Tetrahydroxy Stilbene Glucoside Ameliorates Cognitive Impairments and Pathology in APP/PS1 Transgenic Mice
作者机构：Department of PharmacyXuanwu Hospital of Capital Medical UniversitKey Laboratory for Neurodegenerative Diseases of Ministry of EducationBeiing Institute for Brain DisordersBeijing Engineering Research Center for Nerve System DrugsBeijing 100053China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2021年第41卷第2期
页 面：279-286页
核心收录：
基 金：supported by grants from the National Natural Science Foundation of China(No.81803537) the"Major New Drug Creation"of Major Science and Technology Project(No.2015ZX09101-016) Capital Science and Technology Leading Talent Training Project(No.Z191100006119017) Beijing Hospitals Authority Ascent Plan(No.DFL20190803)
主 题：tetrahydroxy stilbene glucoside APP/PS1 transgenic mice cognitive impairments amyloid-βprotein
摘 要：Cognitive impairment is the main clinical manifestation of Alzheimer s disease(AD),and amyloid-β(AB)deposition and senile plaques are the characteristic neuropathological hallmarks in AD *** study aimed to explore the effect and mechanism of tetrahydroxy stilbene glucoside(TSG)on cognitive function in APP/PS 1 mice during long-term ***,we treated APP/PS1 model mice of AD with different doses of TSG(50 mg/kg and 100 mg/kg)for 5 to 17 months by gavage,and we further observed whether TSG could ameliorate the cognitive decline in APP/PS1 mice using behavioral tests,and investigated the possible mechanisms by immunohistochemistry and Western *** results showed that TSG treatment rescued the spatial and non-spatial learning and memory impairments of APP/PS1 mice at Morris water maze test and novel object recognition ***,Aβ40/42 deposition in the cortex and hippocampus of APP/PS1 mice treated with TSG was significantly reduced compared to the wild type mice using the immunohistochemical ***,Western blotting showed that TSG primarily decreased the APP expression to avoid the Aβplaque deposition in the cortex and hippocampus of *** results reveal the beneficial effects of TSG in APP/PSI-AD mice,which may be associated with the reduction of Aβdeposits in the brain.
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