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Advantage of log odds of positive lymph nodes in prognostic evaluation of patients with early-onset colon cancer

World Journal of Gastrointestinal Surgery 2023年第11期15卷 2430-2444页

作者： heng-bo xia Chen Chen Zhi-Xing Jia Liang Li A-Man Xu Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of General Surgery Anhui Public Health Clinical CenterHefei 230032Anhui ProvinceChina Department of Surgery The Second People’s Hospital of HefeiHefei 230011Anhui ProvinceChina

BACKGROUND Colon cancer(CC)is one of the most common cancers of the digestive tract,the third most common cancer worldwide,and the second most common cause of cancer-related *** studies have demonstrated a higher risk of lymph node metastasis(LNM)in young patients with *** might be reasonable to treat patients with early-onset locally advanced CC with extended lymph node ***,few studies have focused on early-onset CC(ECC)patients with *** present,the methods of predicting and evaluating the prognosis of ECC patients with LNM are *** the data of patients with CC obtained from the Surveillance,Epidemiology,and End Results(SEER)database,data of young patients with ECC(≤50 years old)was *** with unknown data were excluded from the study,while the remaining patients were *** patients were randomly divided into a training group(train)and a testing group(test)in the ratio of 7:3,while building the *** model was constructed by the training group and verified by the testing *** multiple Cox regression models to compare the prediction efficiency of LNM indicators,nomograms were built based on the best model selected for overall survival(OS)and cause-specific survival(CSS).In the two groups,the performance of the nomogram was evaluated by constructing a calibration plot,time-dependent area under the curve(AUC),and decision curve ***,the patients were grouped based on the risk score predicted by the prognosis model,and the survival curve was constructed after comparing the survival status of the high and low-risk *** Records of 26922 ECC patients were screened from the SEER database.N classification,positive lymph nodes(PLN),lymph node ratio(LNR)and log odds of PLN(LODDS)were considered to be independent predictors of OS and *** addition,independent risk factors for OS included gender,race,marital status,primary site,histology,grade,T,and M classification,while the ind

关键词： Early-onset colon cancer Log odds of positive lymph nodes Lymph node metastasis Nomogram Prognosis Surveillance,Epidemiology,and End Results

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Corrugated Graphene Paper Reinforced Silicone Resin Composite for Efficient Interface Thermal Management

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Chinese Journal of Polymer Science 2024年第7期42卷 1002-1014,I0010页

作者： bo-Wen Wang heng Zhang Qing-xia He Hui-Tao Yu Meng-Meng Qin Wei Feng Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China International Engineering Institute Tianjin UniversityTianjin300350China

With the rapid development of high-power-density electronic devices,interface thermal resistance has become a critical barrier for effective heat management in high-performance electronic ***,there is an urgent demand for advanced thermal interface materials(TIMs)with high cross-plane thermal conductivity and excellent compressibility to withstand increasingly complex operating *** achieve this aim,a promising strategy involves vertically arranging highly thermoconductive graphene on ***,with the currently available methods,achieving a balance between low interfacial thermal resistance,bidirectional high thermal conductivity,and large-scale production is ***,we prepared a graphene framework with continuous filler structures in in-plane and cross-plane directions by bonding corrugated graphene to planar graphene *** interface interaction between the graphene paper framework and polymer matrix was enhanced via surface functionalization to reduce the interface thermal *** resulting three-dimensional thermal framework endows the polymer composite material with a cross-plane thermal conductivity of 14.4 W·m^(-1)·K^(-1)and in-plane thermal conductivity of 130W·m^(-1)·K^(-1)when the thermal filler loading is 10.1 wt%,with a thermal conductivity enhancement per 1 wt%filler loading of 831%,outperforming various graphene structures as *** its high thermal conductivity,low contact thermal resistance,and low compressive modulus,the developed highly thermoconductive composite material demonstrates superior performance in TIM testing compared with TFLEX-700,an advanced commercial TIM,effectively solving the interfacial heat transfer issues in electronic *** novel filler structure framework also provides a solution for achieving a balance between efficient thermal management and ease of processing.

关键词： Graphene paper Vertically aligned structure Cross-plane thermal conductivity Low compressive modulus Thermal interface material

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Vibration response and safety control for blasting vibration of the existing tunnel with defects

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Underground Space 2024年第2期15卷 76-89页

作者： Junying xia bo Wang Xinxin Guo Zhuoxiong Xie Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China College of Environment and Civil Engineering Chengdu University of TechnologyChengdu 610059China Guangdong Communication Planning&Design Institute Group Co. LtdGuangzhou 510507China

Current studies on blasting construction of small clear-distance tunnels have not considered the impact of existing tunnel lining defects when establishing safety *** paper offers a series of study results based on the blasting project of a new tunnel adjacent to the existing defect Xinling tunnel to thoroughly examine the dynamic response,safety control standards,and measures of the existing defect ***,structural models were developed to investigate the influence of the presence or absence of specific defects(like lining cracks and cavities behind the lining)on the dynamic response of the current tunnel lining to identify the most unfavorable defect ***,establish safety control standards for intact linings and those with the most unfavorable ***,two types of control measures,single safe charge and reasonable delay time,were studied based on the established safety control *** particular,the most adverse position of cracks was the wall facing the explosion,the rise in depth was more unfavorable for vibration response,and the impact of the longitudinal crack was restricted to the vicinity of the *** the vault was the most adverse cavity position,the rise in cavity area was more damaging,and the influence range varied with longitudinal cavity ***,the impact of cracks was mainly evident in the amplification effect of stress at the crack *** contrast,cavities had varied degrees of amplification effects on the vibration velocity and stress response and a relatively extensive influence *** control research was conducted,when the tunnel was intact,with a right wall crack,a vault cavity,and both vault cavity and crack for this project,the peak particle velocity(PPV)of the safety control standard for vibration velocity was 13,10,13,and 8 cm/s,respectively,and the respective single safe charge could be adjusted at 64,53,37,and 25 ***,the presence of different defects had a relati

关键词： Existing tunnel Defect Blasting construction Vibration response Control standards and measures

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PEGylated bacteria restore intestinal mucosal barrier

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4186-4188页

作者： Menghang Zu Xue xia bo xiao State Key Laboratory of Resource Insects College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054China

The mucosal barrier of the gastrointestinal tract(GIT)is crucial for the overall health of the *** disruption permits the infiltration of intestinal microorganisms into the underlying mucosa,resulting in infections and inflammatory conditions,such as inflammatory bowel disease(IBD),metabolic disorders,and autoimmune diseases1,***,strategies to protect the mucosal barrier from exogenous stimuli or to facilitate its recovery have become increasingly ***,immunomodulators,corticosteroids,and biological agents have been widely employed to treat IBD by alleviating inflammation and enhancing mucosal ***,they can also produce serious systemic toxicity3,4;therefore,there is an urgent need for exploiting innovative strategies to fortify the intestinal mucosal barrier against the invasion of exogenous damaging factors.

关键词： PEGylation Probiotic Mucus penetration Colonic mucosal barrier Colitis Diabetes

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A NEW GLOBAL OPTIMIZATION ALGORITHM FOR MIXED-INTEGER QUADRATICALLY CONSTRAINED QUADRATIC FRACTIONAL PROGRAMMING PROBLEM

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Journal of Computational Mathematics 2024年第3期42卷 784-813页

作者： bo Zhang Yuelin Gao xia Liu xiaoli Huang School of Civil and Hydraulic Engineering School of Mathematics and StatisticsNingxia UniversityYinchuan 750021China School of Mathematics and Information Science North Minzu UniversityYinchuan 750021China Ningxia Province Key Laboratory of Intelligent Information and Data Processing Yinchuan 750021China School of Mathematics and Statistics Ningxia UniversityYinchuan 750021China

The mixed-integer quadratically constrained quadratic fractional programming(MIQCQFP)problem often appears in various fields such as engineering practice,management science and network ***,most of the solutions to such problems are often designed for their unique *** paper puts forward a new global optimization algorithm for solving the problem *** first convert the MIQCQFP into an equivalent generalized bilinear fractional programming(EIGBFP)problem with integer ***,we linearly underestimate and linearly overestimate the quadratic functions in the numerator and the denominator respectively,and then give a linear fractional relaxation technique for EIGBFP on the basis of non-negative *** that,combining rectangular adjustment-segmentation technique and midpointsampling strategy with the branch-and-bound procedure,an efficient algorithm for solving MIQCQFP globally is ***,a series of test problems are given to illustrate the effectiveness,feasibility and other performance of this algorithm.

关键词： Global optimization Branch and bound Quadratic fractional programming Mixed integer programming

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A novel graph oversampling framework for node classification in class-imbalanced graphs

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Science China(Information Sciences) 2024年第6期67卷 214-229页

作者： Riting xia Chunxu ZHANG Yan ZHANG Xueyan LIU bo YANG Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University College of Artificial Intelligence Jilin University College of Computer Science and Technology Jilin University College of Communication Engineering Jilin University

Graph neural network(GNN) is a promising method to analyze graphs. Most existing GNNs adopt the class-balanced assumption, which cannot deal with class-imbalanced graphs well. The oversampling technique is effective in alleviating class-imbalanced problems. However, most graph oversampling methods generate synthetic minority nodes and their edges after applying GNNs. They ignore the problem that the representations of the original and synthetic minority nodes are dominated by majority nodes caused by aggregating neighbor information through GNN before oversampling. In this paper, we propose a novel graph oversampling framework, termed distribution alignment-based oversampling for node classification in classimbalanced graphs(named Graph-DAO). Our framework generates synthetic minority nodes before GNN to avoid the dominance of majority nodes caused by message passing in GNNs. Additionally, we introduce a distribution alignment method based on the sum-product network to learn more information about minority nodes. To our best knowledge, it is the first to use the sum-product network to solve the class-imbalanced problem in node classification. A large number of experiments on four real datasets show that our method achieves the optimal results on the node classification task for class-imbalanced graphs.

关键词： graph neural network class-imbalanced graphs sum-product network oversampling node classification

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Nomogram established using risk factors of early gastric cancer for predicting the lymph node metastasis

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World Journal of Gastrointestinal Oncology 2023年第4期15卷 665-676页

作者： xiao-Cong Jiang xiao-Bing Yao heng-bo xia Ye-Zhou Su Pan-Quan Luo Jian-Ran Sun En-Dong Song Zhi-Jian Wei A-Man Xu Li-xiang Zhang Yu-Hong Lan Department of Radiotherapy Oncology Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina Emergency Surgery Shanghai Seventh People’s HospitalShanghai 200137China Department of General Surgery First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Department of Obstetrics and Gynecology First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Department of Endocrinology The First Affiliated Hospital of USTCDivision of Life Science and MedicineHefei 230031Anhui ProvinceChina Department of Gastroenterology First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina

BACKGROUND For the prognosis of patients with early gastric cancer(EGC),lymph node metastasis(LNM)plays a crucial role.A thorough and precise evaluation of the patient for LNM is now *** To determine the factors influencing LNM and to construct a prediction model of LNM for EGC *** Clinical information and pathology data of 2217 EGC patients downloaded from the Surveillance,Epidemiology,and End Results database were collected and *** on a 7:3 ratio,1550 people were categorized into training sets and 667 people were assigned to testing sets,*** on the factors influencing LNM determined by the training sets,the nomogram was drawn and *** Based on multivariate analysis,age at diagnosis,histology type,grade,T-stage,and size were risk factors of LNM for ***,nomogram was drawn to predict the risk of LNM for EGC *** the categorical variables,the effect of grade(well,moderate,and poor)was the most significant prognosis *** training sets and testing sets,respectively,area under the receiver-operating characteristic curve of nomograms were 0.751[95%confidence interval(CI):0.721-0.782]and 0.786(95%CI:0.742-0.830).In addition,the calibration curves showed that the prediction model of LNM had good *** Age at diagnosis,histology type,grade,T-stage,and tumor size were independent variables for LNM in *** on the above risk factors,prediction model may offer some guiding implications for the choice of subsequent therapeutic approaches for EGC.

关键词： SEER Early gastric cancer Lymph node metastasis Risk factors Nomogram

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Comparative Assessment of Impacts of Future Climate Change on Runoff in Upper Daqinghe Basin,China

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Chinese Geographical Science 2024年第3期34卷 564-578页

作者： INGABIRE Romaine CHANG Yuru LIU xia CAO bo UMUGWANEZA Adeline SHEN Yanjun Key Laboratory of Agricultural Water Resources Hebei-Key Laboratory of Water Saving AgricultureCenter for Agricultural Re-sources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022China Uni-versity of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Desert and Oasis Ecology Xinjiang Insti-tute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China

Assessing runoff changes is of great importance especially its responses to the projected future climate change on local scale basins because such analyses are generally done on global and regional scales which may lead to generalized conclusions rather than specific *** change affected the runoff variation in the past in the upper Daqinghe Basin,however,the climate was mainly considered uncertain and still needs further studies,especially its future impacts on runoff for better water resources management and *** with a set of climate simulations,a daily conceptual hydrological model(MIKE11-NAM)was applied to assess the impact of climate change on runoff conditions in the Daomaguan,Fuping and Zijingguan basins in the upper Daqinghe *** hydrological data(2008–2017)were used to evaluate the applicability of the MIKE11-NAM *** bias correction,future projected climate change and its impacts on runoff(2025–2054)were analysed and compared to the baseline period(1985–2014)under three shared social economic pathways(SSP1-2.6,SSP2-4.5,and SSP5-8.5)scenarios from Coupled Model Intercomparison Project Phase 6(CMIP6)*** MIKE-11 NAM model was applicable in all three Basins,with both R^(2)and Nash-Sutcliffe Efficiency coefficients greater than 0.6 at daily scale for both calibration(2009–2011)and validation(2012–2017)periods,*** uncertainties remain,temperature and precipitation are projected to increase compared to the baseline where higher increases in precipitation and temperature are projected to occur under SSP2-4.5 and SSP5-8.5 scenarios,respectively in all the *** changes will range between 12%–19%whereas temperature change will be 2.0℃–2.5℃ under the SSP2-4.5 and SSP5-8.5 scenarios,*** addition,higher warming is projected to occur in colder months than in warmer ***,the runoff of these three basins is projected to respond to projected climate changes differe

关键词： runoff climate change MIKE11-NAM model Coupled Model Intercomparison Project Phase 6(CMIP6) upper Daqinghe Basin,China

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Efficacy and outcome of extensive intraoperative peritoneal lavage plus surgery vs surgery alone with advanced gastric cancer patients

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 430-439页

作者： En-Dong Song heng-bo xia Li-xiang Zhang Jun Ma Pan-Quan Luo Lai-Zhi Yang Ben-Hong xiang Bai-Chuan Zhou Lei Chen Hui Sheng Yin Fang Wen-Xiu Han Zhi-Jian Wei A-Man Xu Department of General Surgery The First People’s Hospital of Wuhu CityWuhu 241000Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Surgical Oncology Anqing Municipal HospitalAnqing 246000Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Obstetrics and Gynecology East Hospital Area of Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most common malignant *** resection,one of the major problems is its peritoneal dissemination and *** free cancer cells may still exist after *** addition,the surgery itself may lead to the dissemination of tumor ***,it is necessary to remove residual tumor ***,some researchers found that extensive intraoperative peritoneal lavage(EIPL)plus intraperitoneal chemotherapy can improve the prognosis of patients and eradicate peritoneal free cancer for GC ***,few studies explored the safety and long-term outcome of EIPL after curative *** To evaluate the efficacy and long-term outcome of advanced GC patients treated with *** According to the inclusion and exclusion criteria,a total of 150 patients with advanced GC were enrolled in this *** patients were randomly allocated to two *** patients received *** the non-EIPL group,peritoneal lavage was washed using no more than 3 L of warm *** the EIPL group,patients received 10 L or more of saline(1 L at a time)before the closure of the *** surviving rate analysis was compared by the Kaplan-Meier *** prognostic factors were carried out using the Cox appropriate hazard *** The basic information in the EIPL group and the non-EIPL group had no significant *** median follow-up time was 30 mo(range:0-45 mo).The 1-and 3-year overall survival(OS)rates were 71.0%and 26.5%,*** symptoms of ileus and abdominal abscess appeared more frequently in the non-EIPL group(Pborrmann classification,tumor size,N stage,T stage and vascular invasion were significant *** multivariate analysis revealed that EIPL,tumor size,vascular invasion,N stage and T stage were independent prognostic *** prognosis of the EIPL group was better than the non-EIPL group(P<0.001).The 3-year survival rate of

关键词： Extensive intraoperative peritoneal lavage Advanced gastric cancer Prognosis Recurrence Overall survival

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Fluorescent Probes for Cysteine and Cysteine Oxidation Imaging

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Chemical Research in Chinese Universities 2024年第2期40卷 225-236页

作者： ZHANG xia LI Guocheng PAN Wei LI Na LI Yanhua TANG bo College of Chemistry Chemical Engineering and Materials ScienceKey Laboratory of Molecular and Nano ProbesMinistry of EducationCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongInstitute of Molecular and Nano ScienceShandong Normal UniversityJinan250014P.R.China Laoshan Laboratory Qingdao266237P.R.China

Cysteine is an important regulator of redox *** to the nucleophilic and oxidative sensitivity,cysteine residues in proteins can be oxidized by intracellular reactive oxygen species(ROS),which can lead to protein structural and functional ***,the development of fluorescent probes to image cysteine and cysteine oxidation is of great significance for the study of redox homeostasis in living *** this review,the development of fluorescent probes for imaging cysteine and cysteine oxidation was ***,we further analyzed defects of the reported fluorescent probes and made suggestions for the future development of fluorescent *** expect that this review can not only provide a deeper understanding of the role of cysteine and cysteine oxidation in oxidative stress,but also broaden the application of fluorescent probes in imaging cysteine and cysteine oxidation.

关键词： Cysteine Cysteine oxidation Fluorescent probe Oxidative stress

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