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Molecularly defined adult-type hypolactasia in school-aged children with a previous history of cow's milk allergy

World Journal of Gastroenterology 2006年第14期12卷 2264-2268页

作者： heli rasinper Kristiina Saarinen Anna Pelkonen Irma Jrvel Erkki Savilahti Kaija-Leena Kolho Department of Medical Genetics University of Helsinki Finland Hospital for Children and Adolescents University of Helsinki Finland Department of Allergology Skin and Allergy Hospital Helsinki University Central HospitalHelsinkiFinland Department of Medical Genetics University of Helsinki Finland Laboratory of Molecular GeneticsHelsinki University HospitalHelsinkiFinland

AIM： To assess the role of lactase non-persistence/per- sistence in school-aged children and their milk-related symptoms. METHODS： The genotypes for the C/T-13910 variant associated with lactase non-persistence/ persistence were determined using PCR-minisequencing in a group of 172 children with a mean age of 8.6 years （SE = 0.02, 93 boys） participating in a follow-up study for cow＇s milk allergy. The parents were asked to assess their children＇s milk consumption and abdominal symptoms. RESULTS： The presence of allergy to cow＇s milk was not associated with the C/C-13910 genotype related with a decline of lactase enzyme activity during childhood （lactase non-persistence）. The frequency of the C/C-13910 genotype （16%） was similar to published figures for the prevalence of adult-type hypolactasia in Finland. The majority of the children （90%） in this series consumed milk but 26% of their families suspected that their children had milk-related symptoms. Forty-eight percent of the children with the C/C-13910 genotype did not drink milk at all or consumed a low lactose containing diet prior to the genotyping （P〈 0.004 when compared to the other genotypes）. CONCLUSION： Analysis of the C/T-13910 polymorphism is an easy and reliable method for excluding adult-type hypolactasia in children with milk-related symptoms. Genotyping for this variant can be used to advise diets for children with a previous history of cow＇s milk allergy.

关键词： Adult-type hypolactasia Primary lactose malabsorption Genetic testing Cow's milk allergy

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Molecularly defined adult-type hypolactasia among working age people with reference to milk consumption and gastrointestinal symptoms

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World Journal of Gastroenterology 2007年第8期13卷 1230-1235页

作者： Sari R Anthoni heli a rasinper Antti J Kotamies Hanna A Komu Harri K Pihlajamki Kaija-Leena Kolho Irma E Jrvel Hospital for Children and Adolescents University of Helsinki Finland Department of Medical Genetics University of Helsinki Finland Helsinki Centre of Economic Research Helsinki Finland Central Military Hospital Helsinki Finland Helsinki University Central Hospital Laboratory of Molecular Genetics Helsinki Finland

AIM: To study milk consumption and subjective milk- related symptoms in adults genotyped for adult-type hypolactasia. METHODS: A total of 1900 Finnish adults were genotyped for the C/T-13910 variant of adult-type hypolactasia and filled in a structured questionnaire concerning milk consumption and gastrointestinal problems. RESULTS: The C/C-13910 genotype of adult-type hypolactasia was present in 18% of the study population. The prevalence of the C/C-13910 genotype was higher among subjects who were undergoing investigations because of abdominal symptoms (24%, P < 0.05). Those with the C/C-13910 genotype drank less milk than subjects with either the C/T-13910 or the T/T-13910 genotype of lactase persistence (18% vs 38%; 18% vs 36%, P < 0.01). Subjects with the C/C-13910 genotype had experienced more gastrointestinal symptoms (84%) during the preceding three-month period than those with the C/T-13910 (79%, P < 0.05) or the T/T-13910 genotype (78 %, P < 0.05). Only 9% (29/338) of the subjects with the C/C-13910 genotype consumed milk and reported no symptoms from ***: Gastrointestinal symptoms are more common among adults with the C/C-13910 genotype of adult-type hypolactasia than in those with genotypes of lactase persistence.

关键词： Lactase persistence Lactose malabsorption C/T-13910 genotype Abdominal symptoms Milk consumption

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