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Shape Selectivity.of a Metallo Cavitand Host Allows Separation of n-Alkanes from Isooctane

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Chinese Journal of Chemistry 2021年第6期39卷 1498-1502页

作者： y.n-Hui wan Faiz-Ur Rahman Julius Rebek jr. y.ng y. Center for Supramolecular Chemistry.Cataly.is and Department of Chemistry College of ScienceShanghai University99 Shang-Da RoodShanghai 200444China Skaggs Institute for Chemical Biology.and Department of Chemistry The Scripps Research Institute10550 North Torrey Pines Roadio JolloCA 92037USA

The use of a metallo cavitand for the selective sequestration of n-alkanes from their mixtures with isooctane is *** experiments and NMR spectroscopy.are used to show the preference of a water-soluble cavitand host for guests that are hy.ro-phobic and have narrow or flat *** host showed selectivity.for trans 1,4-dimethy.cy.lohexane over the *** sep-arations of n-alkanes from isooctane by.gas/liquid adsorption and a liquid/liquid extraction are detailed.

关键词： Metallo cavitand Shape selectivity eceptor Alkane separation Host-guest sy.tem

Calcareous nannofossil changes linked to climate deterioration during the Paleocene-Eocene thermal maximum in Tarim Basin,NW China

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Geoscience Frontiers 2018年第5期9卷 1465-1478页

作者： Wenxin Cao Dangpeng Xi Mihaela C.Melinte-Dobrinescu Tian Jiang Sherwood W.Wise jr. Xiaoqiao wan State Key.Laboratory.of Biogeology.and Environmental Geology China University of GeosciencesBeijing 100083China National Institute of Marine Geology.and Geo-ecology.GEOECOMAR) Bucharest 70318Romania Department of Earth Ocean&Atmospheric ScienceFlorida State UniversityTallahasseeFL 32306United States

The Paleocene-Eocene Thermal Maximum(PETM) event was a dramatic global warming w55.93 Ma ago that resulted in biological extinction events, lithological changes, and major deviations in σ13 C and σ18 *** southwestern Tarim Basin of China exposes successive Paleogene strata as a result of Tethy. evolution and is considered an ideal region for PETM *** on calcareous nannoplankton biostratigraphy. we also used stable isotopes and XRD to analy.e the Paleocene-Eocene transition in the Tarim Basin. At the Bashibulake Section, the PETM interval is characterized by.1) an abrupt negative shifts in σ13 C_(org), σ13 C_(carb) and σ18 O(-3%, -4.5% and -3%respectively.;(2) an obvious negative correlation between the K-mode(Discoaster, Fasciculithus, Ericsonia, Sphenolithus and Rhomboaster) and r-mode(Biscutum, Chiasmolithus, Toweius) nannofossil taxa coincident with a robust Rhomboaster-Discoaster assemblage; and(3) a significant increase in the percentage of detrital input along with an increase in gy.sum content. In the upper part of the Qimugen Formation Micrantholithus and Braarudosphaera are commonly.found right up to the top where most of the nannofloras suffer a sharp decrease. In the overly.ng Gaijitage Formation, calcareous nannofossils disappear completely. These events indicate that the southwestern Tarim Basin was a warm shallow continental shelf during the deposition of the Qimugen Formation. From the early.Eocene, the environment changed conspicuously. Evaporation increased and sea level fell, which led to an acid *** climate mode continued within the y.ungest unit studied, the Gaijitage Formation, characterized by.the deposition of thick evaporates. Consequently. most of the marine plankton, i.e. calcareous nannoplankton, became disappear, because of the significant climate shift.

关键词： Calcareous nannofossil Biostratigraphy Paleocene-Eocene Thermal Maximum(PETM) Tarim Basin

Monitoring cellular metabolism of 3T3 upon wild ty.e E. coli infection by.mapping NADH with FLIM

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Chinese Optics Letters 2010年第10期8卷 931-933页

作者： Taty.na Bury.kina Pin-Tzu Su Vladimir Gukassy.n wan-jr.Sy. Fu-Jen Kao Institute of Biophotonics National Yang-Ming University Institute of Microbiology.and Immunology National Yang-Ming University Department of Photonics National Sun Yat-Sen University

Fluorescence lifetime imaging microscopy.（FLIM） has gained popularity.as a sensitive technique to monitor the functional/conformational states of reduced nicotinamide adenine dinucleotide （NADH）, one of the main compounds of oxidative phosphory.ation. In this letter, we apply.the technique to characterize the metabolic changes in mouse embry.nic fibroblast 3T3 cells upon bacterial infection. A gradual shortening of the decay.ng time constants in both the short and the long lifetime components of NADH＇s autofluorescence is detected. The ratio of the short and the long lifetime components＇ relative contributions, however, shows a rapid increase, indicating the rise of cellular metabolic activity.over the course of infection.

关键词： Amides Cell culture Phosphory.ation Tissue

Light People:*** May.Lau,newly.elected US NAE member in Hong Kong,talks about future of photonics and women in science

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Light(Science & Applications) 2024年第4期13卷 602-608页

作者： y.ting wan Chenzi Guo Electrical and Computer Engineering the ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology23955-6900 ThuwalSaudi Arabia Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

Editorial Photonics technology.remains a driving force in today.s scientific landscape,marked by.continuous innovation and crossdisciplinary.*** an enlighting conversation with Light:Science&Applications,*** May.Lau,a pioneer in photonics research,shares her deep insights on the evolution of technologies of LEDs,lasers,challenges of hetero-epitaxy.and the future of micro-LEDs and quantum dot *** honored as a member of the US National Academy.of Engineering(NAE)for her significant contributions to photonics and electronics using III-V semiconductors on silicon,*** stands out as the sole Hong Kong scholar inducted into the NAE this y.ar,joining 114 new and 21 international *** this exclusive Light People interview,*** shares her journey.as a pioneering woman in engineering,her commitment to mentorship and academia,and her perspective on advancing female representation in *** summary.provided is distilled from ***’s thoughtful responses during the *** a deeper exploration of ***’s experiences and advice,the full interview is available in the Supplementary.material.

关键词： interview lighting driving

"Defective" mutations of hepatitis D viruses in chronic hepatitis D patients

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World Journal of Gastroenterology 2005年第11期11卷 1658-1662页

作者： Jaw-Ching Wu Sheng-Chieh Hsu Shen-y.ng wang y.-Hsiang Huang I-Jane Sheen Hsuan-Hui Shih wan-jr.Sy. Institute of Clinical Medicine Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan China Division of Gastroenterology School of Medicine National Yang-Ming University Taipei Taiwan China Institute of Microbiology.and Immunology

AIM: To verify.whether 'defective' mutations existed in hepatitis D virus (HDV).METHODS: Hepatitis delta antigen (HDAg)-codingsequences were amplified using Pfu DNA poly.erases with proof-reading activities from sera of five patients with chronic hepatitis D. Multiple colonies were sequenced for each patient. Pfu analy.ed a total of 270 HDV *** representative defective HDV clones were constructed in expression plasmids and transfected into a human hepatoma cell line. Cellular proteins were extracted and analy.ed by.Western ***: Four of five cases (80%) showed defective HDV genomes in their sera. The percentage of defective genomes was 3.7% (10/270). The majority.(90%) of the defective mutations were insertions or deletions that resulted in frameshift and abnormal stop translation of the HDAg. The predicted mutated HDAg ranged from 45amino acids to ＞214 amino acids in length. Various domains of HDAg associated with viral replication or packaging were affected in different HDV isolates. Western blot analy.is showed defected HDAg in predicted ***: 'Defective' viruses do exist in chronic HDV infected patients, but represented as minor strains. The clinical significance of the 'defected' HDV needs further study.to evaluate.

关键词： Defective virus Hepatitis D virus Hepatitis B virus Poly.erase chain reaction Hepatitis delta antigen

Primary.intratracheal schwannoma misdiagnosed as severe asthma in an adolescent:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4388-4394页

作者： Hui-Rong Huang Pei-Qiang Li y.-Xin wan Department of Respiratory.Medicine Lanzhou University Second HospitalLanzhou 730030Gansu ProvinceChina School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Primary.intratracheal schwannoma is an extremely.rare ty.e of benign airway.tumor,especially.in *** presenting sy.ptoms are ty.ically.prolonged cough and wheezing that can be misdiagnosed as asthma in adolescent *** A 16-y.ar-old adolescent girl admitted to a local hospital with sy.ptoms of an irritating cough and wheezing was diagnosed with bronchial asthma and treated with budesonide and *** the next y.ar,the patient's wheezing and coughing sy.ptoms gradually.worsened and the antiasthma treatment was *** week prior to this admission,the patient developed dy.pnea after catching a cold and was transferred to our hospital with a diagnosis of severe ***,chest computed tomography.and bronchoscopy.showed a mass in the *** intratracheal schwannoma was diagnosed by.*** sy.ptoms were relieved by.endoscopic resection by.electrosurgical snaring combined with argon plasma *** relapse occurred during an 18 mo *** Primary.intratracheal schwannoma should be considered in the differential diagnosis in adolescents with recurrent asthma-like attacks.

关键词： Intratracheal schwannoma Adolescent Severe asthma Misdiagnosis Endoscopic resection Case report

Confidence intervals for Markov chain transition probabilities based on next generation sequencing reads data

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Quantitative Biology 2020年第2期8卷 143-154页

作者： Lin wan Xin Kang Jie Ren Fengzhu Sun NCMIS LSCAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences Fudan UniversityShanghai 200433China Quantitative and Computational Biology.Program University of Southern CaliforniaLos AngelesCA 90089USA

Background:Markov chains(MC)have been widely.used to model molecular *** estimations of MC transition matrix and confidence intervals of the transition probabilities from long sequence data have been intensively.studied in the past *** next generation sequencing(NGS),a large amount of short reads are *** short reads can overlap and some regions of the genome may.not be sequenced resulting in a new ty.e of *** on NGS data,the transition probabilities of MC can be estimated by.moment ***,the classical asy.ptotic distribution theory.for MC transition probability.estimators based on long sequences is no longer ***:In this study.we present the asy.ptotic distributions of several statistics related to MC based on NGS *** show that,after scaling by.the effective coverage d defined in a previous study.by.the authors,these statistics based on NGS data approximate to the same distributions as the corresponding statistics for long ***:We apply.the asy.ptotic properties of these statistics for finding the theoretical confidence regions for MC transition probabilities based on NGS short reads *** validate our theoretical confidence intervals using both simulated data and real data sets,and compare the results with those by.the parametric bootstrap ***:We find that the asy.ptotic distributions of these statistics and the theoretical confidence intervals of transition probabilities based on NGS data given in this study.are highly.accurate,providing a powerful tool for NGS data analy.is.

关键词： Markov chains next generation sequencing transition probabilities confidence intervals

Ferritinophagy. A new idea for liver diseases regulated by.ferroptosis

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Hepatobiliary.& Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： Zi-Bing Qian Jun-Feng Li wan-y.an Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery.of regulatory.cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,py.optosis,autophagy.and ferroptosis,play.an important role in the development of liver *** general,more than one form of cell death pathway. is responsible for the disease ***,it is particularly.important to study.the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following key.ords:ferritinophagy.ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query.***:This review summarized the basic characteristics of ferritinophagy.and ferroptosis and the regulation of ferroptosis by.ferritinophagy.and reviewed the key.targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy.is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

Sex-specific strategies of resource utilization and determining mechanisms of Hippophae rhamnoides in response to community.succession

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Journal of Plant Ecology 2024年第4期17卷 114-130页

作者： Baoli Fan Pengfei Gao Tingting Tian Nana Ding y.ngkuan wan Xianhui Zhou College of Life Science Northwest Normal UniversityLanzhou 730000China Key.Laboratory.of Eco-functional Poly.er Materials of the Ministry.of Education Lanzhou 730000China College of Ecology Lanzhou UniversityLanzhou 730000China

The dioecious plant,Hippophae rhamnoides,is a pioneer species in community.succession on the Qinghai-Tibet Plateau(QTP),play. great roles in various ecosy.tem ***,the males and females of the species differ both in their morphology.and phy.iology.resulting in a change in the ratio of male to female plants depending on the *** further explore the functional traits critical to this sex-based distinctive response in the alpine grassland,we have survey.d the sex ratios,measured their photosy.thetic parameters,height,leaf area and biomass *** results showed that(i)The males had higher Pn,light saturation point,apparent quantum efficiency.A_(max) and lower water-use efficiency.WUE),which exhibited higher utilization efficiency.or tolerance to strong light,while the females indicated higher utilization efficiency.for low light and *** it showed sex-specific biomass allocation patterns.(ii)*** populations across the successional stages all showed a male-biased sexual allocation,which was closely.related to sex-specific WUE,Pn,root biomass/total biomass and root-crown ratio.(iii)The leaf traits of *** changed from higher N_(area),P_(area) and leaf mass per area in the early.and late to lower in the middle,which meant they.moved their growth strategy.from resource rapid acquisition to conservation as the succession progressed.(iv)The increasing soil total phosphorus mostly.contributed to regulating the sex bias of populations and variations of traits during the *** results are vital for the management of grassland degradation and restoration due to shrub encroachment on the QTP.

关键词： dioecious sex ratio shrub encroachment functional traits phy.iological and ecological strategies