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Safety assessment of dextrin hydrogel adhesion barrier (AdSpray®) for elective laparoscopic cholecystectomy

Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 61-65页

作者： Toshiro Masuda Hiroshi Takamori Moeko Kato Chisho Mitsuura Yuta Shiraishi Rumi Itoyama Kenji Shimizu Ryuichi Karashima hidetoshi nitta Hideo Baba Department of Surgery Saiseikai Kumamoto HospitalKumamoto861-4193Japan Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto860-0811Japan

Objective:Adhesion barriers have not traditionally been used during laparoscopic cholecystectomy(lapchole),and so there are no data confirming the safety of the dextrin hydrogel adhesion barrier(AdSpray®)for the use during *** aim of this prospective study is to investigate the safety of AdSpray®for elective ***:Between July 2019 and March 2021,we conducted a prospective study at Saiseikai Kumamoto Hospital to assess the safety of applying AdSpray®around the hepatoduodenal ligament,liver surface,and port area after extraction of the gallbladder during elective *** assessed patient morbidity,mortality,and laboratory data on postoperative day 1 and at the outpatient follow-up ***:A total of 100 patients(43 men,57 women)received AdSpray®application during elective lapchole at our *** mean patient age was 56.5±14.8 y,and the mean body mass index was 25.1±4.8 kg/*** gallbladder drainage was performed in 3(3.0%)patients as conservative treatment for acute *** mean operative time was 91.7±35.1 min,and the median blood loss was 5 mL(range,5e120 mL).Intraoperative gallbladder perforation was observed in 4.0%of patients(n=4).There was no intraoperative bile duct ***(1.0%)patient had a postoperative subhepatic fluid collection without bacterial *** mean white blood cell count and C-reactive protein level was significantly elevated on postoperative day 1 but returned to preoperative levels by the time of the follow-up *** patients were successfully discharged after surgery,and the median postoperative hospital stay was 2 d(range,2e9 d).Conclusion:Applying AdSpray®during elective lap-chole is safe,with an acceptable rate of postoperative complications.

关键词： Adhesion barrier Dextrin hydrogel Laparoscopic cholecystectomy

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The Number of Positive Tumor Marker Status Is Beneficial for the Selection of Therapeutic Modalities in Patients with Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 165-168页

作者： Toru Beppu Shigeki Nakagawa hidetoshi nitta Hirohisa Okabe Takayoshi Kaida Katsunori Imai Hiromitsu Hayashi Yuki Koga Kunitaka Kuramoto Daisuke Hashimoto Yo-ichi Yamashita Akira Chikamoto Takatoshi Ishiko Hideo Baba Department of Surgery Yamaga City Medical Center Kumamoto Japan Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan

Hepatic resection (HR) and radiofrequency ablation (RFA) are popular local therapies for early-stage hepatocellular carcinoma (HCC).Alpha-fetoprotein,Lens culinaris agglutininreactive fraction of alpha-fetoprotein,and des-c-carboxy prothrombin are well-known and useful tumor markers for *** positive number status of these tumor markers has recently been demonstrated as beneficial for predicting outcome for HCC patients treated with local *** the normal ranges reported have differed by institution,the positivity of tumor markers is consistent and can easily be *** and Wakayama's group clearly demonstrated the following:1) Regardless of the degree of tumor stage,a triple-positive tumor marker profile can predict poor outcome in HCC patients undergoing HR;2) For RFA alone,HCC patients with double-and triple-positive status,having less than three lesions and lesions ≤3 cm in diameter show comparably insufficient outcomes;3) For HCC patients with lesions ≤5 cm in Child-Pugh grade A,HR is preferred over RFA;4) Microvascular invasion rates increased even in the double-positive patients,while poorly differentiated HCC was frequently observed only in the triple-positive patients;and 5) RFA with chemoembolization,anatomical liver resection,and postoperative adjuvant chemoembolization or hepatic arterial chemotherapy might improve the outcome for patients with highly malignant HCC with multiple positive tumor ***,the impacts of these therapies still need to be evaluated in prospective comparative studies.

关键词： Triple-positive tumor markers Double-positive tumor markers Hepatocellular carcinoma Hepatic resection Radiofrequency ablation Alpha-fetoprotein Des-γ-carboxy prothrombin Lens culinaris agglutinin reactive fraction of alpha-fetoprotein

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Epithelial-mesenchymal transition in gastroenterological cancer

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 183-189页

作者： Hirohisa Okabe Kosuke Mima Seiya Saito Hiromitsu Hayashi Katsunori Imai hidetoshi nitta Daisuke Hashimoto Akira Chikamoto Takatoshi Ishiko Toru Beppu Hideo Baba Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan Department of Multidisciplinary Treatment for Gastroenterological Cancer Kumamoto University HospitalKumamoto 860-8556Japan.

Epithelial-mesenchymal transition(EMT)was first reported as an essential process in embryonic cells and later showed that cancer cells,regardless of the context,exhibited a similar phenomenon that was crucial for tumor *** cells lose their adhesive characteristic capacity which is necessary for their functions but gain a mesenchymal *** change from epithelial to the mesenchymal phenotype of cancer cells makes it difficult to understand the mechanism underlying cancer biology and tumor progression.A number of transcription factors involved in tumor cell EMT and microRNA-regulated EMT have been *** review discussed recent findings and new players in EMT in gastrointestinal *** the molecular mechanisms of tumor progression are sometimes context-dependent,the recent findings of EMT have been reviewed in a context-dependent manner.

关键词： Epithelial-mesenchymal transition gastrointestinal cancer microRNA transcription factor

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