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天津医药 2008年第9期36卷 673-675页

作者：郑权秀加藤修史东泰达国际心血管病医院内二科 300457 日本京都桂病院

目的:探讨糖尿病对直径≥4.0mm的冠状动脉金属裸支架6个月再狭窄率的影响。方法:回顾性分析日本京都桂病院心脏血管中心从2003年1月—2003年12月接受管径≥4.0mm金属裸支架置入(心肌梗死、慢性完全闭塞病变以及再狭窄病变除外),并获得6... 详细信息

目的:探讨糖尿病对直径≥4.0mm的冠状动脉金属裸支架6个月再狭窄率的影响。方法:回顾性分析日本京都桂病院心脏血管中心从2003年1月—2003年12月接受管径≥4.0mm金属裸支架置入(心肌梗死、慢性完全闭塞病变以及再狭窄病变除外),并获得6个月临床和冠状动脉造影随访的147例患者(147个病变)。根据是否合并糖尿病将患者分为糖尿病组和非糖尿病组,对其6个月支架内再狭窄率进行对比研究。结果:糖尿病组的再狭窄率明显高于非糖尿病组(19.0%vs6.7%,P<0.05)。结论:对管径≥4.0mm的冠状动脉支架,糖尿病也是增加再狭窄率的危险因素。

关键词：冠状动脉疾病糖尿病冠状动脉狭窄支架

Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2:A project of the Kyushu University Liver Disease Study Group

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World Journal of Gastroenterology 2006年第5期12卷 784-790页

作者： Norihiro Furusyo Masaki katoh Yuichi Tanabe Eiji Kajiwara Toshihiro Maruyama Junya Shimono Hironori Sakai Makoto Nakamuta Hideyuki Nomura Akihide Masumoto Shinji Shimoda Kazuhiro Takahashi Koichi Azuma Jun Hayashi Kyushu University Liver Disease Study Group Department of General Medicine Kyushu University HospitalFukuokaJapan Department of Medicine Fukuoka City HospitalFukuokaJapan Department of Internal Medicine Nippon Steel Yawata Memorial HospitalKitakyushuJapan Department of Medicine Kitakyushu Municipal Medical CenterKitakyushuJapan Department of Medicine Yahata Saiseikai HospitalKitakyushuJapan Department of Gastroenterology National Hospital Organization Kyushu Medical CenterFukuokaJapan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Internal Medicine ShinKokura HospitalKitakyushuJapan Department of Clinical Research National Hospital OrganizationKokura HospitalKitakyushuJapan Department of Medicine and Biosystemic Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Medicine Hamanomachi HospitalFukuokaJapan Department of Medicine and Clinical Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

AIM： To determine the efficacy of an interferon alpha and ribavirin combination treatment for Japanese patients infected with hepatitis C virus （HCV） of genotype 2, a multi-center study was retrospectively analyzed. METHODS： In total, 173 patients with HCV genotype 2 started to receive interferon-alpha subcutaneously thrice a week and 600-800 mg of ribavirin daily for 24 wk. RESULTS： The overall sustained virological response （SVR）, defined as undetectable HCV RNA in serum, 24 wk after the end of treatment, was remarkably high by 84.4%, （146/173） by an intention-to-treat analysis. A significant difference in SVR was found between patients with and without the discontinuation of ribavirin （46.9% vs 92.9 %）, but no difference was found between those with and without a dose reduction of ribavirin. A significant difference in SVR was also found between patients with less than 16 wk and patients with 16 or more weeks of ribavirin treatment （34.8 % vs 92.0 %）. CONCLUSION： The 24-wk interferon and ribavirin treatment is highly effective for Japanese patients with HCV genotype 2. The significant predictor of SVR is continuation of the ribavirin treatment for up to 16

关键词： Hepatitis C virus Interferon Ribavirin Genotype 2

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二甲醚氧化反应及其添加剂效应

化工学报 2008年第10期59卷 2634-2637页

作者：刘雄民黄品鲜加藤胜美和田有司田村昌三广西大学化学化工学院广西南宁530004 日本产业技术综合研究所日本横滨国立大学

Initiating temperature(To) and activation energy(Ea) for thermal oxidation of dimethyl ether(DME) was measured with accelerating rate calorimeter(ARC).The effect of additives on DME thermal stability was *** product of DME thermal decomposition was analyzed with *** results indicated that the initiating temperature of DME oxidation was 120℃,activation energy was 167.3 kJ·mol-1 in *** stability was dramatically reduced in the presence of *** addition of Fe,Fe2O3 and Al also decreased To and Ea of DME oxidation reaction,especially in the presence of hydrogen peroxide(H2O2) or other organic peroxides which can easy initiate the formation of free *** contrast,the presence of antioxidant can enhance DME thermal stability.

关键词：二甲醚添加剂热稳定性加速量热仪活化能

苹果自花结实性品种花柱S-核酸酶基因的克隆

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园艺学报 2005年第5期32卷 869-871页

作者：李天忠加藤直幹奥野智旦中国农业大学园艺植物研究所北京100094 日本弘前大学农学生命科学部

从苹果二倍体品种‘Ontario’和‘迎秋’花柱中分别克隆到了两个S-核酸酶基因。同源性比较结果,‘Ontario’和‘迎秋’都有一个与‘富士’Sf-核酸酶基因完全相同的序列。‘Ontario’另一个S等位基因编码一个新的S-核酸酶,被命名为S8-核... 详细信息

从苹果二倍体品种‘Ontario’和‘迎秋’花柱中分别克隆到了两个S-核酸酶基因。同源性比较结果,‘Ontario’和‘迎秋’都有一个与‘富士’Sf-核酸酶基因完全相同的序列。‘Ontario’另一个S等位基因编码一个新的S-核酸酶,被命名为S8-核酸酶;‘迎秋’另一个S等位基因与苹果‘红茜’的Sd-核酸酶基因序列相同。

关键词：苹果自花结实性花柱 S-核酸酶基因克隆

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红星苹果花柱S-核酸酶的分离与纯化

农业生物技术学报 2005年第5期13卷 23-26页

作者：李天忠加藤直幹奥野智旦弘前036-8561 日本弘前大学农学生命科学部中国农业大学园艺植物研究所日本弘前大学农学生命科学部北京100094

采用多种蛋白分离纯化技术,结合生物鉴定方法,成功地从红星苹果(Malus domestica Borkh.)花柱中纯化出了一类与自交不亲和性识别反应相关的花柱蛋白。通过聚丙烯酰胺凝胶和等电聚焦电泳分析,确定该蛋白分子量为26和28kD,等电点为10.2和1... 详细信息

采用多种蛋白分离纯化技术,结合生物鉴定方法,成功地从红星苹果(Malus domestica Borkh.)花柱中纯化出了一类与自交不亲和性识别反应相关的花柱蛋白。通过聚丙烯酰胺凝胶和等电聚焦电泳分析,确定该蛋白分子量为26和28kD,等电点为10.2和10.4,为碱性蛋白;核糖核酸酶活性染色和N-末端序列分析结果显示具有核酸酶活性,且与其它蔷薇科植物花柱S-核酸酶N-末端氨基酸序列同源性较高。

关键词：苹果自交不亲和性花柱 S-核酸酶蛋白质纯化

Micro-fabrication and surface modification of fluorinated polymers by means of synchrotron radiation

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辐射研究与辐射工艺学报 2005年第2期23卷 105-105页

作者： Toshiyuki Hyuga Masakazu Washioa Akihiro Oshimaa Hiroyuki Nagaia Nozomi Miyoshia Takanori katoh Yasushi Aoki Advanced Research Institute for Science and Engineering Waseda UniversityAdvanced Research Institute for Science and Engineering Waseda UniversityAdvanced Research Institute for Science and Engineering Waseda UniversityAdvanced Research Institute for Science and Engineering Waseda UniversityAdvanced Research Institute for Science and Engineering Waseda UniversitySumitomo Heavy Industries Ltd.Sumitomo Heavy Industries Ltd.

It is well-known that fluorinated polymers are very unique polymer materials because of their distinguished properties, such as high electrical resistivities, chemical and thermal stabilities, bio-compatibilities, etc. However,polytetrafluoroethylene (PTFE) is degraded by ionizing radiation with a low dose through main chain scission, and the mechanical properties are seriously deteriorated. In early 1990's, it was found that irradiation for PTFE at elevating temperature enhances recombination of radicals induced by ionizing radiation. Thus, crosslinked PTFE had been obtained[1,2]. The crosslinked PTFE shows remarkable improvements for the radiation durability and mechanical properties, *** have performed micro-fabrication by means of synchrotron radiation (SR) for various kinds of PTFEs including crosslinked PTFEs. The direct photo--etching technique using SR is known as TIEGA() technology,which has been developed by Sumitomo Heavy Industries, Ltd. The technology was applied for the micro-fabrication of fluorinated polymers. It has been found that etching rates obtained for crosslinked PTFEs were much larger than those of the non-crosslinked. The fact is strange from the viewpoint of radiation durability of crosslinked PTFEs. Hence, the results are not described by simple consideration such as the G-values of main chain scission. We have proposed that the etching rates should be controlled by the complex mechanism through at least two different steps as polymer decomposition and fragment desorption *** the other hand, we have found that abnormal reactions were induced at the surface region under the SR etching for the various kinds of fluorinated polymers. Through the measurements using differential scanning calorimetory (DSC) and solid state 19F-NMR, we have confirmed crosslinking reactions for the polymers even in solid states. This reaction should be induced by the very high density radicals formation and their recombination in very localized area o

关键词：同步辐射化学蚀刻聚四氟乙烯表面修正

慢性血栓栓塞性肺动脉高压病人的诊断线索和治疗途径

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中华结核和呼吸杂志 1997年第Z1期 109页

作者： Okada O Tanabe N katoh K Yasuda J Yamamoto T Hayashi A Mori N Sugimoto N Kasahara Y Kuriyama T 刘震宇(译) ChibaUniversitySchoolofMedicine Chiba Japan DepartmentofChestMedicine ChibaUniversitySchoolofMedicine Chiba Japan DepartmentofChestMedicine ChibaUniversitySchoolofMedicine Chiba DepartmentofChestMedicine Japan DepartmentofChestMedicine ChibaUniversitySchoolofMedicine Chiba Japan DepartmentofChestMedicine ChibaUniversitySchoolofMedicine Chiba Japan DepartmentofChestMedicine ChibaUniversitySchoolofMedicine ChibaUniversitySchoolofMedicine Chiba Japan DepartmentofChestMedicine ChibaUniversitySchoolofMedicine Chiba Japan DepartmentofChestMedicine ChibaUniversitySchoolofMedicine Chiba Chiba Japan Japan DepartmentofChestMedicine ChibaUniversitySchoolofMedicine Chiba Japan DepartmentofChestMedicine

慢性血栓栓塞性肺动脉高压病人的诊断线索和治疗途径

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中华结核和呼吸杂志 1997年第ZK期20卷 109-109页

作者： Okada O Tanabe N katoh K Yasuda J Yamamoto T Hayashi A Mori N Sugimoto N Kasahara Y Kuriyama T 刘震宇(译) DepartmentofChestMedicine ChibaUniversitySchoolofMedicineChibaJapan

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利于SR和FIB法制备含氟微米/纳米结构材料（英文）

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利于SR和FIB法制备含氟微米/纳米结构材料（英文）