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Neural Regeneration Research 2021年第6期16卷 1144-1149页

作者： Hajime takase Robert W.Regenhardt Department of Neurosurgery Yokohama City University Graduate School of MedicineYokohamaJapan Departments of Radiology and Neurology Massachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA Department of Neurology Massachusetts General Hospital and Harvard Medical SchoolBostonMAUSA

Acute central nervous system injuries are among the most common causes of disability worldwide,with widespread social and economic *** tract injury accounts for the majority of this disability;therefore,there is impetus to understand mechanisms underlying the pathophysiology of injury and subsequent reorganization of the motor tract that may lead to *** acute central nervous system injury,there are changes in the microenvironment and structure of the motor *** example,ischemic stroke involves decreased local blood flow and tissue death from lack of oxygen and *** injury,in contrast,causes stretching and shearing injury to microstructures,including myelinated axons and their surrounding *** involve blood-brain barrier dysfunction,which is an important initial *** acute central nervous system injury,motor tract reorganization occurs in the form of cortical remapping in the gray matter and axonal regeneration and rewiring in the white *** remapping involves one cortical region taking on the role of ***-response-element binding protein is a key transcription factor that can enhance plasticity in the peri-infarct *** regeneration and rewiring depend on complex cell-cell interactions between axons,oligodendrocytes,and other *** RhoA/Rho-associated coiled-coil containing kinase signaling pathway plays a central role in axon growth/regeneration through interactions with myelin-derived axonal growth inhibitors and regulation of actin cytoskeletal *** and their precursors play a role in myelination,and neurons are involved through their voltage-gated calcium *** the pathophysiology of injury and the biology of motor tract reorganization may allow the development of therapies to enhance recovery after acute central nervous system *** include targeted rehabilitation,novel pharmacotherapies,such as growth factors and axonal growt

关键词： corticospinal tract myelin-axon interaction recovery remapping reorganization RhoA/ROCK translation

STUDY ON THE CHARACTERISTICS OF LONG TERM DISCHARGE OF A CATCHMENT

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Journal of Hydrodynamics 2000年第2期12卷 31-41页

作者： Hong, Lin takase, Keiji Sato, Koichi Wuhan Univ of Hydraulic and Electric Engineering Wuhan China

The characteristics of the catchment discharge vary with land use. The characteristics of the long-term discharge of a terraced paddy field catchment were studied. Two kind of tank models for land use were proposed and used to simulate the discharge of the catchment: one is a forest type model used as the upper part of the catchment; the other is a paddy field type model used as the lower part of the catchment. The results of the model simulation were analyzed and compared with that of a forest catchment.

关键词： Discharge (fluid mechanics) Land use Models Tanks (containers)

A radical scavenger edaravone and oligodendrocyte protection/regeneration

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Neural Regeneration Research 2018年第9期13卷 1550-1551页

作者： Hajime takase Josephine Lok Ken Arai Neuroprotection Research Laboratory Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical School

Cerebral white matter is vulnerable to oxidative stress： Oxidative stress is one of the major harmful conditions for the central ner- vous system （CNS）. Oxidative stress is a state from an imbalance between free radical production and their removal by antioxidants, resulting in an excessive amount of reactive oxygen species （ROS） in cells and tissues. ROS causes cell damage due to oxidation of cellular components, including DNAs, proteins, and lipids. During physiological conditions, small amounts of ROS are generated in the process of normal biological activity, and ROS at physiological levels play important roles in maintaining cellular homeostasis （Chen et al., 2018）. However, during pathological conditions, ROS levels are increased and excessive ROS can lead to deleterious ef- fects on many kinds of cells.

关键词：氧化应力新生 ROS 类脂化合物抗氧化剂生物活动不平衡房间

Liposome-Encapsulated Hemoglobin Vesicle Improves Persistent Anti-arrhythmogenesis through Improving Myocardial Electrical Remodeling and Modulating Cardiac Autonomic Activity in a Hemorrhagic Shock-Induced Rat Heart Model

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Current Medical Science 2023年第2期43卷 232-245页

作者： Bonpei takase Yuko Higashimura Haruka Asahina Masayuki Ishihara Hiromi Sakai Department of Intensive Care Medicine National Defense Medical CollegeTokorozawa359-8513Japan Division of Traumatology Research Institute National Defense Medical College Research InstituteTokorozawa359-8513Japan Division of Biomedical Engineering National Defense Medical College Research InstituteTokorozawa359-8513Japan Department of Chemistry School of MedicineNara Medical UniversityNara634-8521Japan

Objective Shock heart syndrome(SHS)is associated with lethal arrhythmias(ventricular tachycardia/ventricular fibrillation,VT/VF).We investigated whether liposome-encapsulated human hemoglobin vesicles(HbVs)has comparable persistent efficacy to washed red blood cells(wRBCs)for improving arrhythmogenesis in the subacute to chronic phase of *** Optical mapping analysis(OMP),electrophysiological study(EPS),and pathological examinations were performed on blood samples from Sprague-Dawley rats following induction of hemorrhagic *** hemorrhagic shock,the rats were immediately resuscitated by transfusing 5%albumin(ALB),HbV,or *** rats survived for 1 *** and EPS were performed on Langendorff-perfused *** arrhythmias and heart rate variability(HRV)were evaluated using awake 24-h telemetry,cardiac function by echocardiography,and pathological examination of *** OMP showed significantly impaired action potential duration dispersion(APDd)in the left ventricle(LV)in the ALB group whereas APDd was substantially preserved in the HbV and wRBCs *** VT/VF was easily provoked by EPS in the ALB *** VT/VF was induced in the HbV and wRBCs ***,spontaneous arrhythmias,and cardiac function were preserved in the HbV and wRBCs *** showed myocardial cell damage and Connexin43 degradation in the ALB group,all of which were attenuated in the HbV and wRBCs *** LV remodeling after hemorrhagic shock caused VT/VF in the presence of impaired *** to wRBCs,HbV persistently prevented VT/VF by inhibiting persistent electrical remodeling,preserving myocardial structures,and ameliorating arrhythmogenic modifying factors in the subacute to chronic phase of hemorrhagic shock-induced SHS.

关键词： artificial oxygen carrier hemorrhage lethal arrhythmia resuscitation heart rate variability

Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases

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World Journal of Stem Cells 2016年第9期8卷 288-296页

作者： Taro Tsujimura Mana Idei Masahiro Yoshikawa Osamu takase Keiichi Hishikawa Department of Advanced Nephrology and Regenerative Medicine Division of Tissue EngineeringUniversity of Tokyo Hospital

The gene encoding bone morphogenetic protein-7(BMP7) is expressed in the developing kidney in embryos and also in the mature organ in adults. During kidney development, expression of BMP7 is essential to determine the final number of nephrons in and proper size of the organ. The secreted BMP7 acts on the nephron progenitor cells to exert its dual functions: To maintain and expand the progenitor population and to provide them with competence to respond to differentiation cues, each relying on distinct signaling pathways. Intriguingly, in the adult organ, BMP7 has been implicated in protection against and regeneration from injury. Exogenous administration of recombinant BMP7 to animal models of kidney diseases has shown promising effects in counteracting inflammation, apoptosis and fibrosis evoked upon injury. Although the expression pattern of BMP7 has been well described, the mechanisms by which it is regulated have remained elusive and the processes by which the secretion sites of BMP7 impinge upon its functions in kidney development and diseases have not yet been assessed. Understanding the regulatory mechanisms will pave the way towards gaining better insight into the roles of BMP7, and to achieving desired control of the gene expression as a therapeutic strategy for kidney diseases.

关键词： Bone morphogenetic protein-7 Therapeutics Kidney Development Nephron progenitor cells Disease Regeneration Chromatin conformation Gene expression Gene regulation

New energy policy and low-carbon society in Japan after the Great East Japan Earthquake

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Chinese Journal of Population,Resources and Environment 2013年第1期11卷 62-68页

作者： Ryuji Matsuhashi Kae takase Koichi Yamada Hiroshi Komiyama Department of Electrical Engineering and Information Systems Graduate School of EngineeringUniversity of TokyoJapan Center for Low Carbon Society Strategy Japan Science and Technology AgencyTokyo 102-0076Japan Department of Environment Systems Graduate School of Frontier SciencesUniversity of TokyoJapan

The Great East Japan Earthquake in March 2011 devastated the eastern region of *** to the resulting nuclear accident,Japanese Cabinet decided to revise its energy *** Energy and Environment Council in National Policy Unit published options on the nation's scenarios for energy and economy in *** estimated the economic impacts of the options to national economy and households in ***,we clarified significant factors to establish a secure,affluent and low-carbon society based on the energy scenarios.

关键词： Great East Japan Earthquake energy scenarios the Energy and Environment Council Affluent Low-carbon Society CO_2 emissions

Effects of land use change on hydrological cycle from forest to upland field in a catchment,Japan

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Frontiers of Structural and Civil Engineering 2013年第4期7卷 456-465页

作者： Chuan ZHANG Keiji takase Hiroki OUE Nobuhiro EBISU Haofang YAN The United Graduate School of Agricultural Sciences Ehime UniversityEhime Pref 790-8577Japan Faculty of Bioresources and Environmental Sciences Ishikawa PrefecturalIshikawa 920-8580Japan Faculty of Agriculture Ehime UniversityEhime Pref 790-8577Japan

Understanding the effects of land use change on the hydrological cycle is very important for development of sustainable water resource in an upland field *** this study,soil and hydrological properties in an upland field catchment,which was reclaimed partially from a forest catchment,were compared with another forest *** soil properties of surface and subsurface layers were investigated in the two *** soil was compacted and waterholding capacity of soil in the upland field catchment became smaller after the reclamation from forest to upland field,which decreased infiltration rate and water storage in the soil *** found that peak discharge and direct runoff in the upland field catchment increased compared with the forest *** evapotranspiration from the upland field catchment tended to be lower due to the change in vegetation type and soil ***,a semi-distributed hydrological model was applied in the upland field catchment to understand the integrated effects of reclamation on the hydrological *** model parameters,which were determined using a nonlinear optimization technique—the Shuffled Complex Evolution method(SCE),were compared between the two *** Nash and Sutcliffe coefficient was used to evaluate the model *** simulated results indicated that evapotranspiration was decreased and change in discharge was more obvious in the surface *** considered that declined infiltration and water storage and increased peak discharge and direct runoff have a negative impact on water resources in the upland field *** study will provide information for forest managers in planning and making decisions for land and water resource management.

关键词： land-use change hydrological processes upland field catchment forest catchment semi-distributed hydrological model

应用文本挖掘方法分析患者跌倒发生的方式和原因

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International Journal of Nursing Sciences 2023年第1期10卷 30-37,I0002页

作者： Miyuki takase School of Nursing Yasuda Women’s UniversityHiroshimaJapan

目的本研究旨在探讨从护士角度审视患者跌倒事件中患者、环境和护士实践的相互作用。方法从日本优质保健委员会项目设立的数据库中检索2016-2020年由护士登记的患者跌倒事件报告,并进行回顾性审查。逐字提取“跌倒的背景”中的文字描述... 详细信息

目的本研究旨在探讨从护士角度审视患者跌倒事件中患者、环境和护士实践的相互作用。方法从日本优质保健委员会项目设立的数据库中检索2016-2020年由护士登记的患者跌倒事件报告,并进行回顾性审查。逐字提取“跌倒的背景”中的文字描述,并采用文本挖掘的方法进行分析。结果共分析了4176例患者跌倒事件报告。这些跌倒事件中,79.0%是护士没有亲眼目睹的,8.7%发生在直接护理期间。通过文件聚类分析,共确定了16个集群。4个集群与患者状况有关,如患者的生理/认知功能下降、失去平衡、以及使用催眠剂和精神药物。3个集群与护士实践有关,其中包括缺乏对实际情形的认识、依赖于患者家属、以及护理程序执行不到位。6个集群与患者和护士有关,包括患者徒劳地使用床头警报器和呼叫铃、穿着不合适的鞋子、使用助行器和床栏杆方面存在问题、以及护士对患者的日常生活活动能力了解不足。1个集群为与椅子有关的跌倒,同时涉及患者和环境因素。2个集群同时涉及患者、护士和环境因素,这些跌倒发生在患者洗澡/淋浴或使用床边坐便器时。结论跌倒往往由于患者、护士和环境之间的动态相互作用引起。由于许多因素很难在短时间内改变,所以必须把重点放在护理和环境因素上,以预防和减少患者跌倒。其中,提高护士对患者跌倒的态势感知能力尤为重要,这影响着他们预防患者跌倒的决定和行动。

关键词：意外跌倒数据挖掘环境跌倒风险护士病人

Exploring factors that motivate nursing students to engage in skills practice in a laboratory setting:A descriptive qualitative design

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International Journal of Nursing Sciences 2021年第1期8卷 79-86,I0006页

作者： Yoko Nakayoshi Miyuki takase Mayumi Niitani Takiko Imai Mari Okada Kumiko Yamamoto Yuri Takei School of Nursing Yasuda Women’s UniversityJapan School of Nursing Prefectural University of HiroshimJapan Division of Health Science Graduate School of MedicineOsaka UniversityJapan

Objectives:The aim of this study was to explore factors that motivate students to engage in skills practice in a laboratory setting,and to identify their motivation types and the regulatory ***:Semi-structured interviews were conducted with 23 nursing students from three universities between November 2017 and January 2018.A thematic analysis was used to identify factors associated with students’motivation to engage in skills practice in a *** types and the regulatory styles of student motivation were identified based on the self-determination ***:Seven motivating factors were *** factors included the students’desire“to acquire the skills necessary to work as a nurse”,the“desire to improve skills in preparation for clinical practicum”,and their felt“obligations to patients as a nurse”.Moreover,“the impetus to study arising from the objective evaluation of oneself and others”and“wanting to pass the skills examination”motivated the students to engage in skills practice.A“learning environment that facilitates students’learning”and the“supportive involvement of educators”facilitated their *** on the self-determination theory,the students were found to embrace extrinsic motivation with four regulatory styles of motivation,namely integrated,identified,introjected,and external ***:Nurse educators should understand the motivating factors of students,and help students embrace a more internally controlled motivation by helping them envision their future careers as nurses,and by fostering their ethical duty to care for patients.

关键词： Laboratories Learning Motivation Nursing students Clinical competence