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通过13N-NH3 PET检测冠脉血流储备和相对血流储备以诊断冠心病

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中华核医学与分子影像杂志 2017年第10期37卷 672-672页

作者：顾佳唐军苏州大学医学部放射医学与防护学院 215123 苏州大学附属第二医院核医学科 215004

目的使用13N-NH，PET显像检测冠脉血流储备（CFR）和相对血流储备（RFR），分析两者之间的关系以诊断冠心病。方法69例稳定性心绞痛患者在2周内接受13N—NH，PET显像和cT冠脉造影（CTA），必要时还行介入冠脉造影（CAG）。通过13N-NH，... 详细信息

目的使用13N-NH，PET显像检测冠脉血流储备（CFR）和相对血流储备（RFR），分析两者之间的关系以诊断冠心病。方法69例稳定性心绞痛患者在2周内接受13N—NH，PET显像和cT冠脉造影（CTA），必要时还行介入冠脉造影（CAG）。通过13N-NH，PET显像检测心肌血流（MBF）、CFR、RFR和相关冠脉供血区域的冠脉血管阻力（CVRref）。采用CTA和CAG评价冠脉明显狭窄（SS）和弥漫性动脉粥样硬化（DA）。比较有和无SS和DA的各冠状动脉的PET检测功能参数。结果有SS和DA的冠状动脉其负荷态MBF显著降低，有SS的冠脉其RFR显著降低，而CFR没有降低。有DA的冠脉其CFR显著降低，而RFR没有降低。在没有SS的冠脉中，有DA的其CFR显著降低，但在有SS的冠脉中，无论有无DA，CFR都相近。相反，无论有无DA，存在SS的冠脉其RFR显著降低。CFR和RFR在24例中（35％）呈不一致的弱正相关性（r=0．269）。在CFR和RFR不一致的冠脉中，CFR降低而RFR正常的冠脉其DA的发生率高于CFR正常而RFR降低的冠脉（75％比25％，P=0．028）。有DA的冠脉其CVR。显著升高，表明DA与潜在的微血管病变具有相关性。结论心肌血流灌注PET显像测定CFR和RFR为诊断CAD提供了更丰富的信息。

关键词：冠心病正电子发射断层显像术冠脉血流储备相对血流储备

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高素质质量专业人士能够度过难关

中国认证认可 2009年第12期 29-29页

作者：亨利·J·林德博格（henry J·lindborg）赵春玲（译）许薇莉（译）

没有哪一个行业可以幸免。制造、IT、金融、医疗卫生、教育、出版和零售业都在受到经济衰退的影响。对于许多人来说，找工作不再是职业发展的一个选择，要紧的是如何保住饭碗。在这种严峻的生存形势下，我们该如何作为，该如何制定自己... 详细信息

没有哪一个行业可以幸免。制造、IT、金融、医疗卫生、教育、出版和零售业都在受到经济衰退的影响。对于许多人来说，找工作不再是职业发展的一个选择，要紧的是如何保住饭碗。在这种严峻的生存形势下，我们该如何作为，该如何制定自己的就业和职业策略？

关键词：专业人士质量素质医疗卫生经济衰退零售业职业金融

胶质母细胞瘤的基因测绘和生存期预测:血流动力学成像生物标志物强化的分子亚型

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国际医学放射学杂志 2013年第3期 279-279页

作者： R.Jain l.Poisson J.Narang D.Gutman l.Scarpace S.N.Hwang 陈超 Division of Neuroradiology Department of RadiologyDepartment of Neurosurgeryand Department of Public Health SciencesHenry Ford Health System

目的使用动态磁敏感T2*加权增强MR成像序列进行脑灌注检查,研究胶质母细胞瘤(GBM)肿瘤血容量和病人生存率的关系,并确定其分子亚类。材料与方法此研究遵从HIPAA回顾性研究的要求并获得机构审查委员会的批准。50例病人进行动态磁敏感对... 详细信息

目的使用动态磁敏感T2*加权增强MR成像序列进行脑灌注检查,研究胶质母细胞瘤(GBM)肿瘤血容量和病人生存率的关系,并确定其分子亚类。材料与方法此研究遵从HIPAA回顾性研究的要求并获得机构审查委员会的批准。50例病人进行动态磁敏感对比增强T2*加权MR灌注成像检查,并从癌症基因组图谱中找到基因表达数据。测定强化病灶的相对脑血容量(rCBV)[最大rCBV(rCBVmax),平均rCBV(rCBVmean)]和非强化灶的相对脑血容量(rCBVNEl)。病人通过Verhaak和Phillips分类模式进行分类,这是基于相似性来定义基因表达信号。通过Cox回归分析rCBV测量数据及分子亚类与病人的总体生存时间的关系。结果 4个Verhaak亚类和3个Phillips亚类,对比增强病变的rCBVmax、rCBVmean或无强化灶的rCBVNEl均无显著的统计学差异。然而rCBV增加与GMS较差的生存期有相关性。无论潜在的混杂因素或分子亚类,rCBVmax(P=0.0131)是最强的生存期预测因子。尤其是作为预测因素,GBMVerhaak分子分类中的rCBVmean与单独的rCBVmean(危险比:1.25,P=0.1918)比较,前者与病人总生存期相关(危险比:1.46,P=0.0212)。Phillips分子亚类既不能作为预测总生存期的因素,也不对rCBV的预测生存期的能力产生影响。结论 rCBVmax可作为独立预测病人总生存期的因素使用,与GBM分子的亚类无关。但是,Verhaak分类提供了额外的信息,表明在未来分子标记物可以和血流动力学成像的生物标志物联合使用。

关键词：生存期病人分子亚类胶质母细胞瘤血流动力生物标志物

Improved measurement of the reactor antineutrino flux and spectrum at Daya Bay

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Chinese Physics C 2017年第1期41卷 11-46页

作者：安丰鹏 A.B.Balantekin H.R.Band M.Bishai S.Blyth 曹德文曹国富曹俊岑吴镕陳日朗常劲帆張立楚张昀陈和生陈泉佑陈少敏陈义学陈羽程佳樺程捷程雅苹成兆侃 J.J.Cherwinka 朱明中 A.Chukanov J.P.Cummings J.de Arcos 邓子艳丁雪峰丁雅韵 M.V.Diwan M.Dolgareva J.Dove D.A.Dwyer W.R.Edwards R.Gill M.Gonchar 龚光华宫辉 M.Grassi 顾文强关梦云郭磊郭如盼郭新恒郭子溢 R.W.Hackenburg 韩然 S.Hans 何苗 K.M.Heeger 衡月昆 A.Higuera Y.K.Hor 熊怡胡貝禎胡涛胡维黄恩泉黄翰雄黄性涛 P.Huber 霍文驹 G.Hussain D.E.Jaffe P.Jaffke 任國綸 S.Jetter 季向盼季筱璐焦健斌 R.A.Johnson D.Jones J.Joshi 康丽 S.H.Kettell S.Kohn M.Kramer 關健强郭文伟郭天能 T.J.langford K.lau l.lebanowski J.lee 李曉菁雷瑞庭 R.leitner 李超李登杰李飞李高嵩李秋菊黎山峰 S.C.li 李卫东李小男李玉峰李志兵梁昊林政儒林贵林林盛鑫林士凱林禹丞凌家杰 J.M.link l.littenberg B.R.littlejohn 刘大为刘江来刘金昌 C.W.loh 陆昌国路浩奇陆稼书陆锦标吕志鹏马秋梅马晓妍马续波马宇倩 Y.Malyshkin D.A.Martinez Caicedo K.T.McDonald R.D.McKeown I.Mitchell M.Mooney Y.Nakajima J.Napolitano D.Naumov E.Naumova 倪浩然宁哲 J.P.Ochoa-Ricoux A.Olshevskiy 潘孝儒 J.Park S.Patton V.Pec 彭仁杰 l.Pinsky 潘振声齐法制祁鸣钱鑫 N.Raper 任杰 R.Rosero B.Roskovec 阮锡超 H.Steiner 孙功星孙吉良唐炜 D.Taychenachev K.TVeskov K.V.Tsang C.E.Tull N.Viaux B.Viren V.Vorobei 王正祥王萌王乃彦王瑞光王为王玺王贻芳王喆王铮王志民魏瀚宇温良剑 K.Whisnant C.G.White l.Whitehead T.Wise 黄显诺黄振辉 E.Worcester 吳珈豪吴群吴文杰夏冬梅夏经凯邢志忠徐建一徐吉磊徐晔薛涛杨长根杨海波杨雷阳马生杨梦婷叶梅 Z.Ye 叶铭芳杨炳麟于泽源曾珊占亮张超张宏浩张家文张清民张玄同张一鸣张一心张玉美张志坚张智勇张子平赵洁赵庆旺赵豫斌钟玮丽周莉 N.Zhou 庄红林邹佳恒 Institute of Modern Physics East China University of Science and Technology University of Wisconsin Department of Physics Yale University Brookhaven National laboratory Department of Physics National Taiwan University National United University Nanjing University Institute of High Energy Physics Chinese University of Hong Kong Institute of Physics National Chiao-Tung University Shandong University Department of Engineering Physics Tsinghua University North China Electric Power University Shenzhen University Sun Yat-Sen (Zhongshan) University Joint Institute for Nuclear Research Siena College Department of Physics Illinois Institute of Technology Department of Physics University of Illinois at Urbana-Champaign lawrence Berkeley National laboratory Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Beijing Normal University Department of Chemistry and Chemical Technology Bronx Community College Department of Physics University of Houston Center for Neutrino Physics Virginia Tech China Institute of Atomic Energy University of Science and Technology of China School of Physics Nankai University Department of Physics University of Cincinnati Department of Physics College of Science and Technology Temple University Dongguan University of Technology Department of Physics University of California Department of Physics The University of Hong Kong Charles University Faculty of Mathematics and Physics Joseph henry laboratories Princeton University Department of Nuclear Science and Technology School of Energy and Power Engineering Xi’an Jiaotong University Instituto de F'?sica Pontificia Universidad Católica de Chile California Institute of Technology College of William and Mary Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute China General Nuclear Power Group College of Electronic Science and Engineering National University of Defense Technology Iowa State University Chongqing University

A new measurement of the reactor antineutrino flux and energy spectrum by the Daya Bay reactor neutrino experiment is reported. The antineutrinos were generated by six 2.9 GWth nuclear reactors and detected by eight antineutrino detectors deployed in two near（560 m and 600 m flux-weighted baselines） and one far（1640 m flux-weighted baseline） underground experimental halls. With 621 days of data, more than 1.2 million inverse beta decay（IBD） candidates were detected. The IBD yield in the eight detectors was measured, and the ratio of measured to predicted flux was found to be 0.946±0.020（0.992±0.021） for the Huber＋Mueller（Ill＋Vogel） model. A 2.9σ deviation was found in the measured IBD positron energy spectrum compared to the predictions. In particular, an excess of events in the region of 4–6 MeV was found in the measured spectrum, with a local significance of 4.4σ. A reactor antineutrino spectrum weighted by the IBD cross section is extracted for model-independent predictions.

关键词： antineutrino flux energy spectrum reactor Daya Bay

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诊断系统性红斑狼疮前后的妊娠结局

世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 8-8页

作者： Dhar J.P. Essenmacher l.M. Ager J.W. Sokol R.J. 李奎 Division of Rheumatology Henry Ford Hospital 2799 West Grand Boulevard Detroit MI 48202 United States Dr.

Objective: The purpose of this study was to evaluate pregnancy outcomes before and after diagnosis of lupus. Study design: Successive selection criterion applied to 148 lupus and 78,905 non-lupus pregnancies, generated 3 groups: lupus group, 84 pregnancies (not-yet-diagnosed group, 15 women; already-diagnosed group, 69 women), and control group, 51,000 pregnancies. Three-way analysis of variance and the chisquared test were used for analyses. Results: Stillbirth outcome was increased in the lupus group compared with the control group (odds ratio, 4.84 95%CI, 1.72,11.08 ); the not-yet-diagnosed group (odds ratio, 9.89 95%CI, 1.09,42.63 ), and the already-diagnosed group (odds ratio, 3.85 95%CI, 1.02,10.31 ). Considering >1 pregnancy per patient would have overestimated the stillbirth rate. Stillbirth risk was increased significantly in severe maternal disease that was marked by central nervous system involvement. The already-diagnosed group had more hypertensive complications (P = .001 and .0001). Both lupus groups showed a significantly greater proportion of preterm births (P = .03),growth restriction (P = .019), and infants in the very low birth weight category (P = .021) compared with the control group. Conclusion: Poor fetal outcomes are seen in pregnancies that are complicated by lupus, even before clinical appearance of disease, which supports a predisease state.

关键词：妊娠结局系统性红斑狼疮胎儿宫内发育中枢神经系统多因素方差分析高血压性统计学分析及已研

乙肝病毒相关肝细胞癌的整合蛋白基因组学特征性研究

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科学新闻 2020年第2期 39-39页

作者：高大明周虎樊嘉 Qiang Gao Hongwen Zhu liangqing Dong Weiwei Shi Ran Chen Zhijian Song Chen Huang Junqiang li Xiaowei Dong Yanting Zhou Qian liu lijie Ma Xiaoying Wang Jian Zhou Yansheng liu Emily Boja Ana I.Robles Weiping Ma Pei Wang Yize li li Ding Bo Wen Bing Zhang henry Rodriguez 中科院分子细胞科学卓越创新中心(原生物化学与细胞生物学研究所) 中科院上海药物研究所中国科学院复旦大学附属中山医院外科

文章简介研究团队利用159例患者手术切除的肿瘤组织和临近的正常组织,首次进行了乙肝病毒相关肝细胞癌的蛋白基因组学特征性研究。通过蛋白基因组学整合分析,我们揭示了乙肝病毒相关肝细胞癌在多组学,关键信号通路激活状态,以及肝脏特... 详细信息

文章简介研究团队利用159例患者手术切除的肿瘤组织和临近的正常组织,首次进行了乙肝病毒相关肝细胞癌的蛋白基因组学特征性研究。通过蛋白基因组学整合分析,我们揭示了乙肝病毒相关肝细胞癌在多组学,关键信号通路激活状态,以及肝脏特异性代谢重编程等方面的诸多一致性和不一致性。在蛋白组学分析中,研究人员根据研究对象

关键词：肝细胞癌乙肝病毒特征性整合蛋白基因组学

关于Bose-Chaudhuri码中的信息数字个数

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吉林大学自然科学学报 1963年第3期 189-200页

作者：苏运霖

Peterson 的文章中谈到了对于某些较长的 Bose-Chaudhuri 码(以下简称为B-C 码),码参数的计算问题。他还针对二进制的情形,对码的长度 n 充分大的 B-C 码证明了“信息比例”趋于零。要确定比例,关键在于算出码的信息数字个数。但是,Pete... 详细信息

Peterson 的文章中谈到了对于某些较长的 Bose-Chaudhuri 码(以下简称为B-C 码),码参数的计算问题。他还针对二进制的情形,对码的长度 n 充分大的 B-C 码证明了“信息比例”趋于零。要确定比例,关键在于算出码的信息数字个数。但是,Peterson 只是给出了对于信息数字个数的估计,没有精确地计算出对于长度为 n 的 t-误差校正码中之信息数字个数。*** 针对这一问题,作了进一步的研究,

关键词：序列个数 Bose-Chaudhuri

The impact of COVID-19 on the birth rate in Nigeria:a report from population-based registries

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Infectious Diseases Research 2023年第1期4卷 14-18页

作者： Charlotte Blanche Oguejiofor Kenechi Miracle Ebubechukwu George Uchenna Eleje Emmanuel Onyebuchi Ugwu Joseph Tochukwu Enebe Kingsley Emeka Ekwuazi Chukwuemeka Chukwubuikem Okoro Boniface Chukwuneme Okpala Charles Chukwunomunso Okafor Nnanyelugo Chima Ezeora Emeka Ifeanyi Iloghalu Chidebe Christian Anikwe Chigozie Geoffrey Okafor Polycarp Uchenna Agu Emeka Philip Igbodike Iffiyeosuo Dennis Ake Arinze Anthony Onwuegbuna Osita Samuel Umeononihu Onyedika Promise Anaedu Odigonma Zinobia Ikpeze David Chibuike Ikwuka henry Ifeanyi Nwaolisa Ekene Agatha Emeka Jude Ogechukwu Okoye Ihechinyerem Kelechi Osuagwu Angela Ogechukwu Ugwu Toochukwu Benjamin Ejikeme Eziamaka Pauline Ezenkwele Chijioke Ogomegbunam Ezeigwe Malarchy Ekwunife Nwankwo Gerald Okanandu Udigwe Joseph Ifeanyichukwu Ikechebelu Grace Agbaeze Chukwuebuka Divine Nwanja Ahizechukwu Chigoziem Eke Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching HospitalNnewi PMB 5025Nigeria Preventive Medicine and Research Department Clina-Lancet LaboratoriesVictoria IslandLagos 101241Nigeria Effective Care Research Unit Department of Obstetrics and GynecologyNnamdi Azikiwe UniversityNnewi Campus 435001Nigeria Department of Obstetrics and Gynecology College of MedicineUniversity of Nigeria Enugu CampusEnuguEnugu State 400102Nigeria Department of Obstetrics and Gynecology University of Nigeria Teaching HospitalItuku OzallaEnugu State 400102Nigeria Department of Obstetrics and Gynecology ESUT Teaching HospitalParklaneEnugu 400102Nigeria Medical Department Divine Medical CentreSouth West IkoyiLagos 1001233Nigeria Department of Obstetrics and Gynecology Havana Specialist HospitalSurulereLagos 100011Nigeria Clinical Trial Division Drug Evaluation and Research DirectorateNAFDAC office ComplexLagos 100011Nigeria Department of Ophthalmology Nnamdi Azikiwe UniversityNnewi campus 435001Nigeria Department of Human Physiology Nnamdi Azikiwe University NnewiAnambra State 435001Nigeria Department of Family Medicine Faculty of MedicineNnamdi Azikiwe UniversityAwka 435001Nigeria Department of Medical laboratory Science Faculty of Health Sciences and TechnologyNnamdi Azikiwe UniversityAwka 435001Nigeria Department of Health Services Federal University of TechnologyOwerri 460103Nigeria Department of Haematology and Immunology College of MedicineUniversity of Nigeria Enugu CampusEnuguEnugu State 400102Nigeria Musgrove Park Hospital Somerset NHS Foundation TrustUnited Kingdom TlTp Medical(UHS) Southampton WS15United Kingdom Division of Maternal Fetal Medicine Department of Gynecology and ObstetricsJohns Hopkins University School of MedicineBaltimore 21201U.S.A

Background and objectives:Coronavirus disease 2019(COVID-19)is a pandemic that has become a major source of morbidity and mortality worldwide,affecting the physical and mental health of individuals influencing *** the threat,it poses to maternal health in sub-Saharan Africa and Nigeria,there is little or no data on the impact it has on fertility,conception,gestation and *** compare the birth rate between pre-COVID and COVID times using selected months of the *** and methods:This was a secondary analysis of cross-sectional analytical study data from the birth registries of three tertiary hospitals,comparing two years[2019(Pre-COVID)]versus[2020(COVID era)]using three months of the year(October to December).The data relied upon was obtained from birth registries in three busy maternity clinics all within tertiary hospitals in South-East Nigeria and we aimed at discussing the potential impacts of COVID-19 on fertility in *** secondary outcome measures were;mode of delivery,booking status of the participants,maternal age and ***:There was a significant decrease in tertiary-hospital based birth rate by 92 births(P=0.0009;95%CI:-16.0519 to-4.1481)among mothers in all the three hospitals in 2020 during the COVID period(post lockdown months)of October to *** was a significant difference in the mode of delivery for mothers(P=0.0096)with a 95%confidence interval of 1.0664 to 1.5916,as more gave birth through vaginal delivery during the 2020 COVID-19 period than ***:Tertiary-hospital based birth rates were reduced during the *** multi-centre study extrapolated on possible factors that may have played a role in this decline in their birth rate,which includes but is not limited to;decreased access to hospital care due to the total lockdowns/curfews and worsening inflation and economic recession in the country.

关键词： birth rates COVID-19 lockdown Nigeria pandemic pre-COVID