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气体燃料发动机的高性能气门座圈材料开发

粉末冶金技术 2011年第1期29卷 64-65页

作者： hideaki Kawata Kunio Maki 520 MinoridaiMatsudo-shiChiba270-2295日本

烧结材料广泛用于气门座圈(VSI)。当用于气体燃料(LPG,CNG)发动机时,由于环境干燥,VSI磨损量增大。介绍了气体燃料发动机用的,两种新开发的高性能VSI材料。为增高耐磨性,这些材料应用的新工艺是,高性能硬质颗粒和固体润滑剂新分布方法。

关键词：耐磨性气门座圈金属间化合物润滑

Circulating tumor DNA dynamics analysis in a xenograft mouse model with esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2021年第41期27卷 7134-7143页

作者： Hiroyuki Terasawa hideaki Kinugasa Kazuhiro Nouso Shumpei Yamamoto Mami Hirai Takehiro Tanaka Akinobu Takaki Hiroyuki Okada Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 7008558Japan Department of Pathology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 7008558Japan

BACKGROUND It remains unclear which factors,such as tumor volume and tumor invasion,influence circulating tumor DNA(ctDNA),and the origin of ctDNA in liquid biopsy is always *** use liquid biopsies clinically,it will be very important to address these *** To assess the origin of ctDNA,clarify the dynamics of ctDNA levels,assess ctDNA levels by using a xenograft mouse after treatment,and to determine whether tumor volume and invasion are related to ctDNA *** Tumor xenotransplants were established by inoculating BALB/c-nu/nu mice with the TE11 cell *** of mice were injected with xenografts at two or four sites and sacrificed at the appropriate time point after xenotransplantation for ctDNA *** of ctDNA was performed by droplet digital PCR,using the human telomerase reverse transcriptase(hTERT)*** Mice given two-site xenografts were sacrificed for ctDNA at week 4 and week *** hTERT was detected at week 4,but it was detected at week ***,in four-site xenograft mice,hTERT was detected both at week 4 and week *** experiments revealed that both tumor invasion and tumor volume were asso ciated with the detection of *** resection experiments,hTERT was detected at resection,but had decreased by 6 h,and was no longer detected 1 and 3 d after *** We clarified the origin and dynamics of ctDNA,showing that tumor volume is an important *** also found that when the tumor was completely resected,ctDNA was absent after one or more days.

关键词： Liquid biopsy Circulating tumor DNA Xenograft Esophageal squamous cell carcinoma Dynamics of circulating tumor DNA

Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy

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World Journal of Gastroenterology 2014年第15期20卷 4316-4328页

作者： Kazuyuki Matsushita hideaki Shimada Yasuji Ueda Makoto Inoue Mamoru Hasegawa Takeshi Tomonaga Hisahiro Matsubara Fumio Nomura Department of Molecular Diagnosis Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of Surgery School of MedicineToho UniversityTokyo 143-8541Japan DNAVEC Corporation 6 OhkuboTsukuba CityIbaraki 300-2611Japan Proteome Research Center Proteome Research ProjectNational Institute of Biomedical InnovationOsaka 567-0085Japan Department of Frontier Surgery Chiba UniversityGraduate School of MedicineChiba 260-8670Japan

AIM: To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element (FUSE)-binding protein-interacting repressor (FIR).

关键词： Cancer gene therapy c-myc suppressor Far up stream element-binding protein-interacting repressor Sendai virus vector

Massive low-grade myxoid liposarcoma of the floor of the mouth:A case report and review of literature

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World Journal of Clinical Cases 2022年第34期10卷 12742-12749页

作者： Takuma Kugimoto Yuko Yamagata Toshimitsu Ohsako hideaki Hirai Naoto Nishii Kou Kayamori Tohru Ikeda Hiroyuki Harada Department of Oral and Maxillofacial Surgical Oncology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan Department of Oral Pathology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan

BACKGROUND Oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign tumor due to its asymptomatic and indolent clinical ***,we report a case of massive low-grade myxoid liposarcoma(MLS)of the floor of the *** SUMMARY A 71-year-old man presented with a huge mass in the left floor of the mouth.A biopsy was performed,and a diagnosis of a myxoid tumor suspicious for lowgrade MLS or myxoma was ***-enhanced T1-weighted magnetic resonance imaging showed an intensely enhanced tumor lesion that occupies the left sublingual space and extends to the submandibular *** dissection,tumor resection,and reconstruction with a radial forearm flap were *** surgical specimen exhibited histologically low-grade *** in sarcoma(FUS,also known as TLS)and DNA damage-inducible transcript 3(DDIT3,also known as CHOP)break-apart was not detected in the fluorescence in situ hybridization *** tumor was completely encapsulated and did not require additional ***,no recurrence was reported 40 mo after *** We experienced an extremely rare,massive,low-grade MLS emerging from the floor of the ***,an MLS of the floor of the mouth lacks significant clinical findings and is often *** no FUS-DDIT3 fusion gene was detected,a low-grade MLS was ultimately diagnosed based on the histological findings.

关键词： Myxoid liposarcoma Floor of mouth Surgery Fluorescence in situ hybridization Sublingual space Case report

Preparation of Microcapsules Containing Triple Core Materials with Interfacial Condensation Reaction

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第4期4卷 275-283页

作者： Yoshinari taguchi Mikihiko Aoki Masato Tanaka Graduate School of Science and Technology Niigata University Niigata Japan

In this manuscript, we describe the novel method for preparing the microcapsules containing α-tocopherol oil droplets as the first core material, calcium chloride powder as the second core material and the fine water droplets as the third core material by the interfacial condensation reaction between hydroxyl propyl methyl cellulose and tannic acid. The interfacial condensation reaction was performed between hydroxyl propyl methyl cellulose dissolved in the continuous water phase and tannic acid dissolved in the inner fine water droplets as the third core material. The calcium chloride powder as the second core material was dispersed in the α-tocopherol oil droplet as the first core material beforehand. The α-tocopherol oil containing the second and the third core materials was dispersed in the continuous water phase to form the [(S + W)/O/W] emulsion. The α-tocopherol oil as the first core material was microencapsulated satisfactorily and the contents of the second core material were increased with the concentration of stearic acid as the oil soluble stabilizer. The mechanical strength of microcapsules increased with the concentration of hydroxyl propyl methyl cellulose. Thermal energy could be released by breaking the microcapsules in water and by dissolving calcium chloride in the continuous water phase.

关键词： Triple Core Materials-Containing-Microcapsule Multiple Emulsions α-Tocopherol Calcium Chloride Dissolution Heat Hydroxy Propyl Methyl Cellulose Tannic Acid

Effect of Polysaccharide Species on Storage Stability of Alginate Capsules Containing <i>α</i>-Tocopherol

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Journal of Encapsulation and Adsorption Sciences 2015年第3期5卷 111-120页

作者： Yusuke Sato Yoshinari taguchi Masato Tanaka Graduate School of Science and Technology Niigata University Niigata-shi Japan

Alginate capsules containing α-tocopherol were prepared adding polysaccharide species such as κ-carrageenan, gellan gum, pectin, curdlan and ghatti gum. The effects of polysaccharide species and the diameters of α-tocopherol on storage stability of the capsules were investigated and characterized in detail. As the contact angle of α-tocopherol to the capsule shell strongly affected storage stability, the contact angle was measured on the model sheet made of calcium alginate with polysaccharide species. The leakage ratio decreased with the contact angle and increased with the diameter of α-tocopherol. The capsules made of calcium alginate with gellan gum showed the largest contact angle and the highest storage stability. The capsules made of calcium alginate with curdlan, ghatti gum and pectin were harder than other capsules and showed higher storage stability. All the capsules showed the almost similar swelling ratio in the acidic solution with pH 4, but showed the different swelling ratios according to the polysaccharide species in the alkali solution with pH 9. The tablets were prepared with the wet and the dried capsules. The tablets prepared with the dried capsules showed higher storage stability.

关键词： Calcium Alginate Capsules α-Tocopherol Gelling in Liquid Method Polysaccharides Storage Stability pH-Responsible Capsules

Two Low Profile Unbalanced Fed Inverted L Elements on Square Conducting Plane for MIMO Applications

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Wireless Engineering and Technology 2014年第2期5卷 34-43页

作者： E. Rohadi M. taguchi Graduate School of Engineering Nagasaki University Nagasaki Japan Graduate School of Engineering Nagasaki University Nagasaki Japan The State Polytechnic of Malang Malang Indonesia

Two ultra low profile inverted L antennas located on the square conducting plane are numerically and experimentally analyzed as the multiple input multiple output (MIMO) antenna system. When the size of conducting plane is 0.45 λ by 0.45 λ and the height of antenna is 0.03 λ, the directive gain of 4.12 dBi and the return loss bandwidth of 3.67% are achieved. The proposed antenna has good diversity gain shown by the correlation coefficient, and becomes less than 0.02 at the frequency of 2.45 GHz band when the distance between inverted L elements is 0.33 λ. The results show the weak mutual coupling of the proposed antenna and its performances are promising as MIMO antenna applications.

关键词： Low Profile Antenna Inverted L Antenna MIMO Antenna Correlation Coefficient WIPL-D

Preparation of Microcapsules Containing Dye Aqueous Solution and Investigation of Release Feature According to Preparation Method

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Journal of Encapsulation and Adsorption Sciences 2017年第2期7卷 83-94页

作者： Yoshinari taguchi Natsukaze Saito Masato Tanaka Graduate School of Science and Technology Niigata University Niigata-shi Japan

Microcapsules containing the dye aqueous solution were prepared with three kinds of preparation methods and the release feature of microcapsules with each preparation method was mainly investigated. As a dye tried to microencapsulate, methylene blue was adopted, because methylene blue aqueous solution was changed in color with light irradiation and utilized in order to check the degree of river pollution. Microencapsulation using multiple emulsion was performed with the suspension polymerization method, the inverse interfacial polycondensation method and the suspension polymerization in parallel with the interfacial polymerization method, respectively. The release feature of microcapsules prepared with each preparation method was estimated with the solute permeability coefficient. It was found that the release feature of dye aqueous solution was different according to the preparation method and could be delicately controlled by microencapsulating with the suspension polymerization in parallel with interfacial polycondensation reaction and forming the polyurethane shell on the surface of the dye aqueous solution droplets.

关键词： Microencapsulation Methylene Blue Permeability Coefficient Multiple Emulsion Suspension Polymerization Interfacial Polycondensation Reaction

Preparation of Composite Particles Made of Biodegradable Polymer and a Few Additives with Phase Separation Followed by Drying-in-Liquid

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Journal of Encapsulation and Adsorption Sciences 2015年第1期5卷 11-20页

作者： Mitsuru Kutsuwada Yoshinari taguchi Masato Tanaka Graduate School of Science and Technology Niigata University Niigata Japan

It was tried to prepare the biodegradable composite particles by the phase separation method followed by the drying-in-liquid method. The composite particles were made of poly-ε-caprolac-tone, quaternary ammonium, carbon black and wax. In the experiment, acetone and water were selected as a good solvent and a poor solvent for poly-ε-caprolactone, quaternary ammonium and wax, respectively. The composite particles were prepared by changing the surfactant species and their concentration, the feeding velocity of water and the weight ratio of poly-ε-caprolactone with larger molecular weight to one with smaller molecular weight. The composite particles with the inner structure in which carbon black, quaternary ammonium and wax were coated well with poly-ε-caprolactone could be prepared by the preparation method presented in this study. The structure and the mean diameter of composite particles were strongly affected by the feeding velocity of water. The higher the feeding velocity of water, the larger the mean diameter of composite particles. The mean diameter was drastically decreased with the surfactant concentration and increased with the added amount of poly-ε-caprolactant with larger molecular weight.

关键词： Biodegradable Composite Particles Phase Separation Drying-in-Liquid Poly-ε-Caprolactone Microencapsulation