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Anemia and risk of periprocedural cerebral injury detected by diffusion-weighted magnetic resonance imaging in patients undergoing transcatheter aortic valve replacement

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World Journal of Emergency Medicine 2022年第1期13卷 32-39页

作者： Stella ng Qi-feng Zhu Ju-bo Jiang Chun-hui liu Jia-qi Fan Ye-ming Xu Xian-bao liu Jian-an Wang Department of Cardiology the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Zhejiang University School of Medicine Hangzhou 310058China

BACKGROUND: Anemia is prevalent in patients undergoing transcatheter aortic valve replacement(TAVR) and has been linked to impaired outcomes after the procedure. Few studies have evaluated the impact of anemia and new ischemic lesions post ***: We prospectively enrolled 158 patients who received TAVR in our center. Anemia was defined according to the World Health Organization criteria as hemoglobin ng(DW-MRI) procedure before and within 4–7 days after TAVR. RESULTS: Anemia was present in 85(53.8%) patients who underwent TAVR, and 126(79.7%) patients had 718 new DW-MRI positive lesions with a mean of 4.54±5.26 lesions per patient. The incidence of new ischemic lesions was 81.2% in patients with anemia versus 78.1% in patients without anemia(P=0.629). Moreover, anemic patients had bigger total volume/lesions in the anterior cerebral artery/middle cerebral artery(ACA/MCA) and MCA regions compared to the non-anemic patients(31.89±55.78 mm^(3) vs. 17.08±37.39 mm^(3), P=0.049;and 54.54±74.72 mm^(3) vs. 33.75±46.03 mm^(3), P=0.034). Anemia was independently associated with the volume/lesion in the ACA/MCA(β=16.796, 95% confidence interval [95% CI] 2.001 to 31.591, P=0.026) and in the MCA zone(β=0.020, 95% CI 0.001 to 0.040, P=0.041). CONCLUSIONS: Patients with pre-procedural anemia may have bigger total volume/lesions in the ACA/MCA and MCA regions compared to the non-anemic patients. Whether the consequences of bigger total volume/lesions impact neurological and cognitive outcomes remains to be investigated.

关键词： Aortic stenosis Anemia Cerebral ischemic lesions Transcatheter aortic valve replacement

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Miniscope3D:optimized single-shot miniature 3D fluorescence microscopy

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Light(Science & Applications) 2020年第1期9卷 367-379页

作者： Kyrollos Yanny Nick Antipa William Liberti Sam Dehaeck Kristina Monakhova Fanglin Linda liu Konlin Shen Ren ng Laura Waller UCB/UCSF Joint Graduate Program in Bioengineering University of CaliforniaBerkeleyCA 94720USA Department of Electrical Engineering&Computer Sciences University of CaliforniaBerkeleyCA 94720USA TIPs Department Universite libre de Bruxelles(ULB)1050 BrusselsBelgium

Miniature fluorescence microscopes are a standard tool in systems ***,widefield miniature microscopes capture only 2D information,and modifications that enable 3D capabilities increase the size and weight and have poor resolution outside a narrow depth ***,we achieve the 3D capability by replacing the tube lens of a conventional 2D Miniscope with an optimized multifocal phase mask at the objective’s aperture *** the phase mask at the aperture stop significantly reduces the size of the device,and varying the focal lengths enables a uniform resolution across a wide depth *** phase mask encodes the 3D fluorescence intensity into a single 2D measurement,and the 3D volume is recovered by solving a sparsity-constrained inverse *** provide methods for designing and fabricating the phase mask and an efficient forward model that accounts for the fieldvarying aberrations in miniature *** demonstrate a prototype that is 17mm tall and weighs 2.5 grams,achieving 2.76μm lateral,and 15μm axial resolution across most of the 900×700×390μm^(3) volume at 40 volumes per *** performance is validated experimentally on resolution targets,dynamic biological samples,and mouse brain *** with existing miniature single-shot volume-capture implementations,our system is smaller and lighter and achieves a more than 2×better lateral and axial resolution throughout a 10×larger usable depth *** microscope design provides single-shot 3D imaging for applications where a compact platform matters,such as volumetric neural imaging in freely moving animals and 3D motion studies of dynamic samples in incubators and lab-on-a-chip devices.

关键词： enable resolution narrow

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Structure regulation for ultra-high luminescence quantum yield lanthanide complex and simultaneous detection of cancer marker and ferrous ion

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Journal of Rare Earths 2021年第10期39卷 1194-1203,I0002页

作者： Min liu Zhifeng Li Jianhui Xiong Yefei Jiang Ting Tang Jinkai Qiu Junwei Yao Seik Weng ng Chenghui Zeng Research Center for Ultra Fine Powder Materials Key Laboratory of Functional Small Organic MoleculeMinistry of Education and Jiangxi's Key Laboratory of Green ChemistryCollege of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China School of Chemical Engineering and Technology Tianshui Normal UniversityTianshui 741001China UCSI University CherasKuala LumpurMalaysia

The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great *** this work,the "one stone two bird" agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium *** luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide ***,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid *** interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic.

关键词： Ultra-high luminescence quantum yield Lanthanide complex Simultaneous detection Cancer marker Ferrous ion Rare earths

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Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2

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Bioactive Materials 2023年第6期24卷 551-562页

作者： Qi Gan Lina Chen Ho-Pan Bei Sze-Wing ng Han Guo Guoqiang liu Hao Pan Changsheng liu Xin Zhao Zijian Zheng Laboratory for Advanced Interfacial Materials and Devices School of Fashion and TextilesThe Hong Kong Polytechnic UniversityKowloon99077Hong Kong Special Administrative Region of China Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237PR China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomHong Kong Special Administrative Region of China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai201204PR China Department of Applied Biology and Chemical Technology Faculty of ScienceThe Hong Kong Polytechnic UniversityKowloon99077Hong Kong Special Administrative Region of China

Preservation of growth factor sensitivity and bioactivity(e.g.,bone morphogenetic protein-2(BMP-2))post-immobilization to tissue engineering scaffolds remains a great ***,we develop a stable and soft surface modification strategy to address this ***-2(a model growth factor)is covalently immobilized onto homogeneous poly(glycidyl methacrylate)(PGMA)polymer brushes which are grafted onto substrate surfaces(Au,quartz glass,silica wafer,or common biomaterials)via surface-initiated atom transfer radical *** surface modification method multiplies the functionalized interfacial area;it is simple,fast,gentle,and has little effect on the loaded protein owing to the cilia *** immobilized BMP-2(i-BMP-2)on the surface of homogeneous PGMA polymer brushes exhibits excellent bioactivity(-87%bioactivity of free BMP-2 in vitro and 20%-50%higher than scaffolds with free BMP-2 in vivo),with conformation and secondary structure well-preserved after covalent immobilization and ethanol ***,the osteogenic activity of i-BMP-2 on the nanoline pattern(PGMA-poly(N-isopropylacrylamide))shows-110%bioactivity of free *** is superior compared to conventional protein covalent immobilization strategies in terms of both bioactivity preservation and therapeutic *** polymer brushes can be used to modify surfaces of different tissue-engineered scaffolds,which facilitates in situ immobilization of growth factors,and accelerates repair of a wide range of tissue types.

关键词： Polymer brush Poly(glycidyl methacrylate) Surface modification Protein immobilization Bioactivity

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Topology modulation of tetraphenylethylene graphdiyne at a liquid-liquid interface

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Nano Research 2024年第6期17卷 4661-4667页

作者： Tingting Xu Pei Wen ng Shaofei Wu Danjun Fu Yunhan Ma Yao liu Lidao Li Xiaofei Zhang Jun Zhu Department of Chemistry National University of SingaporeSingapore 117543Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore

Monomers with low symmetries can form different topological structures in the preparation of organic two-dimensional(2D)***,it remains challenging to modulate the topologies in practical *** theoretical insights into the formation energy of potential structural configurations,we report the topology modulation of a graphdiyne(GDY)derivative constructed from two-fold symmetric tetrakis(4-ethynylphenyl)ethene precursor by changing solvent combinations in a liquid-liquid interfacial *** aqueous-organic(water-dichloromethane)interface afforded GDY with a kagome topology while a rhombic topology was formed at an organic-organic(hexane-acetonitrile)interface.A comprehensive evaluation of their structures and optoelectronic properties was conducted through various characterization techniques and theoretical *** study provided new insights to modulate the topology of not only GDY but also other framework structures and obtain topologically pure materials in situations where different topologies are possible during practical synthesis.

关键词： graphdiyne derivative tetraphenylethylene topology modulation aggregation-induced emission(AIE)two-dimensional(2D)polymers interfacial synthesis

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Enhanced Microwave Absorption Properties of Double-Layer Absorbers Based on Spherical NiO and Co_(0.2)Ni_(0.4)Zn_(0.4)Fe_2O_4 Ferrite Composites

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Acta Metallurgica Sinica(English Letters) 2018年第2期31卷 171-179页

作者： Pei-Jiang liu Zheng-Jun Yao Vincent Ming Hong ng Jin-Tang Zhou Zhi-Hong Yang Ling-Bing Kong College of Materials and Technology Nanjing University of Aeronautics and Astronautics Nanjing 211100 China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing 211100 China School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore

Microwave absorption properties of spherical NiO particles and Co0.2Ni0.4Zn0.4Fe2O4（CNZF） ferrites with single-layer and double-layer absorbers were studied in the frequency range of 2–18 GHz. The spherical NiO particles were synthesized by using a hydrothermal process, while the CNZF powders were prepared by using a sol–gel autoignition method. The double-layer absorbers, composed of 30 wt% NiO as matching layer and 30 wt% CNZF as absorption layer,with a total thickness of 3.2 mm, exhibited a maximum reflection loss（RL） of –67.0 d B at 9.2 GHz and an effective absorbing bandwidth below –10 d B to be 3.9 GHz from 7.0 to 10.9 GHz. The excellent microwave absorption performance of the double-layer absorbers should be ascribed to the high impedance matching ratio, the great microwave attenuation capability, and well-coupled layer.

关键词： Hierarchical NiO particle Ferrite Impedance matching Microwave absorption property

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Thermally Evaporated ZnSe for Efficient and Stable Regular/Inverted Perovskite Solar Cells by Enhanced Electron Extraction

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Energy & Environmental Materials 2023年第5期6卷 440-448页

作者： Xin Li Guibin Shen Xin Ren ng Zhiyong liu Yun Meng Yongwei Zhang Cheng Mu Zhi Gen Yu Fen Lin Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of ChemistryRenmin University of ChinaBeijing 100872China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Shandong Provincial Engineering and Technical Center of Light Manipulation and Shandong Provincial Key Laboratory of Optics and Photonic Devices School of Physics and ElectronicsShandong Normal UniversityJinan 250014China Institute of High Performance Computing A^(*)STARSingapore 138632Singapore

Electron transport layers(ETLs)are crucial for achieving efficient and stable planar perovskite solar cells(PSCs).Reports on versatile inorganic ETLs using a simple film fabrication method and applicability for both low-cost planar regular and inverted PSCs with excellent efficiencies(>22%)and high stability are very ***,we employ a novel inorganic ZnSe as ETL for both regular and inverted PSCs to improve the efficiency and stability using a simple thermal evaporation *** TiO_(2)-ZnSe-FAPbl_(3)heterojunction could be formed,resulting in an improved charge collection and a decreased carrier recombination further proved through theoretical *** optimized regular PSCs based on TiO_(2)/ZnSe have achieved 23.25%efficiency with negligible *** addition,the ZnSe ETL can also effectively replace the unstable bathocuproine(BCP)in inverted ***,the ZnSe-based inverted device realizes a champion efficiency of 22.54%.Moreover,the regular device comprising the TiO_(2)/ZnSe layers retains 92%of its initial PCE after 10:00 h under 1 Sun continuous illumination and the inverted device comprising the C_(60)/ZnSe layers maintains over 85%of its initial PCE at 85℃for 10:00 *** highlights one of the best results among universal ETLs in both regular and inverted perovskite photovoltaics.

关键词： high efficiency long-term stability planar regular/inverted perovskite solar cells thermal evaporation ZnSe electron transport layer

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Ototoxic destruction by co-administration of kanamycin and ethacrynic acid in rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第10期12卷 853-861页

作者： Hong liu Da-lian D1ng Hai-yan JIAng Xue-wen WU Richard SALVI Hong SUN Center for Hearing and Deafness University at Buffalo State University of New York New York 14214 USA Department of Otolaryngology the Third Xiangya Hospital of Central South University Changsha 410013 China Department of Otolaryngology Xiangya Hospital of Central South University Changsha 410008 China

It is well known that ethacrynic acid (EA) can potentiate the ototoxicity of aminoglycoside antibiotics (AmAn) such as kanamycin (KM),if they were applied at the same ***,to create the model of EA-KMinduced cochlear lesion in rats,adult rats received a single injection of EA (75 mg/kg,intravenous injection),or followed immediately by KM (500 mg/kg,intramuscular injection).The hearing function was assessed by auditory brainstem response (ABR) measurement in response to click and/or tone bursts at 4,8,12,16,20,24,and 32 *** static microcirculation status in the stria vascularis after a single EA injection was evaluated with eosin *** pathological changes in cochlear and vestibular hair cells were also quantified after co-administration of EA and *** a single EA injection,blood flow in vessels supplying the stria vascularis rapidly ***,the blood supply to the cochlear lateral wall partially recovered 5 h after EA *** changes in ABR were basically parallel to the microcirculation changes in stria vascularis after single EA ***,disposable co-administration of EA and KM resulted in a permanent hearing loss and severe damage to the cochlear hair cells,but spared the vestibular hair *** the cochlear lateral wall is the important part of the blood-cochlea barrier,EA-induced anoxic damage to the epithelium of stria vascularis may enhance the entry of KM to the ***,experimental animal model of selective cochlear damage with normal vestibular systems can be reliably created through co-administration of EA and KM.

关键词： Ototoxicity Ethacrynic acid Kanamycin Rat Blood-cochlea barrier

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Telomere-dependent and telomereindependent roles of RAP1 in regulating human stem cell homeostasis

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Protein & Cell 2019年第9期10卷 649-667页

作者： Xing Zhang Zunpeng liu Xiaoqian liu Si Wang Yiyuan Zhang Xiaojuan He Shuhui Sun Shuai Ma ng Shyh-Chang Feng liu Qiang Wang Xiaoqun Wang Lin liu Weiqi Zhang Moshi Song Guang-Hui liu Jing Qu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences Beijing 100101China Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China National Laboratory of Biomacromolecules CAS Center for Excellenee in BiomacromoleculesInstitute of Biophysics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China

RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclea匚 Here we generated RAP1 -deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also acted as a transcriptional regulator of RELN by tuning the methylation status of its gene promoter. RAP1 deficiency enhanced self-renewal and delayed senescence in hMSCs, but not in hNSCs, suggesting complicated lineage-specific effects of RAP1 in adult stem ***, these results demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis.

关键词： RAP1 stem cell telomere RELN methylation

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Application of constructed wetlands for wastewater treatment in tropical and subtropical regions(2000–2013)

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Journal of Environmental Sciences 2015年第4期27卷 30-46页

作者： Dong-Qing Zhang K.B.S.N.Jinadasa Richard M.Gersberg Yu liu Soon Keat Tan Wun Jern ng Advanced Environmental Biotechnology Centre Nanyang Environment & Water Research Institute Nanyang Technological University Department of Civil Engineering University of Peradeniya Graduate School of Public Health San Diego State University

Constructed wetlands（CWs） have been successfully used for treating various wastewaters for decades and have been identified as a sustainable wastewater management option for developing countries. With the goal of promoting sustainable engineered systems that support human well-being but are also compatible with sustaining natural（environmental）systems, the application of CWs has become more relevant. Such application is especially significant for developing countries with tropical climates, which are very conducive to higher biological activity and productivity, resulting in higher treatment efficiencies compared to those in temperate climates. This paper therefore highlights the practice,applications, and research of treatment wetlands under tropical and subtropical conditions since 2000. In the present review, removal of biochemical oxygen demand（BOD） and total suspended solid（TSS） was shown to be very efficient and consistent across all types of treatment wetlands. Hybrid systems appeared more efficient in the removal of total suspended solid（TSS）（91.3%）, chemical oxygen demand（COD）（84.3%）, and nitrogen（i.e.,80.7% for ammonium（NH）4-N, 80.8% for nitrate（NO）3-N, and 75.4% for total nitrogen（TN））as compared to other wetland systems. Vertical subsurface flow（VSSF） CWs removed TSS（84.9%）, BOD（87.6%）, and nitrogen（i.e., 66.2% for NH4-N, 73.3% for NO3-N, and 53.3% for TN）more efficiently than horizontal subsurface flow（HSSF） CWs, while HSSF CWs（69.8%）showed better total phosphorus（TP） removal compared to VSSF CWs（60.1%）. Floating treatment wetlands（FTWs） showed comparable removal efficiencies for BOD（70.7%）,NH4-N（63.6%）, and TP（44.8%） to free water surface（FWS） CW systems.

关键词： Constructed wetlands Treatment Nutrient Removal Tropical

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