检索结果-南通市图书馆

The Journal of Biomedical Research 2020年第6期34卷 458-469,I0015-I0020页

作者： Yangfang Yun hengyi song Yin Ji Da Huo Feng Han Fei Li Nan Jiang Key Laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China The State Key Laboratory of Translational and Innovative Drug Development Simcere Pharmaceutical GroupNanjingJiangsu 210042China.

Global prevalence of coronavirus disease 2019(COVID-19)calls for an urgent development of anti-viral *** with the development of new drugs,drug repurposing can significantly reduce the cost,time,and safety *** the fact that coronavirus harnesses spike protein to invade host cells through angiotensinconverting enzyme 2(ACE2),hence we see if any previous anti-virtual compounds can block spike-ACE2 interaction and inhibit the virus *** results of molecular docking and molecular dynamic simulations revealed that remdesivir exhibits better than expected anti-viral invasion potential against COVID-19 among the three types of compounds including remdesivir,tenofovir and *** addition,a positive correlation between the surface area occupied by remdesivir and anti-viral invasion potential was also *** such,the structure of remdesivir was modified by linking an N-benzyl substituted diamidine derivative to its hydroxyl group through an ester *** was found that this compound has a higher anti-viral invasion potential and greater specificity.

关键词： COVID-19 remdesivir diamidine spike angiotensin-converting enzyme 2(ACE2)

高山探险目的地形象对体育旅游参与者行为意向的影响研究——以风险感知和情绪为中介

在线全文

学校读者我要写书评

暂无评论

山东体育学院学报 2024年第5期40卷 116-126页

作者：宋恒义马腾山东体育学院研究生教育学院山东济南250102 山东体育学院运动休闲学院山东济南250102

目的:立足于情绪评价理论,以风险感知和情绪作为中介变量,探究高山探险目的地形象对体育旅游参与者行为意向的影响机制。方法:选取四川省小金县四姑娘山区域为调研采样地,以371名体育旅游参与者为样本,基于结构方程模型的多重中介效应,... 详细信息

目的:立足于情绪评价理论,以风险感知和情绪作为中介变量,探究高山探险目的地形象对体育旅游参与者行为意向的影响机制。方法:选取四川省小金县四姑娘山区域为调研采样地,以371名体育旅游参与者为样本,基于结构方程模型的多重中介效应,运用SPSS 26.0和Amos 24.0软件对数据进行统计分析。结果:(1)目的地形象对风险感知具有显著的负向影响,对情绪和行为意向具有显著的正向影响;(2)风险感知对情绪和行为意向具有显著的负向影响;(3)风险感知和情绪在目的地形象对行为意向的影响过程中发挥着显著的双中介作用。结论:体育旅游参与者行为意向的生成受多重要素驱动,为充分发挥目的地形象的直接效应及风险感知、情绪的双重中介作用,应塑造积极的高山探险旅游目的地形象,注重体育旅游参与者的情绪管理和风险管理,构建综合治理框架,为高山探险旅游消费业态健康发展提供理论支撑与现实指导。

关键词：高山探险体育旅游目的地形象行为意向风险感知情绪

背侧纹状体参与认知功能神经环路信息整合研究进展

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

南京医科大学学报（自然科学版） 2022年第12期42卷 1759-1766页

作者：宋恒毅胥寒韩峰南京医科大学药学院江苏南京211166

纹状体是中枢神经系统中调节精细运动的重要核团。近年来越来越多的研究表明,背侧纹状体参与了认知相关的非运动性功能。认知功能障碍(cognitive impairment,CI)是一种学习与记忆能力缺失的精神疾病,在许多疾病早期均有发生。背侧纹状... 详细信息

纹状体是中枢神经系统中调节精细运动的重要核团。近年来越来越多的研究表明,背侧纹状体参与了认知相关的非运动性功能。认知功能障碍(cognitive impairment,CI)是一种学习与记忆能力缺失的精神疾病,在许多疾病早期均有发生。背侧纹状体作为学习记忆信息处理的中转站,整合上游环路释放的谷氨酸能、多巴胺能等神经递质,再通过直接通路与间接通路将信息输出至下游核团参与认知行为。本文立足于背侧纹状体,阐述其结构功能与神经环路机制,结合现有治疗手段,探究背侧纹状体神经环路中潜在的治疗靶点。

关键词：背侧纹状体认知功能障碍神经环路神经递质

关节镜下带线锚钉缝线桥缝合固定治疗肩锁关节脱位

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2021年第9期25卷 1417-1422页

作者：张尚普鞠晓东宋恒义董智王晨孙国栋冀中能源邢台矿业集团总医院关节骨科河北省邢台市054000 北京大学第三医院运动医学研究所北京市100191

背景:目前肩锁关节脱位手术尚无统一标准,锁骨钩板固定是临床上较为常用的一种固定方式,但是微创的韧带重建技术与关节镜手术已经成为研究的热点。目的:观察关节镜下带线锚钉缝线桥缝合固定治疗肩锁关节脱位的应用价值。方法:选择2016年... 详细信息

背景:目前肩锁关节脱位手术尚无统一标准,锁骨钩板固定是临床上较为常用的一种固定方式,但是微创的韧带重建技术与关节镜手术已经成为研究的热点。目的:观察关节镜下带线锚钉缝线桥缝合固定治疗肩锁关节脱位的应用价值。方法:选择2016年1月至2018年4月冀中能源邢台矿业集团总医院骨外科收治的TossyⅢ型肩锁关节脱位患者,随机分为2组。关节镜组患者采取关节镜下带线锚钉结合缝线桥技术进行复位固定治疗,锁骨钩钢板组患者采用锁骨钩钢板内固定。记录两组患者手术切口长度、手术花费时间、住院时间及恢复工作时间;术后3,6,12个月按照Lazzcano疗效标准对肩关节功能进行评价,并比较两组患者肩部疼痛目测类比评分、外展上举和前屈上举活动度的差异。所有患者均随访1年,记录两组患者并发症发生情况。研究已获得冀中能源邢台矿业集团有限责任公司总医院医学伦理委员会审核批准,且所有研究对象术前均签署知情同意书。结果与结论:①两组患者手术时间比较差异无显著性意义(P>0.05);关节镜组患者手术切口、住院时间、恢复工作时间均显著优于锁骨钩钢板组(P0.05);③两组患者术后3,6,12个月目测类比评分呈逐渐下降趋势(P<0.01),同一时间节点关节镜组患者目测类比评分显著低于锁骨钩钢板组(P<0.01);④两组患者术后3,6,12个月外展上举、前屈上举角度呈逐渐上升趋势(P<0.01),同一时间节点关节镜组患者外展上举、前屈上举角度均大于锁骨钩钢板组(P<0.01);⑤术后1年随访结果显示,关节镜组患者并发症发生率为6%,显著低于锁骨钩钢板组的63%(P<0.01);⑥与锁骨钩钢板固定相比,关节镜下带线锚钉缝线桥缝合固定治疗肩锁关节脱位具有创伤小、恢复快、并发症少、无需再次手术去除内植物等优势,手术同时还可以明确诊断关节内伴随的病变,并在必要时进行治疗,提高修复效果。

关键词：骨肩锁关节脱位关节镜带线锚钉缝线桥 TossyⅢ型钩钢板内固定喙锁韧带

Tectonic modes of mantle convection and their implications for Earth's tectonic evolution based on three-dimensional numerical simulations

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年第1期68卷 270-296页

作者： song XIANG Jinshui HUANG Bingcheng WU School of Earth and Space Sciences University of Science and Technology of China CAS Center of Excellence in Comparative Planetary Studies

Five tectonic modes of mantle convection are obtained and analyzed with three-dimensional numerical models in a spherical shell domain. The five tectonic convective modes are non-plate mobile-lid, plate-like mobile-lid, episodic plate-like mobile-lid, episodic stagnant-lid, and stagnant-lid convective modes, respectively. The typical characteristics of these five tectonic modes and their numerical classification criteria based on plateness, mobility, and their standard deviations are presented and discussed. The results show that the yield stress of the lithosphere has profound effects on the tectonic convective *** the gradual increase of yield stress, the tectonic mode of mantle convection changes from one to another sequentially through the aforementioned five modes. Additionally, as the Rayleigh number increases, the range of yield stress for the platelike mobile-lid convective mode decreases, and the dimensionless transition stress between different tectonic modes ***, the dimensional transition stress between the non-plate mobile-lid convective mode and plate-like mobile-lid convective mode increases with the increase of Rayleigh number, but decreases between other tectonic modes. Furthermore, we find that the transition stress between different tectonic modes is inversely proportional to the internal heating rate, with the transition stress decreasing as the internal heating rate increases. The fitting analysis of the transition stress between tectonic modes shows that Earth's current plate tectonics correspond to a lithospheric yield stress of 150–250 MPa, which aligns with the strength of serpentinized mantle rock determined by experimental petrography. If the Archean mantle was 300°C warmer than it is today, then the Earth was in an episodic stagnant-lid convective mode. The tectonic evolution of the Earth's surface is closely related to the lithospheric strength and the process of thermal evolution. If the lithospheric strength w

关键词： Tectonic mode of mantle convection Plate-like mobile-lid convection Episodic plate-like mobile-lid convection Episodic stagnant-lid convection Plate tectonics and tectonic evolution of the Earth

Molecular dynamics simulations of helium transport through inorganic mineral nanopores

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年第1期68卷 237-252页

作者： Dandan song Ping GUAN Chi ZHANG Jiahao REN School of Earth and Space Sciences Peking University

Helium transport through nanoscale inorganic mineral pores and pore throats is essential for its overall migration. To elucidate helium's transport dynamics within nanopores, we employed equilibrium and non-equilibrium molecular dynamics simulations to investigate helium's static self-diffusion and pressure-driven flow in quartz slit-shaped nanopores. We also introduced water and various gases, including hydrogen, methane, ethane, nitrogen, and carbon dioxide, into the nanopores to assess their influence on helium transport. Our findings indicate minimal helium adsorption on quartz pore surfaces. Under conditions where the pore size is less than 5 nm and the pressure under 10 MPa, environmental factors markedly influence helium diffusion. Large pore sizes, high temperatures, and low gas pressures enhance helium desorption and facilitate faster diffusion. We observed a positive correlation between helium flow velocity and factors such as pore size, pressure gradient, and surface smoothness of the pores. Notably, the presence of pore water and carrier gases in quartz nanopores, which diffuse more slowly than helium, tends to reduce helium surface adsorption and slow its diffusion. Among the carrier gases studied, nitrogen showed similar adsorption capacity, diffusivity, and stability to helium, while carbon dioxide displayed the highest adsorption capacity and the slowest diffusion rate, markedly differing from helium. Based on the simulation results, we concluded that water and carrier gases primarily function as transport mediums in helium migration, moving together with helium. Nitrogen, which shares similar properties with helium, effectively assists in this co-migration process. Conversely, carbon dioxide, due to its high adsorption capacity and slow diffusion, tends to be lost during co-migration. As a result, gas reservoirs with high nitrogen levels and low carbon dioxide levels are more likely to have higher helium concentrations. Additionally, the smaller por

关键词： Helium transport Slit nanopores Molecular dynamics simulations Diffusion Flow carriers

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN QINGHUA song HUA LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

Constraints on holographic QCD phase transitions from PTA observations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run song Shiyi Yin Jiannan Wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

Passive activity enhances residual control ability in patients with complete spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun song Wei song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task