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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao jun liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Multiphase flow physics of room temperature liquid metals and its applications

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Science China(Technological Sciences) 2023年第6期66卷 1483-1510页

作者： QIAO MengWen XING ZeRong FU jun-heng liu Jing CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China Beijing Key Laboratory of Cryo-Biomedical Engineering Beijing 100190China College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYa’an 625014China Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing 100084China

Multiphase flow existing everywhere in the motion evolution of nature,industrial processes,and daily life,has been an interdisciplinary cutting-edge frontier covering rather diverse *** multiphase flow of high melting metals typically involves gas/vapor-liquid two-phase fluidics which usually requests intense energy processes and therefore limits their applications to a large *** from this,the newly emerging room-temperature liquid metals(RTLMs)with fascinating metallic fluidic properties and multifunctional behaviors,not only well resolve the existing challenges facing conventional technologies,but also open up a series of new scientific and engineering *** the conceptual introduction of multiphase composites endows liquid metal with many unconventional fluidic *** further push forward the advancement of this new area,the present article is dedicated to systematically outlining the scientific category of RTLMs multiphase flow physics and interpreting its fundamental and practical *** vision is to provide insights into promising developmental directions of RTLMs multiphase flow and thus facilitate synergetic research and progress among different ***,the traditional metal multiphase flow was briefly ***,we summarized the physics of RTLMs multiphase flow,the common types of liquid metals,the basic physical and chemical properties of their multiphase flow and governing equations,*** that,various typical driving modalities and manipulation methods of RTLMs were ***,important implementations of RTLMs multiphase flow into thermal management,energy harvesting,catalysis,soft machines,biomedicine,and printed electronics were ***,the multiphase flow physics of RTLMs is currently still in its incubation stage and there exist tremendous opportunities and challenges which are worth further pursuing in the coming time.

关键词： room-temperature liquid metals multiphase flow physics composite solution nanofluids fluid mechanics micro-/nanodroplets

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Growth characteristics of directionally solidified Al_2O_3/YAG/ZrO_2 ternary hypereutectic in situ composites under ultra-high temperature gradient

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 121-125页

作者： Hai-jun Su jun Zhang Lin liu heng-zhi Fu State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi＇an 710072 China

Oxide eutectic ceramic in situ composites have attracted significant interest in the application of high-temperature structural materials because of their excellent high-temperature strength,oxidation and creep resistance,as well as outstanding microstructural *** directionally solidified ternary Al2O3/YAG/ZrO2 hypereutectic in situ composite was successfully prepared by a laser zone remelting method,aiming to investigate the growth characteristic under ultra-high temperature *** microstructures and phase composition of the as-solidified hypereutectic were characterized by using scanning electron microscopy（SEM）,energy dispersive spectroscopy（EDS）,and X-ray diffraction（XRD）.The results show that the composite presents a typical hypereutectic lamellar microstructure consisting of fine Al2O3 and YAG phases,and the enriched ZrO2 phases with smaller sizes are randomly distributed at the Al2O3/YAG interface and in Al2O3 *** power and scanning rate strongly affect the sample quality and microstructure ***,coarse colony microstructures were also observed,and their formation and the effect of temperature gradient on the microstructure were discussed.

关键词： eutectics ceramic materials microstructure thermal gradients remelting solidification

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A method to Estimate Dynamic Responses of VLFS Based on Multi-Floating-Module Model Connected by Elastic Hinges

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China Ocean Engineering 2021年第5期35卷 687-699页

作者： HUANG heng CHEN Xu-jun liu jun-yi MIAO Yu-ji JI Song College of Field Engineering Army Engineering University of PLANanjing 210007China China Ship Scientific Research Center Wuxi 214082China

Based on the elastic foundation beam theory and the multi-floating-module hydrodynamic theory,a novel method is proposed to estimate the dynamic responses of VLFS(Very Large Floating Structure).In still water,a VLFS can be simplified as an elastic foundation beam model or a multi-floating-module model connected by elastic *** to equivalent displacement of the two models in static analysis,the problem of rotation stiffness of elastic hinges can be ***,based on the potential flow theory,the dynamic responding analysis of multi-floatingmodule model under wave loads can be computed in ANSYS-AQWA *** assembling the time domain analysis results of each module,the dynamic responses of the VLFS can be *** of the method is conducted through a series of comparison calculations,which mainly includes a continuous structure and a three-part structure connected by hinges in regular *** results of this paper method show a satisfactory agreement with the experiment and calculation data given in relative references.

关键词： Very Large Floating Structure(VLFS) dynamic responses elastic foundation beam multi-floatingmodule model elastic hinge

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从荒漠肉苁蓉分离苯乙醇苷产生的废弃液中结晶甘露醇

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食品工业科技 2017年第3期38卷 215-220页

作者：郭元亨张利军刘伯言曹丽丽赵庆生赵兵中国科学院过程工程研究所生化工程国家重点实验室生物炼制工程研究部北京100190 中国科学院大学北京100049

荒漠肉苁蓉中分离苯乙醇苷的工艺中,大量甘露醇因难以与其它糖类分离而被一起丢弃。为了从这些废弃的糖溶液中分离纯化甘露醇,本文开发了一套甘露醇的结晶工艺。分别对影响结晶过程的3个主要因素(包括糖溶液的密度、结晶时间和结晶温度... 详细信息

荒漠肉苁蓉中分离苯乙醇苷的工艺中,大量甘露醇因难以与其它糖类分离而被一起丢弃。为了从这些废弃的糖溶液中分离纯化甘露醇,本文开发了一套甘露醇的结晶工艺。分别对影响结晶过程的3个主要因素(包括糖溶液的密度、结晶时间和结晶温度)进行了单因素实验。结果表明,适宜的操作参数为:糖溶液的密度为1.21~1.27 g/m L,结晶时间为24~30 d,结晶温度为-10~0℃。在单因素实验的基础上,采用响应曲面法对结晶的工艺参数进行优化。结果表明最优操作条件为:糖溶液的密度为1.24 g/m L,结晶时间为28 d,结晶温度为0℃。在此条件下,甘露醇的回收率和纯度分别可达70.04%和87.17%。以上结果表明,荒漠肉苁蓉中分离苯乙醇苷的工艺中,废弃的糖液可以用于回收甘露醇。本研究获得的模型可以用来优化甘露醇结晶过程。

关键词：荒漠肉苁蓉甘露醇苯乙醇苷结晶工艺响应曲面法

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An efficient PSP-based model for optimized cross-coupled MOSFETs in voltage controlled oscillator

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第3期14卷 205-213页

作者： Li-heng LOU Ling-ling SUN jun liu Hai-jun GAO Institute of VLSI Design Zhejiang University MOE Key Laboratory of RF Circuits and Systems Hangzhou Dianzi University

This paper proposes an efficient PSP-based model for cross-coupled metal-oxide-semiconductor field-effect transistors(MOSFETs) with optimized layout in the voltage controlled oscillator(VCO).The model employs a PSP charge model to characterize the bias-dependent extrinsic capacitance instead of numerical functions with strong *** simulation convergence is greatly improved by this *** original scheme is developed to extract the parameters of the PSP charge model based on S-parameters *** interconnection parasitics of the cross-coupled MOSFETs are modeled based on vector *** model is verified with an LC VCO design,and exhibits excellent convergence during *** results show improvements as high as 60.5% and 61.8% in simulation efficiency and accuracy,respectively,indicating that the proposed model better characterizes optimized cross-coupled MOSFETs in advanced radio frequency(RF) circuit design.

关键词： Layout optimizing Modeling PSP Charge model Cross-coupled Metal-oxide-semiconductor(MOS) Voltage controlled oscillator(VCO)

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China Life Sciences 2025年第1期 303-305页

作者： Ziqian Xu Lianpan Dai jun liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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Occurrence of early epilepsy in children with traumatic brain injury:a retrospective study

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World Journal of Pediatrics 2022年第3期18卷 214-221页

作者： Jian Ji Su-Yun Qian jun liu heng-Miao Gao Pediatric Intensive Care Unit National Center for Children’s HealthBeijing Children’s HospitalCapital Medical UniversityNo.45 Nanlishi RoadBeijing 100045China

Background Early post-traumatic seizures(EPTS)refer to epileptic seizures occurring within one week after brain *** study aimed to define the risk factors of EPTS and the protective factors that could prevent its *** This is a single-center retrospective study in the PICU,Beijing Children's *** diagnosed with traumatic brain injury(TBI),admitted with and without EPTS between January 2016 and December 2020 were included in the *** We included 108 patients diagnosed with *** overall EPTS incidence was 33.98%(35/108).The correlation between EPTS and depressed fractures is positive(P=0.023).Positive correlations between EPTS and intracranial hemorrhage and subarachnoid hemorrhage had been established(P=0.011 and P=0.004,respectively).The detection rates of EPTS in the electroencephalogram(EEG)monitoring was 80.00%.There was a significant difference in the EEG monitoring rate between the two groups(P=0.041).Forty-one(37.86%,41/108)post-neurosurgical patients were treated with prophylactic antiepileptic drugs(AEDs),and eight(19.51%,8/41)still had *** statistical significance was noted between the two groups in terms of prophylactic AEDs use(P=0.519).Logistic regression analysis revealed that open craniocerebral injury and fever on admission were risk factors for EPTS,whereas,surgical intervention and use of hypertonic saline were associated with not developing *** Breakthrough EPTS occurred after severe TBI in 33.98%of pediatric cases in our *** is a higher seizure incidence than that reported *** with fever on admission and open craniocerebral injuries are more likely to develop EPTS.

关键词： Children Early post-traumatic seizures Risk factors Traumatic brain injury

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Preparation and Rheological Characterization of Long Chain Branching Polyglycolide

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Chinese Journal of Polymer Science 2024年第8期42卷 1177-1184页

作者： Wei-Lin liu Ming-Fu Lyu heng-Yuan Zhang Jian-Ye liu Shi-jun Zhang Beijing University of Chemical Technology Beijing 100029China SINOPEC(Beijing)Research Institute of Chemical Industry Co. Ltd.Beijing 100013China

The long chain branching(LCB)polyglycolide(PGA)was successfully prepared by the successive reactions of the terminal hydroxyl groups of PGA with triglycidyl isocyanurate(TGIC)and pyromellitic dianhydride(PMDA).The influence of LCB produced by functional group reaction on rheological and crystallization behavior was studied and discussed through linear rheology,uniaxial elongation and DSC(differential scanning calorimetry).The much higher viscosity and the more notable strain hardening behavior of modified PGA indicates the LCB with high degree of entanglements are *** melt strength of PGA is finally improved greatly and can make su re that the supercritical CO_(2)foaming can be carried out successfully.

关键词： Polyglycolide(PGA) Long chain branching(LCB) Rheology

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