检索结果-南通市图书馆

Evaluation of antibacterial and toxicological activities of essential oil of Ocimum gratissimum *** its major constituent eugenol

引用

Food Bioscience 2022年第6期50卷 2152-2159页

作者： Julio Cesar Silva Raimundo Luiz Silva Pereira Thiago Sampaio de Freitas Janaína Esmeraldo Rocha Nair Silva Macedo Carla de Fatima Alves Nonato Marina Leite Linhares Daniely Sampaio Arruda Tavares Francisco Assis Bezerra da Cunha henrique douglas melo coutinho Sidney Gonçalo de Lima Francisco Nascimento Pereira-Junior Francisco Paulo Araújo Maia Ivo Cavalcante Pita Neto Fabiola Fernandes Galvão Rodrigues George Joaquim Garcia Santos Department of Biological Chemistry Regional University of CaririR.Cel.Antonio Luis 116163105000CratoCEBrazil University Center Doutor Leão Sampaio Av.Leão Sampaio 40063040000Juazeiro do NorteCEBrazil Research and Development Center for Medicines Federal University of CearaR.Coronel Nunes de Melo 100060430275FortalezaCEBrazil Chemistry Department Federal University of PiauiCampus Universitário Ministro Petrônio Portella64049550TeresinaPIBrazil Center for Agricultural and Biodiversity Sciences - CCAB Federal University of CaririCratoCearáBrazil CECAPE - College of Dentistry Juazeiro do NorteCE63024-015Brazil

The present study aimed to comparatively analyze the antibacterial activity,combined with antibiotics,and toxicological activity of the essential oil of *** *** its major compound,*** phytochemical analysis of the essential oil was performed by gas chromatography coupled with mass *** minimum inhibitory concentration and combined antibiotic activity were performed by *** melanogaster was the model organism chosen to evaluate the toxicological response of *** chromatographic assay showed eugenol as the major compound of the essential oil of *** *** microbiological assays showed that in terms of antibacterial activity,both products showed similar activity,quite significant in Gram-negatives,such as those of strains of Pseudomonas *** results were verified in the modulatory activity,allowing the verification that the bioactivity performed by the essential oil of *** *** mainly influenced by its major *** the EC50 of the compounds varied subtly,the essential oil was less toxic compared to *** information obtained in the present study demonstrates that the essential oil of *** *** a promising antibacterial agent and better tolerated than its majority compound alone,in the model organism ***.

关键词： Antibacterial agents Drosophila melanogaster Eugenol Ocimum gratisismumum L.essential oils

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Central depressant effects of Piper tuberculatum Jacq essential oil in mice

引用

Food Bioscience 2022年第4期48卷 620-629页

作者： Valterlúcio dos Santos Sales Francisco Romero Cabral Emmily Petícia do Nascimento Sales Tatyelle Bezerra Carvalho Maria Haiele Nogueira Costa Victor Afonso Pereira de Oliveira Cristina Kelly de Souza Rodrigues Francisco Rodolpho Sobreira Dantas Nobrega de Figueiredo Daniel Souza Bezerra Gyllyandeson de Araújo Delmondes henrique douglas melo coutinho Jose Galberto Martins da Costa Irwin Rose Alencar de Menezes Cícero Francisco Bezerra Felipe Marta Regina Kerntopf Universidade Regional do Cariri Departamento de Química Biol´ogicaCratoCear´aBrazil Universidade Federal de S˜ao Paulo-Departamento de Fisiologia S˜ao PauloSPBrazil Faculdade de Ciˆencias M´edicas da Santa Casa de S˜ao Paulo S˜ao PauloSPBrazil Universidade Federal da Paraíba Departamento de Biologia MolecularJo˜ao PessoaParaíbaBrazil

This study aims to investigate the toxicity and possible effects and mechanism of action of the essential oil obtained from the Piper tuberculatum Jacq.‘s fruit(EOPT)on the central nervous system(CNS)of *** the Hippocratic test,it was observed ambulation reduction,sedation,piloerection and mortality of 25%at the dose of 1000 mg/kg and 50%at the dose of 5000 mg/*** results found demonstrate that the EOPT is endowed with a possible depressant effect,and is characterized by a likely sedative(open field test),anxiolytic-like(elevated plus maze test),anticonvulsant(pentylenetetrazole-induced seizure test)and hypnotic action(pentobarbital-induced sleeping time).These effects may possibly occur due to the interaction between the monoterpenes,present in its essential oil,and the GABAergic pathway confirmed by reversion of the effects by ***,these results demonstrate the therapeutic potential and the validation of the ethnopharmacological use of this species in the treatment of disorders affecting the central nervous system.

关键词： Piper tuberculatum Jacq. Essential oil Sedative Anxiolytic Hypnotic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virulence Factors and Biofilm Formation in Vancomycin Resistant Enterococcus faecalis and Enterococcus faecium Isolates in Brazil

引用

Advances in Microbiology 2023年第6期13卷 299-314页

作者： Bárbara de Azevedo Ramos Marília Manta Manta Sivoneide Maria da Silva Rafael Artur Queiroz Cavalcanti de Sá Natália Lira de Souza henrique douglas melo coutinho Márcia Vanusa da Silva Túlio Diego da Silva Maria Tereza dos Santos Correia Maria Betânia melo de Oliveira Universidade Federal de Pernambuco Pernambuco Brazil Universidade Regional do Cariri Ceará Brazil Instituto de Tecnologia de Pernambuco Pernambuco Brazil

In this work, we evaluated biofilm formation of Vancomycin Resistant of E. faecalis and E. faecium (VRE) in different culture media and adhesion substrate, as well as cellular hydrophobicity and presence of virulence genes. For this, 35 isolates were collected from a public hospital in Recife, Pernambuco, Brazil and identified by the Matrix-Assisted Laser Desorption Ionization - Time-of-flight - Mass Spectrometry (MALDI-TOF-MS) technique. Biofilm formation was analyzed by the Crystal Violet (CV) method and fluorescence microscopy, cellular hydrophobicity by hydrocarbon interaction and the presence of gelE, esp and asa1 genes by Polymerase Chain Reaction (PCR). 12 isolates were identified as E. faecalis and 23 as E. faecium. Most were obtained in Coronary Units (40.0%) and Intensive Care Unit (31.4%). E. faecium isolates were more resistant to the antibiotics tested than E. faecalis;however, E. faecalis stood out as a biofilm producer. Regarding the presence and gene frequency, it was observed that gelE (54.3%) and esp (54.3%) were the most prevalent, followed by asa1 (22.9%). When comparing the gene frequency, it was observed that gelE and esp were predominant (48.6% for both species), while asa1 was more frequent in E. faecalis (20.0%). The data presented here are worrying, because they reveal the virulence potential of isolates VRE, which contributes to the dissemination and persistence of these pathogens in the hospital environment.

关键词： Biofilm Cellular Hydrophobicity Gram-Positive Hospital Environment Virulence Genes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis

引用

World Journal of Gastroenterology 2023年第22期29卷 3440-3468页

作者： henrique Inhauser Riceti Magalhães Felipe Alexandre Machado Roberta Figueiroa Souza Marcos Antônio Ferreira Caetano Vanessa Ribeiro Figliuolo Robson coutinho-Silva Patricia Castelucci Department of Surgery School of Veterinary Medicine and Animal SciencesUniversity of São PauloSão Paulo 05508-270Brazil Department of Anatomy University of São PauloSão Paulo 05508-000Brazil Biophysics Institute Carlos Chagas Filho Federal University of Rio de JaneiroRio de Janeiro 21941-902Brazil

BACKGROUND The literature indicates that the enteric nervous system is affected in inflammatory bowel diseases(IBDs)and that the P2X7 receptor triggers neuronal ***,the mechanism by which enteric neurons are lost in IBDs is *** To study the role of the caspase-3 and nuclear factor kappa B(NF-κB)pathways in myenteric neurons in a P2X7 receptor knockout(KO)mouse model of *** Forty male wild-type(WT)C57BL/6 and P2X7 receptor KO mice were euthanized 24 h or 4 d after colitis induction by 2,4,6-trinitrobenzene sulfonic acid(colitis group).Mice in the sham groups were injected with *** mice were divided into eight groups(n=5):The WT sham 24 h and 4 d groups,the WT colitis 24 h and 4 d groups,the KO sham 24 h and 4 d groups,and the KO colitis 24 h and 4 d *** disease activity index(DAI)was analyzed,the distal colon was collected for immunohistochemistry analyses,and immunofluorescence was performed to identify neurons immunoreactive(ir)for calretinin,P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,and total NF-κ*** analyzed the number of calretinin-ir and P2X7 receptor-ir neurons per ganglion,the neuronal profile area(μm^(2)),and corrected total cell fluorescence(CTCF).RESULTS Cells double labeled for calretinin and P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,or total NF-κB were observed in the WT colitis 24 h and 4 d *** number of calretinin-ir neurons per ganglion was decreased in the WT colitis 24 h and 4 d groups compared to the WT sham 24 h and 4 d groups,respectively(2.10±0.13 vs 3.33±0.17,P<0.001;2.92±0.12 vs 3.70±0.11,P<0.05),but was not significantly different between the KO *** calretinin-ir neuronal profile area was increased in the WT colitis 24 h group compared to the WT sham 24 h group(312.60±7.85 vs 278.41±6.65,P<0.05),and the nuclear profile area was decreased in the WT colitis 4 d group compared to the WT sham 4 d group(104.63±2.49 vs 117.41±1.14,P<0.01).The number of

关键词： Cell death Enteric nervous system Gastroenterology Inflammatory bowel diseases P2X7 receptor Purinergic signaling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

All-electron ZORA triple zeta basis sets for the elements Cs-La and Hf-Rn

引用

Chinese Physics B 2023年第9期32卷 242-249页

作者： Antônio Canal Neto Francisco E.Jorge henrique R.Cda Cruz Departamento de Física Universidade Federal do Espírito Santo29075-910 VitóriaESBrazil

Segmented all-electron basis set of triple zeta valence quality plus polarization functions(TZP)for the elements of the fifth row to be used together with the zero-order regular approximation(ZORA)is carefully *** correctly describe electrons distant from atomic nuclei,the basis set is augmented with diffuse functions giving rise to a set designated as *** the ZORA-B3LYP theoretical level,these sets are used to calculate the ionization energy and mean dipole polarizability of some atoms,bond length,dissociation energy,and harmonic vibrational frequency of diatomic ***,these results are compared with the theoretical and experimental data found in the *** considering that our sets are relatively compact,they are sufficiently accurate and reliable to perform property calculations involving simultaneously electrons from the inner shell and outer *** performances of the ZORA and second-order douglas-Kroll-Hess Hamiltonians are evaluated and the results are also discussed.

关键词： TZP-ZORA and ATZP-ZORA basis sets ZORA-B3LYP method Cs-La and Hf-Rn elements atomic and molecular properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Albumin administration in patients with cirrhosis: Current role and novel perspectives

引用

World Journal of Gastroenterology 2022年第33期28卷 4773-4786页

作者： Angelo Zambam de Mattos douglas Alano Simonetto Carlos Terra Alberto Queiroz Farias Paulo Lisboa Bittencourt Tales henrique Soares Pase Marlon Rubini Toazza Angelo Alves de Mattos Alliance of Brazilian Centers for Cirrhosis Care-the ABC Group Graduate Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55902United States Department of Gastroenterology State University of Rio de JaneiroRio de Janeiro 20550-170Brazil Department of Gastroenterology University of São PauloSão Paulo 01246-903Brazil Gastroenterology and Hepatology Unit Hospital PortuguêsSalvador 40130-030Brazil Internal Medicine Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil 不详

Mortality in cirrhosis is mostly associated with the development of clinical decompensation,characterized by ascites,hepatic encephalopathy,variceal bleeding,or ***,it is important to prevent and manage such ***,the pathophysiology of decompensated cirrhosis was explained by the peripheral arterial vasodilation hypothesis,but it is currently understood that decompensation might also be driven by a systemic inflammatory state(the systemic inflammation hypothesis).Considering its oncotic and nononcotic properties,albumin has been thoroughly evaluated in the prevention and management of several of these decompensating *** are formal evidence-based recommendations from international medical societies proposing that albumin be administered in individuals with cirrhosis undergoing large-volume paracentesis,patients with spontaneous bacterial peritonitis,those with acute kidney injury(even before the etiological diagnosis),and those with hepatorenal ***,there are a few randomized controlled trials and meta-analyses suggesting a possible role for albumin infusion in patients with cirrhosis and ascites(long-term albumin administration),individuals with hepatic encephalopathy,and those with acute-on-chronic liver failure undergoing modest-volume *** studies are necessary to elucidate whether albumin administration also benefits patients with cirrhosis and other complications,such as individuals with extraperitoneal infections,those hospitalized with decompensated cirrhosis and hypoalbuminemia,and patients with hyponatremia.

关键词： Cirrhosis Albumin Paracentesis Spontaneous bacterial peritonitis Acute kidney injury Hepatorenal syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Beverage composed of fruits and soy:Microbiology,colorimetry and effects of refrigerated storage on physical-chemical parameters

引用

Food Bioscience 2022年第5期49卷 1084-1089页

作者： Bruno Fonsˆeca Feitosa Emanuel Neto Alves de Oliveira Francisco Bruno Ferreira de Freitas Juvˆencio Oleg´ario de Oliveira Neto Regilane Marques Feitosa Thamirys Lorranne Santos Lima Maria Lucimar da Silva Medeiros Jo˜ao Vitor Fonseca Feitoza henrique D.M.coutinho State University of Campinas Faculty of Food EngineeringCampinasSP13083-970Brazil Federal Institute of Education Science and Technology of Rio Grande do Norte(IFRN)Pau dos Ferros Campus Pau dos FerrosRio Grande do Norte59900-000Brazil Federal University of Campina Grande Campus Pombal-PB58840-000Brazil Federal Institute of Education Science and Technology of Alagoas57625-000Brazil Federal Institute of Education Science and Technology of Rio Grande do Norte(IFRN)Campus Pau dos FerrosRio Grande do Norte59900-000Brazil Federal Institute of Education Science and Technology of Rio Grande do Norte(IFRN)Campus Currais NovosRio Grande do Norte59380-000Brazil Federal University of Cear´a Center for Agrarian SciencesFortalezaCE59700000Brazil Department of Biological Chemistry Regional University of Cariri-URCA63105-000CratoCEBrazil

The study aimed to develop beverages composed of fruits and soy extract,to evaluate the microbiology,colorimetry and the effects of refrigerated storage(4±2℃)on the physicochemical *** concentrate(50,55,60,65,70,75 and 80%)and myrtle pulp(30,25,20,15,10,5 and 0%)were used for the preparation of seven beverage formulations composed in different proportions,added with inulin and sweetened with honey *** analyzes were performed after processing and physicochemical stability was determined every 4 days for 8 *** beverages composed showed adequate microbiological quality after *** partial replacement of myrtle pulp by mango concentrate influenced mainly the colorimetric parameters,as well as pH,total acidity,total soluble solids and TSS/TTA *** beverages with greater stability were those made with 50 and 55%mango and 30 and 25%myrtle,respectively,both with 13%soy *** is inferred that the development of beverage composed of fruits and soy for specific emerging audiences may be viable,and complementary analyzes and a longer storage period are recommended for more stable beverages.

关键词： Eugenia gracillima Kiaersk Glycine max Mangifera indica L Mixed juice Stability study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Role of Nitrogen Fertilizers in Sugarcane Root Biomass under Field Conditions

引用

Agricultural Sciences 2014年第14期5卷 1527-1538页

作者： Rafael Otto henrique coutinho Junqueira Franco Carlos Eduardo Faroni André Cesar Vitti Emídio Cantidio Almeida de Oliveira Renata Alcarde Sermarini Paulo Cesar Ocheuze Trivelin Department of Soil Science Luiz de Queiroz College of Agriculture University of Sao Paulo Piracicaba Brazil Brazilian Bioethanol Science and Technology Laboratory (CTBE) Rua Giuseppe Maximo Scolfaro Campinas Brazil Sugarcane Research Center (CTC) Piracicaba Brazil Sao Paulo Agency of Agribusiness and Technology (APTA) Piracicaba Brazil Federal Rural University of Pernambuco (UFRPE) Recife Brazil Department of Exact Sciences Luiz de Queiroz College of Agriculture University of Sao Paulo Piracicaba Brazil Center for Nuclear Energy in Agriculture University of Sao Paulo Piracicaba Brazil

Sugarcane is used worldwide for sugar, ethanol and energy production. In Brazil, the shift from burned to unburned harvest systems resulted in increases in nitrogen fertilization rates, which can impact root architecture and biomass. The expectation is also an increase in sugarcane biomass. The study hypothesized that high N rates applied to sugarcane fields increases root growth and N stored in roots, promoting higher biomass and N accumulated in shoots. Two experiments were set up in Southeastern Brazil, on a Typic Kandiudox (TK) and Rhodic Eutrudox (RE). Four treatments were studied 1) N application in the plant-cane (0 and 120 kg·ha-1 N) and 2) N application in the ratoon (0 and 150 kg·ha-1 N). The shoot biomass and the root density (by the core method up to 0.6 m) were evaluated over the first ratoon crop cycle, and the N content in those compartments was also examined. There was no carry over effect on N applied at planting in root and shoot biomass in the ratoon crop cycle. At the RE site, the ratoon N fertilization increased root density in the superficial soil layer (0 - 0.2 m) and close to the plants (<0.3 m). The effect of N addition on root biomass, and biomass and N accumulated in shoot was limited in both sites. Increasing N rates in unburned sugarcane fields do not consistently increases root and shoot biomass under Brazilian field conditions.

关键词： Root System Ratoon Shoot Root: Shoot Ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

透视巴西COR商店

引用

室内设计与装修 2018年第1期 12-13页

作者： BLOCO Arquitetos[巴] Daniel Mangabeira[巴] henrique coutinho e Matheus Seco 麦子

COR商店位于巴西巴西利亚某购物中心的地下停车场,是个用于展示和销售的商业空间。新的店铺一方面可以用来展示油漆品牌,另一方面来自圣保罗的家具设计师Paulo Alves的产品也在其中展示并售卖。同时,空间还能够容纳必要的聚会和活动功... 详细信息

COR商店位于巴西巴西利亚某购物中心的地下停车场,是个用于展示和销售的商业空间。新的店铺一方面可以用来展示油漆品牌,另一方面来自圣保罗的家具设计师Paulo Alves的产品也在其中展示并售卖。同时,空间还能够容纳必要的聚会和活动功能。如何在一个不大的空间中融入这么多功能是设计团队需要接受的挑战。

关键词：巴西利亚 COR 商店家具设计师商业空间地下停车场购物中心多功能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fern extracts potentiate fluconazole activity and inhibit morphological changes in Candida species

引用

Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 1025-1030页

作者： Maria A.Freitas Antonia T.L.Santos Antonio J.T.Machado Ana Raquel P.Silva Fábia F.Campina Maria S.Costa Gioconda M.A.B.Martins Maria Flaviana B.Morais-Braga Saulo R.Tintino Irwin R.A.Menezes Jaime Ribeiro-Filho Altevir P.Medeiros Adeliana S.Oliveira Patrício B.Maracajá henrique D.M.coutinho Universidade Regional do Cariri-URCA Universidade Federal Rural do Semi-A′rido-UFERSA Universidade Federal do Rio Grande do Norte-UFRN Universidade Federal de Campina Grande-UFCG

Objective: To investigate the antifungal activity of the fern species Lygodium venustum(L. venustum) and Pityrogramma calomelanos(P. calomelanos) against Candida albicans and Candida tropicalis ***: The microdilution method was used to evaluate the antifungal activity, as well as the modulating effects of ethanolic extracts of these plants in combination with fluconazole. The minimum inhibitory concentration(MIC), minimum fungicide concentration and morphological changes were also ***: The extract obtained from L. venustum presented a MIC > 8 192 mg/m L, while the extract obtained from and P. calomelanos presented a MIC = 8 192 mg/m L, indicating that they present weak antifungal activity. However, combination of the extracts with Fluconazole potentiated the antifungal activity of this drug. At different experimental conditions, such as concentration of the extract and type of strain, the extracts inhibited hyphae and pseudohyphae formation, indicating that these fern species can affect the morphology of the ***: The extracts obtained from the fern species L. venustum and P. calomelanos dose not present significant antifungal activity. However, P. calomelanos potentiates the activity of fluconazole and both extracts inhibits the morphological changes in Candida species, indicating that they have potential pharmacological activity as modulators of fungal biology. Therefore, novel studies are required to characterize the interference of these extracts in the virulence and pathogenicity of Candida species as well as the potential of fern species to treat fungal infections.

关键词： Dimorphism Candida species Ferns Lygodium venustum Pityrogramma calomelanos

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：