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Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin Qi Qingqiang Min Ming Li Huabing Chen hengte ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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具有癌症诊疗潜力的多功能核壳纳米粒

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材料科学与工艺 2021年第3期29卷 57-63页

作者：宋雪吴静悦张娟吉严蓉景杰翔柯亨特苏州大学药学院江苏苏州215123

采用乳化-溶剂挥发法制备了同时携载Mn_(3)O_(4)纳米粒和CuS白蛋白纳米粒的诊疗一体化多功能核壳纳米粒,可用于磁共振造影成像手段指引下的肿瘤光热消融,实现癌症的高效诊治。首先用高温热解法制备出粒径均一、分散性较好的Mn_(3)O_(4)... 详细信息

采用乳化-溶剂挥发法制备了同时携载Mn_(3)O_(4)纳米粒和CuS白蛋白纳米粒的诊疗一体化多功能核壳纳米粒,可用于磁共振造影成像手段指引下的肿瘤光热消融,实现癌症的高效诊治。首先用高温热解法制备出粒径均一、分散性较好的Mn_(3)O_(4)纳米粒,并通过蛋白模板法制备CuS白蛋白纳米粒,之后采用可降解性聚乳酸-羟基乙酸共聚物(PLGA)作为载体,通过超声乳化法制备同时携载Mn_(3)O_(4)和CuS纳米粒的核壳纳米粒(Mn_(3)O_(4)/PLGA@CuS),并进行理化性质表征及诊疗一体化性能评价。结果表明:紫外-可见-近红外分光光度计测定结果显示该纳米粒被成功制备,其在近红外区具有较强吸收;核壳纳米粒的平均粒径为160 nm,粒径分布较为均匀;体外磁共振造影成像结果显示随着纳米粒中Mn离子浓度的升高,其造影增强效果也明显提升,显示其具有Mn离子浓度依赖的磁共振成像效果,纵向弛豫率为1.351 mM^(-1)·s^(-1);在785及980 nm激光辐照下,该核壳纳米粒均显示出良好的光热升温效果。成功制备了具有良好的磁共振造影成像性能和显著的光热升温效应的核壳纳米粒,有望应用于肿瘤的诊疗一体化。

关键词：诊疗一体化核壳纳米粒白蛋白 CuS Mn_(3)O_(4)

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Precise nanomedicine for intelligent therapy of cancer

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Science China Chemistry 2018年第12期61卷 1503-1552页

作者： Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang hengte ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao State key Laboratoiy of Radiation Medicine and Protection Jiangsu Key Laboratoiy of Neuropsychiatric Diseases College of Pharmaceutical Sciences Soochow University Suzhou 215123 China key Laboratoiy of Biomedical Polymers of Ministry of Education Department of Chemistiy Wuhan University Wuhan 430072 China Laboratoiy of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 USA Molecular Science and Biomedicine Laboratoiy State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistiy and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University Changsha 410082 China Jiangsu key Laboratoiy for Carbon-Based Functional Materials & Devices Institute of Functional Nano & Soft Materials Soochow University Suzhou 215123 China Department of Polymer Science and Engineering College cf Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China State key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China Department of Chemistiy Tsinghua University Beijing 100084 China National Engineering Research Center for Nanomedicine College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Department of Chemistiy and Department of Physiology and Functional Genomics Center for Research at Bio/nano Interface Health Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China CAS key Laboratoiy for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China key Labo

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

关键词： nanomedicine nanoparticles cancer therapy cancer imaging intelligent therapy

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