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功能材料 1975年第2期 68-69页

作者： hideo kaneko 周木森

对添加硅含量对铁铬钴合金磁性能的效应进行了研究。发现磁性能依赖于合金的成份,而最好的性能用Fe—28％Cr—23％Co—1％Si的合金可以获得。在低温下进行阶梯回火,这种合金的磁能积可达5.3MGOe。

关键词：热磁处理 Fe-Cr-Co 磁性能磁能积 Cr Si

The Effects of Rufinamide on <i>in Vitro</i>Spinal Muscular Atrophy Model

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Pharmacology & Pharmacy 2019年第4期10卷 159-168页

作者： Shiori Ando Arisu Sato Michinori Funato Kazuki Ohuchi Satoshi Inagaki Shinsuke Nakamura Masamitsu Shimazawa hideo kaneko Hideaki Hideaki Hara Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical University Gifu Japan Department of Clinical Research National Hospital Organization Nagara Medical Center Gifu Japan

Spinal muscular atrophy (SMA) is devastating genetic disease characterized by progressive loss of motor neuron and skeletal muscle weakness. SMA is the most common lethal genetic disease in infancy. SMA is caused by deletion or mutation of SMN1 gene and subsequent lack of SMN protein. Our purpose in this study was to evaluate the therapeutic potential of rufinamide, an antiepileptic drug. In this study, SMA patient-derived fibroblasts and differentiated spinal motor neurons (MNs) using SMA patient-derived iPSCs were used as in vitro SMA model. SMN mRNA was significantly increased by addition of rufinamide in type III SMA patient-derived fibroblasts. Furthermore, rufinamide stimulated neurite elongation in type III SMA patient derived-iPSCs-MNs. In contrast of the result using type III SMA patient-derived fibroblasts, the expression level of SMN mRNA was not changed after rufinamide treatment in type I SMA patient-derived fibroblasts, and rufinamide did not affect neurite outgrowth in type I SMA patients derived-iPSCs-MNs. These findings indicate that rufinamide may be one of the potential candidate drugs for mild type of SMA.

关键词： Spinal Muscular Atrophy Rufinamide iPSCs

Identification of the Stress Which Causes Optineurin Aggregation

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Neuroscience & Medicine 2019年第2期10卷 150-161页

作者： Satoshi Inagaki Michinori Funato Junko Seki Chizuru Kawase Kazuki Ohuchi Shiori Ando Shinsuke Nakamura Masamitsu Shimazawa hideo kaneko Hideaki Hara Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical University Gifu Japan Department of Clinical Research National Hospital Organization Nagara Medical Center Gifu Japan

Glaucoma is a common neurodegenerative disease that can cause blindness and occurs worldwide. Currently, lowering intraocular pressure is the only therapy available to protect retinal ganglion cells (RGCs). However, this therapy does not prevent RGC death in all patients. Therefore, new therapeutic approaches for glaucoma are urgently required, and neuroprotection of RGCs is a focus for many researchers. Optineurin (OPTN) is one of the normal tension glaucoma (NTG) relative genes, while mutant OPTN can form a characteristic aggregation, causing RGC death. Hence, elucidation of the mechanism of OPTN aggregation might provide a clue to help understand RGC death. To examine whether non-mutant OPTN could also aggregate, we pharmacologically induced some glaucoma-related stresses, such as endoplasmic reticulum (ER) stress, glutamate toxicity, activation of TNF-α signaling, mitochondrial dysfunction, and autophagic flux impairment. Our results showed that ER stress, TNF-α signaling, and autophagic flux are involved in OPTN aggregation. Furthermore, our data indicated that increased ER stress, activation of TNF-α signaling, and impaired autophagic flux induce OPTN aggregation, suggesting that OPTN aggregation might be an important therapeutic target not only for familial NTG with mutated OPTN but also for patients with glaucoma more generally.

关键词： Glaucoma Induced Pluripotent Stem Cells Retinal Ganglion Cells Optineurin Protein Aggregation

Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis

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World Journal of Gastroenterology 2013年第17期19卷 2718-2722页

作者： hideo Suzuki Tsuyoshi kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki Hirayama Ichinosuke Hyodo Department of Gastroenterology Institute of Clinical Medicine University of Tsukuba Graduate School Center of Integrative Medicine Tsukuba University of Technology

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation.

关键词： Qing Dai Herbal medicine Ulcerative colitis Hydroxyl radical Electron spin resonance

エコセメントコンクリ一トの流動化効果に関する実験的研究

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青岛理工大学学报 2009年第4期30卷 107-114页

作者：金子樹嵩英雄 (財)建材試験センタ一 (社)建築振興協会青島理工大学

エコセメントを用いたコンクリ一トは、一般のコンクリ一トより単位水量が増加し、スランプの経時変化も大きくなる傾向がある。本研究はエコセメントコンクリ一トにおよぼす流動化剤の流動化効果について、2種類の実験を行った。Phase... 详细信息

エコセメントを用いたコンクリ一トは、一般のコンクリ一トより単位水量が増加し、スランプの経時変化も大きくなる傾向がある。本研究はエコセメントコンクリ一トにおよぼす流動化剤の流動化効果について、2種類の実験を行った。Phase .1では流動化剤添加量を変えた実験を行い、添加後のスランプ増大量、圧縮強度、耐久性について普通ポルトランドセメントと比較し、同等の流動化効果が得られることを明らかにした。Phase .2ではスランプロスしたコンクリ一トに流動化剤を後添加した場合のスランプ回復効果について実験を行い、Phase .1同様に普通ポルトランドセメントと同等の効果があることを明らかにした。

关键词：流动化剂压缩强度耐久性变化

コンクリ一トの強度に及ぼすフライアッシュの過剰添加の影響

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青岛理工大学学报 2009年第4期30卷 5-11,16页

作者：嵩英雄金子樹丸章夫 (社)建築振興協会青島理工大学 (財)建材試験センタ一 (株)地質鉱物エンジリアリング内蒙古師範大学

本論文は、フライアッシュの過剰混入がコンクリ一トの強度特性に及ぼす影響を明らかにすることを目的として実施した実験研究の報告である.実験は普通ポルトランドセメントに対するフライアッシュの打ち割り混入率0、10%、20%、30%、40... 详细信息

本論文は、フライアッシュの過剰混入がコンクリ一トの強度特性に及ぼす影響を明らかにすることを目的として実施した実験研究の報告である.実験は普通ポルトランドセメントに対するフライアッシュの打ち割り混入率0、10%、20%、30%、40%、60%、80%とし、フレッシュ性状と材齢91日までの圧縮強度および静弾性係数を試験した.フライアッシュを大量に混入すると空気連行性が低下し、スランプの大きな変化は認められなかったが、圧縮強度と静弾性係数はフライアッシュの混入率の増加に伴う水セメント比の増加に対一して著しく低下した.粉末X線回折試験では、フライアッシュの混入率の増加に伴うゲル容積の増加、ポルトランダイトの減少、カルシウムアルミネ一トの増加等のセメント硬化体の変化が認められた.

关键词：置换率压缩强度静弹性系数粉末X线回折

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo kaneko Takahisa Kawaguchi hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung