Central depressant effects of Piper tuberculatum Jacq essential oil in mice

作     者：Valterlúcio dos Santos Sales Francisco Romero Cabral Emmily Petícia do Nascimento Sales Tatyelle Bezerra Carvalho Maria Haiele Nogueira Costa Victor Afonso Pereira de Oliveira Cristina Kelly de Souza Rodrigues Francisco Rodolpho Sobreira Dantas Nobrega de Figueiredo Daniel Souza Bezerra Gyllyandeson de Araújo Delmondes Henrique Douglas Melo Coutinho Jose Galberto Martins da Costa Irwin Rose Alencar de Menezes Cícero Francisco Bezerra Felipe Marta Regina Kerntopf 

作者机构：Universidade Regional do CaririDepartamento de Química Biol´ogicaCratoCear´aBrazil Universidade Federal de S˜ao Paulo-Departamento de FisiologiaS˜ao PauloSPBrazil Faculdade de Ciˆencias M´edicas da Santa Casa de S˜ao PauloS˜ao PauloSPBrazil Universidade Federal da ParaíbaDepartamento de Biologia MolecularJo˜ao PessoaParaíbaBrazil 

出 版 物：《Food Bioscience》 (食品生物科学（英文）)

年 卷 期：2022年第48卷第4期

页      面：620-629页

核心收录：

学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学] 

基　　金：Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq Financiadora de Estudos e Projetos, FINEP Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico, FUNCAP 

主　　题：Piper tuberculatum Jacq. Essential oil Sedative Anxiolytic Hypnotic 

摘      要：This study aims to investigate the toxicity and possible effects and mechanism of action of the essential oil obtained from the Piper tuberculatum Jacq.‘s fruit(EOPT)on the central nervous system(CNS)of *** the Hippocratic test,it was observed ambulation reduction,sedation,piloerection and mortality of 25%at the dose of 1000 mg/kg and 50%at the dose of 5000 mg/*** results found demonstrate that the EOPT is endowed with a possible depressant effect,and is characterized by a likely sedative(open field test),anxiolytic-like(elevated plus maze test),anticonvulsant(pentylenetetrazole-induced seizure test)and hypnotic action(pentobarbital-induced sleeping time).These effects may possibly occur due to the interaction between the monoterpenes,present in its essential oil,and the GABAergic pathway confirmed by reversion of the effects by ***,these results demonstrate the therapeutic potential and the validation of the ethnopharmacological use of this species in the treatment of disorders affecting the central nervous system.