检索结果-南通市图书馆

Coat protein of Chinese wheat mosaic virus upregulates and interacts with cytosolic glyceraldehyde-3-phosphate dehydrogenase,a negative regulator of plant autophagy,to promote virus infection

引用

Journal of Integrative Plant Biology 2022年第8期64卷 1631-1645页

作者： Erbo Niu Chaozheng Ye Wanying Zhao hideki kondo Yunfeng Wu Jianping Chen Ida Bagus Andika Liying Sun State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&F UniversityXi'an 712100China Institute of Plant Science and Resources Okayama UniversityKurashiki 710‐0046Japan State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‐products Institute of Plant VirologyNingbo UniversityNingbo 315211China College of Plant Health and Medicine Qingdao Agricultural UniversityQingdao 266109China

Autophagy is an intracellular degradation mechanism involved in antiviral defense,but the strategies employed by plant viruses to counteract autophagy-related defense remain unknown for the majority of the ***,we describe how the Chinese wheat mosaic virus(CWMV,genus Furovirus)interferes with autophagy and enhances its infection in Nicotiana *** two-hybrid screening and in vivo/in vitro assays revealed that the 19 k Da coat protein(CP19 K)of CWMV interacts with cytosolic glyceraldehyde-3-phosphate dehydrogenases(GAPCs),negative regulators of autophagy,which bind autophagy-related protein 3(ATG3),a key factor in ***19 K also directly interacts with ATG3,possibly leading to the formation of a CP19 K–GAPC–ATG3 ***19 K–GAPC interaction appeared to intensify CP19 K–ATG3 ***,CP19 K expression upregulated GAPC gene transcripts and reduced autophagic ***,the silencing of GAPC genes in transgenic *** reduced CWMV accumulation,whereas CP19 K overexpression enhanced ***,our results suggest that CWMV CP19 K interferes with autophagy through the promotion and utilization of the GAPC role as a negative regulator of autophagy.

关键词： antiviral defense autophagy plant virus protein interaction viral coat protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

引用

World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori kondo Takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of Kupffer cells and platelets on ischemia-reperfusion injury in mild steatotic liver

引用

World Journal of Gastroenterology 2013年第9期19卷 1396-1404页

作者： Koichi Ogawa Tadashi kondo Takafumi Tamura hideki Matsumura Kiyoshi Fukunaga Tatsuya Oda Nobuhiro Ohkohchi Department of Surgery Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba 305-8575 Japan

AIM: To investigate the effect of mild steatotic liver on ischemia-reperfusion injury by focusing on Kupffer cells (KCs) and platelets. METHODS: Wistar rats were divided into a normal liver group (N group) and a mild steatotic liver group (S group) induced by feeding a choline-deficient diet for 2 wk. Both groups were subjected to 20 min of warm ischemia followed by 120 min of reperfusion. The number of labeled KCs and platelets in sinusoids and the blood perfusion in sinusoids were observed by intravital microscopy (IVM), which was performed at 30, 60 and 120 min after reperfusion. To evaluate serum alanine aminotransferase as a marker of liver deterioration, blood samples were taken at the same time as ***: In the S group, the number of platelets adhering to KCs decreased significantly compared with the N group (120 after reperfusion; 2.9±1.1 cells/acinus vs 4.8±1.2 cells/acinus, P<0.01). The number of KCs in sinusoids was significantly less in the S group than in the N group throughout the observation periods (before ischemia, 19.6±3.3 cells/acinus vs 28.2±4.1 cells/acinus, P<0.01 and 120 min after reperfusion, 29.0±4.3 cells/acinus vs 40.2±3.3 cells/acinus, P<0.01). The blood perfusion of sinusoids 120 min after reperfusion was maintained in the S group more than in the N group. Furthermore, elevation of serum alanine aminotransferase was lower in the S group than in the N group 120 min after reperfusion (99.7±19.8 IU/L vs 166.3±61.1 IU/L, P=0.041), and histological impairment of hepatocyte structure was prevented in the S group. CONCLUSION: Ischemia-reperfusion injury in mild steatotic liver was attenuated compared with normal liver due to the decreased number of KCs and the reduction of the KC-platelet interaction.

关键词： Steatotic liver Mild steatotic liver Kupffer cell Platelet Ischemia-reperfusion Intravital microscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New microsome-associated HT-family proteins from Nicotiana respond to pollination and define an HT/NOD-24 protein family

引用

Molecular Plant 2008年第4期1卷 634-644页

作者： Katsuhiko kondo Bruce McClure Department of Biochemistry Interdisciplinary Plant Group and the Christopher S. Bond Life Sciences Center University of Missouri MI USA

HT-family proteins have been identified in Nicotiana, Solanum, and Petunia. HT-B-type proteins are implicated in S-RNase-based self-incompatibility, but the functions of other family members are unknown. Screening for cDNA sequences with an expression pattern similar to HT-B in Nicotiana alata revealed a new group of small HT-family proteins, designated HT-M. HT-M proteins resemble HT-B in several respects： their pistil-specific expression pattern is indistinguishable from HT-B, they pellet with a microsome fraction, and their abundance decreases after pollination. Unlike HT-B, there is no S-specificity to this response, and RNAi experiments show that HT-M proteins are not necessary for self-incompatibility. Identification of a third group of pistil-specific HT-family proteins helps better define the characteristics of the family and allowed identification of putative new family members. By searching the databases with only the most conserved HT- family sequence elements, the signal sequence and cysteine motifs, we identified nodulin-24-1ike proteins and several small glycine-rich proteins as putative HT-family members. Like HT-M and HT-B, nodulin-24 is membrane associated. We propose that the conserved features in HT-family proteins are important for targeting or modification and refer to the broader family that includes both HT- and nodulin-24-1ike proteins as the HT/NOD-24-family.

关键词： New microsome-associated HT-family pollination an HT/NOD-24 protein family

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of Zn Diffusion on Bandwidth and Extinction in MQW Electroabsorption Modulators Buried with Semi-Insulating InP

引用

光学学报 2003年第S1期23卷 439-440页

作者： Takayuki Yamanaka hideki Fukano Ken Tsuzuki Munehisa Tamura Ryuzo Iga Matsuyuki Ogasawara Yasuhiro kondo Tadashi Saitoh NTT Photonics Laboratories NTT Corporation 3-1 Morinosato Wakamiya Atsugi Kanagawa 243-0198 JAPANNTT Photonics Laboratories NTT Corporation 3-1 Morinosato Wakamiya Atsugi Kanagawa 243-0198 JAPANNTT Photonics Laboratories NTT Corporation 3-1 Morinosato Wakamiya Atsugi Kanagawa 243-0198 JAPANNTT Photonics Laboratories NTT Corporation 3-1 Morinosato Wakamiya Atsugi Kanagawa 243-0198 JAPANNTT Photonics Laboratories NTT Corporation 3-1 Morinosato Wakamiya Atsugi Kanagawa 243-0198 JAPANNTT Photonics Laboratories NTT Corporation 3-1 Morinosato Wakamiya Atsugi Kanagawa 243-0198 JAPANNTT Photonics Laboratories NTT Corporation 3-1 Morinosato Wakamiya Atsugi Kanagawa 243-0198 JAPANNTT Photonics Laboratories NTT Corporation 3-1 Morinosato Wakamiya Atsugi Kanagawa 243-0198 JAPAN

A comprehensive analysis of multi-quantum-well electroabsorption modulators buried with semi-insulating (SI)-InP is presented. We quantitatively demonstrate that suppression of Zn diffusion into the burying and optica... 详细信息

关键词： MQW Influence of Zn Diffusion on Bandwidth and Extinction in MQW Electroabsorption Modulators Buried with Semi-Insulating InP Zn EAM in with of on

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immunological role of sulfatide in the pathogenesis of multiple sclerosis

引用

Neural Regeneration Research 2023年第9期18卷 1950-1951页

作者： Mio Hamatani Takayuki kondo Institute for the Advanced Study of Human Biology Kyoto UniversityKyotoJapan Department of Neurology Kansai Medical University Medical CenterMoriguchiJapan

Multiple sclerosis(MS) is a chronic inflammatory demyelinating disease of the central nervous system.A certain population of patients with MS present with a relapse-remitting disease course(RRMS) during the early phase and eventually advance to a progressive course(PMS).While immune modulation therapies have recently seen tremendous success in RRMS,our limited knowledge of pathogenesis hampers the development of effective treatments for PMS.

关键词： pathogenesis sclerosis eventually

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatitis C infected patients need vitamin D3 supplementation in the era of direct acting antivirals treatment

引用

World Journal of Gastroenterology 2017年第8期23卷 1325-1327页

作者： Yasuteru kondo Department of Hepatology Sendai Kousei HospitalAobaSendai City 980MiyagiJapan

It has been reported that the serum level of vitamin D3(Vit D3) could affect the natural course of chronic hepatitis C(CH-C) and the response to treatment with pegylated interferon(Peg-IFN) and ribavirin. Although several mechanisms for the favorable effects of Vit D3 supplementation were reported, the total effect of Vit D3 supplementation remains unclear. Previously, we reported that supplementation with 1(OH)Vit D3 could enhance the Th1 response inducing not only a favorable immune response for viral eradication but also HCC control. Recently, the main treatment of CH-C should be direct acting antivirals(DAAs) without PegIFN. Peg-IFN is a strong immune-modulator. Therefore, an immunological analysis should be carried out to understand the effect of Vit D3 after treatment of DAAs without Peg-IFN. The induction of a favorable immune response by adding Vit D3 might be able to suppress the hepatocarcinogenesis after achieving SVR, especially in children and elderly patients with severe fibrosis lacking sufficient amounts of VitD 3.

关键词： Vitamin D Hepatitis C virus Direct acting antivirals Hepatocarcinogenesis Immune response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metal-free catalytic reduction of aldehydes,ketones,aldimines,and ketimines

引用

Chinese Chemical Letters 2010年第11期21卷 1314-1317页

作者： Hiroaki Matsuoka Kazuhiro kondo Graduate School of Medical Sciences Nagoya City University Graduate School of Pharmaceutical Sciences Nagoya City University

The metal-free combination of catalytic amounts of PPh3,B（C6F5）3,and PhSiH_3 can efficiently hydrosilylate aldehydes, ketones,aldimines and ketimines to afford the corresponding reduction products in good yields.

关键词： Metal-free hydrosilylation Reduction Ketone Ketimine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immune checkpoint and inflammation as therapeutic targets in pancreatic carcinoma

引用

World Journal of Gastroenterology 2016年第33期22卷 7440-7452页

作者： Shiro Kimbara Shunsuke kondo Department of Experimental Therapeutics National Cancer Center Hospital

Pancreatic adenocarcinoma(PAC) is one of the most deadly malignant neoplasms,and the efficacy of conventional cytotoxic chemotherapy is far from satisfactory. Recent research studies have revealed that immunosuppression and inflammation are associated with oncogenesis,as well as tumor development,invasion,and metastasis in PAC. Thus,immunosuppressionrelated signaling,especially that involving immune checkpoint and inflammation,has emerged as novel treatment targets for PAC. However,PAC is an immuneresistant tumor,and it is still unclear whether immune checkpoint or anti-inflammation therapies would be an ideal strategy. In this article,we will review immune checkpoint and inflammation as potential targets,as well as clinical trials and the prospects for immunotherapy in PAC.

关键词： Immune checkpoint Therapeutic anticancer target Inflammation Randomized clinical trial Pancreatic adenocarcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of molten metal spreading and solidification behaviors utilizing moving particle full-implicit method

引用

Frontiers in Energy 2021年第4期15卷 959-973页

作者： Ryo YOKOYAMA Masahiro kondo Shunichi SUZUKI Koji OKAMOTO Department of Nuclear Engineering and Management The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Research Center for Computational Design of Advanced Functional materials(CD-FMat) Department of Materials and ChemistryNational Institute of Advanced Industrial Science and Technology(AIST)Central 21-1-1UmezonoTsukubaIbaraki 305-8568Japan Institute of Engineering Innovation School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Nuclear Professional School The University of Tokyo2-22 ShirakataTokai-muraIbaraki 319-1188Japan

To retrieve the fuel debris in Fukushima Daiichi Nuclear Power Plants(1F),it is essential to infer the fuel debris *** particular,the molten metal spreading behavior is one of the vital phenomena in nuclear severe accidents because it determines the initial condition for further accident scenarios such as molten core concrete interaction(MCCI).In this study,the fundamental molten metal spreading experiments were performed with different outlet diameters and sample amounts to investigate the effect of the outlet for spreading-solidification *** the numerical analysis,the moving particle full-implicit method(MPFI),which is one of the particle methods,was applied to simulate the spreading *** the MPFI framework,the melting-solidification model including heat transfer,radiation heat loss,phase change,and solid fraction-dependent viscosity was developed and *** addition,the difference in the spreading and solidification behavior due to the outlet diameters was reproduced in the *** simulation results reveal the detailed solidification procedure during the molten metal *** is found that the viscosity change and the solid fraction change during the spreading are key factors for the free surface condition and solidified ***,it is suggested that the MPFI method has the potential to simulate the actual nuclear melt-down phenomena in the future.

关键词： molten metal spreading solidification particle method severe accident fuel debris decommissioning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：