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Genetic diseases conferring resistance to infectious diseases

Genes & Diseases 2015年第3期2卷 247-254页

作者： Isabelle C.Withrock Stephen J.Anderson Matthew A.Jefferson Garrett R.McCormack Gregory S.A.Mlynarczyk Aron Nakama Jennifer K.Lange Carrie A.Berg Sreemoyee Acharya Matthew L.Stock Melissa S.Lind K.C.Luna Naveen C.Kondru Sireesha Manne Bhavika B.Patel Bierlein Mde la Rosa Kuei-Pin huang Shaunik Sharma hilary z.hu Sri Harsha Kanuri Steve A.Carlson Department of Biomedical Sciences Iowa State University College of Veterinary MedicineAmesIA 50011USA Department of Psychology Iowa State University College of Liberal Arts and SciencesAmesIA 50011USA Department of Kinesiology Iowa State University College of Liberal Arts and SciencesAmesIA 50011USA Department of Genetics Developmental and Cell BiologyIowa State University College of Liberal Arts and SciencesAmesIA 50011USA Neuroscience Interdepartmental Program Iowa State UniversityAmesIA 50011USA

This review considers available evidence for mechanisms of conferred adaptive advantages in the face of specific infectious *** short,we explore a number of genetic conditions,which carry some benefits in adverse circumstances including exposure to infectious *** examples discussed are conditions known to result in resistance to a specific infectious disease,or have been proposed as being associated with resistance to various infectious *** infectious diseasedgenetic disorder pairings include malaria and hemoglobinopathies,cholera and cystic fibrosis,tuberculosis and Tay-Sachs disease,mycotic abortions and phenylketonuria,infection by enveloped viruses and disorders of glycosylation,infection by filoviruses and NiemannePick C1 disease,as well as rabies and myasthenia *** also discuss two genetic conditions that lead to infectious disease hypersusceptibility,although we did not cover the large number of immunologic defects leading to infectious disease *** of the resistance-associated pairings(malaria/hemogloginopathies,cholera/cystic fibrosis,tuberculosis/Tay-Sachs,and mycotic abortions/phenylketonuria)appear to be a result of selection pressures in geographic regions in which the specific infectious agent is *** other pairings do not appear to be based on selection pressure and instead may be ***,research investigating these relationships may lead to treatment options for the aforementioned diseases by exploiting established mechanisms between genetically affected cells and infectious *** may prove invaluable as a starting point for research in the case of diseases that currently have no reliably curative treatments,e.g.,HIV,rabies,and Ebola.

关键词： Disease Infectious Pathogen Polymorphism Resistance Susceptibility

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Rational design of AgGaS/znS/znS quantum dots with a near-unity photoluminescence quantum yield via double shelling scheme

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Journal of Materials Science & Technology 2024年第2期169卷 235-242页

作者： H.X.Lu H.Liu z.z.Fu Y.Y.Chen H.Q.Dai z.hu W.L.zhang R.Q.Guo Institute for Electric Light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China Yiwu Research Institute of Fudan University YiwuZhejiang 322000China zhongshan-Fudan Joint Innovation Center Zhongshan 528437China

In this study,a two-step method was used to synthesize highly luminescent AgGaS/znS/znS quantum dots(QDs).In the first step,an inner znS shell was formed via a one-pot method,which resulted in a smaller lattice mismatch between the AgGaS core and the outer znS shell,thereby facilitating the formation of a thick outer *** the two-step shelling process,the synthesized AgGaS/znS/znS QDs showed an excellent photoluminescence quantum yield(PLQY)of 96.4%with a peak wavelength of 508 nm,repre-senting the highest PLQY reported thus far for AgGaS ***,the effect of halogen ions in zn precursors on the shelling process was *** was proposed that the capacity of halogen ions to coordinate with the QDs influenced the balance between zn cation diffusion and znS shelling ***,the znS shelling reaction was dominant when znCl_(2)was employed,while zn cation diffusion was the dominant process under the I^(−)-rich *** work provides insights into the interfacial restructuring during the znS shelling and offers a clear map for the tailored synthesis of core/shell QDs.

关键词： AgGaS Quantum dots Photoluminescence Core/shell Alloyed core/shell interface

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Air pollution and liver cancer: A systematic review

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Journal of Environmental Sciences 2023年第4期126卷 817-826页

作者： Ting Gan hilary Bambrick Shilu Tong Wenbiao hu School of Public Health and Social Work Queensland University of TechnologyQueensland 4059Australia National Centre for Epidemiology and Population Health Australian National UniversityAustralian Capital Territory 2601Australia Shanghai Children’s Medical Center School of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Air pollution has previously been linked to several adverse health outcomes, but the potential association between air pollution and liver cancer remains unclear. We searched Pub Med, EMBASE, and Web of Science from inception to 10 October 2021, and manually reviewed the references of relevant papers to further identify any related literature investigating possible associations between air pollution and liver cancer. Risk estimates values were represented by statistical associations based on quantitative analyses. A total of 13cohort studies obtained from 11 articles were included, with 10,961,717 participants. PM_(2.5)was the most frequently examined pollutant(included in 11 studies), followed by NO_(2)and NOx(included in 6 studies), and fewer studies focused on other pollutants(PM_(2.5)absorbance,PM_(10), PM_(2.5–10), O_(3), and BC). In all the 16 associations for liver cancer mortality, 14 associations reported the effect of PM_(2.5)on liver cancer mortality. Eight associations on PM_(2.5)were significant, showing a suggestive association between PM_(2.5)and liver cancer mortality. Among24 associations shown by risk estimates for liver cancer incidence, most associations were not statistically significant. For other air pollutants, no positive associations were presented in these studies. PM_(2.5)was the most frequently examined pollutant, followed by NO_(2)and NOx, and fewer studies focused on other pollutants. PM_(2.5)was associated with liver cancer mortality, but there was no association for other air pollutants. Future research should use advanced statistical methods to further assess the impact of multiple air pollutants on liver cancer in the changing socio-environmental context.

关键词： Air pollution PM_(2.5) Liver cancer Incidence Mortality Systematic review

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Tsinghua Science and Technology 2020年第5期25卷 604-613页

作者： Jinchang hu Jinfu Chen Lin zhang Yisong Liu Qihao Bao hilary Ackah-Arthur Chi zhang the School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang 212013China

Developing secure software systems is a major challenge in the software industry due to errors or weaknesses that bring vulnerabilities to the software *** address this challenge,researchers often use the source code features of vulnerabilities to improve vulnerability *** the success achieved by these techniques,the existing studies mainly focus on the conceptual description without an accurate definition of vulnerability *** this study,we introduce a novel and efficient Memory-Related Vulnerability Detection Approach using Vulnerability Features (MRVDAVF).Our framework uses three distinct strategies to improve vulnerability *** the first stage,we introduce an improved Control Flow Graph (CFG) and Pointer-related Control Flow Graph (PCFG) to describe the features of some common vulnerabilities,including memory leak,doublefree,and ***,two algorithms,namely Vulnerability Judging algorithm based on Vulnerability Feature (VJVF) and Feature Judging (FJ) algorithm,are employed to detect memory-related ***,the proposed model is validated using three test cases obtained from Juliet Test *** experimental results show that the proposed approach is feasible and effective.

关键词： vulnerability feature Control Flow Graph(CFG) Memory Leak(ML) Double-Free(DF) Use-After-Free(UAF)

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Beta-blockers and physical frailty in patients with endstage liver disease

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World Journal of Gastroenterology 2018年第33期24卷 3770-3775页

作者： Selena z Kuo Blanca Lizaola hilary Hayssen Jennifer C Lai Division of Gastroenterology/Hepatology Department of Medicine University of CaliforniaSan Francisco

AIM To investigate beta-blocker(BB) use in patients with cirrhosis and determine their effects on physical frailty and overall *** Adult outpatients with cirrhosis listed for liver transplantation underwent testing of physical frailty using the performance-based Liver Frailty Index, comprised of chair stands, grip strength, and balance testing, as well as self-reported assessments of exhaustion and physical activity. BB use was assessed from medical chart review. Univariable and multivariable logistic regression were performed to determine BB use and their association with measures of physical frailty. Competing risk analyses were performed to determine the effect of BB use on wait-list mortality, as defined by death or delisting for being too sick for *** Of 344 patients, 35% were female, median age was 60, median model for end stage liver disease was 15, and 53% were prescribed a BB. Compared to those not on BB, patients on BB were similar except for percentage female(25% vs 46%; P zation when indicated.

关键词： Beta-blockers Cirrhosis End-stage liver disease Frailty

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Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： Chen Chen Hongyu Xue Qilin hu Mengfan Wang Pan Shang ziyan Liu Tao Peng Deyang zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

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Mechanical Alloying Effect on the Structure of Fe-Al-(Si) Alloy

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Journal of Materials Science & Technology 1997年第3期13卷 219-222页

作者： zhang, JQ Wu, BY hu, z Wang, GQ SOUTHEAST UNIV DEPT MECH ENGNNANJING 210096PEOPLES R CHINA NANJING UNIV DEPT CHEMNANJING 210008PEOPLES R CHINA NANJING UNIV DEPT PHYSNANJING 210008PEOPLES R CHINA

The mechanical alloying effects on the structures of Fe71.3Al28.4(CeO2)(0.3) and Fe73.3Al9.8-Si-16.6(CeO2)(0.3) samples have been investigated mainly by Mossbauer spectroscopy and X-ray diffraction. it is found that with the increase of milling time, a substituting disordered alpha-Fe solution is formed gradually and almost completed after milled for 72 h. Further increasing milling time causes the atomic rearrangement within the powders. Correspondingly, the average lattice parameter and average crystalline size change until 72 h and remain constant after 72 h. The addition of Si leads to the higher disordered degree reflected in the smaller average hyperfine field and larger mean square deviation.

关键词： Iron alloys

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Numerical investigation on the flowfield of “swallowtail” cavity for supersonic mixing enhancement

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Acta Mechanica Sinica 2009年第1期25卷 37-44页

作者： C. Wang z. Jiang z. hu J. Lu Institute or Mechanics. Chinese Academy of Sciences 100190 Beijing China ReCAPT Gyeongsang National University JinjuKyeongnam 660-701 South Korea

A ＂swallowtail＂ cavity for the supersonic combustor was proposed to serve as an efficient flame holder for scramjets by enhancing the mass exchange between the cavity and the main flow. A numerical study on the ＂swallow- tail＂ cavity was conducted by solving the three-dimensional Reynolds-averaged Navier-Stokes equations implemented with a k-e turbulence model in a multi-block mesh. Turbu- lence model and numerical algorithms were validated first, and then test cases were calculated to investigate into the mechanism of cavity flows. Numerical results demonstrated that the certain mass in the supersonic main flow was sucked into the cavity and moved spirally toward the combustor walls. After that, the flow went out of the cavity at its lateral end, and finally was efficiently mixed with the main flow. The comparison between the ＂swallowtail＂ cavity and the conventional one showed that the mass exchanged between the cavity and the main flow was enhanced by the lateral flow that was induced due to the pressure gradient inside the cavity and was driven by the three-dimensional vortex ring generated from the ＂swallowtail＂ cavity structure.

关键词： Supersonic mixing - Flame holder "Swallowtail" cavity - Combustion ignition Numerical simulation

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Weather Variability,Socioeconomic Factors,and Pneumonia in Children Under Five-Years Old——Bangladesh,2012−2016

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China CDC weekly 2021年第29期3卷 620-623,I0001,I0002页

作者： Mohammad zahid Hossain Shilu Tong hilary Bambrick Md Alfazal Khan Wenbiao hu School of Public Health and Social Work Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneQueenslandAustralia Infectious Diseases Division International Centre for Diarrhoeal Disease ResearchBangladeshMohakhaliDhakaBangladesh Shanghai Children’s Medical Centre School of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Public Health Institute of Environment and Population HealthAnhui Medical UniversityHefeiAnhuiChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsuChina Health System and Population Studies Division International Centre for Diarrhoeal Disease ResearchBangladeshMohakhaliDhakaBangladesh

Summary What is already known on this topic?Different socioecological factors were associated with childhood pneumonia in ***,previous studies did not assess spatial patterns,and socioecological factors and spatial va... 详细信息

关键词： pneumonia Bangladesh ecological

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A modified averaging scheme with application to the secondary Hopf bifurcation of a delayed van der Pol oscillator

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Acta Mechanica Sinica 2008年第4期24卷 449-454页

作者： z.H.Wang H.Y.hu Institute of Sciences PLA University of Science and Technology Nanjing 211101 China Institute of Vibration Engineering Research Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

In this paper, a modified averaging scheme is presented for a class of time-delayed vibration systems with slow variables. The new scheme is a combination of the averaging techniques proposed by Hale and by Lehman and Weibel, respectively. The averaged equation obtained from the modified scheme is simple enough but it retains the required information for the local nonlinear dynamics around an equilibrium. As an application of the present method, the delay value for which a secondary Hopf bifurcation occurs is successfully located for a delayed van der Pol oscillator.

关键词： Time delay ·Secondary Hopf bifurcation·The averaging technique van der Pol oscillator

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