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冠心病中7个凝血基因的多态性:对66155例冠心病患者及91307例对照者的荟萃分析

世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 8-9页

作者： higgins j.p. j. Danesh 马超 Department of public Health and primary Care University of Cambridge Strangeways Site Wort's Causeway Cambridge CB1 8RN United KingdomProf.

Background: Variants of certain haemostatic genes(such as that encoding factor V Leiden) are involved in the development of venous thrombosis, but studies of such variants in coronary disease have reported apparently conflicting results. We did meta-analyses on seven such haemostatic genetic variants for which the available evidence on each comprises at least 5000 coronary disease cases and at least 5000 controls. Methods: Meta-analyses were done of 191 studies in relation to factor V G1691A(ie, factor V Leiden), factor VII G10976A, prothrombin G20210A, plasminogen activator inhibitor-1(pAI-1) [-675] 4G/5G, and three platelet glycoprotein(Gp)receptor variants(GpIa C807T, GpIbα T[-5]C,GpIIIa C1565T), involving a total of 66 155 coronary disease cases and 91 307 controls. We explored potential sources of heterogeneity. Findings: In a combined analysis of all studies, the per-allele relative risks(RR) for coronary disease of factor V 1691A and of prothrombin 20210A were 1.17(95% CI 1.08-1.28) and 1.31(1.12-1.52), respectively. Combined analyses of studies of the pAI-1 [-675] 4G variant yielded a per-allele relative risk for coronary disease of 1.06(1.02-1.10), but there was an indication of publication bias in these studies. Combined analyses of the factor VII 10976A, GpIa 807T, GpIbα [-5]C, and GpIIIa 1565T variants showed no significant overall associations with coronary disease, yielding per-allele RRs of 0.97(0.91-1.04), 1.02(0.97-1.08), 1.05(0.96-1.13), and 1.03(0.98-1.07) , respectively. Interpretation: The 1691A variant of the factor V gene and the 20210A variant of the prothrombin gene, both of which increase circulating thrombin generation, might each be moderately associated with the risk of coronary disease. Further studies are merited to assess these associations in greater detail(including any gene-gene and gene-environment interactions) and to determine any implications with regard to potential therapies designed to reverse patients prothrombotic phenoty

关键词：凝血因子VII 基因的多态性冠心病患者荟萃分析纤溶酶原激活物抑制剂 G20210A 静脉血栓形成基因变异血小板糖蛋白

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Selection of digital fabrication technique in the construction industry--A multi-criteria decision-making approach

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 977-997页

作者： M.p.SALAIMANIMAGUDAM j.jAYApRAKASH Department of Structural and Geotechnical Engineering School of Civil EngineeringVellore Institute of TechnologyVellore 632014India

Digital fabrication techniques,in recent decades,have provided the basis of a sustainable revolution in the construction ***,selecting the digital fabrication method in terms of manufacturability and functionality requirements is a complex *** paper presents alternatives and criteria for selection of digital fabrication techniques by adopting the multi-criteria decision-making *** alternatives considered in the study are concrete three-dimensional(3D)printing,shotcrete,smart dynamic casting,material intrusion,mesh molding,injection concrete 3D printing,and thin forming *** criteria include formwork utilization,reinforcement incorporation,geometrical complexity,material enhancement,assembly complexity,surface finish,and build *** demonstrates different multi-criteria decision-making techniques,with both subjective and objective weighting *** given ranking is based on the current condition of digital fabrication in the construction *** study reveals that in the selection of digital fabrication techniques,the criteria including reinforcement incorporation,build area,and geometrical complexity play a pivotal role,collectively accounting for nearly 70% of the overall *** the evaluated techniques,concrete 3D printing emerged as the best performer,however the shotcrete and mesh molding techniques in the second and third positions.

关键词： digital fabrication multicriteria decision-making concrete 3D printing

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proteins as nanomagnets and magnetoreceptors

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Zoological Research 2024年第4期45卷 831-832页

作者： p.j.Hore Department of Chemistry University of OxfordUK

It is an appealing notion that a protein molecule could act as a nanomagnet.A genetically encodable biomolecule with a permanent magnetic moment at room temperature could have a range of applications:a magnetogenetic actuator,a magnetic tag for purifying and immobilizing enzymes,a contrast agent for magnetic resonance imaging,and a basis for a biomimetic magnetic sensing device,to name just a few.A magnetic protein could perhaps also function as the sensor in the magnetic compass that enables small songbirds to navigate the huge distances between their breeding and wintering *** though such possibilities may be,how realistic are they?

关键词： magnetic magnets enable

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不同断喙方法对肉仔鸡生产性能的影响

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饲料博览 2009年第3期 39-40页

作者： Henderson S N Barton j T Wolfenden A D higgins S E higgins j p Kuenzel W j Lester C A Tellez G Hargis B M

在商业肉鸡的饲养中断喙是必要的,其可以避免或减少生长过程中因啄伤造成的危害。试验旨在研究两种不同断喙方法与不断喙对鸡生产性能的影响。电烙断喙器(ECD)是从鸡的喙尖部进行烧伤断喙。红外断喙器(IBT)则在大约初孵的10d里应用红外... 详细信息

在商业肉鸡的饲养中断喙是必要的,其可以避免或减少生长过程中因啄伤造成的危害。试验旨在研究两种不同断喙方法与不断喙对鸡生产性能的影响。电烙断喙器(ECD)是从鸡的喙尖部进行烧伤断喙。红外断喙器(IBT)则在大约初孵的10d里应用红外光束,使活体基底组织与坚硬角质导完全分离。第二部分试验选择当地孵化场刚孵化出的708只Ross鸡,并对鸡群的1/3雏鸡进行IBT断喙。然后将所有的雏鸡运往另一个孵化场,对剩余的2/3雏鸡一半采用ECD断喙,另一半则不进行断喙(NBT)。断喙过程均由断喙技术熟练的人员操作。此后所有的雏鸡被运往阿肯色大学试验基地。按照试验设计,对每只雏鸡进行颈部标记及称重,并用游标卡尺测量喙径。试验结果表明,在第11天时IBT组雏鸡体重比NBT组和ECD组分别提高7.8和8.7g,差异极显著(ppp>0.05),而在第21天和42天时,IBT组、ECD组与NBT组间在体重及体重增加上均无显著差异(p>0.05)。可见,在孵化当天便由技术熟练、经验丰富的人员对雏鸡断喙,不会对6周龄内雏鸡的生产性能产生明显影响。一般认为鸡生产性能的下降与其身体和精神敏感性应激有关。经红外烧灼断喙的雏鸡到达性成熟时体重显著减少,说明只要操作得当,任何断喙方法对鸡造成的身体和精神的应激,均不会影响其早期生长速度。

关键词：断喙早期生长性能体重

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Wettability,reactivity,and interface structure in Mg/Ni system

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journal of Magnesium and Alloys 2024年第2期12卷 659-672页

作者： S.Terlicka N.Sobczak Ł.Maj p.Darłak j.j.Sobczak Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta Str.KrakowPoland Faculty of Foundry Engineering AGH University23 Reymonta Str.KrakowPoland

The sessile drop method was applied to the experimental investigation of the wetting and spreading behaviors of liquid Mg drops on pure Ni *** comparison,the experiments were performed in two variants:(1)using the Capillary purification(Cp)procedure,which allows the non-contact heating and squeezing of a pure oxide-free Mg drop;(2)by classical Contact Heating(CH)*** high-temperature tests were performed under isothermal conditions(Cp:760℃for 30 s;CH:715℃for 300 s)using Ar+5 wt%H_(2) *** the sessile drop tests,images of the Mg/Ni couples were recorded by CCD cameras(57 fps),which were then applied to calculate the contact angles of metal/substrate *** and transmission electron microscopy analyses,both coupled with energy-dispersive X-ray spectroscopy,were used for detailed structural characterization of the solidified *** was found that an oxide-free Mg drop obtained by the Cp procedure showed a wetting phenomenon on the Ni substrate(an average contact angleθpreading and good wetting over the Ni substrate(θ_((Cp))~20°in 5 s)to form a final contact angle ofθ_(f(Cp))~18°.In contrast,a different wetting behavior was observed for the CH procedure,where the unavoidable primary oxide film on the Mg surface blocked the spreading of liquid Mg showing apparently non-wetting behavior after 300 s contact at the test ***,in both cases,the deep craters formed in the Ni substrates under the Mg drops and significant change in the structure of initially pure Mg drops to Mg-Ni alloys suggest a strong dissolution of Ni in liquid Mg and apparent values of the final contact angles measured for the Mg/Ni system.

关键词： Magnesium-based alloys Sessile drop tests Capillary purification procedure Wettability Reactivity Contact angle

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On the analytical solution of transient friction in channel flows

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： F.j.GARCíA-GARCíA p.FARINAS-ALVARINO Department of Naval&Industrial Engineering Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Integraciones Técnicas de Seguridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The transient friction in channel mean flows is the sum of two contributions,i.e.,the underlying laminar flow(ULF)and the purely turbulent component(pTC),and the contributions are analyzed separately by theoretical *** is found that,the transient friction may be higher or remarkably lower than that in equal-Reynolds number steady-state *** universal time constant for plane-parallel laminar flows is reported,and the role of the time constant in a turbulent mean flow is *** is shown that the time constant is related to the turbulence's frozen ***,a study of the logarithmic layer during the transient flow is accomplished,which shows that the logarithmic layer is destroyed.

关键词： transient friction transient flow unsteady channel flow

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Drought events influence nutrient canopy exchanges and green leaf partitioning during senescence in a deciduous forest

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Forest Ecosystems 2024年第1期11卷 110-119页

作者： j.Touche C.Calvaruso p.De Donato M.-p.Turpault INRAE BEFF-54000NancyFrance UMR 7359 GeoRessourcesFaculte des Sciences-Campus des Aiguillettes54506Vandoeuvre Les NancyFrance EcoSustain Environmental Engineering OfficeResearch and DevelopmentKanfen57330France

The increase in the frequency and intensity of drought events expected in the coming decades in Western Europe may disturb forest biogeochemical cycles and create nutrient deficiencies in *** possible origin of nutrient deficiency is the disturbance of the partitioning of the green leaf pool during the leaf senescence period between resorption,foliar leaching and senesced ***,the effects of drought events on this partitioning and the consequences for the maintenance of tree nutrition are poorly *** experiment in a beech forest in Meuse(France)was conducted to assess the effect of drought events on nutrient canopy exchanges and on the partitioning of the green leaf pool during the leaf senescence *** aim was to identify potential nutritional consequences of droughts for *** nutrient dynamics,including resorption,chemistry of green and senesced leaves,foliar absorption and leaching in mature beech stands from 2012 to 2019 allowed us to compare the nutrient exchanges for three nondry and three dry years(i.e.,with an intense drought event during the growing season).During dry years,we observed a decrease by almost a third of the potassium(K)partitioning to resorption(*** efficiency),thus reducing the K reserve in trees for the next growing *** result suggests that with the increased drought frequency and intensity expected for the coming decades,there will be a risk of potassium deficiency in trees,as already observed in a rainfall exclusion experiment on the same study *** foliar leaching and higher parititioning to the senesced leaves for K and phosphorus(p)were also *** addition,a slight increase in nitrogen(N)resorption efficiency occurred during dry years which is more likely to improve tree *** calcium(Ca)negative resorption decreased,with no apparent consequence in our study *** results show that nutrient exchanges in the canopy and the partitioning of the green leaf

关键词： Natural drought Beech forest Canopy Resorption Foliar leaching Senesced leaves Nutrition

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CO oxidation under lean and stoichiometric conditions over ceriazirconia with very low metal contents(Cu,Co,Ag and pt)

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journal of Rare Earths 2024年第9期42卷 1669-1681,I0002页

作者： j.C.Martínez-Munuera M.p.Yeste A.García-García MCMA Group Department of Inorganic Chemistry and Institute of MaterialsUniversity of AlicanteCarretera de San Vicente del Raspeig s/n03690San Vicente del RaspeigAlicanteSpain Solid Chemistry and Catalysis Group Department of Materials ScienceMetallurgic Engineering and Inorganic ChemistryInstitute of Electronic Microscopy and Materials ResearchUniversity of CádizAp.40E-11510Puerto RealCádizSpain

In this work,several ceria-zirconia based catalysts with very lo w(and equimolar) metal contents were prepared,characterised and tested for the CO oxidatio n reaction(under lean and stoichiometric conditions),trying to emulate those conditions found in a diesel oxidation catalyst(DOC) system from a diesel engine and those encountered under gasoline exhaust(λ=1).The metals chosen are Cu,Co,Ag and pt(as a reliable benchmark).The results reveal enormous differences among reducibility and catalytic activity despite quite similar structural and textural properties of the catalysts,showing differences among dispersion(Ag-catalyst seems to present a low level of dispersion).This catalyst seems to be characterised,as well,by a strong electronic interaction between Ce and Ag centres which is suggested to yield an improved reducibility under H_(2)-TpR ***,the order in catalytic activity(Cu>Ag>Co≈pt>>support) seems not to follow the order found in reducibility and the Cu-catalyst seems to be the most active independently on the reaction conditions,yielding nearly overlapped CO oxidation catalytic *** restingly,a stro ng correlation between the catalytic activity under the two conditions tested and the OSC values of the Ce_(0.8)Zr_(0.2)O_(2)-supported metal catalysts is ***,OSC parameter measured at 150℃ can be used as a relevant descriptor to evaluate the CO oxidation activity at low and medium conversions for the investigated catalysts,much better than the H_(2)-TpR measurements.

关键词： CO oxidation Low metal content Ceria-zirconia Copper species OSC parameter Rare earths

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Laser-induced graphene-coated wearable smart textile electrodes for biopotentials signal monitoring

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Frontiers of Materials Science 2024年第1期18卷 95-111页

作者： C.M.Vidhya Yogita Maithani Sakshi Kapoor j.p.Singh Department of physics Indian Institute of Technology DelhiHauz KhasNew Delhi 110016India

This paper describes how to produce a wearable dry electrode at a reasonable cost and how to use it for the monitoring of biopotentials in *** textiles in wearable technologies have made a great advancement in the health care management and living standards of *** was manufactured using the low-cost single-step process,laser ablation of polyimide,a commercial *** dispersions were made using solvent isopropyl alcohol which has low boiling point,nontoxicity,and environmental *** successive coating of the graphene dispersion on the cotton fabric to make it conductive,the sheet resistance of the resulting fabric dropped to 3% of its initial *** laser-induced graphene(LIG)cotton dry electrodes thus manufactured are comparable to Ag/AgCl wet electrodes in terms of the skin-to-electrode impedance,measuring between 78.0 and 7.2 kΩ for the frequency between 40 Hz and 1 *** LIG cotton electrode displayed a signal-to-noise ratio of 20.17 *** to its comfort,simplicity,and good performance over a longer period of time,the textile electrode appears suited for medical applications.

关键词： biopotential electrocardiogram electromyogram flexible electrode textile porous graphene

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Europium recovery process by means of polymeric nanoparticles functionalized with acrylic acid,curcumin and fumaramide

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journal of Rare Earths 2024年第10期42卷 1950-1959页

作者： p.A.Martínez-Montoya j.M.del Río A.de j.Morales-Ramirez M.Corea Escuela Superior de Ingeniería Química e Industrias Extractivas ESIQIE-IPNDepartamento de Ingeniería Metalúrgica UPALM S/N Col.Lindavista Escuela Superior de Ingenieria Química e Industrias Extractivas ESIQIE-IPNLaboratorio de Investigación en Polímeros y NanomaterialesUPALM S/N Col.Lindavista Centra de Investigación e Innovación Tecnológica CIITEC-IPNCda.de CECATIs/n

polymeric nanoparticles of poly(methyl methacrylate) were obtained by emulsion polymerization techniques in a proce ss of two *** particles were functionalized with acrylic acid,curcumin,and fumaramide and three series of polymeric particles were *** incorporation of functional groups was confirmed by Fourier transform-infrared spectrosocopy(FT-IR) and ultraviolet-visible(UV-Vis) *** spherical morphology of particles with an average diameter of 100 nm was observed by scartning electron microscopy(SEM).The polymeric materials were used for recovery of [Eu]from synthetic *** nanoparticles show excellent chelation capacity to trap rare-earth ions,because they recover more than 85% of [Eu] at pH of *** images of SEM after extraction process show arrays between particles with larger average particle sizes to 1.5 *** addition,the particles have a good stripping capacity,exceeding 50% of it,maintaining their homogeneity in morphology and good stability in dispersion for the recovery and stripping processes.A pseudo-second model order is obtained for the extraction and stripping processes while the best results of stripping process are obtained at pH of6.

关键词： Chelating effect Emulsion polymerization Extraction process Rare earths Stripping process [Eu]recovery

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