The plant Mediator and its role in noncoding RNA production

作     者：Yun Ju KIM Xuemei CHEN 

作者机构：Department of Botany and Plant Sciences and Institute of Integrative Genome BiologyUniversity of CaliforniaRiversideCA 92521USA 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2011年第6卷第2期

页      面：125-132页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 0836[工学-生物工程] 0713[理学-生态学] 10[医学] 

主　　题：small RNA noncoding RNA Mediator Pol II Pol IV Pol V 

摘      要：Mediator,a conserved multiprotein complex in animals,plants,and fungi,is a cofactor of RNA polymerase II(Pol II).It is known to promote basal Pol II-mediated transcription as well as bridge sequence-specific transcriptional regulators and Pol II to integrate regulatory *** II transcribes not only protein-coding genes but also intergenic regions to generate noncoding RNAs such as small RNAs(microRNAs and small interfering RNAs)and long noncoding ***,two plant-specific polymerases,Pol IV and Pol V,have evolved from Pol II and play a role in the production of small interfering RNAs and long noncoding RNAs at heterochromatic regions to maintain genome stability through transcriptional gene silencing(TGS).Recent studies have defined the composition of the plant Mediator and evaluated its role in noncoding RNA production in relationship to Pol II,Pol IV and Pol ***,we review the functions of Mediator and that of noncoding RNAs generated by Pol II,Pol IV and Pol V in plants,and discuss a role of Mediator in epigenetic regulation via noncoding RNA production.