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Diagnosis and treatment of heart failure with preserved left ventricular ejection fraction

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World journal of Cardiology 2020年第1期12卷 7-25页

作者： Robert j henning College of Public Health University of South Florida

Nearly six million people in United States have heart *** percent of these people have normal left ventricular(LV)systolic heart function but abnormal diastolic function due to increased LV myocardial *** commonly,these patients are elderly women with hypertension,ischemic heart disease,atrial fibrillation,obesity,diabetes mellitus,renal disease,or obstructive lung *** annual mortality rate of these patients is 8%-12%per *** diagnosis is based on the history,physical examination,laboratory data,echocardiography,and,when necessary,by cardiac *** with obesity,hypertension,atrial fibrillation,and volume overload require weight reduction,an exercise program,aggressive control of blood pressure and heart rate,and *** devices inserted into patients for pulmonary artery pressure monitoring provide early warning of increased pulmonary pressure and *** significant coronary heart disease is present,coronary revascularization should be considered.

关键词： Diastolic heart failure Myocardial stiffness Incomplete left ventricular relaxation Echocardiographic heart failure criteria Pulmonary artery pressure monitoring Drug treatment

Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants

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神经科学通报:英文版 2023年第8期39卷 1327-1329页

作者： Qing Ye Si‑Si Lin henning Ulrich Yong Tang International joint Research Centre on Purinergic Signalling/School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Biochemistry Institute of ChemistryUniversity of São PauloSão Paulo 05508Brazil Acupuncture and Chronobiology Key Laboratory of Sichuan Province/School of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610075China

Major depressive disorder(MDD)is one of the most common psychiatric disorders,and~4.7%of the world's population has an onset of depression in any one-year *** causes constant distress,impairs social function and physiological health,and even leads to suicide[1].Numerous studies support the classic monoamine hypothesis of depressive *** majority of clinical antidepressants have been developed on the basis of this hypothesis to increase 5-hydroxytryptamine(5-HT).

关键词： distress hypothesis clinical

PIEZO1 channels in cutaneous free nerve endings:novel insights into itch-scratch-mechanisms

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Signal Transduction and Targeted Therapy 2023年第2期8卷 319-320页

作者： Manuel Pedro Pereira henning Wiegmann Sonja Ständer Department of Dermatology and Center for Chronic Pruritus University Hospital Münster48149MünsterGermany

A recent study published in Nature by Hill et al.1 identified mechano-sensitive PIEZO1 ion channels in pruriceptive ***,PIEZO1 is involved in acute itch transmission and in mechanical alloknesis in chronic pruritus(CP... 详细信息

关键词： ZO1 insight scratch

Understanding health literacy from a traditional Chinese medicine perspective

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journal of Integrative Medicine 2023年第3期21卷 215-220页

作者： Zhiyi Qian Grace Y.Wang Marcus henning Yan Chen Centre for Medical and Health Science Education University of AucklandAuckland 1010New Zealand School of Psychology and Wellbeing University of Southern QueenslandToowoombaQueensland 4350Australia

Health literacy is critical to improving individual and public ***,indigenous perceptions of health are largely absent from Western-derived measurements,contributing to disparities in health outcomes between indigenous and non-indigenous *** is the country with the world's largest population and only officially introduced the term"health literacy"in *** measures of health literacy in China are primarily based on Western-derived constructs,which have been shown to have poor comparability to the unique dual medical system in *** its significant importance to health management globally,understanding health perceptions from a traditional Chinese medicine perspective is *** review explores the concept and core elements of indigenous health literacy,evaluates the existing definitions and measurement tools as applied to the concept,and proposes a new model of traditional Chinese medicine health literacy.

关键词： Traditional Chinesemedicine Health literacy Conceptual model Measurement

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AI如何助力提高人类表现

商学院 2024年第1期 14-14页

作者： Fabian Gaessler henning Piezunka 庞培法布拉大学经济与商业系宾夕法尼亚大学沃顿商学院

宾夕法尼亚大学沃顿商学院最近的研究揭示了AI(人工智能)训练和增强人类表现的能力,特别是在复杂的战略互动中要了解AI如何培训企业员工并提高绩效,不妨先回顾一下过去。国际象棋计算机一直处于AI的前沿,体现在复杂性和模仿人类思维过... 详细信息

宾夕法尼亚大学沃顿商学院最近的研究揭示了AI(人工智能)训练和增强人类表现的能力,特别是在复杂的战略互动中要了解AI如何培训企业员工并提高绩效,不妨先回顾一下过去。国际象棋计算机一直处于AI的前沿,体现在复杂性和模仿人类思维过程的能力两个基本方面。我们的分析表明,使用国际象棋计算机可以加快棋手的学习速度,并为棋手带来竞争优势,不过AI系统必须超越棋手的技术水平,才能提供有效的训练,否则,棋手就能预测AI的棋步,会限制训练价值。

关键词：宾夕法尼亚大学沃顿商学院人工智能技术水平国际象棋思维过程 AI 战略互动

On Designing Biopolymer-Bound Soil Composites (BSC) for Peak Compressive Strength

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journal of Renewable Materials 2020年第8期8卷 845-861页

作者： Isamar Rosa henning Roedel Maria I.Allende Michael D.Lepech David j.Loftus Department of Civil and Environmental Engineering Stanford UniversityStanfordCA 94305USA Division of Space Biosciences NASA Ames Research CenterMoffet FieldCA 94035USA

Biopolymer-bound Soil Composites(BSC),are a novel bio-based construction material class,produced through the mixture and desiccation of biopolymers with inorganic aggregates with applications in soil stabilization,brick creation and in situ construction on Earth and *** paper introduces a mixture design methodology to produce maximum strength for a given soil-biopolymer *** protein and sand mix designs were investigated,with varying amounts of biopolymer solution and compaction regimes during *** ultimate compressive strength,density,and shrinkage of BSC samples are *** is observed that the compressive strength of BSC materials increases proportional to tighter particle packing(soil dry bulk density)and binder content.A theory to explain this peak compressive strength phenomenon is presented.

关键词： Compressive strength biopolymer composites material design soil bulk density in situ material utilization sustainable materials

Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction

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World journal of Gastroenterology 2009年第35期15卷 4392-4401页

作者： Stephanie Schulz-Geske Kati Erdmann Ronald j Wong David K Stevenson henning Schrder Nina Grosser Department of Pharmacology and Toxicology School of PharmacyMartin Luther University Halle-Wittenberg06099 HalleGermany Department of Pediatrics Stanford University School of MedicineStanfordCA 94305 United States Department of Pharmaceutics College of PharmacyUniversity of MinnesotaMinneapolisMN 55455 United States

AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1(HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern *** blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species(ROS) formation was measured with lucigenin-enhanced ***-1 promoter activity in mouse fibroblasts,stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed using in vivo bioluminescence imaging. RESULTS:Lansoprazole increased HO-1 mRNA levels in endothelial cells and HO-1 protein levelsin *** addition,lansoprazole-induced ferritin protein levels in both cell ***, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS *** radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor,chromium mesoporphyrin *** of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However,the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter activity. CONCLUSION:Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002.

关键词：血红素加氧酶兰索拉唑分子机制荧光素酶报告基因 Western印迹法诱导丝裂原活化蛋白激酶介导

Modulation properties of solitary and optically injected phased-array semiconductor lasers

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Photonics Research 2018年第9期6卷 908-917页

作者： NIANQIANG LI H.SUSANTO B.R.CEMLYN I.D.henning M.j.ADAMS School of Computer Science and Electronic Engineering University of Essex Department of Mathematical Sciences University of Essex

We study modulation properties of two-element phased-array semiconductor lasers that can be described by coupled mode theory. We consider four different waveguide structures and modulate the array either in phase or out of phase within the phase-locked regions, guided by stability diagrams obtained from direct numerical simulations. Specifically, we find that out-of-phase modulation allows for bandwidth enhancement if the waveguide structure is properly chosen; for example, for a combination of index antiguiding and gain-guiding, the achievable modulation bandwidth in the case of out-of-phase modulation could be much higher than the one when they are modulated in phase. Proper array design of the coupling, controllable in terms of the laser separation and the frequency offset between the two lasers, is shown to be beneficial to slightly improve the bandwidth but not the resonance frequency, while the inclusion of the frequency offset leads to the appearance of double peak response curves. For comparison, we explore the case of modulating only one element of the phased array and find that double peak response curves are found. To improve the resonance frequency and the modulation bandwidth, we introduce simultaneous external injection into the phased array and modulate the phased array or its master light within the injection locking region. We observe a significant improvement of the modulation properties, and in some cases, by modulating the amplitude of the master light before injection,the resulting 3 dB bandwidths could be enhanced up to 160 GHz. Such a record bandwidth for phased-array modulation could pave the way for various applications, notably optical communications that require high-speed integrated photonic devices.

关键词：半导体激光器发展现状通讯技术技术创新

The vascular endothelial growth factor system-a new player in the pathogenesis and development of metabolic dysfunction-associated steatotic liver disease

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 963-965页

作者： henning Grønbæk Anders Mellemkjær Søren Nielsen Faidon Magkos Department of Hepatology&Gastroenterology Aarhus University HospitalAarhusDenmark Clinical Institute Aarhus UniversityAarhusDenmark Steno Diabetes Center Aarhus Aarhus University HospitalAarhusDenmark Department of Nutrition Exercise and SportsUniversity of CopenhagenFrederiksbergDenmark

The pathogenesis of liver disease from simple steatosis-metabolic dysfunction-associated steatotic liver disease(MASLD)-and the transition to inflammation and fibrosis-metabolic dysfunction-associated steatohepatitis(... 详细信息

关键词： Vascular endothelial growth factor B(VEGF-B) metabolic dysfunction-associated steatotic liver disease(MASLD) non-alcoholic fatty liver disease(NAFLD)