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Spatially resolved transcriptomic profiling of placental development in dairy cow

Zoological Research 2024年第3期45卷 586-600页

作者： Guang-Hui Tan Shi-Jie liu Ming-Le Dou De-Feng Zhao Ao Zhang heng-kuan li Fu-Nong Luo Tao Shi Hao-Ping Wang Jing-Yuan Lei Yong Zhang Yu Jiang Yi Zheng Fei Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Northwest A&F UniversityYanglingShaanxi 712100China College of Information Engineering Northwest A&F UniversityYanglingShaanxi 712100China

The placenta plays a crucial role in successful mammalian *** animals possess a semi-invasive placenta characterized by a highly vascularized structure formed by maternal endometrial caruncles and fetal placental cotyledons,essential for full-term fetal *** cow placenta harbors at least two trophoblast cell populations:uninucleate(UNC)and binucleate(BNC)***,the limited capacity to elucidate the transcriptomic dynamics of the placental natural environment has resulted in a poor understanding of both the molecular and cellular interactions between trophoblast cells and niches,and the molecular mechanisms governing trophoblast differentiation and *** fill this knowledge gap,we employed Stereo-seq to map spatial gene expression patterns at near single-cell resolution in the cow placenta at 90 and 130 days of gestation,attaining high-resolution,spatially resolved gene expression *** on clustering and cell marker gene expression analyses,key transcription factors,including YBX1 and NPAS2,were shown to regulate the heterogeneity of trophoblast cell *** communication and trajectory analysis provided a framework for understanding cell-cell interactions and the differentiation of trophoblasts into BNCs in the placental *** analysis of cell trajectories identified a set of genes involved in regulation of trophoblast ***,spatial modules and co-variant genes that help shape specific tissue structures were ***,these findings provide foundational insights into important biological pathways critical to the placental development and function in cows.

关键词： Spatial transcriptomics Dairy cow Placenta Gestation

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Data complexity-based batch sanitization method against poison in distributed learning

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Digital Communications and Networks 2024年第2期10卷 416-428页

作者： Silv Wang Kai Fan kuan Zhang Hui li Yintang Yang State Key Laboratory of Integrated Service Networks Xidian UniversityXi'an710126China Department of Electrical and Computer Engineering University of Nebraska-LincolnLincolnNE68588USA Key Lab.of the Minist.of Educ.for Wide Bandgap Semiconductor Materials and Devices Xidian UniversityXi'an710071China

The security of Federated Learning(FL)/Distributed Machine Learning(DML)is gravely threatened by data poisoning attacks,which destroy the usability of the model by contaminating training samples,so such attacks are called causative availability indiscriminate *** the problem that existing data sanitization methods are hard to apply to real-time applications due to their tedious process and heavy computations,we propose a new supervised batch detection method for poison,which can fleetly sanitize the training dataset before the local model *** design a training dataset generation method that helps to enhance accuracy and uses data complexity features to train a detection model,which will be used in an efficient batch hierarchical detection *** model stockpiles knowledge about poison,which can be expanded by retraining to adapt to new *** neither attack-specific nor scenario-specific,our method is applicable to FL/DML or other online or offline scenarios.

关键词： Distributed machine learning security Federated learning Data poisoning attacks Data sanitization Batch detection Data complexity

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Application of GNSS-PPP on Dynamic Deformation Monitoring of Offshore Platforms

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China Ocean Engineering 2024年第2期38卷 352-361页

作者： YU li-na XIONG kuan GAO Xi-feng li Zhi FAN li-long ZHANG Kai Institute of Ocean Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China China Railway Construction Bridge Engineering Bureau Group Co.LTD Tianjin 300300China School of Civil Engineering Tianjin UniversityTianjin 300072China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Precision Blasting Jianghan UniversityWuhan 430056China

The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe *** Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively ***,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains ***,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore *** address these concerns,vibration table tests with different amplitudes and frequencies are *** results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with ***,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of *** monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN *** comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load *** research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.

关键词： GNSS-PPP offshore platform dynamic deformation monitoring improved CEEMDAN de-noising

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Numerical investigation on thermomechanical behavior of alumina–calcium hexaluminate refractories for purging plug

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Journal of Iron and Steel Research(International) 2024年第2期31卷 389-400页

作者： li-ping Pan Ya-wei li Fang-guan Tan Yi-chen Chen Yang-fan Xu Zhu He Bao-kuan li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina National-Provincial Joint Engineering Research Center of High Temperature Materials and lining Technology Wuhan University of Science and TechnologyWuhan430081HubeiChina

Alumina–spinel refractories used in slit-type purging plugs are susceptible to cross-sectional damage,resulting in a serious mismatch between their service life and that of ***–calcium hexaluminate refractories have gradually become the new trend in purging plug materials with the development of refining *** thermomechanical damage of slit-type purging plugs with alumina–calcium hexaluminate refractory was investigated by the thermo-solid coupling *** with the polynomial fitting and design of experiments methods,the influence of thermophysical parameters on temperature and thermal stress of alumina–calcium hexaluminate refractories for purging plugs was systematically *** results show that the maximum thermal stress of the purging plugs appears during the stages of steel transporting and stirring,and the vulnerable parts are located above Y=0.323 *** thermal conductivity and the coefficient of thermal expansion of the material are the most sensitive parameters to the temperature and thermal stress inside the structure,*** addition of more calcium hexaluminate can relieve the stress concentration and large deformation around the ***,when the content of calcium hexaluminate is 47 wt.%and in the form of aggregate-binder,the temperature and thermal stress distribution inside the refractory are optimal,which can effectively improve the service life of the slit-type purging plug.

关键词： Purging plug Thermomechanical damage Refractory Design of experiments method Stress

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Fracture mechanism of inclusions in thick plate center under tensile loading

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Journal of Iron and Steel Research(International) 2024年第5期31卷 1196-1209页

作者： Lei Hu li-qin Zhang Feng Hu Guo-hong Zhang kuan Zheng Collaborative Innovation Center for Advanced Steels Wuhan University of Science and TechnologyWuhan430081HubeiChina Department of Applied Physics Wuhan University of Science and TechnologyWuhan430081HubeiChina Analysis and Testing Center Wuhan University of Science and TechnologyWuhan430081HubeiChina

Segregation of solute atoms in the center of thick plates of the tempered steel can cause an inhomogeneous structural transformation and generate micron-sized inclusions,which leads to lamellar tearing of thick plate and decreases the plasticity and *** formation and fragmentation mechanisms of micron-sized inclusions,like MnS and(Nb,Ti)C,in the center of thick plates were investigated by using thermodynamic calculations,finite element simulations,and electron backscatter diffraction characterization *** results show that micron-sized inclusions nucleate and grow in the liquid phase,and under tensile loading,they exhibit three fragmentation *** local stress during the fragmentation of inclusions is lower than the critical fracture stress of adjacent grains,and phase boundaries can effectively impede crack propagation into the *** existence of a low proportion of high-angle grain boundaries(58.1%)and high Kernel average misorientation value(0.534°)in the segregation band promotes inclusions fragmentation and crack *** difference in crack initiation and propagation direction caused by the morphology of inclusions and physical properties,as well as different matrix arrest abilities,is the main reasons for the diversity of inclusion fragmentation.

关键词： Thick plate Inclusion Finite element simulation Critical fracture stress Fracture mechanism

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Increasing the toughness while reducing the viscosity of carbon nanotube/ polyether imide/polyether ether ketone nanocomposites

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新型炭材料（中英文） 2024年第4期39卷 715-728页

作者： SONG Jiu-peng ZHAO Yan li Xue-kuan XIONG Shu li Shuang WANG Kai School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Polyether ether ketone(PEEK)has good mechanical ***,its high viscosity when molten limits its use because it is hard to *** nanocomposites containing both carbon nanotubes(CNTs)and polyether imide(PEI)were pre-pared by a direct wet powder blending method using a vertical injection molding *** addition of an optimum amount of PEI lowered the viscosity of the molten PEEK by approximately 50%while producing an increase in the toughness of the nanocom-posites,whose strain to failure increased by 129%,and fracture energy increased by 97%.The uniformly dispersed CNT/PEI powder reduced the processing difficulty of PEEK nanocomposites without affecting the thermal *** improvement of the strength and viscosity of PEEK facilitate its use in the preparation of thermoplastic composites.

关键词： Nanocomposites Mechanical properties Rheological properties Microstructural analysis

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Gp78 regulates PMP22 and causes ER stress and autophagy in EV71-VP1-overexpressing mouse Schwann cells

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BIOCELL 2024年第4期48卷 653-664页

作者： DANPING ZHU GUANGMING liU kuan FENG SUYUN li DANDAN HU SIDA YANG PEIQING li Pediatric Emergency Department Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina Department of Child Health Care Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina Pediatric Neurology Department Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina

Background:During Enterovirus type 71(EV71)infection,the structural viral protein 1(VP1)activates endoplasmic reticulum(ER)stress associated with peripheral myelin protein 22(PMP22)accumulation and induces ***,the speciﬁc mechanism behind this process remains ***:In this research,we used the VP1-overexpressing mouse Schwann cells(SCs)models co-transfected with a PMP22 silencing or Autocrine motility factor receptor(AMFR/gp78)overexpressing vector to explore the regulation of gp78 on PMP22 and its relationship with autophagy and ***:The activity of gp78 could be inﬂuenced by EV71-VP1,leading to a decrease in the ubiquitination and degradation of PMP22,resulting in PMP22 accumulation in *** VP1-overexpressing mouse SCs,all three ER stress sensors,including pancreatic endoplasmic reticulum kinase(PERK),activating transcription factor 6(ATF6)and inositol-requiring enzyme 1(IRE1)and the related downstream signals(C/EBP-homologous protein(CHOP)and Caspase 12)were activated,as well as the ER-resident chaperone Glucose-regulated protein 78(GRP78).In addition,VP1 upregulated the autophagy marker Microtubule-associated protein 1 light chain 3 beta(LC3B),while PMP22 silencing or gp78 overexpression reversed the ***,PMP22 silencing or gp78 overexpression increased proliferation of EV71-VP1-transfected mouse ***:Gp78 could regulate PMP22 accumulation through ubiquitination degradation and cause ER stress and autophagy in EV71-VP1-overexpressing mouse ***,the gp78/PMP22/ER stress axis might emerge as a promising therapeutic target for myelin and neuronal damage induced by EV71 infection.

关键词： Enterovirus type 71 AMFR/gp78 PMP22 Autophagy Schwann cells

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Rationally designing electrolyte additives for highly improving cyclability of liNi_(0.5)Mn_(1.5)O_(4)/Graphite cells

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Journal of Energy Chemistry 2024年第4期91卷 266-275页

作者： Zhiyong Xia kuan Zhou Xiaoyan lin Zhangyating Xie Qiurong Chen Xiaoqing li Jie Cai Suli li Hai Wang Mengqing Xu Weishan li School of Chemistry South China Normal UniversityGuangzhou 510006GuangdongChina China Zhuhai CosMX Battery Co. Ltd.Zhuhai 519180GuangdongChina National and Local Joint Engineering Research Center of MPTES in High Energy and Safety liBs Engineering Research Center of MTEES(Ministry of Education)and Key Lab.of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006GuangzhouChina

High voltage is necessary for high energy lithium-ion batteries but difficult to achieve because of the highly deteriorated cyclability of the batteries.A novel strategy is developed to extend cyclability of a high voltage lithium-ion battery,liNi_(0.5)Mn_(1.5)O_(4)/Graphite(LNMO/Graphite)cell,which emphasizes a rational design of an electrolyte additive that can effectively construct protective interphases on anode and cathode and highly eliminate the effect of hydrogen fluoride(HF).5-Trifluoromethylpyridine-trime thyl lithium borate(LTFMP-TMB),is synthesized,featuring with *** anion TFMPTMB-tends to be enriched on cathode and can be preferentially oxidized yielding TMB and radical TFMP-.Both TMB and radical TFMP can combine HF and thus eliminate the detrimental effect of HF on cathode,while the TMB dragged on cathode thus takes a preferential oxidation and constructs a protective cathode *** the other hand,LTFMP-TMB is preferentially reduced on anode and constructs a protective anode ***,a small amount of LTFMP-TMB(0.2%)in 1.0 M liPF6in EC/DEC/EMC(3/2/5,wt%)results in a highly improved cyclability of LNMO/Graphite cell,with the capacity retention enhanced from 52%to 80%after 150 cycles at 0.5 C between 3.5 and 4.8 *** as-developed strategy provides a model of designing electrolyte additives for improving cyclability of high voltage batteries.

关键词： Electrolyte additive Design and synthesis Cyclability High voltage batteries Cathode and anode interphases

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Understanding Bridging Sites and Accelerating Quantum Efficiency for Photocatalytic CO_(2) Reduction

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Nano-Micro Letters 2024年第1期16卷 68-84页

作者： Kangwang Wang Zhuofeng Hu Peifeng Yu Alina M.Balu kuan li Longfu li lingyong Zeng Chao Zhang Rafael Luque Kai Yan Huixia Luo School of Materials Science and Engineering State Key Laboratory of Optoelectronic Materials and TechnologiesGuangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesKey Lab of Polymer Composite and Functional MaterialsSun Yat-Sen UniversityNo.135Xingang Xi RoadGuangzhou 510275People’s Republic of China School of Environmental Science and Engineering Sun Yat-Sen UniversityNo.135Xingang Xi RoadGuangzhou 510275People’s Republic of China Departamento de Química Orgánica Universidad de CórdobaCampus Universitario de RabanalesEdificio Marie Curie(C3)14014 CórdobaSpain Center for Refining and Advanced Chemicals King Fahd University of Petroleum and Minerals31261 DhahranSaudi Arabia Universidad ECOTEC Km 13.5 SamborondónEC092302 SamborondónEcuador

We report a novel double-shelled nanoboxes photocatalyst architecture with tailored interfaces that accelerate quantum efficiency for photocatalytic CO_(2) reduction reaction(CO_(2)RR)via Mo–S bridging bonds sites in S_(v)–In_(2)S_(3)@2H–MoTe_(2).The X-ray absorption near-edge structure shows that the formation of S_(v)–In_(2)S_(3)@2H–MoTe_(2) adjusts the coordination environment via interface engineering and forms Mo–S polarized sites at the *** interfacial dynamics and catalytic behavior are clearly revealed by ultrafast femtosecond transient absorption,time-resolved,and in situ diffuse reflectance–Infrared Fourier transform spectroscopy.A tunable electronic structure through steric interaction of Mo–S bridging bonds induces a 1.7-fold enhancement in S_(v)–In_(2)S_(3)@2H–MoTe_(2)(5)photogenerated carrier concentration relative to pristine S_(v)–In_(2)S_(3).Benefiting from lower carrier transport activation energy,an internal quantum efficiency of 94.01%at 380 nm was used for photocatalytic CO_(2)*** study proposes a new strategy to design photocatalyst through bridging sites to adjust the selectivity of photocatalytic CO_(2)RR.

关键词： Quantum efficiency Electronic structure Steric interaction Bridging sites CO_(2)reduction

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Spatially resolved transcriptomic profiling of placental development in dairy cow

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动物学研究 2024年第3期 586页

作者： Guang-Hui Tan Shi-Jie liu Ming-Le Dou De-Feng Zhao Ao Zhang heng-kuan li Fu-Nong Luo Tao Shi Hao-Ping Wang Jing-Yuan Lei Yong Zhang Yu Jiang Yi Zheng Fei Wang

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