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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal nógrádi Andreas H.Teuschl-woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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A multilocus molecular phylogeny for the avian genus liocichla(Passeriformes:leiothrichidae:liocichla)

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Chinese Birds 2015年第3期6卷 140-152页

作者： Herman l Mays Bailey D Mc Kay Dieter Thomas Tietze Cheng-Te Yao lindsey n Miller Kathleen n moreland Fumin lei Department of Biological Sciences Marshall University Cincinnati Museum Center American Museum of natural History Institute of Pharmacy and Molecular Biotechnology Heidelberg University Endemic Species Research Institute Biotechnology Program Loveland High School Institute of Zoology Chinese Academy of Sciences

Background:Historically the babblers have been assigned to the family Timaliidae but several recent studies have attempted to rest the taxonomy of this diverse passerine assemblage on a more firm evolutionary *** result has been a major rearrangement of the group.A well?supported and comprehensive phylogeny for this widespread avian group is an important part of testing evolutionary and biogeographic hypotheses,especially in Asia where the babblers are a key component of many forest ***,the genus liocichla is poorly represented in these prior studies of babbler ***:we used a multilocus molecular genetic approach to generate a phylogenetic hypothesis for all five cur?rently recognized species in the avian genus *** DnA sequence data was used to construct individ?ual gene trees using maximum likelihood and species trees were estimated from gene trees using Bayesian *** dates were obtained using a molecular clock ***:Molecular data estimate a probable window of time for the origin for the liocichla from the mid to late Miocene,between 5.55 and 12.87 *** plumage similarities between the insular Taiwan endemic,***,and the continental *** and ***,molecular data suggest that *** is the sister taxon to all continen?tal *** continental liocichla are comprised of two lineages;a lineage containing *** and *** and a lineage comprised of *** and *** comparatively early divergence of *** within the liocichla may be illusory due to extinct and therefore unsampled *** and *** are parapatric with a Pleistocene split(0.07–1.88 Ma) occurring between an Eastern Himalayan *** and a northern Indo?china distributed *** and *** underwent a similar split between the Eastern Himalaya(***) and Central China(***) divided by the Hengduan ***

关键词： Biogeography Himalayas leiothrichidae liocichla Phylogenetics Phylogeography Taiwan

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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On the uncertainty of interwell connectivity estimations from the capacitance-resistance model

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Petroleum Science 2014年第2期11卷 265-271页

作者： Gustavo A Moreno larry w lake YPF Macacha Güemes 515 YPF-Tecnología Baradero S/N (1925) Center for Petroleum and Geosystems Engineering University of Texas at Austin

The capacitance-resistance model （CRM） is an alternative to conventional reservoir simulation. CRM, a simplification of complex numerical models, uses production and injection rates to infer a reservoir description. There is no prior geologic model. The principal output of CRM fitting is the fraction of injected fluid （usually water） that is produced at a producer at steady-state. These fractions are interwell connectivities. Interwell connectivities are fundamental information needed to manage waterfloods in oil reservoirs. The data-driven CRM is a fast tool to estimate these parameters in mature fields and allows one to make full use of the dynamic data available. This paper considers the problem of setting an upper bound on the uncertainty of interwell connectivities for linear-constrained models. Using analytical bounds and numerical simulations, we derive a consistent upper limit on the uncertainty of interwell connections that can be used to quantify the information content of a given dataset.

关键词： Data-driven models capacitance-resistance model secondary recovery waterfloodoptimization interwell connectivities

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos lisette leyton Cellular Communication laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Input signal design to estimate interwell connectivities in mature fields from the capacitance-resistance model

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Petroleum Science 2014年第4期11卷 563-568页

作者： Gustavo A.Moreno larry w.lake YPF-Tecnología Baradero S/N (1925) EnsenadaBuenos AiresArgentina YPF Macacha Guemes 515CABAArgentina CPARM University of Texas at AustinAustinTXUSA

Interwell connectivities are fundamental parameters required to manage waterfloods in oil reservoirs. Data-driven models, such as the capacitance-resistance model （CRM）, are fast tools to estimate these parameters from time-correlations of input （injection rates） and output （production rates） signals. noise and structure of the input time-series impose limits on the information that can be extracted from a given data-set. This work uses the CRM to study general prescriptions for the design of input signals that enhance the information content of injection/production data in the estimation of well-to-well interactions. numerical schemes and general features of the optimal input signal strategy are derived for this problem.

关键词： Intervell connectivity capacitance-resistance model mature field experiment design

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

with people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Participative Research:what Are the Advantages of Thinking about Research on the Cancer Care Pathway?Views of Two Patient Co-Researchers

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Psycho-Oncologie 2023年第3期17卷 195-199页

作者： Sylvie Faiderbe nadège Berlioz Patient-Researcher Regnéville-Sur-Mer50590France Patient-Researcher Paris75000France

Two patients relate their experience as co-researchers in a research project in the human and social *** the genesis of the research project to the results,they detail their participation in each stage of this project alongside care professionals and researchers:their difficulties,their contributions,their pleasure,and speculations on the conditions for improving this type of active collaboration in a participative research project.

关键词： Participative research patient researcher patient expert patient partner care pathway

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