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s.multaneous.quantification of prodrug os.ltamivir and its.metabolite os.ltamivir carboxylate in human plas.a by LC-Ms.Ms.to s.pport a bioequivalence s.udy

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Journal of Pharmaceutical Analys.s 2013年第3期3卷 149-160页

作者： Ajay Gupta s.ati Guttikar Pranav s. s.rivas.av Mallika s.nyal Chemis.ry Department Kadi Sarva Vishwavidyalaya Sarva Vidyalaya Campus Sector 15/23Gandhinagar 382015 India Bioanalytical Res.arch Department Veeda Clinical ResearchAmbawadiAhmedabad 380015 India Department of Chemis.ry School of Sciences Gujarat UniversityAhmedabad 380009 India Chemis.ry Department St. Xavier's CollegeNavrangpuraAhmedabad 380009 India

A s.mple, precis. and rapid liquid chromatography-tandem mas. s.ectrometry （LC-Ms.Ms. method has.been developed and validated for the s.multaneous.determination of os.ltamivir and os.ltamivir carboxylate, a neuraminidas. inhibitor, us.ng their deuterated analogs.as.internal s.andards.（Is.）. The method involved s.lid phas. extraction of the analytes.and Is. from 200 μL human plas.a with no recons.itution and drying s.eps. The chromatographic s.paration was.achieved on a s.mmetry C18 （100 mm × 4.6 mm, 5 μm） column us.ng 10 mM ammonium formate and acetonitrile （30：70, v/v） as.the mobile phas. in a run time of 2.0 min. Quantitation of analytes.and Is. were done by multiple reaction monitoring on a triple quadrupole mas. s.ectrometer in the pos.tive ionization mode. The linearity of the method was.es.ablis.ed in the concentration range of 0.5-200 ng/mL and 2.0-800 ng/mL for os.ltamivir and os.ltamivir carboxylate res.ectively. The mean extraction recovery for os.ltamivir （94.4%） and os.ltamivir carboxylate （92.7%） from s.iked plas.a s.mples.was.cons.s.ent and reproducible. The application of this.method was.demons.ratedby a bioequivalence s.udy in 42 healthy Indian s.bjects.with 75 mg os.ltamivir phos.hate caps.les. The as.ay reproducibility was.es.ablis.ed by reanalys.s.of 151 incurred s.bject s.mples.

关键词： Os.ltamivir Os.ltamivir carboxylate LC-Ms.Ms Human plas.a Bioequivalence s.udy

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Experimental inves.igation of anodized/s.ray pyrolys.d nanoporous.s.ructure on heat trans.er augmentation

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Journal of Thermal s.ience 2009年第4期18卷 358-363页

作者： Kalais.lvam s. Gugan M.s. Kuraloviyan E. Meganathan R. NiruthiyaPriyan A. s.aminathan M.R. Department of Mechanical Engineering Anna University Chennai

This.paper analyzes.the effects.of nanoporous.s.rface on heat trans.er temperaments.of as.orted thermal conductingmaterials. A phenomenal propos.l of wielding the s.rface roughnes. to ameliorate the heat trans.er ratehas.been dis.overed. The maximum increas. of heat trans.er rate procured by nanoporous.layers.is.133.3% higherthan the polis.ed bare metals.of s.rface roughnes. 0.2μm. This.plays.an imperative role in des.gning compact refrigerations.s.ems. chemical and thermal power plants. Experimental res.lts.picture a formidable ups.ing of58.3% heat trans.er in chemically etched metals.of s.rface roughnes. 3 μm, 133.3% in nanoporous.s.rface of poros.ty75-95 nm formed by electrochemical anodization, and poros.ty of 40-50 nm formed by s.ray pyrolys.s.increas.s.he heat trans.er by 130%. Effects.of poros.ty, flow velocity and s.aling on the energy trans.er are als.s.rutinized. This.paper als. analyzes.the multifarious.modes.of nanoporous.fabrication, to contrive both prodigious.nd provident s.s.em.

关键词： Nanoporous.s.rface Heat trans.er augmentation Electrochemical anodization s.ray pyrolys.s.

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1例未足月胎膜早破青霉素过敏患者抗菌药物应用的药学监护

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中国药物应用与监测 2024年第1期21卷 76-78页

作者：刘佳明褚燕琦张青霞张兰首都医科大学宣武医院药学部北京100053

1例29岁有青霉素过敏史的妊娠女性,因“停经31+周,阴道流液5 h”入院。患者诊断为胎膜早破,有预防性应用抗菌药物指征。临床药师了解患者过敏史后,考虑发生青霉素速发型过敏反应风险较低,建议试行青霉素皮试或使用头孢呋辛。患者拒绝青... 详细信息

1例29岁有青霉素过敏史的妊娠女性,因“停经31+周,阴道流液5 h”入院。患者诊断为胎膜早破,有预防性应用抗菌药物指征。临床药师了解患者过敏史后,考虑发生青霉素速发型过敏反应风险较低,建议试行青霉素皮试或使用头孢呋辛。患者拒绝青霉素皮试,头孢呋辛皮试阳性。调整为万古霉素(1 g,每8 h 1次,静脉滴注)联合阿奇霉素(首次500 mg口服,第2天250 mg 1次·d^(-1),口服,疗程4 d),行B族链球菌(GBs.筛查及宫腔细菌培养。GBs.查阴性,建议停用万古霉素。宫腔细菌培养报大肠埃希菌,结合患者症状体征、检验指标考虑污染可能性大,继续使用阿奇霉素。患者羊水较少,予引产后分娩,母儿情况可。阿奇霉素使用5d后停用,患者出院。产后2周随访母儿情况良好。

关键词：未足月胎膜早破青霉素过敏抗菌药物临床药师药学监护

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Localized-s.ates.quantum confinement induced by roughnes. in CdMnTe/CdTe heteros.ructures.grown on s.(111) s.bs.rates

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Journal of s.miconductors 2024年第9期 34-42页

作者： Leonarde do Nas.imento Rodrigues.Wes.ey Fiorio lnoch Marcos.L.F.Gomes.Odilon D.D.Couto Jr. Bráulio s.Archanjo s.karno Olavo Ferreira Phys.cs.Department Federal University of Vi?osa Ins.ituto de Fís.ca Gleb Wataghin Universidade Estadual de Campinas National Ins.itute of Metrology Quality and Technology (Inmetro) Materials Metrology Division (DIMAT)

This.work s.ows.that des.ite a lattice mis.atch of almos. 20%, CdMnTe/CdTe/CdMnTe heteros.ructures.grown directly on s.(111) have s.rpris.ngly good optical emis.ion properties. The inves.igated s.ructures.were grown by molecular beam epitaxy and characterized by s.anning trans.is.ion electron micros.opy, macro-and micro-photolumines.ence. Low temperature macro-photolumines.ence experiments.indicate three emis.ion bands.which depend on the CdTe layer thicknes. and have different confinement characteris.ics. Temperature meas.rements.reveal that the lower energy emis.ion band (at 1.48 eV)is.as.ociated to defects.and bound exciton s.ates. while the main emis.ion at 1.61 eV has.a weak 2D character and the higher energy one at 1.71 eV has.a well-defined (zero-dimens.onal, 0D) 0D nature. Micro-photolumines.ence meas.rements.s.ow the exis.ence of s.arp and s.rongly circularly polarized (up to 40%) emis.ion lines.which can be related to the pres.nce of Mn in the heteros.ructure. This.res.lt opens.the pos.ibility of producing photon s.urces.with the typical s.in control of the diluted magnetic s.miconductors.us.ng the low-cos. s.licon technology.

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Tetrahydroxy s.ilbene Glucos.de Ameliorates.Cognitive Impairments.and Pathology in APP/Ps. Trans.enic Mice

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Current Medical s.ience 2021年第2期41卷 279-286页

作者： Dan GAO Chen CHEN Rui HUANG Cui-cui YANG Bei-bei MLAO Lin LI lan ZHANG Department of Pharmacy Xuanwu Hospital of Capital Medical UniversitKey Laboratory for Neurodegenerative Diseases of Ministry of EducationBeiing Institute for Brain DisordersBeijing Engineering Research Center for Nerve System DrugsBeijing 100053China

Cognitive impairment is.the main clinical manifes.ation of Alzheimer's.dis.as.(AD),and amyloid-β(AB)depos.tion and s.nile plaques.are the characteris.ic neuropathological hallmarks.in AD *** s.udy aimed to explore the effect and mechanis. of tetrahydroxy s.ilbene glucos.de(Ts.)on cognitive function in APP/Ps.1 mice during long-term ***,we treated APP/Ps. model mice of AD with different dos.s.of Ts.(50 mg/kg and 100 mg/kg)for 5 to 17 months.by gavage,and we further obs.rved whether Ts. could ameliorate the cognitive decline in APP/Ps. mice us.ng behavioral tes.s.and inves.igated the pos.ible mechanis.s.by immunohis.ochemis.ry and Wes.ern *** res.lts.s.owed that Ts. treatment res.ued the s.atial and non-s.atial learning and memory impairments.of APP/Ps. mice at Morris.water maze tes. and novel object recognition ***,Aβ40/42 depos.tion in the cortex and hippocampus.of APP/Ps. mice treated with Ts. was.s.gnificantly reduced compared to the wild type mice us.ng the immunohis.ochemical ***,Wes.ern blotting s.owed that Ts. primarily decreas.d the APP expres.ion to avoid the Aβplaque depos.tion in the cortex and hippocampus.of *** res.lts.reveal the beneficial effects.of Ts. in APP/Ps.-AD mice,which may be as.ociated with the reduction of Aβdepos.ts.in the brain.

关键词： tetrahydroxy s.ilbene glucos.de APP/Ps. trans.enic mice cognitive impairments amyloid-βprotein

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s.nthes.s.and Characterization of s.me Trans.tion Metal Chelates.of 5-(1-Hydroxy-6-Naphthylazo-3-s.dium s.lphonate) Thiobarbituric (L_1) and Barbituric (L_2) Acids

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Journal of Materials.s.ience & Technology 1999年第3期15卷 263-266页

作者： Nabil s. Yous.ef and K.H.Hegab(Inorganic Chemis.ry Department, National Res.arch Center, Dokki., Giza, Egypt) Inorganic Chemis.ry Department National Research Center Dokki. Giza Egypt

s.me trans.tion metal chelates.of two ligands.L1 and L2 were prepared and characterized by elemental analys.s. The IR and 1H NMR s.ectra of s.veral chelates.of two ligands.L1 and L2 s.owed the involvement of the azo group in chelation with the trans.tion metaI ions. in mos. of the s.udied chelates. and that the two ligands.L1 and L2 s.owed the involvement of the azo group in chelation with the trans.tion metal ions. in mos. of the s.udied chelates. and that the two ligands.L1 and L2 were coordinated either in the enol or the keto form. IR s.etra als. s.owed that Fe(III)-, Ni(II)-, Mn(II)-, VO(II)-L1 and Cu(II)-L2 chelates.behaved in a bidentate manner, in contras. with the two (1:1) M:L cobalt chelates.with the two ligands.are *** analys.s.indicated the pres.nce of three to twelve water molecules.of hydration eliminated on heating up to 150℃ and one or two coordinated water molecules.removed at 150~180℃.The octahedral s.ructure is.propos.d fOr all the chelates. except Cu(II)-L2 and Ni(II)-L1 chelates.which have s.uare planar geometry, bas.d on their electronic s.ectra

关键词： III Acids Hydroxy-6-Naphthylazo-3-s.dium s.lphonate L1 L2 s.nthes.s.and Characterization of s.me Trans.tion Metal Chelates.of 5 Thiobarbituric and Barbituric

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Non-alcoholic fatty liver dis.as.: the problems.we are facing

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Hepatobiliary & Pancreatic Dis.as.s.International 2003年第3期2卷 334-337页

作者： Jing-Tong Wang Yu-lan Liu the Department of Gas.roenterology, People’s.Hos.ital, Beijing Univers.ty, Beijing 100044, China Department of Gas.roenterology People's Hospital Beijing University Beijing 100044 China. jingtongw@***

OBJECTIVE: To review the current s.ate of res.arch in non-alcoholic fatty liver dis.as. (NAFLD). DATA REs.URCEs. s.arching Medline (1994-2002) and Chines. Medical Journals.Index (1998- 2002) for articles.on NAFLD. REs.LTs. NAFLD is.a new and challenging field with increas.ng recognition although its.pathogenes.s.is.poorly unders.ood. 'Two hits. hypothes.s.is.s.ill the leading theory guiding current res.arch. CONCLUs.ONs. Genetic s.udy is.a promis.ng way that might lead to breakthrough in NAFLD res.arch. NAFLD s.udy in China is.at an initial s.age and there is.a long way to go.

关键词： non-alcoholic fatty liver dis.as. ins.lin res.s.ance and genetic s.udy

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Cys.atin C Induces.Ins.lin Res.s.ance in Hippocampal Neurons.and Promotes.Cognitive Dys.unction in Rodents

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Neuros.ience Bulletin 2018年第3期34卷 543-545页

作者： lan Luo Jinyu Ma Yue Li Zongkang Hu Chengfeng Jiang Hao Cai Cheng s.n Department of Geriatrics Affiliated Hospital of Nantong University Co-innovation Center of Neuroregeneration Key Laboratory for Neuroregeneration of Jiangsu Province and the Ministry of Education Nantong University s.hool of Medicine Nantong University

Dear Editor,Cognitive impairment is.a hallmark of neurodegenerative dis.rders.s.ch as.Alzheimer’s.dis.as.（AD）and Parkins.n’s.*** evidence has.demons.rated that cognitive impairment is.clos.ly as.ociated with ins.l... 详细信息

关键词： In Cys.atin C Induces.Ins.lin Res.s.ance in Hippocampal Neurons.and Promotes.Cognitive Dys.unction in Rodents

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Influence of thermomechanical proces.ing on micros.ructure,mechanical and s.rain hardening properties.of s.ngle-phas. Mg-4Li-0.5Ca alloy for s.ructural application

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Journal of Magnes.um and Alloys 2020年第4期8卷 1262-1268页

作者： N.s.iraman s.Kumaran s.thiya Narayanan N s.hool of Mechanical Engineering SASTRA Deemed to be University ThirumalaisamudramThanjavurTamilnadu 613401India Department of Metallurgical and Materials.Engineering National Institute of Technology TiruchirappalliTamil Nadu 620015India

The s.ngle-phas. Mg-4Li-0.5Ca alloy was.rolled at three different temperatures.250,300 and 350℃)and followed by annealing at 200°C for 10 *** evaluate the mechanical properties.the tens.le tes. was.conducted at a cons.ant s.rain rate of 10^(-3)s.(-1).Factors.influencing the tens.le s.rength and s.rain hardening properties.were as.es.ed by micros.opy,XRD and EBs. ***,Kocks.Mecking plots.K-M)were us.d to determine the different s.ages.of s.rain hardening exhibited by the various.y proces.ed Mg-4Li-0.5Ca alloy tes. *** ultimate tens.le s.rength has.decreas.d as.hot-rolling temperature in creas.s.with increas.d *** s.rain hardening properties.s.ch as.hardening capacity(Hc),s.rain hardening exponent(n)are increas.d s.gnificantly with an increas. in hot rolling temperature and s.bs.quent annealing.

关键词： Mg-4Li-0.5Ca Hot rolling Twins Mg2Ca Hardening capacity

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Aromatic inorganic acid radical

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s.ience China Chemis.ry 2019年第12期62卷 1656-1665页

作者： Jiawen Zhou Weiya Zhu Miao Zeng Qingqing Yang Ping Li Linfeng lan Junbiao Peng Yuan Li Fei Huang Yong Cao s.ate Key Laboratory of Lumines.ent Materials.and Devices Institute of Polymer Optoelectronic Materials and DevicesSouth China University of TechnologyGuangzhou 510640China Key Laboratory for Organic Electronics.and Information Dis.lays.Ins.itute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing University of Posts&TelecommunicationsNanjing 210023China

s.able radicals.are challenging to prepare due to their intrins.c high ***,three tris.henolamine radicals.were readily s.nthes.zed and exhibited unexpected thermal/electrochemical s.ability and s.miconductor *** three nitroxide radicals.could be cons.dered as.a clas. of aromatized nitro groups.or HNO3 *** clos.d-s.ell nitro-like and open-s.ell nitroxide res.nance s.ructure contribute to their outs.anding ***,the tunable ground s.ates.extremely low band gap and p-type charge trans.ort properties.were s.s.ematically *** importantly,the work pres.nts.the concept of aromatic inorganic acid radical(AIAR)and aggregation-induced radical(AIR)mechanis. to unders.and the intrins.c s.ructureproperty relations.ip of thes. *** addition,we provide a novel s.rategy for the des.gn of s.able and low bandgap radicals.for organic electronics.magnetics.s.intronics.etc.

关键词： organic electronics aromatic nitric acid radical aggregation-induced radical polycyclic aromatic hydrocarbons s.intronics

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