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ITPK1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.

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Molecular Plant 2021年第11期14卷 1864-1880页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider Adolfo Saiardi Dorothea Fiedler henning j.jessen Gabriel Schaaf Ricardo F.H.Giehl Department of Plant Nutrition Institute of Crop Science and Resource ConservationRheinische Friedrich-Wilhelms-Universitat Bonn53115 BonnGermany Department of Chemistry and Pharmacy and CIBSS-Centre for Integrative Biological Signalling Studies Albert-Ludwigs University Freiburg79104 FreiburgGermany Medical Research Council Laboratory for Molecular Cell Biology(MRC-LMCB) University College LondonLondon WC1E 6BTUK Department of Biochemistry Indian Institute of ScienceBengaluruKarnataka 560012India Leibniz-Forschungsinstitut fur Molekulare Pharmakologie 13125 BerlinGermany Department of Chemistry Humboldt Universitat zu Berlin12489 BerlinGermany Institute of Agronomy and Crop Physiology Justus-Liebig University Giessen35392 GiessenGermany Department of Physiology&Cell Biology Leibniz-lnstitute of Plant Genetics and Crop Plant Research06466 GaterslebenGermany

In plants, phosphate (Pi) homeostasis is regulated by the interaction of PHR transcription factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates. Here, we combined different methods to obtain a comprehensive picture of how inositol (pyro)phosphate metabolism is regulated by Pi and dependent on the inositol phosphate kinase ITPK1. We found that inositol pyrophosphates are more responsive to Pi than lower inositol phosphates, a response conserved across kingdoms. With CE-ESI-MS we could separate different InsP7 isomers in Arabidopsis and rice, and identify 4/6-InsP7 and a PP-InsP4 isomer hitherto not reported in plants. We found that the inositol pyrophosphates 1/3-InsP7, 5-InsP7 and InsP8 increase severalfold in shoots after Pi resupply and that tissue-specific accumulation of inositol pyrophosphates relies on ITPK1 activities and MRP5-dependent InsP6 compartmentalization. Notably, ITPK1 is critical for Pi-dependent 5-InsP7 and InsP8 synthesis in planta and its activity regulates Pi starvation responses in a PHR-dependent manner. Furthermore, we demonstrate that ITPK1-mediated conversion of InsP6 to 5-InsP7 requires high ATP concentrations and that Arabidopsis ITPK1 has an ADP phosphotransferase activity to dephosphorylate specifically 5-InsP7 under low ATP. Collectively, our study provides deeper insights into Pi-dependent changes in nutritional and energetic states with the synthesis of regulatory inositol pyrophosphates.

关键词： diphosphoinositol pentakisphosphate kinase inositol 1,3,4-trisphosphate 5/6-kinase 1 inositol phosphates inositol pyrophosphates phosphate homeostasis phosphate signaling

Diagnosis and treatment of heart failure with preserved left ventricular ejection fraction

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World journal of Cardiology 2020年第1期12卷 7-25页

作者： Robert j henning College of Public Health University of South Florida

Nearly six million people in United States have heart *** percent of these people have normal left ventricular(LV)systolic heart function but abnormal diastolic function due to increased LV myocardial *** commonly,these patients are elderly women with hypertension,ischemic heart disease,atrial fibrillation,obesity,diabetes mellitus,renal disease,or obstructive lung *** annual mortality rate of these patients is 8%-12%per *** diagnosis is based on the history,physical examination,laboratory data,echocardiography,and,when necessary,by cardiac *** with obesity,hypertension,atrial fibrillation,and volume overload require weight reduction,an exercise program,aggressive control of blood pressure and heart rate,and *** devices inserted into patients for pulmonary artery pressure monitoring provide early warning of increased pulmonary pressure and *** significant coronary heart disease is present,coronary revascularization should be considered.

关键词： Diastolic heart failure Myocardial stiffness Incomplete left ventricular relaxation Echocardiographic heart failure criteria Pulmonary artery pressure monitoring Drug treatment

Targeting cell death signaling in colorectal cancer:Current strategies and future perspectives

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World journal of Gastroenterology 2014年第8期20卷 1923-1934页

作者： Bruno Christian Koehler Dirk jger henning Schulze-Bergkamen National Center for Tumor Diseases University Hospitals Heidelberg69120 HeidelbergGermany

The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in colorectal cancer. Nearly any non-invasive cancer treatment finally aims to induce cell death. However, apoptosis resistance is the major cause for insufficient therapeutic success and disease relapse in gastrointestinal oncology. Various compounds have been developed and evaluated with the aim to meet with this obstacle by triggering cell death in cancer cells. The aim of this review is to illustrate current approaches and future directions in targeting cell death signaling in colorectal cancer. The complex signaling network of apoptosis will be demonstrated and the “druggability” of targets will be identified. In detail, proteins regulating mitochondrial cell death in colorectal cancer, such as Bcl-2 and survivin, will be discussed with respect to potential therapeutic exploitation. Death receptor signaling and targeting in colorectal cancer will be outlined. Encouraging clinical trials including cell death based targeted therapies for colorectal cancer are under way and will be demonstrated. Our conceptual understanding of cell death in cancer is rapidly emerging and new types of controlled cellular death have been identified. To meet this progress in cell death research, the implication of autophagy and necroptosis for colorectal carcinogenesis and therapeutic approaches will also be depicted. The main focus of this topic highlight will be on the revelation of the complex cell death concepts in colorectal cancer and the bridging from basic research to clinical use.

关键词： Colorectal cancer Apoptosis Necroptosis Autophagy Clinical trial Bcl-2 proteins BH-3 mimetics Inflammatory bowel disease

Organotypic hippocampal slices,an emerging tool to model synucleinopathies

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Neural Regeneration Research 2021年第5期16卷 999-1000页

作者： Sara Elfarrash Poul henning jensen Department of Physiology Faculty of MedicineMansoura UniversityMansouraEgypt DANDRITE‑Danish Research Institute of Translational Neuroscience and Department of Biomedicine Aarhus UniversityAarhusDenmark

Parkinson’s disease(PD)is the second most common neurodegenerative disease after Alzheimer’s *** has been traditionally considered a motoric disorder characterized by tremor,rigidity and bradykinesia,however it is now settled that PD also comprises a range of non-motor symptoms like hyposmia,sleep disturbances and cognitive impairments(Tysnes and Storstein,2017).

关键词： Alzheimer impairment settled

The molecular profile of nerve repair: humans mirror rodents

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Neural Regeneration Research 2021年第7期16卷 1440-1441页

作者： Matthew B.Wilcox Kristjan R.jessen Tom j.Quick james B.Phillips Peripheral Nerve Injury Research Unit Royal National Orthopaedic HospitalStanmoreUK Department of Pharmacology UCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK UCL Centre for Nerve Engineering University College LondonLondonUK Department of Cell and Developmental Biology University College LondonLondonUK

Peripheral nerve injuries(PNI)are common following blunt or penetrating trauma and can lead to disability and chronic pain in affected individuals,with limited options available to promote regeneration and functional *** animal models,it is known that the regenerative capacity of the peripheral nervous system(PNS)is heavily dependent upon the remarkable ability of Schwann cells to undergo a phenotypic shift from a supportive/myelinating/maintaining phenotype to one that encourages neural regeneration.

关键词： injuries mirror neural

Observation of supersymmetric pseudo-Landau levels in strained microwave graphene

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Light(Science & Applications) 2020年第1期9卷 611-617页

作者： Matthieu Bellec Charles Poli Ulrich Kuhl Fabrice Mortessagne henning Schomerus Institut de Physique de Nice(INPHYNI) Universite Cote d’AzurCNRS06108 NiceFrance Department of Physics Lancaster UniversityLancaster LA14YBUK

Using an array of coupled microwave resonators arranged in a deformed honeycomb lattice,we experimentally observe the formation of pseudo-Landau levels in the whole crossover from vanishing to large pseudomagnetic field *** result is achieved by utilising an adaptable setup in a geometry that is compatible with the pseudo-Landau levels at all field *** adopted approach enables us to observe the fully formed flat-band pseudo-Landau levels spectrally as sharp peaks in the photonic density of states and image the associated wavefunctions spatially,where we provide clear evidence for a characteristic nodal structure reflecting the previously elusive supersymmetry in the underlying low-energy *** particular,we resolve the full sublattice polarisation of the anomalous 0th pseudo-Landau level,which reveals a deep connection to zigzag edge states in the unstrained case.

关键词： microwave strained Landau

On Designing Biopolymer-Bound Soil Composites (BSC) for Peak Compressive Strength

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journal of Renewable Materials 2020年第8期8卷 845-861页

作者： Isamar Rosa henning Roedel Maria I.Allende Michael D.Lepech David j.Loftus Department of Civil and Environmental Engineering Stanford UniversityStanfordCA 94305USA Division of Space Biosciences NASA Ames Research CenterMoffet FieldCA 94035USA

Biopolymer-bound Soil Composites(BSC),are a novel bio-based construction material class,produced through the mixture and desiccation of biopolymers with inorganic aggregates with applications in soil stabilization,brick creation and in situ construction on Earth and *** paper introduces a mixture design methodology to produce maximum strength for a given soil-biopolymer *** protein and sand mix designs were investigated,with varying amounts of biopolymer solution and compaction regimes during *** ultimate compressive strength,density,and shrinkage of BSC samples are *** is observed that the compressive strength of BSC materials increases proportional to tighter particle packing(soil dry bulk density)and binder content.A theory to explain this peak compressive strength phenomenon is presented.

关键词： Compressive strength biopolymer composites material design soil bulk density in situ material utilization sustainable materials

Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction

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World journal of Gastroenterology 2009年第35期15卷 4392-4401页

作者： Stephanie Schulz-Geske Kati Erdmann Ronald j Wong David K Stevenson henning Schrder Nina Grosser Department of Pharmacology and Toxicology School of PharmacyMartin Luther University Halle-Wittenberg06099 HalleGermany Department of Pediatrics Stanford University School of MedicineStanfordCA 94305 United States Department of Pharmaceutics College of PharmacyUniversity of MinnesotaMinneapolisMN 55455 United States

AIM： To investigate the molecular mechanism and functional consequences of heme oxygenase-1 （HO-1） activation by lansoprazole in endothelial cells and macrophages. METHODS： Expression of HO-1 mRNA was analyzed by Northern blotting. Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species （ROS） formation was measured with lucigenin-enhanced chemiluminescence. HO-1 promoter activity in mouse fibroblasts, stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed usingin vivo bioluminescence imaging. RESULTS： Lansoprazole levels in endothelial cells increased HO-1 mRNA and HO-1 protein levels in macrophages. In addition, lansoprazole-induced ferritin protein levels in both cell systems. Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation. The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor, chromium mesoporphyrin IX. Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However, the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter ***： Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002.

关键词： Antioxidants Ferritin Heme oxygenase-1 Lansoprazole Reactive oxygen species

Aboveground resilience to species loss but belowground resistance to nitrogen addition in a montane plant community

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journal of Plant Ecology 2018年第3期11卷 351-363页

作者： Quentin D.Read jeremiah A.henning Aimée T.Classen Nathan j.Sanders Department of Ecology and Evolutionary Biology University of Tennessee569 Dabney HallKnoxvilleTN 37996USA Rocky Mountain Biological Laboratory PO Box 615Crested ButteCO 81224USA Center for Macroecology Evolutionand ClimateNatural History Museum of DenmarkUniversity of CopenhagenUniversitetsparken 152100 CopenhagenDenmark Rubenstein School of Environment and Natural Resources University of VermontBurlingtonVT 05405USA

Aims Decades of empirical work have demonstrated how dominant plant species and nitrogen fertilization can influence the structure and function of plant *** recent studies have examined the interplay between these factors,but few such studies use an explicit trait-based *** this study,we use an explicit trait-based approach to identify potential mechanisms for community-level responses and to test ecological niche *** We experimentally manipulated plant communities(control,−dom-inant species,−random biomass)and nitrogen(N)inputs(control,+organic N,+inorganic N)in a fully factorial *** predicted that traits related to plants’ability to take up different forms of soil N would differ between dominant and subordinate species,resulting in interactive effects of dominant species loss and N fertilization on plant community structure and *** study took place in a montane meadow in the Rocky Mountains,Colorado,*** Findings After four years,the plant community in removal plots converged toward a species composition whose leaf and root functional traits resembled those of the previously removed dominant *** productivity generally increased with N addition:soil carbon efflux was~50%greater when either form of N was added,while inorganic N addition increased aboveground biomass pro-duction by~60%relative to *** increase in production was mediated by increased average height,leaf mass:area ratio and leaf dry matter content in plant communities to which we added inorganic *** to our predictions,there were no interactive effects of N fertilization and dominant species loss on plant com-munity structure or ecosystem *** plant community com-position in this study exhibited resistance to soil N addition and,given the functional convergence we observed,was resilient to spe-cies ***,our results indicate that the ability of species to compensate functionally for species loss confers

关键词： dominant species fertilization functional trait removal experiment resilience