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MicroRNAs and JAK/STAT3 signaling:A new promising therapeutic axis in blood cancers

Genes & Diseases 2022年第4期9卷 849-867页

作者： Mehdi Sajjadi-Dokht Talar Ahmad Merza Mohamad heshu sulaiman rahman Marwah Suliman Maashi Svetlana Danshina Navid Shomali Saeed Solali Faroogh Marofi Elham Zeinalzadeh Morteza Akbari Ali Adili Ramin Aslaminabad Majid Farshdousti Hagh Mostafa Jarahian Immunology Research Center Tabriz University of Medical SciencesTabriz ***Iran Department of Pharmacology College of PharmacyHawler Medical UniversityErbil 44001Iraq Department of Physiology College of MedicineUniversity of SulaymaniyahSulaymaniyah 46001Iraq Department of Medical Laboratory Sciences Komar University of Science and TechnologySulaymaniyah 46002Iraq Department of Propaedeutics of Dental Diseases I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Department of Immunology Faculty of MedicineTabriz University of Medical SciencesTabriz ***Iran Department of Oncology Tabriz University of Medical SciencesTabriz ***Iran German Cancer Research Center(DKFZ) Toxicology and Chemotherapy Unit(G401)Heidelberg 69120Germany Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre Jeddah 21589Saudi Arabia

Blood disorders include a wide spectrum of blood-associated malignancies resulting from inherited or acquired defects.The ineffectiveness of existing therapies against blood disorders arises from different reasons,one of which is drug resistance,so different types of leukemia may show different responses to treatment.Leukemia occurs for a variety of genetic and acquired reasons,leading to uncontrolled proliferation in one or more cell lines.Regarding the genetic defects,oncogene signal transducer and activator of transcription(STAT)family transcription factor,especially STAT3,play an essential role in hematological disorders onset and progress upon mutations,dysfunction,or hyperactivity.Besides,microRNAs,as biological molecules,has been shown to play a dual role in either tumorigenesis and tumor suppression in various cancers.Besides,a strong association between STAT3 and miRNA has been reported.For example,miRNAs can regulate STAT3 via targeting its upstream mediators such as IL6,IL9,and JAKs or directly binding to the STAT3 gene.On the other hand,STAT3 can regulate miRNAs.In this review study,we aimed to determine the role of either microRNAs and STAT3 along with their effect on one another's activity and function in hematological malignancies.

关键词： Interleukin JAKs Leukemia miRNAs STAT3

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Molecular characterization of sweet potato(Ipomoea batatas[L.]Lam)germplasms for desirable traits by using simple sequence repeats markers

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BIOCELL 2023年第1期47卷 227-237页

作者： KHANDAKAR ABUMDMOSTAFIZAR rahman ABDUL SHUKOR JURAIMI MDREZWAN MOLLA MUHAMMAD ASYRAFMD HATTA ZULKEFLY BIN sulaiman SHAMIMA SULTANA AHMED GABER BENUKAR BISWAS AKBAR HOSSAIN Tuber Crop Research Centre Bangladesh Agricultural Research InstituteGazipur1701Bangladesh Department of Crop Science Faculty of AgricultureUniversiti Putra MalaysiaUPMKuala Lumpur43400Malaysia Plant Genetic Resources Centre Bangladesh Agricultural Research InstituteGazipur1701Bangladesh Department of Agriculture Technology Faculty of AgricultureUniversiti Putra MalaysiaUPMKuala Lumpur43400Malaysia Regional Agricultural Research Station Bangladesh Agricultural Research InstituteCumilla3500Bangladesh Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Agronomy Bidhan Chandra Krishi ViswavidyalayaNadiaWB741252India Division of Agronomy Bangladesh Wheat and Maize Research InstituteDinajpur5200Bangladesh

Every breeding program that aims to create new and improved cultivars with desired traits mostly relies on information related to genetic diversity.Therefore,molecular characterization of germplasms is important to obtain target cultivars with desirable traits.Sweet potato[Ipomoea batatas(L.)Lam]is widely considered the world’s most important crop,with great diversity in morphological and phenotypic traits.The genetic diversity of 20 sweet potato germplasms originating from Bangladesh,CIP,Philippines,Taiwan,and Malaysia were compared,which was accomplished by genetic diversity analysis by exploring 20 microsatellite DNA markers for germplasm characterization and utilization.This information was effective in differentiating or clustering the sweet potato genotypes.A total of 64 alleles were generated using the 20 primers throughout the 20 germplasm samples,with locus IBS97 having the highest number of alleles(5),whereas locus IbU33 had the fewest alleles(2).The alleles varied in size from 105(IbU31)to 213 base pairs(IBS34).The Polymorphism Information Content(PIC)values for the loci IbL46 and IBS97 varied from 0.445 to 0.730.IBS97 has the highest number of effective alleles(3.704),compared to an average of 2.520.The average Shannon’s diversity index(H)was 1.003,ranging from 0.673 in IbU3 to 1.432 in IBS97.The value of gene flow(Nm)varied between 0.000 and 0.005,with an average of 0.003,whereas genetic differentiation(FST-values)ranged between 0.901 and 1.000.The sweet potato germplasm included in this study had a broad genetic base.SP1 vs.SP9 and SP12 vs.SP18 germplasm pairings had the greatest genetic distance(GD=0.965),while SP1 vs.SP2 germplasm couples had the least genetic diversity(GD=0.093).Twenty genotypes were classified into two groups in the UPGMA dendrogram,with 16 genotypes classified as group“A”and the remaining four genotypes,SP10,SP18,SP19,and SP20,classified as group“B.”According to cluster analysis,the anticipated heterozygosity(gene diversity)of Nei(1973)was 0.591 on average.In summary,SSR marker

关键词： Sweet potato Simple sequence repeats(SSRs) Genetic diversity Dendrogram

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Measuring Reliability of A Web Portal Based on Testing Profile

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Computers, Materials & Continua 2023年第3期74卷 6641-6663页

作者： Malik Muhammad Ali Shahid Shahida sulaiman Mohammed Al-Sarem Aqeel Ur rahman Salman Iqbal Rab Nawaz Bashir Arfat Ahmad Khan Momen M.Alrawi Rashiq R.Marie Settawit Poochaya COMSATS University Islamabad Vehari Vehari61100Pakistan Universiti Teknologi Malaysia Johor Bahru81310Malaysia College of Computer Science and Engineering Taibah UniversityMedina41477Saudi Arabia Information System Department Sheba Region UniversityMarib14400Yemen Suranaree University of Technology Nakhon Ratchasima30000Thailand Khon Kaen University Khon Kaen40000Thailand Umm Al-Qura University Mecca24382Saudi Arabia Taibah University Medina42353Saudi Arabia

Conventionally,the reliability of a web portal is validated with generalized conventional methods,but they fail to provide the desired results.Therefore,we need to include other quality factors that affect reliability such as usability for improving the reliability in addition to the conventional reliability testing.Actually,the primary objectives of web portals are to provide interactive integration of multiple functions confirming diverse requirements in an efficient way.In this paper,we employ testing profiles tomeasure the reliability through software operational profile,input space profile and usability profile along with qualitative measures of reliability and usability.Moreover,the case study used for verification is based on aweb application that facilitates information and knowledge sharing among its online members.The proposed scheme is compared with the conventional reliability improvement method in terms of failure detection and reliability.The final results unveil that the computation of reliability by using the traditional method(utilizing failure points with the assistance of Mean Time Between Failures(MTBF)and Mean Time To Failure(MTTF)becomes ineffective under certain situations.Under such situations,the proposed scheme helps to compute the reliability in an effective way.Moreover,the outcomes of the study provide insight recommendations about the testing and measurement of reliability for Web based software or applications.

关键词： Software usability software reliability web portals software testing software testing profile

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Molecular epidemiology of piliated pneumococcal isolates at a major tertiary hospital in the Klang Valley,Malaysia

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Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 80-88页

作者： Nurul Diana Dzaraly Mohd Nasir Mohd Desa Abdulrahman Muthanna Siti Norbaya Masri Niazlin Mohd Taib Nurul Hana Zainal Baharin Nurshahira sulaiman Nurul Asyikin Abdul rahman Navindra Kumari Palanisamy Zarizal Suhaili Semiat Opeyemi Yusuff Nor Iza A.rahman Tuan Suhaila Tuan Soh Fatimah Haslina Abdullah Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaUPM SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaUPM SerdangSelangorMalaysia School of Biology Faculty of Applied SciencesUniversiti Teknologi MARA Negeri SembilanKuala Pilah BranchKuala PilahNegeri SembilanMalaysia Department of Medical Microbiology and Parasitology Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusJalan HospitalSungai BulohSelangorMalaysia School of Animal Science Aquatic Science and EnvironmentFaculty of Bioresources and Food IndustryUniversiti Sultan Zainal AbidinBesut CampusBesutTerengganuMalaysia Faculty of Medicine Universiti Sultan Zainal AbidinJalan Sultan MahmudKuala TerengganuTerengganuMalaysia Department of Pathology Sungai Buloh HospitalJalan HospitalSungai BulohSelangorMalaysia Department of Pathology Sultanah Nur Zahirah HospitalJalan Sultan MahmudKuala TerengganuTerengganuMalaysia

Objective:To characterise a collection of pili-carrying and none pili-carrying pneumococcal isolates of clinical origin for serotypes,antibiotic resistance and genotype.Methods:In total,42 clinical isolates were collected between October 2017 and December 2019.Those isolates were analysed for antimicrobial susceptibility,serotype distribution,detection of pneumococcal virulence and pilus genes.Multilocus sequence typing was performed only for piliated isolates,followed by phylogenetic analysis.Results:The common isolation sites among the pneumococcal isolates were tracheal aspirate(28.6%),blood(26.2%),and sputum(23.8%).Fifty percent isolates were resistant to erythromycin,tetracycline(50.0%)and trimethoprim-sulfamethoxazole(43.0%).The most frequent were serotypes 19F(28.6%),6A/B(23.8%)and 19A(14.3%).Piliated isolates were detected in a small proportion(33.3%);64.3%were multidrug-resistant.ST320 was the prevalent sequence type among the piliated isolates and genetically related to the Pneumococcal Molecular Epidemiology Network clones Taiwan19F-14(CC271).In the phylogenetic analysis,some piliated isolates showed a close association having similar ST320,carrying serotype 19A and both pilus genes indicating their clonal spread.Conclusions:Pneumococcal lineages of piliated isolates have been globally disseminated and pili could have played a role in the spread of antibiotic resistant clones.

关键词： Pneumococci Pili Genotype Malaysia

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Jordan Γ*-Derivation on Semiprime Γ-Ring M with Involution

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Advances in Linear Algebra & Matrix Theory 2016年第2期6卷 40-50页

作者： Ali Kareem Hajar sulaiman Abdul-rahman Hameed Majeed School of Mathematical Sciences Universiti Sains Malaysia Penang Malaysia Department of Mathematics University of Baghdad Baghdad Iraq

Let M be a 2-torsion free semiprime G-ring with involution satisfying the condition that ( and ). In this paper, we will prove that if a non-zero Jordan G*-derivation d on M satisfies for all and , then .

关键词： Γ-Ring M with Involution Jordan Γ*-Derivation Commutative Γ-Ring

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Earnings Management and Fraudulent Financial Reporting： The Malaysian Story

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Journal of Modern Accounting and Auditing 2016年第2期12卷 91-101页

作者： Rashidah Abdul rahman Saliza sulaiman Eiman Saleh Fadel Soheil Kazemian King Abdul Aziz University Jeddah Saudi Arabia Universiti Teknologi MARA (UiTM) Shah Alam Malaysia

Earnings management research has a long and rich history. The agency conflict, incentives, rationalization, opportunity plus having the capability among the managers to manipulate the financial statements lead them to commit fraud. The loopholes in the standards or the deviation from real operational activities promote this situation to prolong. In relation to this issue, this study examines the earnings management behavior among fraud firms in Malaysia. Further, this study examines the relationship between accruals earnings management as a proxy variable for discretionary accruals and real earnings management as the proxy variable for discretionary cash flow. Sample of 57 alleged fraud firms was selected based on the fraudulent financial reporting offences announced in Bursa Malaysia website. The sample data are collected from public firms which committed fraud from 2001 to 2013. This study found a significant negative relationship between accruals earnings management and real earnings management among the fraud firms in Malaysia suggesting that these firms aggressively manage earnings downwards or upwards essentially to avoid regulators scrutiny apart from aiming to achieve personal incentives. The study significantly finds evidence that fraud firms manage earnings on a sequential basis between accruals earnings management and real earnings management prior to fraud year. The findings indicate that firms opt for real earnings management and make full use of its distinguished features of not easily traceable to continue managing earnings immediately subsequent to fraud year. This study may assist regulators, auditors, and policymakers to curb earnings management patterns that have high likelihood of becoming part of fraud antecedent.

关键词：会计审计方法技术

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Genetic population structure of red snapper(Lutjanus malabaricus)and orange-spotted grouper(Epinephelus coiodes)in Brunei and Sabah

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Integrative Zoology 2008年第3期3卷 208-215页

作者： Zohrah H.sulaiman Khadijah H.ABDUL rahman Teo Y.YING Hussein H.TAHA NurQistina H.MUHD TAHA Department of Biology Faculty of ScienceUniversity Brunei DarussalamJalan Tungku LinkGadongBrunei Darussalam

The genetic population structure of red snapper Lutjanus malabaricus and orange-spotted grouper Epinepheluscoiodes in Brunei and Sabah was investigated using allozyme electrophoresis. Samples were collected from threesites in Brunei for E. coiodes and from three sites in Brunei and Sabah for L. malabaricus. A total of 22 loci and 16loci were scored, respectively. The index of fixation (FST) for the E. coiodes population was 0.176 but, in general, itlacked within-population structuring. The FST was particularly high between Brunei Bay/Jerudong and Brunei Bay/Kuala Belait, suggesting genetic subdivision on a small spatial scale. Isolation of Brunei Bay from the South ChinaSea may constrain the movement of adult fishes and larval dispersal, thereby reducing homogeneity amongsubpopulations. All variable loci for E. coiodes were in Hardy–Weinberg equilibrium except for MDH* and GTDHP*(P < 0.01), in which two subpopulations showed an excess of heterozygotes (P < 0.01). The study on the L.malabaricus population showed a heterozygote deficit of approximately 60% in variable loci (FIS, genetic variationwithin population = 0.45;P < 0.05);however, the mean observed heterozygosity for the population far exceeded L.malabaricus populations in Australia and Indonesia. A FST value of 0.076 revealed moderate genetic differentiationamong subpopulations of L. malabaricus. The genotypes were likely to be drawn from the same distribution inJerudong and Kuala Belait. This study infers that sustainable management of snapper and grouper resources inBrunei waters must take into account the presence of a single stock and two stocks, respectively.

关键词： allozymes fishery resource genetic structure of fish grouper snapper

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