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中国病理生理杂志 2001年第11期 62-62页

作者： hideyuki niimi Dept of Vascular Physiology National Cardiovascular Center Suita Os aka 565-8655 Japan

Cerebral microcirculatory changes in hypovolemic hypotension we re investigat ed in rats with a cardio-pulmonary bypass (CPB) during pulsatile and non-pulsati le flow. The hypovolemic hypotension was induced by reducing the CPB flow-rate. In the non-pulsatile flow, the cardiac beat was stopped using a fibrilator, whi le in the pulsatile flow the cardiac function was retained. The pial microcircul ation was observed and recorded during CPB, using fluorescence videomicroscopy. The arteriolar diameter and red cell velocity were measured based on the recorde d videoimages. The flow-rate was calculated from the measured diameter and veloc ity data. The present results showed that the flow-rate remained almost constant up to 60 mmHg arterial pressure during pulsatile flow. On the other hand, in n on-pulsatile flow, the flow-rate decreased with a decrease in arterial pressure, indicating the impairment of microvascular autoregulation. It was suggested th at pulsatile flow has an advantage over non-pulsatile flow in a view-point of ce rebral microcirculatory changes in hypovolemic hypotension. Collaborating researchers: Drs. T. Yamakawa, S. Yamaguchi, Y. Ohnishi (National Cardiovascular Center, Osaka,Japan)

关键词： flow Cerebral microcirculatory changes during pulsatile and non

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小鼠脑微循环研究的方法——封闭式颅窗法

微循环学杂志 2003年第1期13卷 31-32,F004页

作者：胡青华孙瑞娟庄逢源 hideyuki niimi 中日友好医院临床医学研究所心血管生物工程研究室邮政编码北京100029 日本国立循环器病中心脉管生理部

目的 :介绍一种新的观察脑微循环的技术。方法 :在猫、鼠脑封闭式颅窗的技术基础上 ,试用小鼠安装脑颅窗 ,在显微镜下观察微循环的变化。根据观察目的不同 ,可利用其生理特点选择不同型的小鼠。实验中严格控制动脉血PaO2 和PaCO2 ,同时... 详细信息

目的 :介绍一种新的观察脑微循环的技术。方法 :在猫、鼠脑封闭式颅窗的技术基础上 ,试用小鼠安装脑颅窗 ,在显微镜下观察微循环的变化。根据观察目的不同 ,可利用其生理特点选择不同型的小鼠。实验中严格控制动脉血PaO2 和PaCO2 ,同时利用荧光标记的方法 ,将血管管径及红细胞流速做图像定量分析。结果 :利用此方法可以得到清晰的血管及血流图像。操作步骤简单 ,减少生理上的损伤。结论 :选择小鼠安装脑颅窗 ,并以此达到观察微循环的目的 ,是可选择的方法。

关键词：小鼠脑微循环研究方法封闭式颅窗法

Potential utility of aldose reductase-deficient Schwann cells IKARS1 for the study of axonal degeneration and regeneration

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Neural Regeneration Research 2018年第6期13卷 979-980页

作者： Naoko niimi Kazunori Sango Diabetic Neuropathy Project Department of Sensory and Motor Systems Tokyo Metropolitan Institute of Medical Science

Diabetic peripheral neuropathy（DPN）is one of the most common and intractable complications of diabetes *** irritating symptoms,such as paresthesia,hyperalgesia and allodynia,can be causes of insomnia and depression;whereas its progression to more advanced stages can result in serious consequences,such as lower limb amputations and lethal arrhythmias.

关键词： DPN Potential utility of aldose reductase-deficient Schwann cells IKARS1 for the study of axonal degeneration and regeneration NGF NCV AR PNS

Cerebral microcirculatory changes during pulsatile and non -pulsatile flow in hypovolemic hypotension

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中国病理生理杂志 2001年第11期17卷 1101-1101页

作者： hideyuki niimi Dept of

关键词：血容量减少低血压 CPB 脑微循环改变动物实验

养血清脑颗粒对双侧颈动脉结扎-再通引起的蒙古沙鼠脑皮层微循环障碍和脑灌流量的改善作用

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世界科学技术-中医药现代化 2008年第3期10卷 112-117页

作者：徐想顺王芳刘育英廖福龙樊景禹新见英幸马治中王传社韩晶岩北京大学医学部天士力微循环研究中心北京100083 北京大学医学部基础医学院中西医结合教研室北京100083

目的:研究养血清脑颗粒(Cerebralcare Granule,CG)对双侧颈动脉结扎再通引起的蒙古沙鼠脑皮层微循环障碍和脑灌流量的改善作用。方法:采用蒙古沙鼠双侧颈动脉缺血再灌注(is—chemia/erperfusion,I/R)模型,在正立显微镜微循环观察系统... 详细信息

目的:研究养血清脑颗粒(Cerebralcare Granule,CG)对双侧颈动脉结扎再通引起的蒙古沙鼠脑皮层微循环障碍和脑灌流量的改善作用。方法:采用蒙古沙鼠双侧颈动脉缺血再灌注(is—chemia/erperfusion,I/R)模型,在正立显微镜微循环观察系统下,观察脑皮层细静脉管径、细静脉红细胞流速、dihydrorhodamine 123(DHR)萤先强度和血浆白蛋白漏出的变化,记录脑表面血流量。一部分沙鼠在缺血前90min灌胃给予CG0.8 g/kg。结果:I/R 30min后,粘附于细静脉壁的白细胞数量、细静脉过氧化物、血浆白蛋白漏出显著增加,脑血流量降低。CG可以显著地抑制上述变化。结论:CG前给药可以抑制双侧颈动脉结扎再通引起的脑微循环障碍和脑灌流量,该作用可能与抑制过氧化物产生有关。

关键词： I/R损伤脑微循环障碍白细胞黏附白蛋白漏出过氧化物

Running-in friction of hip joint replacements can be significantly reduced:The effect of surface-textured acetabular cup

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Friction 2020年第6期8卷 1137-1152页

作者： David NECAS Hatsuhiko USAMI Tatsuya niimi Yoshinori SAWAE Ivan KRUPKA Martin HARTL Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic Faculty of Science and Technology Meijo UniversityNagoya 468-8502Japan Kanefusa Corporation Nagoya 480-0192Japan Faculty of Engineering Kyushu UniversityFukuoka 819-0395Japan

Hip joint replacements represent the most effective way of treatment for patients suffering from joint *** the rapid improvement of implant materials over the last few decades,limited longevity associated with wear-related complications persists as the main ***,improved tribological perfor-mance is required in order to extend the service life of *** effect of surface texturing of ultra-high molecular weight polyethylene(UHMWPE)acetabular cup was investigated in the present *** tilling method was utilized for manufacturing the dimples with controlled diameter and depths on the contact surface of the *** experiments with four commercial femoral components and two model lubricants were *** main attention was paid to a coefficient of friction considering the differences between the original and the dimpled *** showed remarkable lowering of friction,in *** on the simulated human synovial fluid,friction was reduced by 40%(alumina ceramic),38.8%(zirconia toughened ceramic),25.5%(metal),and 9.9%(oxinium).In addition,the dimples helped to keep the friction stable without *** conclude,the paper brings a new insight into frictional behaviour of the hip replacements during running-in phase which is essential for overall implant *** is believed that proper surface texturing may rapidly improve the life quality of millions of patients and may lead to considerable financial savings.

关键词： hip joint replacement friction texturing dimple longevity

Meropenem as an Alternative Antibiotic Agent for Suppression of Agrobacterium in Genetic Transformation of Orchid

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Agricultural Sciences in China 2006年第11期5卷 839-846页

作者： CAO Ying niimi Yoshiyuki HU Shang-lian School of Life Science and Engineering Southwest University of Science and Technology Mianyang 621000 P.R. China Department of Plant Resources Hiroshima Prefectural University Hiroshima 727-0027 Japan

A case of Meropenem as a novel antibacterial agent to suppress and eliminate Agrobacterium tumefaciens in the Agrobacterium-mediated transformation of orchid protocorm-like bodies （PLBs） has been reported in this article. The in vitro activities of meropenem and four comparator antibacterial agents against three Agrobacterium tumefaciens strains, LBA4404, EHA101, and GV3101, were assessed. In addition, the effect of meropenem on the growth of Dendrobium phalaenopsis PLBs was determined. Compared with other commonly used antibiotics （including ampicillin, carbenicillin, cefotaxime, and cefoperazone）, meropenem showed the highest activity in suppressing all tested A. tumefaciens strains （minimum inhibitory concentration [MIC] 〈 0.5 mg L^-1, which is equal to minimum bactericidal concentration [MBC]）. Meropenem, at all tested concentrations, except for 10 mg L^-1 concentration, had little negative effect on the growth of orchid tissues. The A. tumefaciens strain EHA101 in genetic transformation with vector plG121Hm in infected PLBs of the orchid was visually undetectable after a two-month subculture in 1/2 MS medium with 50 mg L^-1 meropenem and 25 mg L^-1 hygromacin. The expression and incorporation of the transgenes were confirmed by GUS histochemical assay and PCR analysis. Meropenem may be an alternative antibiotic for the effective suppression of A. tumefaciens in genetic transformation.

关键词： antibiotics meropenem Agrobacterium tumefaciens antibacterial activity genetic transformation protocormlike bodies (PLBs)

Macrophage-derived matrix metalloproteinase-1 enhances aortic aneurysm formation in transgenic rabbits

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The Journal of Biomedical Research 2019年第4期33卷 271-279页

作者： Manabu niimi Kazutoshi Nishijima Shuji Kitajima Fumikazu Matsuhisa Kaneo Satoh Hirokazu Yamazaki Jifeng Zhang Y. Eugene Chen Jianglin Fan Department of Molecular Pathology Graduate School of MedicineUniversity of YamanashiYamanashi 409-3898Japan Animal Research Laboratory Bioscience Education-Research Support CenterAkita UniversityAkita 010-8502Japan Analytical Research Center for Experimental Sciences Saga UniversitySaga 840-8502Japan Department of Laboratory Medicine Graduate School of MedicineUniversity of YamanashiYamanashi 409-3898Japan Center for Advanced Models for Translational Sciences and Therapeutics University of Michigan Medical CenterAnn ArborMI 48109USA School of Biotechnology and Health Sciences Wuyi UniversityJiangmenGuangdong 529020China

Increased expression of matrix metalloproteinase-1(MMP-1)has been observed in the lesions of atherosclerosis and aneurysms;however,it is not fully understood whether macrophage-derived MMP-1 affects these *** investigate whether macrophage-derived MMP-1 participates in the development of vascular diseases,we generated transgenic(Tg)rabbits expressing human MMP-1 in the monocyte/macrophage lineage under the control of the human scavenger receptor enhancer/*** rabbits exhibited no visible abnormalities throughout their *** blotting analysis revealed that the amount of MMP-1 proteins in the conditioned media secreted from peritoneal macrophages of Tg rabbits was up to 3-fold higher than that in non-Tg *** the first experiment,Tg and non-Tg rabbits were fed a cholesterol diet for 16 weeks,and aortic and coronary atherosclerosis were *** gross lesion area of aortic atherosclerosis in Tg rabbits was not significantly different from that in non-Tg rabbits,but Tg rabbits had marked destruction of the medial elastic lamina of the aortic lesions on microscopic *** the second experiment,we generated aortic aneurysms by incubating with *** with non-Tg rabbits,Tg rabbits exhibited a significantly greater aortic *** macrophage-derived MMP-1 led to increased medial destruction in both aortic atherosclerosis and *** results demonstrate that MMP-1 plays a different role in the pathogenesis of atherosclerosis and aneurysms.

关键词： matrix metalloproteinase-1 macrophage atherosclerosis aneurysm transgenic rabbit

Lossless data hiding using bit-depth embedding for JPEG2000 compressed bit-stream

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通讯和计算机（中英文版） 2009年第2期6卷 35-39页

作者： Shogo Ohyama Michiharu niimi Kazumi Yamawaki Hideki Noda Department of Systems Design and Informatics Kyushu Institute of Technology Kawazu 808-0135 Japan

We have proposed a reversible information hiding for binary images. In this paper, we present a lossless data hiding method for JPEG2000 compressed data based on the reversible information hiding. In JPEG2000 compression, wavelet coefficients of an image are quantized, therefore, the least significant bit plane (LSB) can be extracted. The proposed method recovers the quantized wavelet coefficients of cover images from Stego images. To realize this, we embed not only secret data and the JBIG2 bit-stream of a part of the LSB plane but also the bit-depth of the quantized coefficients on some code-blocks. Experimental results demonstrate the feasibility of application of the proposed method to image alteration detection for JPEG2000 compressed data.

关键词：二进制图像 JPEG2000压缩数据图像处理计算机技术