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异基因造血干细胞移植治疗脑型肾上腺脑白质营养不良中国专家共识(2023)

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中华儿科杂志 2024年第4期62卷 303-309页

作者：中华医学会儿科学分会血液学组中华医学会儿科学分会神经学组中华医学会儿科学分会内分泌遗传代谢学组中华医学会放射学分会中华儿科杂志编辑委员会陈静黄小航付斌不详国家儿童医学中心上海交通大学医学院上海儿童医学中心血液肿瘤科上海200127

肾上腺脑白质营养不良(ALd)是一种罕见X连锁隐性遗传病,其中脑型ALd(cALd)是最严重的类型,常于儿童期隐匿起病,极易误诊且进展迅速。异基因造血干细胞移植是治疗cALd的有效方法。中华医学会儿科学分会血液学组、神经学组、内分泌遗传代... 详细信息

肾上腺脑白质营养不良(ALd)是一种罕见X连锁隐性遗传病,其中脑型ALd(cALd)是最严重的类型,常于儿童期隐匿起病,极易误诊且进展迅速。异基因造血干细胞移植是治疗cALd的有效方法。中华医学会儿科学分会血液学组、神经学组、内分泌遗传代谢学组、放射学分会联合中华儿科编辑委员会组织制定本共识,旨在对cALd患者的诊断、治疗及多学科随访提供指导意见。

关键词：肾上腺脑白质营养不良中华医学会放射学分会异基因造血干细胞移植儿科学分会中国专家共识脑型遗传代谢

P48-Triggered transmembrane signaling transduction of human monocytes:mobilization of calcium ion and activation of protein kinase C(PKC)

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Cell Research 1995年第1期5卷 101-114页

作者： CHANG ZL RE HALL.(Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.)(dept. of medicine, director of div. of hematology /On-cology, Univ. of Tennessee Medical Center, Knoxville, TN 37920.) Shanghai Institute of Cell Biology Chinese Academy of Sciences Shanghai China dept. of medicine Director of Div. of Hematology /Oncology Univ. of Tennessee Medical Center Knoxville

P48 is a cytokine which induces monocyte differentia-tion and the induction of cytotoxic activity. In this study,the signal transduction events involved in the stimulation of monocytes with the membrane form of P48 (mP48) were investigated. Monocyte stimulation with mP48 was found to involve the mobilization of intracellular calcium (Ca2+)and the activation and translocation of PKC from the cy-tosol to the membrane. Membane P48 induced a rapid rise of intracellular Ca2+ in a dose dependent maner. Simi-larly the stimulation of monocytes with P48 was found to involve the activation and translocation of PKC. The translocation of PKC was rapid (within 0-5 min) yet tran-sient with PKC activity returning to control levels by 8 min. The functional role of protein kineses in P48 induced TNF secretion was studied using various kinese inhibitors. The PKC inhibitors, H-7 and sphingosine, were found to inhibit P48 induced TNF secretion with 50% inhibition at 5μM HA1004, which inhibts cyclic nucleotide-dependent kinase (PKA, Ki 1.2μM), did not inhibit TNF secretion. H-8 (PKA inhibitor) was found to be an effective inhibitor of TNF secretion only at high concentrations(30μp. The Calmodulin-dependent kinase inhibitor, W7 (Ki 12μM)was found to be effective at concentration above 5μ*** findings suggest that P48-triggered TNF secretion involves transmembrane Ca2+ signaling and the subse-quent activation of at least two protein kineses, PKC and CaMK.

关键词： P48 monocyte differentiation inducing factor Signal transduction Ca~+ mobilization PKC activation TNF secretion

Expression and significance of microRNA-32 in multiple myeloma

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The Chinese-German Journal of Clinical oncology 2014年第10期13卷 472-475页

作者： Tenglong Zhang Weili Jia Li Sun Xiaoyan Wang Xiuhua Xing Shuai Gong Chunrui Yu department of oncology Qingdao Municipal Hospital department of hematology Qingdao Municipal Hospital department of Anesthesiology Qingdao Municipal Hospital

Objective: This study was aimed to explore the expression of microRNA-32(miR-32) in multiple myeloma(MM), and study its association with β2-microglobulin and staging of MM by durie-Salmon classification. Methods: The expression level of miR-32 in bone marrow mono-nuclear cells of MM were examined by real-time polymerase chain reaction(real-time PCR), and the correlations between the expression level of miR-32 and related clinic pathologic features β2-microglobulin, staging of MM by durie-Salmon classification were further analyzed. Results: The expression of miR-32 in MM patients was obviously higher than that in normal control(P d/ refractory MM patients was obviously higher than that in newly diagnosed MM patients. The expression of miR-32 in MM patients decreased after chemical therapy than that before treatment, especially in effective group(P 0.05).The expression of miR-32 was associated to staging of MM and β2-microglobulin level. Conclusion: Expression level of miR-32 in MM patients is significantly higher than that in normal bone marrow, these data indicated that miR-32 may play an important role in the development of MM. High-regulated expression of miR-32 was associated with β2-microglobulin and staging of MM by durie-Salmon classification.

关键词： microRNA-32(miR-32) multiple myeloma(MM) real-time polymerase chain reaction(real-time PCR)

三氧化二砷诱导K562细胞凋亡过程中IκB-α,NF-κB蛋白表达的研究

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实用肿瘤杂志 2004年第4期19卷 292-295页

作者：张晓红苏立达吕庆华梁赟赵小英浙江大学医学院附属第二医院血液科浙江杭州310009 浙江大学肿瘤研究所浙江杭州310009

目的　探讨三氧化二砷 (As2 O3)诱导慢性粒细胞性白血病 K5 6 2细胞凋亡过程中 IκB- α以及 NF- κB的表达变化。方法　应用不同剂量 As2 O3诱导 K5 6 2细胞凋亡 ,以 Western- Blot免疫印迹电泳检测 NF- κB,IκB- α的表达 ,流式细胞... 详细信息

目的　探讨三氧化二砷 (As2 O3)诱导慢性粒细胞性白血病 K5 6 2细胞凋亡过程中 IκB- α以及 NF- κB的表达变化。方法　应用不同剂量 As2 O3诱导 K5 6 2细胞凋亡 ,以 Western- Blot免疫印迹电泳检测 NF- κB,IκB- α的表达 ,流式细胞术检测 K5 6 2细胞凋亡及分析 IκB- α的阳性表达率变化。结果　 As2 O3可诱导 K5 6 2细胞凋亡 ,随着As2 O3浓度从 1μmol/ L 到 4 μmol/ L 的增高细胞凋亡率由 16 .0 %增加到 6 0 .6 % ,胞浆中 IκB- α阳性表达率则由88.1%减少到 4 9.2 % ,胞核中 p6 5量逐渐增加。结论　 As2 O3可诱导 K5 6 2细胞凋亡 ,在此过程中伴有 NF-κB的激活 ,在一定剂量范围内激活的程度随着砷剂浓度的增加而增强。砷剂激活 NF-κB通过其抑制蛋白

关键词：三氧化二砷 K562细胞 IκB-α NF-κB 细胞凋亡慢性粒细胞性白血病

Chinese Society of Clinical oncology(CSCO) diagnosis and treatment guidelines for malignant lymphoma 2021(English version)

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Chinese Journal of Cancer Research 2021年第3期33卷 289-301页

作者： Jun Zhu Jun Ma Union for China Lymphoma Investigators of Chinese Society of Clinical oncology Zhixiang Shen Zifen Gao Huiqiang Huang Xiaoqiu Li Yexiong Li Lugui Qiu Weili Zhao Qingyuan Zhang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China department of hematology&oncology Harbin Institute of Hematology&OncologyHarbin 150010China 不详 Peking university Health Science Center Sun Yat-sen university Cancer Center Fudan university Shanghai Cancer Center Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Institute of hematology and Blood diseases Hospital Chinese Academy of Medical Science and Peking Union Medical College Ruijin Hospital affiliated to Shanghai Jiao Tong university School of medicine Harbin Medical university Cancer Hospital

1. General guidelines2. diagnosis3. Staging4. Treatment4.1 diffuse large B-cell lymphoma(dLBCL)4.2 Follicular lymphoma(FL)4.3 Mantle cell lymphoma(MCL)4.4 Marginal zone lymphoma(MZL)4.5 Burkitt lymphoma(BL)4.6 CLL/Small lymphocytic lymphoma(SLL)4.7 Extra-nodal natural killer/T-cell lymphoma(ENKTCL), nasal type4.8 Peripheral T-cell lymphoma(PTCL)4.9 HL4.10 Primary central nervous system lymphoma5. Prognosis Lymphomas are a group of heterogeneous diseases.

关键词： lymphoma diagnosis lymphocytic

中国慢性淋巴细胞白血病/小淋巴细胞淋巴瘤的诊断与治疗指南（2015年版）

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中华血液学杂志 2015年第10期36卷 809-813页

作者：中华医学会血液学分会中国抗癌协会血液肿瘤专业委员会中华医学会血液学分会、中国抗癌协会血液肿瘤专业委员会

近年，慢性淋巴细胞白血病（CLL）的基础研究、新的预后标志、诊断标准及治疗等方面取得了巨大进展。为提高我国血液科医师对CLL诊断、鉴别诊断及规范化治疗水平，中华医学会血液学分会和中国抗癌协会血液肿瘤专业委员会组织相关专家对2... 详细信息

近年，慢性淋巴细胞白血病（CLL）的基础研究、新的预后标志、诊断标准及治疗等方面取得了巨大进展。为提高我国血液科医师对CLL诊断、鉴别诊断及规范化治疗水平，中华医学会血液学分会和中国抗癌协会血液肿瘤专业委员会组织相关专家对2011年版CLL诊断与治疗指南进行了更新修订，制订本版指南。一、定义CLL／小淋巴细胞淋巴瘤（SLL）是主要发生在中老年人群的一种成熟B淋巴细胞克隆增殖性肿瘤，以淋巴细胞在外周血、骨髓、脾脏和淋巴结聚集为特征。

关键词：小淋巴细胞淋巴瘤慢性淋巴细胞白血病中国抗癌协会治疗指南诊断标准淋巴细胞克隆血液肿瘤规范化治疗

新加良附方影响人胃癌裸小鼠移植瘤新生血管形成的研究

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山西中医 2010年第4期26卷 50-52页

作者：倪磊田劭丹马成杰孔焕宇陈信义北京中医药大学东直门医院中国中医科学院望京医院教育部北京市重点实验室(中医内科学)

目的:观察新加良附方对人胃癌裸小鼠移植瘤血管内皮生长因子(VEGF)表达和微血管密度(microvessel density,MVd)的影响,以探索其对人胃癌新生血管形成的作用。方法:建立移植型人胃癌MGC803实体瘤模型后,予模型对照及新加良附方大、中、... 详细信息

目的:观察新加良附方对人胃癌裸小鼠移植瘤血管内皮生长因子(VEGF)表达和微血管密度(microvessel density,MVd)的影响,以探索其对人胃癌新生血管形成的作用。方法:建立移植型人胃癌MGC803实体瘤模型后,予模型对照及新加良附方大、中、小剂量4种处理并分组,分别取4组肿瘤组织,以免疫组化染色法检测肿瘤组织VEGF表达和以Cd31为血管内皮标记的MVd。结果:与模型组比较,新加良附大、中剂量组有抑制MVd的作用,三者MVd值分别为68 880.66±35 846.10,37 386.44±20 175.69和40 531.48±20 817.34,后两者较前者有统计学意义(P<0.05)。且与模型组相比,新加良附大、中剂量组能够下调VEGF表达,其值分别为16 227.80±7 620.67,4 453.73±1 717.25和5 566.35±3 686.67,其差异有统计学意义(P<0.01)。结论:新加良附方能够抑制人胃癌新生血管形成。新加良附方抑制胃癌的作用可能与抑制胃癌新生血管形成有关。

关键词：新加良附方胃癌血管内皮生长因子微血管密度实验研究

流式细胞学在非霍奇金淋巴瘤诊断中的应用专家共识

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中华病理学杂志 2017年第4期46卷 217-222页

作者：王慧君吴雨翁香琴徐卫邱录贵李建勇周剑锋中国医学科学院血液病医院病理中心南京医科大学第一附属医院血液科上海交通大学附属瑞金医院血液学研究所中国医学科学院血液病医院淋巴肿瘤中心南京医科大学第一附属医院血液科 210029 华中科技大学同济医学院附属同济医院血液科 430030

淋巴瘤是临床上诊断难度较大的一类疾病，需要综合血液病理学（包括组织和细胞形态学、免疫表型、遗传学和分子生物学）与临床特征才能做出精确诊断。

关键词：非霍奇金淋巴瘤流式细胞学诊断专家应用临床特征细胞形态学血液病理学

The expression of human mutant dHFR gene in murine bone marrow and long-term protection of murine hemacytogenesic function from lethal doses of MTX

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中国实验血液学杂志 1997年第3期5卷 329-330页

作者： Wen-Qing Zhang, Guang-Wei Xu, Zuo-Liang Xu Beijing Instiiute for Cancer Research, School of oncology, Beijing Medical university, Beijing100034

Chemotherapy is one of the curative treatmentmodality for several types of tumors. However, thedosage of antitumor drugs was limited by cytotoxicityof drugs to normal tissues, especially for bone marrow(myelosuppression). drug resistantce gene (hMdRI,hdHFR etc.) is expressed in many normal tissues. Itsover-expression in tumor cells give rise to the tumorresistant to many drugs. But, if we transfer the drugresistance gene into the normal hematopoietic stemcell (HSC), the expression of the foreign gene

关键词： lethal curative antitumor doses hematopoietic mutant murine mucosa cytotoxicity markedly