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Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

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npj Flexible Electronics 2022年第1期6卷 840-853页

作者： ju Young Lee Sang Hoon Park Yujin kim Young Uk Cho Jaejin Park jung-Hoon Hong Kyubeen kim Jongwoon Shin Jeong Eun ju In Sik Min Mingyu Sang Hyogeun Shin Ui-Jin Jeong Yuyan Gao Bowen Li Aizhan Zhumbayeva Kyung Yeun kim Eun-Bin Hong Min-Ho Nam Hojeong Jeon Youngmee jung Huanyu Cheng Il-Joo Cho Ki jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-KIST Convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous

Weave-pattern-dependent fabric piezoelectric pressure sensors based on polyvinylidene fluoride nanofibers electrospun with 50 nozzles

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npj Flexible Electronics 2022年第1期6卷 699-707页

作者： Da Bin kim ju Han Sun Min Sung Min Seong kim Bo Kyoung Choi Sung jun Park Hyae Rim Hong Hong Je Choi Byeong Kon kim Chung Hee Park Jong Hoo Paik Joon-Seok Lee Yong Soo Cho Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Textile Engineering and Technology Yeungnam UniversityGyeongsan 38541Republic of Korea Deparment of Textile Merchandising and Fashion DesignSeoul National UniversitySeoul 08826Republic of Korea Samsung Electro-Mechanics Co.Ltd. Suwon 16674Republic of Korea Ceratorq Inc. Seoul 08511Republic of Korea Electronic Materials and Component Center Korea Institute of Ceramic Engineering and TechnologyJinju 52851Republic of Korea

Wearable pressure sensors having versatile device structures have been extensively investigated to achieve high sensitivity under mechanical ***,we introduce piezoelectric pressure sensors based on fabrics woven using polyvinylidene fluoride(PVDF)weft and polyethylene terephthalate(PET)warp yarns with different weave structures:1/1(plain),2/2,and 3/3 weft rib *** dependence of the pressure-sensing performance on the weave pattern is demonstrated with an actual large-scale fabric up to the~2 m *** optimized pressure sensor with a 2/2 weft rib pattern produced a high sensitivity of 83 mV N−1,which was 245%higher than that of the 1/1 *** detection performance of the optimal fabric was extensively evaluated with a variety of ambient input sources,such as pressing,bending,twisting,and crumpling,as well as various human ***,a large allfabric pressure sensor with arrayed touch pixel units demonstrated highly sensitive and stable sensing performance.

关键词： pattern fluoride piezoelectric

Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib

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Cancer Communications 2023年第4期43卷 455-479页

作者： jungWoo Eun jung Hwan Yoon Hye Ri Ahn Seokhwi kim Young Bae kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon ju A Son Ji HyangWeon Soon Sun kim Hyo jung Cho Jae Youn Cheong Department of Gastroenterology Ajou University School of MedicineSuwonSouth Korea Department of Pathology College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedical Sciences AjouUniversity Graduate School of MedicineSuwonSouth Korea Department of Pathology Ajou University School of MedicineSuwonSouth Korea Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea The Moagen IncDaejeonSouth Korea

Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of *** study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to *** then performed in vitro and in vivo experiments to validate selected targets and related *** associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression ***:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI ***1 inhibitors reversed CAF-induced TKI resistance in vitro and in ***-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI ***:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT *** inhibition represents a promising therapeutic strategy against TKI resistance ***,plasma SPP1 level before TKI treatment represents a potential biomar

关键词： drug resistance epithelial-to-mesenchymal transition hepatocellular carcinoma secreted phosphoprotein 1

Solvent extraction and stripping of lithium ion from aqueous solution and its application to seawater

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Rare Metals 2016年第12期35卷 948-953页

作者： Gregorius Rionugroho Harvianto Seok-Hyeon kim Chang-Sik ju Department of Chemical Engineering Pukyong National University

For the development of lithium ion recovery process from seawater, a series of experimental researches were performed. Solvent extraction of lithium ion from aqueous solution using kerosene as solvent was proposed. Lithium ion is effectively extracted by thenoyltrifluoroace- tone-trioctylphosphine oxide （TTA-TOPO） in kerosene within 80 min. Extraction efficiency is severely influenced by stoichiometric parameters. Among the stoichiometric parameters, volume ratio of aqueous （A） to extraction （E） solution is the most influential parameter. After extrac- tion, lithium ion could be easily stripped from the extraction solution by acidic solutions. Stripping efficiency decreases with pH of acidic solutions, and the kind of acid does not affect the stripping efficiency. Extraction efficiency main- tains at more than 93 % even when the extraction solution is recycled three times. 65 % of lithium ion can be extracted from seawater by this solvent extraction process when magnesium ion is precipitated by NHaOH prior to solvent extraction process. Other metallic ions in seawater decrease the extraction efficiency of lithium ion.

关键词： Lithium Thenoyltrifluoroacetone Trioctylphosphine oxide Solvent extraction Stripping Recycling

All-fiber acousto-optic modulator based on a cladding-etched optical fiber for active mode-locking

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Photonics Research 2017年第5期5卷 391-395页

作者： JIHWAN kim JOONHOI KOO ju HAN LEE School of Electrical and Computer Engineering University of Seoul

An all-fiber acousto-optic modulator(AOM), which features a compact structure and a low-driving voltage, is experimentally demonstrated for the active mode-locking of a fiber laser. The proposed AOM is based on the short length of the cladding-etched fiber, the ends of which are fixed on a slide glass. On top of the cladding-etched fiber, a piezoelectric transducer was overlaid. A chemical wet-etching technique, which is based on a mixed solution of NH_4F and (NH_4)2SO_4, is used to reduce the fiber diameter down to ～25 μm, and the length of the etched section is only 0.5 cm. The fabricated device exhibited a modulation depth of 73.10% at an acoustic frequency of 918.9 kHz and a peak-to-peak electrical voltage of 10 V, while a laser beam was coupled at 1560 *** using the prepared AOM within an erbium-doped-fiber ring cavity, the mode-locked pulses with a temporalwidth of 2.66 ps were readily obtained at a repetition rate of 1.838 MHz.

关键词： All-fiber acousto-optic modulator based on a cladding-etched optical fiber for active mode-locking

Performance evaluation of the use of tire-derived fuel fly ash as mineral filler in hot mix asphalt concrete

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第2期7卷 249-258页

作者： Min ju Choi Yong Joo kim Hyeok jung kim Jae jun Lee BILTZONE Co. Ltd.Hwaseong 18514South Korea Korea Institute o f Civil Engineering and Building Technology Goyang-Si 10223South Korea Industry-Academic Cooperation Foundation Center Hankyong National UniversityAnseong-si 17579South Korea Department of Civil Engineering Chonbuk National UniversityJeonju 54896South Korea

According to deplete natural resources and need to protect the environment,the demand of a usage of waste material has significantly *** studies are currently being carried out on the development of innovative and environmentally friendly materials for securing the safety of road users and improving the performance and durability of *** example,studies are currently being conducted on the use of waste tires as a substitute for currently used *** the development of the automobile industry,the amount of waste tire has continuously increased in accordance with the increased vehicle ***-derived fuel(TDF)has been used as a fuel source with generated TDF fly *** filler,made of fine mineral particles of a physical size passing the number 200 standard mesh sieve(75 micron),plays an important role in asphalt mixtures *** paper presents an application of TDF fly ash as filler in hot mix asphalt(HMA).In this study,the performance of TDF fly ash was confirmed through a comparison with three other mineral fillers:stone dust,cement,and hydrated *** tests including Marshall stability test,moisture sensitivity test,dynamic immersion test,and a wheel tracking test were performed to investigate the difference in the behaviors of the samples with different parameters considered in this *** results show that the mechanical performance of hot mix asphalt using TDF fly ash satisfied the quality standard specification of the Ministry of Land,Infrastructure and Transport(MOLIT),*** can be concluded that the use of TDF fly ash as a mineral filler in HMA not only satisfied the mechanical properties,but also reduced the volume of the pollutants waste in the environment.

关键词： Asphalt mixture TDF fly ash Marshal stability Moisture sensitive TSR

Correlation between macular ganglion cell-inner plexiform layer thickness and visual acuity after resolution of the macular edema secondary to central retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 256-261页

作者： Hyun ju kim Han Gyul Yoon Seong Taeck kim Department of Ophthalmology Chosun University School of Medicine

AIM： To examine the thickness of the ganglion cell-inner plexiform layer（GCIPL） in eyes with resolved macular edema（ME） in non-ischemic central retinal vein occlusion（CRVO）, applying spectral-domain optical coherence tomography（SD-OCT）, and its relationship with visual ***： The retrospective observational case-control study included 30 eyes of non-ischemic CRVO patients with resolved ME（ME eyes） after treatment, and 30 eyes of non-ischemic CRVO patients without ME（non-ME eyes）. The macular GCIPL thickness, peripapillary retinal nerve fiber layer（p RNFL） thickness and central macular thickness（CMT） were measured on a SD-OCT scan. Linear regression analyses were performed to determine the correlation between the thickness of each and the visual acuity（VA）.RESULTS： No significant difference in average GCIPL thickness, mean pR NFL thickness and CMT were observed between ME group and non-ME group（P=0.296, 0.183, 0.846）. But, minimum GCIPL thickness was reduced in ME eyes compared with non-ME eyes（P=0.022）. Final VA significantly correlated with the minimum GCIPL thickness in ME eyes（r=-0.482, P=0.007）, whereas no correlation was found with average GCIPL thickness, average pR NFL thickness and mean ***： Minimum GCIPL thickness is reduced in ME eyes compared with non-ME eyes, and correlated with the VA in non-ischemic CRVO. These results propose that inner retinal damage occurring in patients with ME secondary to non-ischemic CRVO may lead to permanent visual defect after treatment.

关键词： central retinal vein occlusion ganglion cellinner plexiform layer optical coherence tomography

Tumor response assessment by the single-lesion measurement per organ in small cell lung cancer

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Chinese Journal of Cancer Research 2016年第2期28卷 161-167页

作者： Soong Goo jung jung Han kim Hyeong Su kim Kyoung ju kim Ik Yang Department of Internal Medicine Kangnam Sacred-Heart HospitalHallym University Medical CenterHallym University College of MedicineSeoulRepublic of Korea Department of Radiation Oncology Kangnam Sacred-Heart HospitalHallym University Medical CenterHallym University College of MedicineSeoulRepublic of Korea Department of Radiology Kangnam Sacred-Heart HospitalHallym University Medical CenterHallym University College of MedicineSeoulRepublic of Korea

Background： The criterion of two target lesions per organ in the Response Evaluation Criteria in Solid Tumors （RECIST） version I. 1 is an arbitrary one, being supported by no objective evidence. The optimal number of target lesions per organ still needs to be investigated. We compared tumor responses using the RECIST 1.1 （measuring two target lesions per organ） and modified RECIST I. 1 （measuring the single largest lesion in each organ） in patients with small cell lung cancer （SCLC）. Methods： We reviewed medical records of patients with SCLC who received first-line treatment between January 2004 and December 2014 and compared tumor responses according to the two criteria using computed tomography. Results： There were a total of 34 patients who had at least two target lesions in any organ according to the RECIST 1.1 during the study period. The differences in the percentage changes of the sum of tumor measurements between RECIST 1.1 and modified RECIST 1.1 were all within 13%. Seven patients showed complete response and fourteen showed partial response according to the RECIST I.I. The overall response rate was 61.8%. When assessing with the modified RECIST 1.1 instead of the RECIST 1.1, tumor responses showed perfect concordance between the two criteria （k= 1.0）. Conclusions： The modified RECIST 1.I showed perfect agreement with the original RECIST 1.I in the assessment of tumor response of SCLC. Our result suggests that it may be enough to measure the single largest target lesion per organ for evaluating tumor response.

关键词： Target lesion Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1) modified Response Evaluation Criteria in Solid Tumors tumor response I.I (modified RECIST 1.1) small cell lung cancer (SCLC)

The plant Mediator and its role in noncoding RNA production

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Frontiers in Biology 2011年第2期6卷 125-132页

作者： Yun ju kim Xuemei CHEN Department of Botany and Plant Sciences and Institute of Integrative Genome Biology University of CaliforniaRiversideCA 92521USA

Mediator,a conserved multiprotein complex in animals,plants,and fungi,is a cofactor of RNA polymerase II(Pol II).It is known to promote basal Pol II-mediated transcription as well as bridge sequence-specific transcriptional regulators and Pol II to integrate regulatory *** II transcribes not only protein-coding genes but also intergenic regions to generate noncoding RNAs such as small RNAs(microRNAs and small interfering RNAs)and long noncoding ***,two plant-specific polymerases,Pol IV and Pol V,have evolved from Pol II and play a role in the production of small interfering RNAs and long noncoding RNAs at heterochromatic regions to maintain genome stability through transcriptional gene silencing(TGS).Recent studies have defined the composition of the plant Mediator and evaluated its role in noncoding RNA production in relationship to Pol II,Pol IV and Pol ***,we review the functions of Mediator and that of noncoding RNAs generated by Pol II,Pol IV and Pol V in plants,and discuss a role of Mediator in epigenetic regulation via noncoding RNA production.

关键词： small RNA noncoding RNA Mediator Pol II Pol IV Pol V