检索结果-南通市图书馆

Screening for mutations in human cardiomyopathy- is RBM24 a new but rare disease gene?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2019年第6期10卷 393-394页

作者： Anna Gaertner andreas Brodehl hendrik Milting Erich and Hanna Klessmann Institute Heart and Diabetes Center NRW University Hospital of the Ruhr-Udiversity Bochum Georgstrasse 11 32545 Bad Oeynhausen Germany

With great interest we have read the study of Liu et al.(2018) revealing the role of RNA binding protein 24 (RBM24) on global alternative splicing and dilated cardiomyopathy (DCM) in mice. As suggested previously, deficiency of Rbm24 causes embryonic lethality limiting the functional analyses (Yang et al., 2014). To circumvent this limitation the authors generated cardiac specific Rbm24 deficient mice and showed that homozygous deletion of Rbm24 at postnatal stage leads to rapidly progressive DCM and heart failure (Liu et al., 2018).

关键词： great interest study of Liu functional analyses

Success factors for high-quality oak forest(Quercus robur, Q. petraea) regeneration

在线全文

学校读者我要写书评

暂无评论

Forest Ecosystems 2019年第4期6卷 367-383页

作者： andreas M?lder Holger Sennhenn-Reulen Christoph Fischer hendrik Rumpf Egbert Sch?nfelder Johannes Stockmann Ralf-Volker Nagel Department A (Forest Growth) Northwest German Forest Research Institute(NW-FVA)

Background: Within the framework of close-to-nature forestry, oak forest(Quercus robur, Q. petraea) regeneration techniques that consider both silvicultural and nature conservation demands have become a very important *** there are many experimental and local studies that aim at disentangling the relationships between different environmental and silvicultural factors and the success of oak regeneration, systematic supra-regional studies at the greater landscape level are missing so *** this background, the first objective(a) of this study was to present an efficient and sufficiently accurate sampling scheme for supra-regional forest regrowth inventories, which we applied to young oaks stands. The second, and major, objective(b) was to identify the crucial success factors for high-quality oak forest regeneration in northwest ***: Objective(a): Factors that have been identified as potentially crucial for the success or failure of oak regeneration were either included in a field inventory procedure or extracted from forest inventory databases. We found that the collected data were suitable to be analyzed in a three-step success model, which was aimed at identifying the crucial success factors for high-quality oak forest ***(b): Our modeling procedure, which included a Bayesian estimation approach with spike-and-slab priors,revealed that competitive pressure from the secondary tree species was the most decisive success factor;no competition, or low competition by secondary tree species appeared to be particularly beneficial for the success of high-quality oak regeneration. Also fencing and the absence of competitive vegetation(weeds, grass, bracken)seemed to be beneficial factors for the success of oak ***: Trusting in biological automation was found to be mostly useless regarding economically viable oak forest regeneration. To efficiently organize oak regeneration planning and silvicultural decision-ma

关键词： Close-to-nature forestry Competition Ecological continuity Forest inventory Forest management Plantplant interactions Quercus robur Quercus petraea Regeneration Silviculture

Directly addressable GaN-based nano-LED arrays: fabrication and electro-optical characterization

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2020年第1期6卷 275-284页

作者： Daria D.Bezshlyakh hendrik Spende Thomas Weimann Peter Hinze Steffen Bornemann Jan Gulink Joan Canals Joan Daniel Prades Angel Dieguez andreas Waag Institute of Semiconductor Technology Technische Universitat BraunschweigHans-Sommer Str.6638106 BraunschweigGermany Laboratory for Emerging Nanometrology Langer Kamp 6 a/b38106 BraunschweigGermany Epitaxy Competence Center ec2 Technische Universitat BraunschweigHans-Sommer Str.6638106 BraunschweigGermany Nanostructuring and Clean Room Center Infrastructure Physikalisch-Technische BundesanstaltBundesallee 10038116 BraunschweigGermany Department of Electronic and Biomedical Engineering University of BarcelonaCarrer Marti i Franques 108028 BarcelonaSpain

The rapid development of display technologies has raised interest in arrays of self-emitting,individually controlled light sources atthe *** nitride(GaN)micro-light-emitting diode(LED)technology meets this ***,the current technology is not suitable for the fabrication of arrays of submicron light sources that can be controlled *** approach is based on nanoLED arrays that can directly address each array element and a self-pitch with dimensions below the wavelength of *** design and fabrication processes are explained in detail and possess two geometries:a 6×6 array with 400 nm LEDs and a 2×32 line array with 200 nm *** nanoLEDs are developed as core elements of a novel on-chip super-resolution *** technology,based on its physical properties,is an ideal platform for such nanoLEDs.

关键词： arrays GaN optical

RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2017年第4期8卷 342-349页

作者： Max J Friedrich Matthias D Wimmer Jan Schmolders andreas C Strauss Milena M Ploeger hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau Department of Orthopedics and Trauma Surgery University Clinic of Bonn

AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard *** One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance.

关键词： Aseptic loosening Diagnostic RANK-ligand Periprosthetic joint infection Biomarker Osteoprotegerin

利用GOME卫星资料分析北京大气NO_2污染变化

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

应用气象学报 2006年第1期17卷 67-72页

作者：江文华马建中颜鹏 andreas Richter John P.Burrows hendrik Nǖβ 中国气象科学研究院 Institute of Environmental Physics University of Bremen

利用GOME(Global Ozone Monitoring Experiment,全球臭氧监测实验)1996年1月—2002年12月NO2对流层柱浓度月平均卫星遥感资料以及根据北京市2001年1月1日—2002年12月31日NO2污染指数数据计算出的地面NO2日均质量浓度值,分析了北京市城... 详细信息

利用GOME(Global Ozone Monitoring Experiment,全球臭氧监测实验)1996年1月—2002年12月NO2对流层柱浓度月平均卫星遥感资料以及根据北京市2001年1月1日—2002年12月31日NO2污染指数数据计算出的地面NO2日均质量浓度值,分析了北京市城市大气NO2污染变化的季节变化特征以及年际变化,并将2001年1月—2002年12月北京上空GOME NO2对流层柱浓度月平均值变化与北京市地面NO2日均质量浓度月平均值变化进行了比较,结果表明两者随时间的变化趋势具有较好的一致性,据此可以利用GOME NO2对流层柱浓度月平均卫星遥感资料来分析特定区域大气NO2的季节变化和年际变化。

关键词：卫星遥感 GOME NO2空气污染指数城市环境

RBM20 mutations in left ventricular non-compaction cardiomyopathy

在线全文

学校读者我要写书评

暂无评论

Pediatric Investigation 2020年第1期4卷 61-63页

作者： Anna Gaertner Barbel Klauke andreas Brodehl hendrik Milting Heart and Diabetes Center NRW University Hospital of the Ruhr-University BochumClinic of Thoracic and Cardiovascular SurgeryErich and Hanna Klessmann Institute for Cardiovascular Research and DevelopmentGeorgstrasse 11D-32545 Bad OeynhausenGermany

Cardiomyopathies are among the most prevalent causes of premature death in the Western world.A significant amount of cardiomyopathies has a genetic ***,mutations in more than 170 genes associated with different cardio... 详细信息

关键词： involvement ventricular cardiomyopathy

磷酸盐缓冲液对人外周血单个核细胞趋化因子分泌的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生命科学仪器 2011年第2期9卷 7-11页

作者： Michael LICHTENAUER Stefanie NICKL Konrad HOETZENECKER andreas MANGOLD andreas MITTERBAUER Stefan HACKER Matthias ZIMMERMANN hendrik Jan ANKERSMIT 不详

磷酸盐缓冲液(PBS)通常在实验室中被作为稀释液、冲洗细胞悬浮液以及用于清洗培养瓶和培养皿,也常作为细胞培养基的添加物。这项研究评估了含有不同浓度的钙离子和镁离子的PBS溶液基质对人外周血液单个核细胞(PB-MCs)趋化因子释放的影... 详细信息

磷酸盐缓冲液(PBS)通常在实验室中被作为稀释液、冲洗细胞悬浮液以及用于清洗培养瓶和培养皿,也常作为细胞培养基的添加物。这项研究评估了含有不同浓度的钙离子和镁离子的PBS溶液基质对人外周血液单个核细胞(PB-MCs)趋化因子释放的影响。当PBMCs暴露于含量增加的+/+PBS中时,发现白介素-8也会相应增加。因为细胞外钙离子浓度对细胞迁移有一定影响,趋化因子的分泌表明细胞培养过程中增加钙离子浓度是另一种很重要的调节机理。

关键词：外周血单个核细胞磷酸盐缓冲液趋化因子分泌钙离子浓度细胞悬浮液细胞培养基外周血液

新疆吐鲁番盆地中侏罗统张北足迹(Changpeipus,兽脚类)的重新研究(英文)

在线全文

学校读者我要写书评

暂无评论

古脊椎动物学报 2014年第2期52卷 233-259页

作者：邢立达 hendrik KLEIN Martin G. LOCKLEY andreas WETZEL 李忠东李建军 Gerard D. GIERLINSKI 张建平松川正树 Julien D. DIVAY 周隆中国地质大学(北京)地球科学与资源学院北京100083 中国科学院脊椎动物演化与人类起源重点实验室北京100044 德国古爬行及两栖动物博物馆诺伊马克特D-92318 美国科罗拉多大学丹佛分校恐龙足迹博物馆丹佛80217 瑞士巴塞尔大学地质古生物研究所巴塞尔CH-4056 成都省地矿局物探队资源与环境研究所成都610072 北京自然博物馆研究部北京100050 波兰侏罗纪公园奥斯特罗维茨427-400 波兰地质研究所华沙400-975 日本东京学艺大学环境科学系东京184-8501 加拿大阿尔伯塔大学生物科学系埃德蒙顿T6G 2E9

详细描述了中国西北部新疆吐鲁番市鄯善足迹点、中侏罗统三间房组的兽脚类足迹组合。连同新发现在内,共描述了143个足迹,并阐明其不同的保存状况与额外形态变化。在足迹分类学上,这批足迹被归入石炭张北足迹(Changpeipus carbonicus),... 详细信息

详细描述了中国西北部新疆吐鲁番市鄯善足迹点、中侏罗统三间房组的兽脚类足迹组合。连同新发现在内,共描述了143个足迹,并阐明其不同的保存状况与额外形态变化。在足迹分类学上,这批足迹被归入石炭张北足迹(Changpeipus carbonicus),该足迹种常见于中国其他侏罗纪足迹点。前人的研究认为此地有两种不同的足迹形态,但研究表明这是由软且湿滑的基底造成的额外形态变化。足迹的结构特征亦不支持此地存在不同的足迹种。此外,对比了其他化石点类似的足迹,认为张北足迹为单型属,即模式种石炭张北足迹。鄯善足迹点的足迹长度从12.2 cm(几个孤立的样本)到47 cm,足迹应由不同年龄段的、小型至中型的同类造迹者或不同类的造迹者所留。奇异的足迹状态包括了一个滑动造成的足迹,足迹由三道平行条带构成,条带应为第II,III和IV趾所留。一个与其关联的"正常"足迹可能与该滑动足迹构成一个单步。与足迹共生的、丰富的无脊椎动物遗迹化石支持该化石点的沉积环境是一个逐步扩大和深化的湖泊。前人的研究将此地的无脊椎动物遗迹化石归入洛克迹(Lockeia),新的研究将其归入福尔斯迹(Fuersichnus),这类遗迹被归于泥食性昆虫幼虫或其他无脊椎动物所留。福尔斯迹指示的环境特征是在泥泞的河漫滩或湖泊边缘居住与/或觅食。

关键词：新疆鄯善中侏罗世三间房组张北足迹福尔斯迹

Severe Weight Loss and Dropped Head Syndrome in MuSK Myasthenia Gravis

在线全文

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2014年第11期3卷 587-591页

作者： Daniel Yu Bing Tan Willem hendrik Joseph Peter Linssen Boris Liberov Department of Neurology Sint Lucas Andreas Hospital Amsterdam The Netherlands Department of Internal Medicine Zaans Medisch Centrum The Netherlands

Muscle Specific Receptor Thyrosine Kinase (MuSK) Myasthenia Gravis (MG) is a rare auto-immune disorder of the neuromuscular junction. The clinical presentation of MG is dominated by fluctuating weakness of the extra-ocular, orofacial and limb muscles. The clinical presentation of MuSK MG can vary, which may delay diagnostic procedures. We present a patient who initially presented with severe weight loss and slowly progressive developing neck extensor weakness and diplopia. A single fiber EMG led to the diagnosis MG and antibodies directed towards MuSK were detected. He was treated with prednisone and the steroid sparing agent azathioprine after which he made full recovery.

关键词： Myasthenia Gravis Muscle Specific Receptor Thyrosine Kinase Dropped Head Syndrome