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Trends in the hyperfine interactions of magnetic adatoms on thin insulating layers

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npj Computational Materials 2021年第1期7卷 787-796页

作者： Sufyan Shehada Manuel dos santos Dias filipe Souza Mendes Guimarães Muayad Abusaa Samir Lounis Peter Grünberg Institut and Institute for Advanced Simulation Forschungszentrum Jülich&JARAJülichGermany Department of Physics RWTH Aachen UniversityAachenGermany Jülich Supercomputing Center Forschungszentrum Jülich&JARAJülichGermany Department of Physics Arab American UniversityJeninPalestine Faculty of Physics University of Duisburg-Essen&CENIDEDuisburgGermany

Nuclear spins are among the potential candidates prospected for quantum information technology.A recent breakthrough enabled to atomically resolve their interaction with the electron spin,the so-called hyperfine interaction,within individual atoms utilizing scanning tunneling microscopy(STM).Intriguingly,this was only realized for a few species put on a two-layers thick ***,we systematically quantify from first-principles the hyperfine interactions of the whole series of 3d transition adatoms deposited on various thicknesses of MgO,NaF,NaCl,h–BN,and Cu2N *** identify the adatom-substrate complexes with the largest hyperfine interactions and unveil the main trends and *** reveal the core mechanisms at play,such as the interplay of the local bonding geometry and the chemical nature of the thin films,which trigger transitions between high-and low-spin states accompanied with subtle internal rearrangements of the magnetic *** providing a general map of hyperfine interactions,our work has immediate implications in future STM investigations aiming at detecting and realizing quantum concepts hinging on nuclear spins.

关键词： quantum utilizing breakthrough

Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring

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Neural Regeneration Research 2019年第3期14卷 491-500页

作者： Christiano Spindler Ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza filipe Mega Gabriela dos santos Salvalaggio Matilde Achaval Viviane Rostirola Elsner Simone Marcuzzo Programa de Pos-Graduacao em Neurociencias Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Laboratorio de Histofisiologia Comparada Departamento de Ciencias Morfologicas Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Programa de Pos-Graduacao em Biociências e Reabilitacao Centro Universitario Metodista-IPA

It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear.

关键词： epigenetics preconception methylation learning treadmill running fetal programming inheritance sperm nerve regeneration

Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives

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World Journal of Clinical Pediatrics 2022年第2期11卷 105-119页

作者： Maria Luísa Cordeiro santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito filipe Antônio França da Silva Hanna santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use.

关键词： Functional abdominal pain disorder Pediatrics Rome IV Behavioral intervention Nonpharmacological treatment Complementary medicine

Mining Contribution to Municipalities Development

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Journal of Environmental Science and Engineering(B) 2017年第8期6卷 436-442页

作者： Jose Aroudo Mota Jose Emanoel de Carvalho Nazairio Jorge filipe dos santos Jose oswaldo Siqueira Paulo Cesar Horta Moreira ITV （Vale Institute of Technology） Belem 66055-090 Brazil Ferrosos Norte Vale S. A. Parauapebas 68515-000 Brazil

Mining activity in Brazil has significantly contributed to the country development. However, this contribution is not always fully noticed by society. This study aims to bring more evidence to this mining activity contribution, based on highly regarded development indicators, such as the HDI （Human Development Index）, created by the UNDP （United Nations Development Programme）. The HD1 was traditionally designed as an instrument to evaluate the degree of countries development and was subsequently deployed to states and municipalities （IDHM （Municipal Human Development Index） for Brazilian municipalities）. In addition to lDHM released by the UNDP, FIRJAN （Federation of the Industries of the State of Rio de Janeiro） developed its own IFDM （FIR JAN Municipal Development Index）. The statistical analysis shows that the average of the municipalities with mining activities has superior development indices than those with non-mining activities, especially in the two major mining states： Minas Gerais and Parfi.

关键词： Mineral activity human development 1DHM (Municipal Human Development Index) IFDM (F1RJAN MunicipalDevelopment Index).

Nephrotoxicity in cancer treatment:An overview

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World Journal of Clinical Oncology 2020年第4期11卷 190-204页

作者： Maria Luísa Cordeiro santos Breno Bittencourt de Brito filipe Antonio FranÇa da Silva Anelise Costa dos santos Botelho Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil

Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer *** kidney is an important elimination pathway for many antineoplastic drugs and their metabolites,which occurs by glomerular filtration and tubular *** agents,both conventional cytotoxic agents and molecularly targeted agents,can affect any segment of the nephron including its microvasculature,leading to many clinical manifestations such as proteinuria,hypertension,electrolyte disturbances,glomerulopathy,acute and chronic interstitial nephritis,acute kidney injury and at times chronic kidney *** clinician should be alert to recognize several factors that may maximize renal dysfunction and contribute to the increased incidence of nephrotoxicity associated with these drugs,such as intravascular volume depletion,the associated use of nonchemotherapeutic nephrotoxic drugs(analgesics,antibiotics,proton pump inhibitors,and bonetargeted therapies),radiographic ionic contrast media or radiation therapy,urinary tract obstruction,and intrinsic renal *** of patients at higher risk for nephrotoxicity may allow the prevention or at least reduction in the development and severity of this adverse ***,the aim of this brief review is to provide currently available evidences on oncologic drug-related nephrotoxicity.

关键词： Acute kidney injury Cancer Chemotherapy Conventional cytotoxic agents Molecularly targeted agents Nephrotoxicity

Neurocognitive Disorders in Patients with HIV Infection with Virologic Suppression for More than 10 Years

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World Journal of AIDS 2017年第1期7卷 59-66页

作者： André filipe dos santos-Silva Joana Margarida Almeida Alves Isabel Ramos Maria del Cármen Piñ eiro-Calvo Cláudia sousa Maria do Rosário Serrã o António Carlos Eugénio Megre Sarmento Infectious Diseases Department S&atilde o Joã o Hospital Centre Oporto Portugal Faculty of Medicine of the University of Oporto Oporto Portugal Psychiatry and Mental Health Department S&atilde o Joã o Hospital Centre Oporto Portugal Neurology Department S&atilde o Joã o Hospital Centre Oporto Portugal

Background: HIV-associated neurocognitive disorder (HAND) may appear in patients with viral and immunological response to treatment and remain unnoticed during the initial stage of the infection. The goal of this study is to evaluate the development and/or progression of HAND in patients with undetectable viral load for more than ten years. Methods: We included adult HIV-infected patients who were under antiretroviral treatment and had undetectable plasma viral load for more than ten years (blips were included). These patients had already been subjected to neurocognitive evaluation five years previously. Demographic, clinical and analytical data were analysed. For the neurocognitive evaluation, the WAIS-III subtests (digit symbol coding and symbol search), trail making test (TMT) A and B, Stroop test and categorical verbal fluency (animals) tests were used. SPSS??version 22.0 for Windows was used for statistical analysis. Results: In this re-evaluation, performed 4.76 (±1.82) years after the first one, 9 (36%) patients showed deficits in processing speed (WAIS-III and TMT A), 8 (32%) executive function (TMT B and Stroop) and 12 (48%) verbal fluency. There were significant statistical differences between the past and current executive function tests (p = 0.029 and p = 0.01), highlighting worsening of deficits. No differences were found for the other tests. No association was found between deficit progression and the studied variables. Conclusions: Although not generally noticed on regular appointments, in this small population, worsening of executive function deficits (mental flexibility and divided attention) was found. Classical risk factors for HAND did not appear to interfere in its progression. Speed of information processing and categorical verbal fluency remained stable.

关键词： HIV HAND Dementia Impairment

Creativity and innovation:A contribution of behavioral economics

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International Journal of Innovation Studies 2019年第1期3卷 12-21页

作者： Jose Chavaglia Neto Jose Antonio filipe Antonio Bento Caleiro Fundacao Getulio Vargas(EESP-FGV) Itapeva StreetSao Paulo01332-000Brazil Instituto Universitario de Lisboa(ISCTE-IUL) Information SciencesTechnologies and Architecture Research Center(ISTAR-IUL)Business Research Unit-IUL(BRU-IUL)Lisbon1649-026Portugal Departamento de Economia Universidade de EvoraLargo Dos Colegiais2Evora7002-554Portugal

Innovation in products and services is seen by scholars,by specialized media in management,and by some managers as the main currency in modern *** is because it allows high average market profits,fame for innovators,or brand growth,for ***,in practice,most managers still treat innovation as a secondary issue on their *** problem results from the inability of market professionals to analyze people inside and outside their *** is not possible to develop innovative products in a systematic way without treating this point ***,in this process,creativity is a necessary,but not necessarily sufficient,condition to be fulfilled and requires behavioral *** this context,it is believed that behavioral economics can make a sufficient contribution in the form of an analytical marketing tool by offering an analysis closer to human beings'reality,and,thus,allow a better understanding of people's behavior in the process of innovation in the market.

关键词： Behavioral economics Neuroeconomics Innovation Creativity

Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

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Bioactive Materials 2023年第11期29卷 151-176页

作者： filipe V.Ferreira Alana G.Souza Rubina Ajdary Lucas P.de Souza Jo˜ao H.Lopes Daniel S.Correa Gilberto Siqueira Hernane S.Barud Derval dos S.Rosa Luiz H.C.Mattoso Orlando J.Rojas Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa Instrumentation-Rua XV de Novembro1452S˜ao CarlosSP13560-979Brazil Center for Engineering Modelingand Applied Social Sciences(CECS)Federal University of ABC(UFABC)Santo Andr´eBrazil Department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityP.O.Box 16300AaltoEspooFIN-00076Finland College of Engineering and Physical Sciences Aston Institute of Materials ResearchAston UniversityBirminghamUK Department of Chemistry Division of Fundamental Sciences(IEF)Technological Institute of Aeronautics(ITA)S˜ao Jose dos CamposSPBrazil Laboratory for Cellulose&Wood Materials Empa-Swiss Federal Laboratories for Materials Science and TechnologyÜberlandstrasse 1298600DübendorfSwitzerland Biopolymers and Biomaterials Laboratory(BIOPOLMAT) University of Araraquara(UNIARA)Araraquar114801-340S˜ao PauloBrazil Bioproducts Institute Department of Chemical&Biological EngineeringDepartment of Chemistry andDepartment of Wood ScienceThe University of British Columbi12360 East MallVancouverBCV6T 1Z3Canada

We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure-property-function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

关键词： Cellulose nanofibrils Cellulose nanocrystals Regenerative medicine Biomaterial Sustainable materials Green nanomaterials

The Assessment of Medical Students’ Chronotypes

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World Journal of Neuroscience 2017年第3期7卷 275-281页

作者： José Reinaldo Maximo Gomes Fátima Karine Ferreira santos Isaac filipe Melo de Freitas Ilma Ferreira de Oliveira Hete Aguida dos santos José Cláudio da Silva Janise Dal Pai Lysien Ivania Zambrano Euclides Mauricio Trindade Filho Milton Vieira Costa Laboratório de Neurociência e comportamento Universidade Estadual de Ciências da Saúde de Alagoas—UNCISAL Maceió Brazil Universidade Nove de Julho (UNINOVE) S&atilde o Paulo Brazil Facultad de Ciencias Medicas Universidad Nacional Autónoma de Honduras Tegucigalpa Honduras

Objective: This study aimed to investigate the circadian typology of medical students at public universities from one of the northeastern states in Brazil, active in the morning and afternoon shifts, checking the compatibility between their study time, productivity, income and chronotype. Methods: To obtain the results, the assessment of the chronotype in 342 medical students of both sexes was considered. Each participant was submitted to the questionnaire developed by Horne and Ostberg, adapted by Cardinali, Colomberk and Rey. It’s composed of 9 questions, providing the general ranking of each individual. Based upon scored, the chronotypes were classified. Results: The sample was composed of 49.12% (168) male and 50.87% (174) female subjects, a similar gender distribution of enrolled students during data collection time. By applying the questionnaire, the prevalent rating among the medical students as moderately morning (29.82%) and intermediate (43.85%) has been relevant. The academic performance assessment in two morning-intermediate groups (8.16) had no significant distance from others considered afternoon active (8.20). Conclusion: The health sciences student, especially Medicine, faces constant adaptation of scheduling, in the attempt of fulfilling the requirements throughout the course, causing chronogram desynchronization effects and forced readaptation to each different school semester.

关键词： Circadian Rhythm Chronobiology Disorders Delivery of Health Care Medicine Sleep Disorders