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Frontiers of Medicine 2018年第5期12卷 580-585页

作者： Wei Wang Shuqin Jiang Zhirui Cui Xiangyang Luo Lingli Shi heli zheng Pediatric Endocrinology Clinic Third Affiliated Hospital of Zhengzhou University Zhengzhou 450000 China Third Affiliated Hospital ofzhengzhou University Zhengzhou 450000 China

This study aimed to evaluate the effects of thyroid hormone supplementation on growth rate of children with idiopathic short stature (ISS) and low-normal serum free thyroxine FT4 who were receiving growth hormone therapy. We selected 64 prepubertal children with FT4 levels in the lowest third of the normal range as the lower FT4 group, and these children were divided randomly into two subgroups: L-thyroxine (L-T4)-treated subgroup was treated with L-T4 (0.5-3.0 g/(kg·d)) from the beginning of the study, and the non-L-T4-treated subgroup received placebo. We also selected 39 ISS children with FT4 in the upper two-thirds of the normal range as the higher FT4 group. During the first year, the lower FT4 group featured lower FT3, FT4, thyroid stimulating hormone (TSH), and insulin-like growth factor-I standard deviation score (IGF-I SDS) and significantly lower height velocity (HV) compared with the higher FT4 group. However, in the lower FT4 group, the L-T4-treated subgroup presented higher FT4, FT3, TSH, and IGF-I SDS concentrations and significantly higher HV compared with children in the non-L-T4-treated subgroup. In children with ISS, the negative effect of thyroid hormone deficiency on growth rate should be considered when FT4 level lies in the low-normal range prior to recombinant human growth hormone treatment.

关键词： free T4 idiopathic short-stature children recombinant human growth hormone the first year therapeutic

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尖锐湿疣短期局部治疗效果观察

中国性科学 2006年第12期15卷 20-22页

作者：张合立北京市通州区潞河医院皮肤性病科北京101100

尖锐湿疣是性病门诊常见的疾病,患者常有不洁性行为,当他们发现或被告知患有此种性病之后,多数人都具有惊恐和焦虑的心情,常常要求大夫在短时间根除疾病恢复健康.本文就56例门诊尖锐湿疣患者的短期局部治疗效果做一总结.

关键词：尖锐湿疣治疗效果不洁性行为疾病门诊

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食品添加剂技术实际应用中存在的问题

现代食品 2016年第11期1卷 18-19页

作者：罗琳郑鹤立广东省汕头市质量计量监督检测所广东汕头515041 西陇化工股份有限公司广东汕头515041

本文从食品添加剂技术的标准混乱、性能安全和违法滥用等3个角度来阐述食品添加剂在实际运用过程中存在的问题。

关键词：食品添加剂应用问题

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加氢裂化装置提高轻油收率方案的探讨

齐鲁石油化工 2016年第4期44卷 326-330页

作者：朱赫礼王尧郑卫清苏适中国石油锦西石化分公司辽宁葫芦岛125001

对国内加氢裂化装置提高石脑油收率的方案进行分析和探讨。结果表明：通过提高反应温度和降低空速，轻重石脑油总收率可以提高13．02个百分点；通过掺炼催化裂化柴油，轻重石脑油收率可增加0．96～4．24个百分点；通过提高尾油循环量可... 详细信息

对国内加氢裂化装置提高石脑油收率的方案进行分析和探讨。结果表明：通过提高反应温度和降低空速，轻重石脑油总收率可以提高13．02个百分点；通过掺炼催化裂化柴油，轻重石脑油收率可增加0．96～4．24个百分点；通过提高尾油循环量可以大幅度提高轻重石脑油收率，轻重石脑油收率最高可达60．78％，比原生产方案高37．59个百分点；通过提高石脑油于点也可以提高石脑油的收率，这些措施为寻求提高石脑油收率的同类装置提供了一定的借鉴和参考。

关键词：加氢裂化探讨柴油石脑油

丙戊酸钠联合鼠神经生长因子治疗难治性癫痫的效果评价

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右江医学 2024年第7期52卷 629-633页

作者：王静郑贺丽王沾管刘娟河南省周口市妇幼保健院小儿神经内科河南周口466000

目的研究丙戊酸钠联合鼠神经生长因子治疗难治性癫痫的效果。方法选择2021年1月至2022年6月收治的60例难治性癫痫患儿为研究对象,根据随机数字表分为对照组、联合组,各30例。对照组采用丙戊酸钠口服液治疗,联合组采用丙戊酸钠口服液联... 详细信息

目的研究丙戊酸钠联合鼠神经生长因子治疗难治性癫痫的效果。方法选择2021年1月至2022年6月收治的60例难治性癫痫患儿为研究对象,根据随机数字表分为对照组、联合组,各30例。对照组采用丙戊酸钠口服液治疗,联合组采用丙戊酸钠口服液联合鼠神经生长因子治疗。比较两组临床疗效、治疗前、治疗8周后、治疗16周后癫痫发作频次、认知功能(定向力、计算力、语言能力、记忆力)、血清胶质纤维酸性蛋白(GFAP)、神经元特异性烯醇化酶(NSE)、α-突触核蛋白(α-syn)、热休克蛋白70(HSP70)水平、不良反应发生率。结果联合组临床总有效率为93.33%,对照组临床总有效率为70.00%,两组比较差异有统计学意义(P0.05)。结论采用丙戊酸钠口服液联合鼠神经生长因子治疗难治性癫痫患儿临床疗效更高,可显著缓解癫痫发作及神经功能损伤,提高认知功能,安全性较好。

关键词：丙戊酸钠鼠神经生长因子难治性癫痫 α-突触核蛋白热休克蛋白70

重组人生长激素干预对特发性矮小患儿颅面部生长发育的影响

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中华实用儿科临床杂志 2019年第10期34卷 785-787页

作者：郑贺丽王伟姜书琴罗向阳王之祥肖雅闫大芸郑州大学第三附属医院儿科 450000 郑州大学第三附属医院医学影像科 450000

目的探讨重组人生长激素(rhGH)干预对特发性矮小(ISS)患儿颅面部生长发育的影响。方法选取2016年12月至2017年12月在郑州大学第三附属医院儿童内分泌科诊断并经rhGH规范干预1年的青春期前22例患儿(ISS组),与同年龄、性别,面型端正,侧貌... 详细信息

目的探讨重组人生长激素(rhGH)干预对特发性矮小(ISS)患儿颅面部生长发育的影响。方法选取2016年12月至2017年12月在郑州大学第三附属医院儿童内分泌科诊断并经rhGH规范干预1年的青春期前22例患儿(ISS组),与同年龄、性别,面型端正,侧貌基本协调,面型无明显前突和后缩,未接受过正畸治疗的健康青春期前儿童20例作为健康对照组。在rhGH干预前、干预(或随访)1年后,均行头颅螺旋CT扫描,由工作站进行颅面骨三维重建,使用三维测量软件对颅面骨三维影像各项线性及角度指标进行测量,通过t检验分析各项指标变化。结果***干预前,与健康对照组比较,ISS女童及男童呈骨性Ⅱ类面型倾向(上下牙槽座点与N点夹角:5.19°±0.46°比3.16°±0.25°,3.77°±0.18°比3.02±0.13°),差异均有统计学意义(t=12.390、10.442,均P<0.05)。***干预1年后,ISS女童前下面高及前面高均大于健康对照组[(66.60±1.07) mm比(64.51±1.61) mm,(124.06±1.31) mm比(119.52±2.42) mm],差异均有统计学意义(t=3.412、5.215,均P<0.05)。***干预1年后,ISS男童前下面高大于健康对照组[(68.31±1.34) mm比(66.67±1.75) mm],差异有统计学意义(t=2.372,P<0.05)。结论rhGH短期内治疗可促进患儿颅面部骨骼生长发育,轻微改善患儿面部轮廓,且未发现不对称生长迹象。

关键词：颅面骨生长激素特发性矮小面部轮廓

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中空纤维膜组件壳体流体分布与阻力研究

膜科学与技术 2018年第3期38卷 25-33页

作者：庄黎伟许振良魏永明杨虎马晓华汤初阳李金荣宋振郑安丽郑鹤立西陇科学股份有限公司汕头515000 化学工程国家重点实验室华东理工大学膜科学与工程研发中心上海200237

采用计算流体力学(CFD)和辅助实验的方法,在操作流量范围内(4.62~20m^3/h),研究了中空纤维膜组件壳体的流动分布和各部件阻力.研究结果显示:壳体各部件的阻力随着体积流量的增大而增大,且增速均不断提高;顶部胶水层的阻力曲线较其他部件... 详细信息

采用计算流体力学(CFD)和辅助实验的方法,在操作流量范围内(4.62~20m^3/h),研究了中空纤维膜组件壳体的流动分布和各部件阻力.研究结果显示:壳体各部件的阻力随着体积流量的增大而增大,且增速均不断提高;顶部胶水层的阻力曲线较其他部件,更接近线性.随操作流量的提高,顶部胶水层阻力占总能耗的比例不断下降,而其余部件则相反.整个壳体惯性阻力系数较高,所以在实际操作过程中,高流量运行会降低总能耗分配于过滤推动力的比例.底部分布器造成不均匀的初始流动分布,但分布的均匀性会随着高度的增大而变好.在组件正常操作流量范围,壳体内速度分布仅与几何结构有关,与操作流量无关.

关键词：中空纤维膜组件 CFD 流体分布阻力

Numerical simulation method of surge experiments on gas turbine engines

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Chinese Journal of Aeronautics 2023年第3期36卷 107-120页

作者： Xinqian zheng Hanxuan ZENG Baotong WANG Mengyang WEN heli YANG Zhenzhong SUN School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China Institute for Aero Engine Tsinghua UniversityBeijing 100084China

In order to obtain the surge margin of an aero-engine during its operation,an engine surge experiment is required.A multi-dimensional simulation method for an aero-engine is established in this *** simulation of a surge experiment using high-pressure air-injection is then carried out on a turbo-shaft engine to obtain the surge boundary using this *** specifically,firstly,a body-force model is employed to calculate the compressor performance owing to its capability of capturing the main three-dimensional features of compressor surge and avoiding excessive simulation time required by the traditional fully-three-dimensional Reynolds Averaged Navier-Stokes(RANS)***,a one-dimensional model combining a lumped-parameter plenum model is used for the combustor to account for the propagation of pressure waves and the heat-release process,and a zero-dimensional throttle model is used to mimic the choking effect at the turbine ***,the air-injection system is modeled by imposing an injection boundary condition,which can be used conveniently in changing injection *** on the established method,the influences of different test parameters,such as the air-injection location,the pressure,the orifice size,the number of injection orifices,and the injection time duration on the surge characteristics and boundary are further studied,which offer effective guidance to optimize an actual experimental design.

关键词： Air-injection Body-force model Gas turbine engine Numerical method Surge experiment

Compressor geometric uncertainty quantification under conditions from near choke to near stall

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Chinese Journal of Aeronautics 2023年第3期36卷 16-29页

作者： Junying WANG Baotong WANG heli YANG Zhenzhong SUN Kai ZHOU Xinqian zheng State Key Laboratory of Automotive Safety and Energy School of Vehicle and MobilityTsinghua UniversityBeijing 100084China Department of Aerodynamics and Thermodynamics Institute for Aero EngineTsinghua UniversityBeijing 100084China

Geometric and working condition uncertainties are inevitable in a compressor,deviating the compressor performance from the design ***’s necessary to explore the influence of geometric uncertainty on performance deviation under different working *** this paper,the geometric uncertainty influences at near stall,peak efficiency,and near choke conditions under design speed and low speed are ***,manufacturing geometric uncertainties are ***,correlation models between geometry and performance under different working conditions are constructed based on a neural *** the Shapley additive explanations(SHAP)method is introduced to explain the output of the neural *** show that under real manufacturing uncertainty,the efficiency deviation range is small under the near stall and peak efficiency ***,under the near choke conditions,efficiency is highly sensitive to flow capacity changes caused by geometric uncertainty,leading to a significant increase in the efficiency deviation amplitude,up to a magnitude of-3.6%.Moreover,the tip leading-edge radius and tip thickness are two main factors affecting efficiency ***,to reduce efficiency uncertainty,a compressor should be avoided working near the choke condition,and the tolerances of the tip leading-edge radius and tip thickness should be strictly controlled.

关键词： Compressor Geometric uncertainty quantification Interpretable machine learning Multiple conditions Neural network

Response of Tomato Sugar and Acid Metabolism and Fruit Quality under Different High Temperature and Relative Humidity Conditions

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Phyton-International Journal of Experimental Botany 2022年第9期91卷 2033-2054页

作者： Yanjiao zheng Zaiqiang Yang Tingting Wei heli Zhao Jiangsu Provincial Key Laboratory of Agrometeorology Nanjing University of Information Science and TechnologyNanjing210044China Binjiang College Nanjing University of Information Science and TechnologyWuxi214063China

The combined stress of high temperature and high relative air humidity is one of the most serious agrometeorological disasters that restricts the production capacity of protected ***,there is little information about the precise interaction between them on tomato fruit *** objectives of this study were to explore the effects of the combined stress of high temperature and relative humidity on the sugar and acid metabolism and fruit quality of tomato fruits,and to determine the best relative air humidity for fruit quality under high temperature *** temperature treatments(32℃,35℃,38℃,41℃),three relative air humidity(50%,70%,90%)and four duration(3,6,9,12 d)orthogonal experiments were conducted,with 28℃,50%as *** results showed that under high temperature and relative air humidity,the activity of sucrose metabolizing enzymes in young tomato fruits changed,which reduced fruits soluble sugar content;in addition,enzyme activities involved phosphopyruvate carboxylase(PEPC),mitochondria aconitase(MDH)and citrate synthetase(CS)increased which increased the content of organic acids(especially malic acid).Eventually,vitamin C,total sugar and sugar-acid ratio decreased significantly,while the titratable acid increased,resulting in a decrease in fruit flavor quality and nutritional quality in ripe ***,a temperature of 32℃and a relative air humidity of 70%were the best cultivation conditions for tomato reproductive growth period under high *** results indicating that fruit quality reduced under high temperature at the flowering stage,while increasing the relative air humidity to 70%could alleviate this negative *** results are benefit to better understand the interaction between microclimate parameters under specific climatic conditions in the greenhouse environment and their impact on tomato flavor quality.

关键词： Heat stress relative air humidity organic acid metabolism fruit flavor quality tomato