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Influence of quenching medium on the dendrite morphology,hardness,and tribological behaviour of cast Cu-Ni-sn spinodal alloy for defence application

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Defence Technology（防务技术） 2023年第12期30卷 83-100页

作者： Bipin sankar Karthik V shankar Vamu sunil hemanth kashyap s Nikhil Nair Adarsh A.Nair Abhinav P M Department of Mechanical Engineering Amrita Vishwa VidyapeethamAmritapuriIndia

Cu-Ni-sn spinodal alloys(spinodal bronze)are potential materials with robust applications in components associated with defence applications like bearings,propellers,bushes,and shafts of heavily loaded aircraft,off-road vehicles,and *** paper presents a comparative study using water,Brine solution,and sAE 40 oil as the quenching media in regular bronze(Cu-6sn)and spinodal bronze(Cu-9Ni-6sn)*** analysis was conducted by optical microscopy,transmission electron microscopy(TEM),and X-ray diffraction technique(XRD)on bronze and spinodal bronze samples immersed in the three different quenching media to understand the grain size and hardness values *** analysis was performed to analyze the effect of quenching media on the wear aspects of bronze and spinodal bronze *** hardness value of the brine-aged spinodal bronze samples was as high as 320 Hv,and the grain size was very low in the range of 60μm.A quantitative comparison between brine-aged regular bronze and brine-aged spinodal bronze showed that the hardness(Hv)was almost 80%higher for brine-aged spinodal ***,the grain size was approximately 30%finer for spinodal bronze when compared with regular *** the load was increased in spinodal bronze samples,there was an initial dip in wear rate followed by a marginal *** was a steady increase in friction coefficient with a rise in load for brine-aged regular bronze and spinodal bronze *** results indicate that brine solution is the most effective quenching medium for cast Cu-Ni-sn spinodal alloys.

关键词： Quenching Water Brine sAE 40 oil Grain size Hardness Wear rate spinodal decomposition Cusn spinodal alloy CuNisn

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Bioinspired nanomaterials for wearable sensing and human–machine interfacing

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Nano Research 2024年第2期17卷 445-461页

作者： Vishesh kashyap Junyi Yin Xiao Xiao Jun Chen Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA

The inculcation of bioinspiration in sensing and human–machine interface(HMI)technologies can lead to distinctive characteristics such as conformability,low power consumption,high sensitivity,and unique properties like self-healing,self-cleaning,and *** sensing and HMI are fields rife with opportunities for the application of bioinspired nanomaterials,particularly when it comes to wearable sensory systems where biocompatibility is an additional *** review discusses recent development in bioinspired nanomaterials for wearable sensing and HMIs,with a specific focus on state-of-the-art bioinspired capacitive sensors,piezoresistive sensors,piezoelectric sensors,triboelectric sensors,magnetoelastic sensors,and electrochemical *** also present a comprehensive overview of the challenges that have hindered the scientific advancement in academia and commercialization in the industry.

关键词： bioinspired nanomaterials human–machine interface wearable sensors wearable bioelectronics

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Early antiplatelet therapy used for acute ischemic stroke and intracranial hemorrhage

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World Journal of Clinical Cases 2024年第4期12卷 677-680页

作者： Venkata Buddhavarapu Rahul kashyap salim surani Department of Medicine Banner Baywood Medical CenterMesaAZ 85206United States Department of Research Wellspan HealthYorkPA 17403United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

In this editorial we comment on the article published by Zhang et al in the recent issue of World Journal of Clinical *** evaluate their claims on the benefit of use of Aspirin in the early management of patients with ischemic *** also comment on their contention of using aspirin in the early management of patients with intracranial hemorrhage,a practice not seen in modern *** clinical trials such as the International stroke Trial and the Chinese Acute stroke Trial have shown the benefit of Aspirin use within 48 h of patients with Acute Ischemic *** findings were corroborated in the open-label trial performed by Zhang et al in a smaller sample group of 25 patients where they showed improvement in functional scores at 90 days without an increase in adverse *** such,this intervention is also recommended by the American Heart Association stroke guidelines from *** regard to Intracranial hemorrhage,traditional practice has been to discontinue or avoid antiplatelet therapy in these patient ***,no studies have been done to evaluate this management strategy that is more borne out of the mechanism behind Aspirin’s effect on the coagulation *** et al evaluate the benefits of Aspirin on patients with low-volume intracranial hemorrhage,i.e.,less than 30 mL on computed tomo-graphy imaging,and show no increase in *** caveat of this finding is that all outcomes were pooled into one group for results,and the number of patients was *** more studies with larger patient groups are required,the data from Zhang et al suggests that patients with small-volume intracranial hemorrhages may benefit from Aspirin administration in the acute phase of management.

关键词： Aspirin Ischemic stroke Intracranial hemorrhage CVA Antiplatelet therapy

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Dupuytren’s disease:A review

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Chinese Journal of Plastic and Reconstructive surgery 2024年第3期6卷 142-148页

作者： Malay sarkar Nitin kashyap Irappa Madabhavi Department of Pulmonary Medicine Indira Gandhi Medical CollegeShimla 171001Himachal PradeshIndia Department of Plastic and Reconstructive surgery Atal Institute of Medical SuperspecialitiesShimla 171001Himachal PradeshIndia Department of Medical and Pediatric Oncology and Hematology Jawaharlal Nehru Medical CollegeKLE Academy of Higher Education and ResearchBelagaviKarnataka 590010India

Dupuytren’s disease is a well-known benign fibroproliferative disorder that affects the palmar and digital fasciae of the *** spectrum includes nodule formation,cord formation,and flexion contracture of the digits,which may result in functional *** deformities are often progressive and *** is a cornerstone *** review discusses the epidemiology,pathophysiology,risk factors,clinical manifestations,and management of Dupuytren’s disease.

关键词： Dupuytren’s contracture Dupuytren’s disease Palmar aponeurosis Fasciectomy

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Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： hemanth P.R.Vikram Tegginamath Pramod Kumar Gunjan Kumar Narasimha M.Beeraka Rajashree Deka sheik Mohammed suhail sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur s.Chandan Pramod Kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

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Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

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Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra kashyap Nidhi Varshney Tarun Prakash Verma Ajay Kumar Jain Debi Chatterji Vinod Kumar Amit Mishra Awanish Kumar Hem Chandra Jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(***)is the strongest known risk factor for gastric cancer(GC).*** is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that *** infection can induce oncogenic properties in AGs cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

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Dupuytren's disease: A review

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Chinese Journal of Plastic and Reconstructive surgery 2024年第3期 142-148页

作者： Malay sarkar Nitin kashyap Irappa Madabhavi Department of Pulmonary Medicine Indira Gandhi Medical College Department of Plastic and Reconstructive surgery Atal Institute of Medical Superspecialities Department of Medical and Pediatric Oncology and Hematology Jawaharlal Nehru Medical College KLE Academy of Higher Education and Research

Dupuytren's disease is a well-known benign fibroproliferative disorder that affects the palmar and digital fasciae of the hands. This spectrum includes nodule formation, cord formation, and flexion contracture of the digits,which may result in functional limitations. These deformities are often progressive and irreversible. surgery is a cornerstone therapy. This review discusses the epidemiology, pathophysiology, risk factors, clinical manifestations, and management of Dupuytren's disease.

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Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

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Journal of Pharmaceutical Analysis 2024年第6期14卷 934-936页

Original statement in the section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning

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Influence of quenching medium on the dendrite morphology,hardness, and tribological behaviour of cast Cu-Ni-sn spinodal alloy for defence application

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Defence technology 2023年第12期

作者： Bipin sankar Karthik V shankar Vamu sunil hemanth kashyap s Nikhil Nair Adarsh A.Nair Abhinav P M

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An Effective Density Based Approach to Detect Complex Data Clusters Using Notion of Neighborhood Difference

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International Journal of Automation and computing 2017年第1期14卷 57-67页

作者： s. Nagaraju Manish kashyap Mahua Bhattachraya Visual Information Processing Lab Indian Institute of Information Technology and Management Gwalior India

The density based notion for clustering approach is used widely due to its easy implementation and ability to detect arbitrary shaped clusters in the presence of noisy data points without requiring prior knowledge of the number of clusters to be identified. Density-based spatial clustering of applications with noise （DBsCAN） is the first algorithm proposed in the literature that uses density based notion for cluster detection. since most of the real data set, today contains feature space of adjacent nested clusters, clearly DBsCAN is not suitable to detect variable adjacent density clusters due to the use of global density parameter neighborhood radius Y,.ad and minimum number of points in neighborhood Np~,. so the efficiency of DBsCAN depends on these initial parameter settings, for DBsCAN to work properly, the neighborhood radius must be less than the distance between two clusters otherwise algorithm merges two clusters and detects them as a single cluster. Through this paper： 1） We have proposed improved version of DBsCAN algorithm to detect clusters of varying density adjacent clusters by using the concept of neighborhood difference and using the notion of density based approach without introducing much additional computational complexity to original DBsCAN algorithm. 2） We validated our experimental results using one of our authors recently proposed space density indexing （sDI） internal cluster measure to demonstrate the quality of proposed clustering method. Also our experimental results suggested that proposed method is effective in detecting variable density adjacent nested clusters.

关键词： Density based clustering neighborhood difference density-based spatial clustering of applications with noise (DBsCAN),space density indexing (sDI) core object.

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