环境文化中心作为城市森林的巨大潜力。

关键词：墨西哥城设计参考温带森林民族植物学自然景观生态系统自然与文化总体规划

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Heavy Metals Removal from Swine Wastewater Using Constructed Wetlands with Horizontal Sub-Surface Flow

引用

Journal of Environmental Protection 2012年第8期3卷 871-877页

作者： Jorge A. Cortes-Esquivel Germán Giácoman-Vallejos Icela D. Barceló-Quintal Roger Méndez-Novelo María C. ponce-Caballero Departamento de Ciencias Básicas Universidad Autónoma Metropolitana Unidad Azcapotzalco México D.F. Facultad de Ingeniería Universidad Autónoma de Yucatán Mérida México

The removal efficiency of Cu and Zn from swine wastewater was evaluated as effected by three variables: the hydraulic retention time (HRT) (24, 48, 72 and 96 hours), two different plant species (Typha domingensis Pers. and Eleocharis cellulosa) and two different sizes of filter media (5 and 15 mm) using a horizontal sub-surface flow constructed wetland. From the results, a significant difference was observed in the removal efficiency of Cu and Zn with respect to different hydraulic retention times. The best results were obtained in the HRT of 96 hours for Zn where 96% removal of Zn with Typha domingensis Pers. specie with gravel of 15 mm (experimental unit 6) was achieved. For Cu, at 72 hours of HRT, the efficiency was nearly 100% in five of the six study units (1, 2, 3, 5 and 6). In contrast, in experimental unit 4 with gravel of 15 mm and without plants, only 86% Cu removal was achieved.

关键词： Swine Wastewater Typha domingensis Pers. Eleocharis cellulosa Heavy Metals Constructed Wetlands Horizontal Sub-Surface Flow

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：