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新型淀粉样蛋白成像PET显像剂18F-FPYBF-2的生物分布和辐射剂量:首次在人体中的测定评估

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中华核医学与分子影像杂志 2018年第9期38卷 646-647页

作者：李雪娜 Ryuichi Nishii Tatsuya Higashi Shinya Kagawa Chio Okuyama Yoshihiko Kishibe Masaaki Takahashi Tomoko Okina Norio Suzuki Hiroshi Hasegawa Yasuhiro Nagahama Koichi Ishizu Naoya Oishi Hiroyuki Kimura Hiroyuki Watanabe Masahiro Ono hideo saji Hiroshi Yamauchi 中国医科大学附属第一医院核医学科 Shiga Medical Center Research Institute Dept.of Molecular Imaging and Theranostics National Institute of Radiological Sciences (NIRS)National Institutes for Quantum and Radiological Science and Technology( QST)

目的近年来,苯并呋喃衍生物5-(5-(2-(2-(2-18F-氟乙氧基)乙氧基)乙氧基)苯并呋喃-2-基)-N-甲基吡啶-2-胺(18F-FPYBF-2)被证实是淀粉样蛋白成像的显像剂。已发现18F-FPYBF-2PET/CT是评估阿尔茨海默病（AD）有用且可靠的诊断工具（Higashi... 详细信息

目的近年来,苯并呋喃衍生物5-(5-(2-(2-(2-18F-氟乙氧基)乙氧基)乙氧基)苯并呋喃-2-基)-N-甲基吡啶-2-胺(18F-FPYBF-2)被证实是淀粉样蛋白成像的显像剂。已发现18F-FPYBF-2PET/CT是评估阿尔茨海默病（AD）有用且可靠的诊断工具（Higashi等,Ann Nucl Med,https://***/10.1007/s12149-018-1236-1,2018）。该研究首次在健康志愿者中评估诊断剂量18F-FPYBF-2的生物分布和辐射。方法 4名健康志愿者[男3名,女1名;平均年龄（40±17）岁,年龄范围25～56岁]行18FFPYBF-2 PET/CT显像,以评估辐射暴露和药代动力学。注射后0～10 min进行身体（胸部和腹部）的动态PET/CT显像,在注射18F-FPYBF-2后进行6次15 min的全身静态显像。重建PET和CT图像数据后,通过拟合动态显像和全身显像的感兴趣体积数据来估量个体器官时间-活度曲线。用OLINDA/EXM 2.0软件判定全身有效剂量（ED）。结果动态PET显像示肝胆系统和肾是18F-FPYBF-2清除的主要途径。肝脏、胆囊、胃和肾脏呈放射性高摄取,其次是肠和膀胱。成人剂量学模型估测的ED为（8.48±1.25）μSv/MBq。男性和女性中较高吸收剂量的器官为:肝脏[（28.98±12.49）和（36.21±15. 64）μGy/MBq],大脑[（20.93±4.56）和（23.05±5.03）μGy/MBq],成骨细胞[（9.67±1.67）和（10.29±1.70）μGy/MBq],小肠[（9.12±2.61）和（11.12±3.15）μGy/MBq]和肾脏[（7.81±2.62）和（8.71±2.90）μGy/MBq]。结论成人剂量学模型的ED与用于淀粉样蛋白PET显像的其他药物所致ED相似。18F-FPYBF-2作为评估AD的诊断工具,其诊断剂量185～370 MBq对患者而言是可耐受的。

关键词：阿尔茨海默病淀粉样蛋白显像健康志愿者正电子发射断层显像术生物分布辐射剂量测定 OLINDA/EXM

Variation in physico-chemical, organoleptic and microbial qualities of intermediate moisture pineapple (Ananas comosus (L.) Merr.) slices during storage

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Food Production, Processing and Nutrition 2022年第1期4卷 58-68页

作者： saji Gomez Bintu Kuruvila P.K.Maneesha Meagle Joseph Department of Post Harvest Technology College of AgricultureKerala Agricultural UniversityVellanikkaraThrissur680656India

Pineapple is a commercial tropical fruit ranking sixth in global fruit production. Seasonal market gluts result in huge postharvest losses in all pineapple-growing nations. To reduce postharvest losses of fruits, viable, cost-effective and market-oriented value-added products are needed urgently. The present study was carried out to determine the suitability of two commercial varieties, Kew and Mauritius, for the development of intermediate moisture (IM) fruits and to evaluate product quality during storage. Pineapple slices were steam blanched for 2 min, followed by immersion in osmotic solution containing sucrose and sorbitol (fruit: solution ratio of 1:4), in combination with 0.5% ascorbic acid and 0.25% potassium metabisulfite, for 6 h and were subsequently dehydrated in a tray drier at 50 °C until the moisture content of the product attained equilibrium. The initial moisture contents of IM Kew and Mauritius pineapple slices were 26.53 and 21.65 g/100 g, respectively, while the water activity ranged between 0.671 and 0.666. The L* and b* values showed a decreasing trend, while a* value increased throughout storage, irrespective of variety and storage conditions. The initial TSS of IM pineapple from both varieties was 72 0 Brix, which declined during storage. Though titratable acidity of the product decreased during storage, the decline was insignificant. The total carotenoids of the product from Mauritius was significantly higher (0.809 mg 100 g− 1) compared to the one from Kew (0.215 mg 100 g− 1). Total phenolics contents in IM slices showed an increasing trend during storage, irrespective of varieties and storage conditions. IM pineapple slices from the variety Mauritius had significantly higher flavonoids (40.50 mg) than the product from Kew (30.0 mg 100 g− 1). DPPH radical scavenging activity was highest (3.0 μl ml− 1) in IM slices from the variety Mauritius as compared to those from Kew (5.0 μl ml− 1). IM pineapple from Mauritius recorded higher organolepti

关键词： Intermediate moisture(IM) Pineapple Physico-chemical Organoleptic Microbial

Recent progress in superhydrophobic and superamphiphobic coatings for magnesium and its alloys

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Journal of Magnesium and Alloys 2021年第3期9卷 748-778页

作者： Viswanathan S.saji Center of Research Excellence in Corrosion King Fahd University of Petroleum&Minerals(KFUPM)Dhahran 31261Saudi Arabia

Superhydrophobic coatings are projected as a practical approach to tackle the weak aqueous corrosion resistance of Mg/Mg *** present review provides the most recent updates in this *** various low surface energy treatments reported are presented first,followed by the methods employed for developing hierarchical surface micro/*** works in different application areas,including anti-corrosion,biomedical and anti-icing are systematically *** descriptions of self-healing characteristics and long-term durability of the superhydrophobic surfaces *** on superamphiphobic surfaces also deliberated.

关键词： Magnesium Mg alloys Superhydrophobic Superamphiphobic Coatings Self-healing Corrosion

The impact of emergency department length of stay on the outcomes of trauma patients requiring hospitalization: a retrospective observational study

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World Journal of Emergency Medicine 2023年第2期14卷 96-105页

作者： Ahmed Faidh Ramzee Ayman El-Menyar Mohammad Asim Ahad Kanbar Khalid Ahmed Bahaa Daoud saji Mathradikkal Ahmad Kloub Hassan Al-Thani Sandro Rizoli Trauma Surgery Section Hamad General Hospital(HGH)Doha P.O Box 3050Qatar Clinical Research Trauma&Vascular Surgery SectionHGHDoha P.O Box 3050Qatar Clinical Medicine Weill Cornell Medical CollegeDoha P.O Box 3050Qatar

BACKGROUND: We aimed to explore the impact of the emergency department length of stay(EDLOS) on the outcome of trauma ***: A retrospective study was conducted on all trauma patients requiring hospitalization between 2015 and 2019. Patients were categorized into 4 groups based on the EDLOS(24 h). Data were analyzed using Chi-square test(categorical variables), Student’s t-test(continuous variables), correlation coefficient, analysis of variance and multivariate logistic regression analysis for identifying predictors of short EDLOS and hospital ***: The study involved 7,026 patients with a mean age of 32.1±15.6 years. Onefifth of patients had a short EDLOS(24 h were older(P=0.001) and had more comorbidities(P=0.001) and fewer deaths(P=0.001). Multivariate regression analysis showed that the predictors of short EDLOS were female gender, GCS, SI, hemoglobin level, ISS, and blood transfusion. The predictors of mortality were TTA-1(odds ratio [OR]=4.081, 95%CI: 2.364–7.045), head injury(OR=3.920, 95%CI: 2.413–6.368), blood transfusion(OR=2.773, 95%CI: 1.668–4.609), SI(OR=2.132, 95%CI: 1.364–3.332), ISS(OR=1.077, 95%CI: 1.057–1.096), and age(OR=1.040, 95%CI: 1.026–1.054). CONCLUSIONS: Patients with shorter EDLOS had different baseline characteristics and hospital outcomes compared with patients with longer EDLOS. Patients with prolonged EDLOS had better outcomes;however, the burden of prolonged boarding in the ED needs further elaboration.

关键词： Emergency department Length of stay Trauma Management Outcomes Trauma activation criteria

Electrochemical behavior of Co-Cr and Ni-Cr dental cast alloys

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中国有色金属学会会刊：英文版 2009年第4期19卷 785-790页

作者： Viswanathan S. saji Han-Cheol CHOE Department of Dental Materials College of DentistryChosun University

The cast structures influencing the electrochemical corrosion behavior of Co-Cr and Ni-Cr dental alloys were studied using potentiodynamic polarization and AC impedance in 0.9% (mass fraction) NaCl solution at (37±1) ℃. The phase and microstructure of the alloys that were fabricated using two different casting methods viz. centrifugal casting and high frequency induction casting, were examined using X-ray diffraction analysis, scanning electron microscopy and energy dispersive spectroscopy. The roles of alloying elements and the passive film homogeneity on the corrosion resistance of Co-Cr-Mo and Ni-Cr-Mo dental cast alloys were reviewed. The results of electrochemical study show that the dependence of corrosion resistance on the microstructure associated with the casting methods is marginal. The Co-Cr alloy exhibits more desirable corrosion resistance properties than the Ni-Cr alloy. There is severe preferential dissolution of Ni-rich, Cr and Mo depleted zones in the Ni-Cr alloy.

关键词：镍铬合金合金铸造电化学行为牙科电化学腐蚀行为 X射线衍射分析 NaCl溶液钴

Potential Anticancer Effect of Bioactive Extract of Monk Fruit (Siraitia grosvenori) on Human Prostate and Bladder Cancer Cells

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Journal of Cancer Therapy 2023年第5期14卷 211-224页

作者： Rogerio Haung Akhil saji Muhammad Choudhury Sensuke Konno Department of Urology New York Medical College Valhalla USA

Prostate and bladder cancers are the two prevalent urological cancers, and several therapeutic options are currently available but the outcomes have not been satisfactory. To find the better therapeutic option, we investigated if the bioactive extracts of monk fruit, mogrosides, with potential anticancer activity might have anticancer effect against prostate and bladder cancer cells. Four of commercial products made of mogrosides known as Lakantoò (LKT) products, LK1, LK2, LLE, and MOG, were then tested. A dose-dependent study at given concentrations of four products showed that LK1 and LK2 had little effects, while LLE and MOG showed a significant cell viability reduction in both PC-3 and T24 cells. To explore the anticancer mechanism of such products, cell cycle analysis was first performed. Such analysis revealed that LLE and MOG, not LK1 and LK2, led to a G1 cell cycle arrest. Potential induction of endoplasmic reticulum (ER) stress was next examined because it is known to be linked to a cell cycle arrest. The three key regulators involved in ER stress were all up-regulated with LLE or MOG, indicating induction of ER stress. As ER stress is also known to induce apoptosis, this possibility was tested. The two apoptotic regulators were modulated in a specific manner with LLE or MOG, indicating induction of apoptosis. Lastly, to validate anticancer effect of LLE or MOG, anticancer effect of four chemotherapeutic drugs was also assessed in comparison with that of LLE/MOG. None of drugs had any effects but two products showed significant anticancer effect. In conclusion, two monk fruit products, LLE and MOG, demonstrated anticancer activity against PC-3 and T24 cells, significantly reducing cell viability and ultimately inducing apoptosis. Therefore, these two LKT products with few side effects may have clinical implications in the treatment of urological cancers.

关键词： Monk Fruit Mogroside Anticancer Prostate Cancer Bladder Cancer Lakanto

Synchronal Measurement of Flow Structure and Heat Transfer of Impingement Jet

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Journal of Thermal Science 2010年第3期19卷 228-233页

作者： Shoichi MATSUDA Naomichi saji Minoru YAGA Masaaki ISHIKAWA Kenyu OYAKAWA Dept.Mech.Systems Eng. Univ.of the RyukyusSenbaru 1NishiharaOkinawaJapan903-0213 Graduate student Faculty of Eng.Univ.of the RyukyusSenbaru 1NishiharaOkinawaJapan903-0213

This paper will present the characteristics of flow behavior and thermal field of both free and impingement jet issued from a circular orifice nozzle at Re=*** flow behavior of a single round jet and impingement jet was observed by smoke flow visualization recorded by a high speed camera using 5000 frame per *** transfer coefficient on the impingement surface was measured by means of infrared camera (TVS-8500,Avio) with a two-dimensional array of Indeum-Antimony (In Sb) sensors varying in the separation distance between the nozzle and the target *** heat transfer coefficient changes in time and ***,the root mean square distribution of the heat transfer was obtained from the *** a result,it was confirmed that the longitudinal vortex was observed outside of the ring vortex,and then the longitudinal vortex was penetrated in the jet ***,the high value of root mean square of the heat transfer coefficient has spread radially in stripy manner,which is caused as the results of the longitudinal vortexes flowing in the radial direction on the impingement plate.

关键词：冲击射流流动结构同步测量撞击平均传热系数热传递流动行为摄影机使用

Castration-induced expression of caspase-1 in epithelia of accessory sex organs in male rats

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Asian Journal of Andrology 2001年第2期3卷 105-108页

作者： Masao Izawa Mitunori Kimura Tomiko Yamada Makoto saji Department of Biosignaling School of Life Science Faculty of Medicine Tottori University Yonago 683-8503 JapanDepartment of Neurobiology School of Life Science Faculty of Medicine Tottori University Yonago 683-8503 JapanDepartment of Biosignaling School of Life Science Faculty of Medicine Tottori University Yonago 683-8503 JapanDepartment of Neurobiology School of Life Science Faculty of Medicine Tottori University Yonago 683-8503 Japan

Aim: As an attempt to clarify the molecular basis of castration-induced apoptosis, this study was undertaken todemonstrate the expression of caspase-1 in male accessory sex organs of rats. Methods and results; cDNA of ratcaspase-1 was cloned by reverse transcription-polymerase chain reaction from the ventral prostates. The open readingframe predicts 402 amino acids, which shows more than 91% and 63% identity to those of mouse and human, respec-tively. Northern analyses demonstrated the presence of castration-induced up-regulation of the 1.6 kb transcript in theventral prostate and the seminal vesicles. Finally, the authors demonstrated the caspase-1 transcripts in the epithelia ofthese tissues by in situ hybridization analyses. Conclusion; Castration induces the expression of caspase-1 tran-scripts in the epithelia of ventral prostate and seminal vesicle. These observations suggest a possible role of caspase-1 inapoptosis in male accessory sex organs.

关键词： prostate seminal vesicles tissue involution apoptosis caspase-1 cDNA cloning castration epithelium rats

Anti de Sitter horospherical flat timelike surfaces

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Science China Mathematics 2014年第9期57卷 1841-1866页

作者： CHEN Liang IZUMIYA Shyuichi PEI DongHe saji Kentaro School of Mathematics and Statistics Northeast Normal University Department of Mathematics Faculty of ScienceHokkaido University Department of Mathematics Faculty of ScienceKobe University

We investigate a special timelike surfaces in Anti de Sitter *** call such a timelike surface an Anti de Sitter horospherical flat surface which belongs to a class of surfaces given by one parameter families of Anti de Sitter *** give a generic classification of singularities and study the geometric properties of such surfaces from the viewpoint of Legendrian singularity theory.

关键词：西特平板奇点理论类时曲面几何性质表面平坦